The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning
Tóm tắt
Từ khóa
Tài liệu tham khảo
Bruunsgaard, 1999, Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections, J. Infect. Dis., 180, 551, 10.1086/314873
Bruunsgaard, 2003, Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people, Clin. Exp. Immunol., 132, 24, 10.1046/j.1365-2249.2003.02137.x
Bruunsgaard, 2003, Elevated levels of tumor necrosis factor alpha and mortality in centenarians, Am. J. Med., 115, 278, 10.1016/S0002-9343(03)00329-2
Ershler, 2000, Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty, Annu. Rev. Med., 51, 245, 10.1146/annurev.med.51.1.245
Evrin, 2005, Serum C-reactive protein in elderly men and women: association with mortality, morbidity and various biochemical values, Scand. J. Clin. Lab. Invest., 65, 23, 10.1080/00365510510013505
Ferguson, 1995, Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors, J. Gerontol. A Biol. Sci. Med. Sci., 50, B378, 10.1093/gerona/50A.6.B378
Folstein, 1975, Mini-mental state. A practical method for grading the cognitive state of patients for the clinician, J. Psychiatr. Res., 12, 189, 10.1016/0022-3956(75)90026-6
Forsey, 2003, Plasma cytokine profiles in elderly humans, Mech. Ageing Dev., 124, 487, 10.1016/S0047-6374(03)00025-3
Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N.Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x
Fulop, 2005, Dysregulation of T-cell function in the elderly: scientific basis and clinical implications, Drugs Aging, 22, 589, 10.2165/00002512-200522070-00005
Goronzy, 2001, Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals, J. Virol., 75, 12182, 10.1128/JVI.75.24.12182-12187.2001
Hadrup, 2006, Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional CMV specific T cells in the very elderly, J. Immunol., 176, 2645, 10.4049/jimmunol.176.4.2645
Harris, 1999, Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly, Am. J. Med., 106, 506, 10.1016/S0002-9343(99)00066-2
Huppert, 2003, Survival in a population sample is predicted by proportions of lymphocyte subsets, Mech. Ageing Dev., 124, 449, 10.1016/S0047-6374(03)00021-6
Ingenbleek, 2002, Significance of transthyretin in protein metabolism, Clin. Chem. Lab. Med., 40, 1281, 10.1515/CCLM.2002.222
Johansson, B., 1988/89. The MIR-Memory in Reality Test. Psykologiförlaget AB, Stockholm, Sweden.
Khan, 2002, Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals, J. Immunol., 169, 1984, 10.4049/jimmunol.169.4.1984
Khan, 2004, Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection, J. Immunol., 173, 7481, 10.4049/jimmunol.173.12.7481
Klonoff-Cohen, 1992, Albumin levels as a predictor of mortality in the healthy elderly, J. Clin. Epidemiol., 45, 207, 10.1016/0895-4356(92)90080-7
Krabbe, 2004, Inflammatory mediators in the elderly, Exp. Gerontol., 39, 687, 10.1016/j.exger.2004.01.009
Murasko, 1987, Decline in mitogen induced proliferation of lymphocytes with increasing age, Clin. Exp. Immunol., 70, 440
Nilsson, 2003, Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols, Mech. Ageing Dev., 124, 469, 10.1016/S0047-6374(03)00024-1
O’Mahony, 1998, Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production, Clin. Exp. Immunol., 113, 213, 10.1046/j.1365-2249.1998.00641.x
Olsson, 2000, Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study, Mech. Ageing Dev., 121, 187, 10.1016/S0047-6374(00)00210-4
Ouyang, 2003, Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old, J. Clin. Immunol., 23, 247, 10.1023/A:1024580531705
Ouyang, 2004, Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly, Exp. Gerontol., 39, 607, 10.1016/j.exger.2003.11.016
Pawelec, 2005, Human immunosenescence: is it infectious?, Immunol. Rev., 205, 257, 10.1111/j.0105-2896.2005.00271.x
Pedersen, 2003, Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes, Mech. Ageing Dev., 124, 495, 10.1016/S0047-6374(03)00027-7
Reuben, 2002, Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons, J. Am. Geriatr. Soc., 50, 638, 10.1046/j.1532-5415.2002.50157.x
Roberts-Thomson, 1974, Ageing, immune response, and mortality, Lancet, 2, 368, 10.1016/S0140-6736(74)91755-3
Roubenoff, 2003, Catabolism of aging: is it an inflammatory process?, Curr. Opin. Clin. Nutr. Metab. Care, 6, 295, 10.1097/01.mco.0000068965.34812.62
Sala, 2003, Peripheral cytokine release in Alzheimer patients: correlation with disease severity, Neurobiol. Aging, 24, 909, 10.1016/S0197-4580(03)00010-1
Saurwein-Teissl, 2002, Lack of antibody production following immunization in old age: association with CD8(+)CD28(−) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines, J. Immunol., 168, 5893, 10.4049/jimmunol.168.11.5893
Steensberg, 2003, IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans, Am. J. Physiol. Endocrinol. Metab., 285, E433, 10.1152/ajpendo.00074.2003
Tarkowski, 2002, Cytokines in dementias, Curr. Drug Targets Inflamm. Allergy, 1, 193, 10.2174/1568010023344670
Trzonkowski, 2003, Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination—an impact of immunosenescence, Vaccine, 21, 3826, 10.1016/S0264-410X(03)00309-8
Wayne, 1990, Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60, J. Gerontol., 45, M45, 10.1093/geronj/45.2.M45
Weijenberg, 1997, Serum albumin, coronary heart disease risk, and mortality in an elderly cohort, Epidemiology, 8, 87, 10.1097/00001648-199701000-00014
Wikby, 1994, Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study, Exp. Gerontol., 29, 531, 10.1016/0531-5565(94)90036-1
Wikby, 1998, Changes in CD8 and CD4 lymphocyte subsets. T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study, Mech. Ageing Dev., 102, 187, 10.1016/S0047-6374(97)00151-6
Wikby, 2002, Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study, Exp. Gerontol., 37, 445, 10.1016/S0531-5565(01)00212-1
Wikby, 2005, An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans, J. Gerontol. A. Biol. Sci. Med. Sci., 60, 556, 10.1093/gerona/60.5.556
Wilson, 2002, Cytokines and cognition—the case for a head-to-toe inflammatory paradigm, J. Am. Geriatr. Soc., 50, 2041, 10.1046/j.1532-5415.2002.50619.x
Volpato, 2001, Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study, Circulation, 103, 947, 10.1161/01.CIR.103.7.947