Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Ana P. Gomes1,2, Filipe V. Duarte1, Patricia Nunes1, Basil P. Hubbard2, João S. Teodoro1, Ana T. Varela1, John G. Jones1, David A. Sinclair2, Carlos M. Palmeira1,3, Anabela P. Rolo1,4
1Center for Neurosciences and Cell Biology, Department of Life Sciences, University of Coimbra 3004-517 Coimbra, Portugal
2Harvard Medical School Department of Pathology/Genetics, Paul F. Glen Laboratories for the Biological mechanisms of Aging 77 Ave Louis Pasteur Boston, MA 02115, USA
3Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, 3004-517 Coimbra, Portugal
4Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal

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