Numeric simulation can be used to predict heat transfer during the blanching of leaves and intact plants

Yeum, 2002, Carotinoid bioavailability and bioconversion, Annu. Rev. Nutr., 22, 483, 10.1146/annurev.nutr.22.010402.102834

Saikia, 1997, Evaluation of pulp and paper making characteristics of certain fast growing plants, Wood Sci. Technol., 31, 467, 10.1007/BF00702569

Komis, 2015, Biotechnological aspects of cytoskeletal regulation in plants, Biotechnol. Adv., 10.1016/j.biotechadv.2015.03.008

Yachmenev, 2002, Intensification of the bio-processing of cotton textiles by combined enzyme/ultrasound treatment, J. Chem. Technol. Biotechnol., 77, 559, 10.1002/jctb.579

Krifa, 2006, Compact spinning effect on cotton yarn quality: interactions with fiber characteristics, Text Res. J., 76, 388, 10.1177/0040517506062648

Laibach, 2015, The characteristics and potential applications of structural lipid droplet proteins in plants, J. Biotechnol., 201, 15, 10.1016/j.jbiotec.2014.08.020

Doran-Peterson, 2008, Microbial conversion of sugars from plant biomass to lactic acid or ethanol, Plant J., 54, 582, 10.1111/j.1365-313X.2008.03480.x

Hiatt, 1989, Production of antibodies in transgenic plants, Nature, 342, 76, 10.1038/342076a0

Zimran, 2011, Pivotal trial with plant cell-expressed recombinant glucocerebrosidase taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease, Blood, 118, 5767, 10.1182/blood-2011-07-366955

Buyel, 2015, Process development trategies in plant molecular farming, Curr. Pharm. Biotechnol., 16, 966, 10.2174/138920101611150902115413

Stoger, 2014, Plant molecular pharming for the treatment of chronic and infectious diseases, Annu. Rev. Plant Biol., 65, 743, 10.1146/annurev-arplant-050213-035850

Commandeur, 2003, The biosafety of molecular farming in plants, AgBiotechNet, 5, 1

Schillberg, 2005, Opportunities for recombinant antigen and antibody expression in transgenic plants–technology assessment, Vaccine, 23, 1764, 10.1016/j.vaccine.2004.11.002

Fischer, 2012, GMP issues for recombinant plant-derived pharmaceutical proteins, Biotechnol. Adv., 30, 434, 10.1016/j.biotechadv.2011.08.007

Hassan, 2014, Breakage of transgenic tobacco roots for monoclonal antibody release in an ultra-scale down shearing device, Biotechnol. Bioeng., 111, 196, 10.1002/bit.25006

Buyel, 2014, Scale-down models to optimize a filter train for the downstream purification of recombinant pharmaceutical proteins produced in tobacco leaves, Biotechnol. J., 9, 415, 10.1002/biot.201300369

Buyel, 2015, Extraction and downstream processing of plant-derived recombinant proteins, Biotechnol. Adv., 33, 902, 10.1016/j.biotechadv.2015.04.010

Buyel, 2014, Generic chromatography-based purification strategies accelerate the development of downstream processes for biopharmaceutical proteins produced in plants, Biotechnol. J., 9, 566, 10.1002/biot.201300548

Buyel, 2014, Rational design of a host cell protein heat precipitation step simplifies the subsequent purification of recombinant proteins from tobacco, Biochem. Eng. J., 88, 162, 10.1016/j.bej.2014.04.015

Buyel, 2014, A juice extractor can simplify the downstream processing of plant-derived biopharmaceutical proteins compared to blade-based homogenizers, Process Biochem., 50, 859, 10.1016/j.procbio.2015.02.017

Beiss, 2015, Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein, Biotechnol. Bioeng., 112, 1297, 10.1002/bit.25548

Wilken, 2012, Recovery and purification of plant-made recombinant proteins, Biotechnol. Adv., 30, 419, 10.1016/j.biotechadv.2011.07.020

Welty, 1976

Magerramov, 2007, Heat capacity of natural fruit juices and of their concentrates at temperatures from 10 to 120°C, J. Eng. Phys. Thermophys., 80, 9, 10.1007/s10891-007-0138-1

Lozano, 2006

Voitkevich, 2012, Thermodynamic properties of plant biomass components. heat capacity, combustion energy, and gasification equilibria of lignin, J. Chem. Eng. Data, 57, 1903, 10.1021/je2012814

Blokhin, 2011, Thermodynamic properties of plant biomass components. heat capacity, combustion energy, and gasification equilibria of cellulose, J. Chem. Eng. Data, 56, 3523, 10.1021/je200270t

Bendzko, 1988, Temperature-induced phase transitions in proteins and lipids. Volume and heat capacity effects, Biophys. Chem., 29, 301, 10.1016/0301-4622(88)85052-X

Jayalakshmy, 2010, Thermophysical properties of plant leaves and their influence on the environment temperature, Int. J. Thermophys., 31, 2295, 10.1007/s10765-010-0877-7

Hedlund, 2000, Heat capacity of birch determined by calorimetry: implications for the state of water in plants, Thermochim. Acta, 349, 79, 10.1016/S0040-6031(99)00499-2

