Synthesis and cytotoxic activity of N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal

Liu, 1992, Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone, J. Med. Chem., 35, 3672, 10.1021/jm00098a012 Mignot, 1980, Thiosemicarbazones d'aldéhydes aromatiques antiinflammatoires: pharmacologie, étude pharmacocinétique préliminaire, action sur le fibroblaste en culture, Eur. J. Med. Chem., 15, 33 Domagk, 1946, Über eine neue, gegen Tuberkelbazillen in vitro wirksame Verbindungsklasse, Naturwissenschaften, 33, 315, 10.1007/BF00624524 Bernstein, 1951, The chemotherapy of experimental tuberculosis. III. The synthesis of thiosemicarbazones and related compounds, J. Am. Chem. Soc., 73, 906, 10.1021/ja01147a007 Teytz, 1994, Inhibition of human immunodeficiency virus by N-methylisatin-beta4′:4′-diethylthiosemicarbazone and N-allylisatin-beta4′:4′-diallythiosemicarbazone, Antiviral Res., 24, 305, 10.1016/0166-3542(94)90077-9 Teytz, 1994, Relationships between structure and antiretroviral activity of thiosemicarbazone derivatives, Chemotherapy, 40, 195, 10.1159/000239192 Hall, 1995, Cytotoxicity of imides-N-alkyl semicarbazones, thiosemicarbazones, acetylhydrazones and related derivatives, Anticancer Drugs, 6, 147, 10.1097/00001813-199502000-00017 Acton, 1979, Improved antitumor effects in 3′-branched homologues of 2′-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose, J. Med. Chem., 22, 518, 10.1021/jm00191a012 Corey, 1979, Useful procedures for the oxidation of alcohols involving pyridinium dichromate in aprotic media, Tetrahedron Lett., 5, 399, 10.1016/S0040-4039(01)93515-4 Eagle, 1955, Propagation in a fluid medium of a human epidermoide carcinoma, strain KB. (21811), 89, 362 Eagle, 1959, Amino acid metabolism in mammalian cell cultures, Science, 130, 432, 10.1126/science.130.3373.432 Geran, 1972, Protocols for screening chemical agents and natural products against animal tumors and other biological systems, Can. Chem. Rep., 3, 1 Oyama, 1956, Measurement of cell growth in tissue culture with a phenol reagent (Folin-ciocalteus), 91, 305