Effect of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines in humans: A pilot study
Tóm tắt
This study was undertaken to evaluate the effects of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines in humans. Twenty adult healthy subjects were supplemented with 1g/day fish oil concentrate capsules for 2 weeks. Fasting blood samples were taken at baseline and again after 2 week intervention. Fish oil supplementation significantly lowered fasting serum concentrations of total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (P < 0.01). Also high density lipoprotein increased significantly compared with baseline value (P < 0.01). Fish oil did not significantly altere the fasting blood glucose concentration but significantly reduced the serum cytokines (P < 0.001). This study demonstrated that eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) supplementation altered serum lipids, lipoprotein and cytokine concentrations in normal human subjects even at the small dose of 660 mg of EPA plus DHA per day. It appears that EPA plus DHA can be a safe and perhaps beneficial supplement to inflammatory diseases.
Tài liệu tham khảo
Holub DJ, Holub BJ. Omega-3 fatty acids from fish oils and cardiovascular disease. Mol Cell Biochem 2004; 263:217–225.
Zeman, M, Zak A, Vecka M. n-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. J Nutr Biochem 2006; 17:379–384.
Macdonald A. Omega-3 fatty acids as adjunctive therapy in Crohns disease. Gastroenterol Nurs 2006; 29:295–301.
Peet M, Stokes C. Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs 2005; 65:1051–1059.
Salem N, Simopoulos AP, Galli, C, Lagarde M, Knapp HR. Fatty acids and lipids from cell biology to human disease. Lipids 1996; 31:321–326.
Balk EM, Lichtenstein AH, Chung M. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review. Atherosclerosis 2006;189:19–30.
Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006; 83:1505–1519.
Blok WL, Katan MB, Van der Meer JW. Modulation of inflammation and cytokine production by dietary(n-3) fatty acids. J Nutr 1996;126:1515–1533.
Side X, Donald Cohen, Lindah H. Effects of fish oil on cytokines and immune functions of mice with murine AIDS. J Lipid Res 1998;39:1677–1687.
Stark K, Park E, Maines V, Holub B. Effect of a fish-oil concentrate on serum lipids in post-menopausal women receiving and not receiving hormone replacement therapy. Am J Clin Nutr 2000; 72:389–394.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma. Clin Chem 1972; 18:499–502.
Gaziano JM, Hennekens CH, O’Donnell CJ. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation 1977; 96:2520–2525.
Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 1998;81:7–12.
Torres I, Mira L, Ornelas C, Melim A. Study of the effects of dietary fish intake on serum lipids and lipoproteins in two populations with different dietary habits. Br J Nutr 2000; 83:371–379.
Nestel P. Fish oil and cardiovascular disease: lipids and arterial function. Am J Clin Nutr 2000; 71:228–231.
Harris WS. n-3 Fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 1997;65:1645–1654.
Blok W, Katan MB, van der Meer JW. Modulation of inflammation and cytokine production by dietary (n-3) fatty acids. J Nutr 1996; 126:1515–1533.
Ariza Ariza R, Mestanza Peralta M, Cardiel MH. Omega-3 fatty acids in rheumatoid arthritis: an overview. Semin Arthritis Rheum 1998;27:366–370.
Nielsen AA, Jorgensen LG, Nielsen JN, Eivindson M. Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn’s disease compared with omega-6 fatty acids. Aliment Pharmacol Ther 2005;22:1121–1128.
Deckelbaum RJ, Worgall TS, Seo T. n-3 fatty acids and gene expression. Am J Clin Nutr 2006; 83:1520–1525.