Costa, 2013, Thermography to explore plant-environment interactions, J. Exp. Bot., 64, 3937, 10.1093/jxb/ert029

Buyel, 2015, Determination of the thermal properties of leaves by non-invasive contact free laser probing, J. Biotechnol., 217, 100, 10.1016/j.jbiotec.2015.11.008

Smelt, 2014, Thermal inactivation of microorganisms, Crit. Rev. Food Sci. Nutr., 54, 1371, 10.1080/10408398.2011.637645

Ragaee, 2014, The impact of milling and thermal processing on phenolic compounds in cereal grains, Crit. Rev. Food Sci. Nutr., 54, 837, 10.1080/10408398.2011.610906

Kumar, 2009, Methods for pretreatment of lignocellulosic biomass for efficient hydrolysis and biofuel production, Ind. Eng. Chem. Res., 48, 3713, 10.1021/ie801542g

Chaturvedi, 2013, An overview of key pretreatment processes employed for bioconversion of lignocellulosic biomass into biofuels and value added products, 3 Biotech, 3, 415, 10.1007/s13205-013-0167-8

FDA, 2002, Guidance for Industry: Drugs, Biologics, and Medical Devices Derived from Bioengineered Plants for Use in Humans and Animals, 30

Hazewinkel, 1994

Geiser, 2006, Transient numerical study of temperature gradients during sublimation growth of SiC: dependence on apparatus design, J. Cryst. Growth, 297, 20, 10.1016/j.jcrysgro.2006.08.046

Li, 2010, Numerical simulation of thermocapillary convection in a shallow rectangular cavity under the action of combining horizontal temperature gradient with vertical heat flux, Microgr. Sci. Technol., 22, 361, 10.1007/s12217-010-9205-x

Liebermeister, 2005, Biochemical network models simplified by balanced truncation, FEBS J., 272, 4034, 10.1111/j.1742-4658.2005.04780.x

Carnahan, 1969

Towler, 2013

White, 2006

Schwartzberg, 1968, Fluid and particle motion in turbulent stirred tanks – fluid motion, Ind. Eng. Chem. Fund, 7, 1, 10.1021/i160025a001

Haynes, 2012

Kestin, 1978, Viscosity of liquid water in range -8-degrees-C to 150-degrees-C, J. Phys. Chem. Ref. Data, 7, 941, 10.1063/1.555581

Ginzburg, 1980

Ramires, 1994, Thermal-conductivity of aqueous sodium-chloride solutions, J. Chem. Eng. Data, 39, 186, 10.1021/je00013a053

Ramires, 1995, Standard reference data for the thermal-conductivity of water, J. Phys. Chem. Ref. Data, 24, 1377, 10.1063/1.555963

Linacre, 1964, Determinations of the heat transfer coefficient of a leaf, Plant Physiol., 39, 687, 10.1104/pp.39.4.687

Roth-Nebelsick, 2001, Computer-based analysis of steady-state and transient heat transfer of small-sized leaves by free and mixed convection, Plant Cell Environ., 24, 631, 10.1046/j.1365-3040.2001.00712.x

Salvucci, 2001, Exceptional sensitivity of rubisco activase to thermal denaturation in vitro and in vivo, Plant Physiol., 127, 1053, 10.1104/pp.010357

Buyel, 2014, Synthetic polymers are more effective than natural flocculants for the clarification of tobacco leaf extracts, J. Biotechnol., 195, 37, 10.1016/j.jbiotec.2014.12.018

Beghin, 1993, Differential scanning calorimetric studies of the effects of ions and pH on ribulose 1,5-bisphosphate carboxylase/oxygenase, Int. J. Bio. Macromol., 15, 195, 10.1016/0141-8130(93)90037-M

Burova, 1991, Conformational stability of ribulose 1, 5 biphosphate carboxylase from tobacco-leaves according to the differential scanning microcalorimetry, Nahrung-Food, 35, 317, 10.1002/food.19910350311

Bracewell, 2015, The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control, Biotechnol. Bioeng., 112, 1727, 10.1002/bit.25628

Buyel, 2013, The use of quantitative structure-activity relationship models to develop optimized processes for the removal of tobacco host cell proteins during biopharmaceutical production, J. Chromatogr. A, 1322, 18, 10.1016/j.chroma.2013.10.076

Vesala, 1998, On the concept of leaf boundary layer resistance for forced convection, J. Theor. Biol., 194, 91, 10.1006/jtbi.1998.0747

Williams, 2004, Leaf to landscape, 133

Nobel, 2012

Dorai, 2011, Characterization of the proteases involved in the N-terminal clipping of glucagon-like-peptide-1-antibody fusion proteins, Biotechnol. Prog., 27, 220, 10.1002/btpr.537

Gao, 2011, Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity, Biotechnol. Bioeng., 108, 977, 10.1002/bit.22982

Sack, 2015, The increasing value of plant-made proteins, Curr. Opin. Biotechnol., 32, 163, 10.1016/j.copbio.2014.12.008

Rathore, 2009, Roadmap for implementation of quality by design (QbD) for biotechnology products, Trends Biotechnol., 27, 546, 10.1016/j.tibtech.2009.06.006