Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study

Fox RI, Kang HI. Pathogenesis of Sjogren's syndrome. Rheum Dis Clin North Am 1992;18:517–538 Anaya, 1997, Sjögren's syndrome and connective tissue diseases associated with other immunologic disorders, 1561 Tsubota, 1994, Expression of granzyme A and perforin in lacrimal gland of Sjogren's syndrome, Adv Exp Med Biol, 350, 637, 10.1007/978-1-4615-2417-5_106 Anaya, 1999, Sjögren's syndrome comes of age, Semin Arthritis Rheum, 28, 355, 10.1016/S0049-0172(99)80001-8 Bacman, 1998, Autoantibodies against lacrimal M3 muscarinic acetylcholine receptors in patients with primary Sjögren's syndrome, Invest Ophthalmol Vis Sci, 39, 151 Lemp, 1995, Report of the National Eye Institute/Industry Workshop on clinical trials in dry eyes, CLAO, 21, 221 Shimazaki, 1995, (Dry Eye Research Group, Diagnostic Criteria Committee). [Definition and diagnostic criteria of dry eye], Ophthalmology, 37, 765 Fox, 1999, Current issues in the diagnosis and treatment of Sjögren's syndrome, Curr Opin Rheumatol, 11, 364, 10.1097/00002281-199909000-00007 Shimmura, 1995, Sodium hyaluronate eyedrops in the treatment of dry eyes, Br J Ophthalmol, 79, 1007, 10.1136/bjo.79.11.1007 Tsubota, 1994, Spectacle side panels and moist inserts for the treatment of dry-eye patients, Cornea, 13, 197, 10.1097/00003226-199405000-00001 Lemp, 1992, Diagnosis and treatment of tear deficiency, Clin Ophthalmol, 4, 1 Dohlman, 1978, Punctal occlusion in keratoconjunctivitis sicca, Ophthalmology, 85, 1277, 10.1016/S0161-6420(78)35555-X Tsubota, 1999, Treatment of dry eye by autologus serum application in Sjögren's syndrome, B J Ophthalmol, 83, 390, 10.1136/bjo.83.4.390 Fox, 2000, Sjögren's syndrome, Expert Opin Investig Drugs, 9, 2007, 10.1517/13543784.9.9.2007 Ono, 1995, Sjögren's syndrome and eye, Curr Ther, 13, 2123 Iga, 1998, (±)-cis-2-Methylspiro[1,3-oxathiolane-5,3′-quinuclidine]hydrochloride, hemihydrate (SNI-2011, cevimeline hydrochloride) induces saliva and tear secretions in rats and mice, Jpn J Pharmacol, 78, 373, 10.1254/jjp.78.373 Ichikawa, 2001, A randomized, double-blinded, placebo-controlled clinical study of on SNI-2011 for the treatment of dry mouth in Sjogren's syndrome, Medical Consultation and New Remedies, 38, 349 Vivino, 1999, Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjögren's syndrome, Arch Intern Med, 159, 174, 10.1001/archinte.159.2.174 Petrone, 2002, Double blind, randomized, plasebo-controled study of Cevimeline in Sjogren's syndrome Patients with xerostomia and keratoconjunctivitis sicca, Arthritis Rheum, 46, 748, 10.1002/art.510 Research Committee on Sjögren's Syndrome (Leader: Tadashi Ofuji). Diagnostic criteria of Sjögren's syndrome. Achievements of the Research Committee on Sjögren's Syndrome of the Ministry of Health and Welfare. Tokyo, 1978 Ono, 1998, Evaluation of Schirmer tests by two types of tear clearance tests, Adv Exp Med Biol, 438, 869, 10.1007/978-1-4615-5359-5_122 van Bijsterveld, 1969, Diagnostic tests in the sicca syndrome, Arch Ophthalmol, 82, 10, 10.1001/archopht.1969.00990020012003 Toda, 1993, Practical double vital staining for ocular surface evaluation, Cornea, 12, 366, 10.1097/00003226-199307000-00015 Lemp, 1975, The effect of tear substitutes on tear film break-up time, Invest Ophthalmol, 14, 255 Norn, 1992, Diagnosis of dry eye, 133 Nelson, 1988, Impression Cytology, Cornea, 1, 71 Xu, 1995, Tear function index. A new measure of dry eye, Arch Ophthalmol, 113, 84, 10.1001/archopht.1995.01100010086025 Kurihashi, 1977, A modified Schirmer test, J Pediatr Ophthalmol, 14, 390 Sall, 2000, Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease, CsA Phase 3 Study Group, 107, 631 Shimazaki, 1998, Meibomian gland dysfunction in patients with Sjogren syndrome, Ophthalmology, 105, 1485, 10.1016/S0161-6420(98)98033-2 Dartt, 1994, Regulation of tear secretion, Adv Exp Med Biol, 350, 1, 10.1007/978-1-4615-2417-5_1 Rios JD, Forde K, Diebold Y, Lightman J, Zieske JD, Dartt DA. Development of conjunctival goblet cells and their neuroreceptor subtype expression. Invest Ophthalmol Vis Sci 2000 Jul;41:2127–37 Dartt DA, McCarthy DM, Mercer HJ, Kessler TL, Chung EH, Zieske JD. Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr Eye Res 1995 Nov;14:993–1000 Sullivan, 1999, Androgens and dry eye in Sjögren's syndrome, Ann N Y Acad Sci, 876, 312, 10.1111/j.1749-6632.1999.tb07656.x Ono, 1994 Tsubota, 2001, Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren's syndrome, Lancet, 357, 688, 10.1016/S0140-6736(00)04140-4