Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cells

Adebayo-Tayo, 2008, Antimicrobial activity of Coula edulis, Res. J. Med. Plants, 2, 86, 10.3923/rjmp.2008.86.91 Adepoju, 2011, Effect of consumption of Cucurbita pepo seeds on haematological and biochemical parameters, Afr. J. Pharm. Pharm., 5, 18, 10.5897/AJPP10.186 Adeyemi, 2002, Analgesic and anti-inflammatory effects of the aqueous extract of leaves of Persea americana mill (Lauraceae), Fitoterapia, 73, 375, 10.1016/S0367-326X(02)00118-1 Adham, 2015, Ethnobotanical evaluation of plants used in the traditional treatment of gastrointestinal disease in Erbil-Kurdistan region/Iraq, World J. Pharm. Sci., 3, 1776 Akiyama, 1985, Isolation and genetic characterization of human KB cell lines resistant to multiple drugs, Somat. Cell Mol. Genet., 11, 117, 10.1007/BF01534700 Alnemri, 1996, Human ICE/CED-3 protease nomenclature, Cell, 87, 171, 10.1016/S0092-8674(00)81334-3 Andreu, 2005, Mangiferin, a natural occurring glucosyl xanthone, increases susceptibility of rat liver mitochondria to calcium-induced permeability transition, Arch. Biochem. Biophys., 439, 184, 10.1016/j.abb.2005.05.015 Bass, 1983, Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation, J. Immunol., 130, 1910, 10.4049/jimmunol.130.4.1910 Bhowmik, 2009, Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on non diabetic type-1 and type-2 diabetic model rats. Bangladesh, Bangladesh J. Pharmacol., 4, 110, 10.3329/bjp.v4i2.2488 Bidla, 2004, Antiplasmodial activity of seven plants used in African folk medicine, Indian J. Pharmacol., 36, 245 Biedler, 1994, Reverse transformation of multidrug-resistant cells, Cancer Metastas. Rev., 13, 191, 10.1007/BF00689636 Boik, 2001 Braga, 2014, Antioxydant, antibacterial and antitumor activity of Psidium guajava leaves, Am. J. Plant Sci., 5, 3492, 10.4236/ajps.2014.523365 Burkill, 1985 Carbin, 1990, Treatment of benign prostatic hyperplasia with phytosterols, J. Urol., 66, 639, 10.1111/j.1464-410X.1990.tb07199.x Carvalho, 2002, Atividade antimicrobiana in vitro de extratos hidroalcoólicos Psidium guajava L. Sobre bactérias Gram negativas, Acta Farm Bonaer., 21, 255 Cavalcante, 2013, Antimicrobial activity of Artocarpus heterophyllus L. on the development of Streptococcus pneumoniae and Escherichia coli, Sci. Plena, 9, 1 Chan, 2007, Antioxidant activity of Camellia sinensis leaves and tea from a lowland plantation in Malaysia, Food Chem., 102, 1214, 10.1016/j.foodchem.2006.07.009 Chen, 2010, Action mechanism and signal pathways of Psidium guajava L. aqueous extract in killing prostate cancer LNCaP cells, Nutr. Cancer, 62, 260, 10.1080/01635580903407130 Cordell, 1991, Can ethnopharmacology contribute to development of new anti-cancer?, J. Ethnopharmacol., 32, 117, 10.1016/0378-8741(91)90110-Y Cossarizza, 2009, Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry, Nat. Protoc., 4, 1790, 10.1038/nprot.2009.189 Cousin, 2002, Medicinal properties in the diet of gorillas: an ethno-pharmacological evaluation, Afr. Study Monogr., 23, 65 Cueva, 2017, Antibacterial effects of Uvilla (Physalis peruviana L.) extracts against Listeria spp. isolated from meat in Ecuador, Int. J. Curr. Microbiol. Appl. Sci., 6, 1146, 10.20546/ijcmas.2017.604.141 Debnath, 2012, A survey on pineapple and its medicinal value, Sch. Acad. J. Pharm., 1, 24 Dewi, 2015, In vitro study of Myristica fragrans seed (nutmeg) ethanolic extract and quercetin compound as an anti-inflammatory agent, Int. J. Res. Med. Sci., 3, 2303, 10.18203/2320-6012.ijrms20150621 Dixon, 2012, Ferroptosis: an iron-dependent form of nonapoptotic cell death, Cell, 149, 1060, 10.1016/j.cell.2012.03.042 Dixon, 2014, Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis, Elife, 3, e02523, 10.7554/eLife.02523 Dixon, 2014, The role of iron and reactive oxygen species in cell death, Nat. Chem. Biol., 10, 9, 10.1038/nchembio.1416 Dongmo, 2009, 30 Doyle, 1998, A multidrug resistance transporter from human MCF-7 breast cancer cells, Proc. Natl. Acad. Sci. USA, 95, 15665, 10.1073/pnas.95.26.15665 Duke, J.A., 1983. Arachis hypogaea L. 〈https://www.hort.purdue.edu/newcrop/duke_energy/Arachis_hypogaea.html〉 (Accessed 18 May 2015). Dzotam, 2017, Antibacterial and antibiotic-modifying Activity of methanol extracts from Six Cameroonian food plants against multidrug-resistant enteric bacteria, Biomed. Res. Int., 2017, 1583510, 10.1155/2017/1583510 Dzoyem, 2012, Cytotoxicity and antimicrobial activity of the methanol extract and compounds from Polygonum limbatum, Planta Med., 78, 787, 10.1055/s-0031-1298431 Efferth, 2003, Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines, Naunyn Schmiede. Arch. Pharmacol., 367, 56, 10.1007/s00210-002-0632-0 Efferth, 2003, Molecular modes of action of artesunate in tumor cell lines, Mol. Pharmacol., 64, 382, 10.1124/mol.64.2.382 Efferth, 2017, Multiple resistance to carcinogens and xenobiotics: p-glycoproteins as universal detoxifiers, Arch. Toxicol., 91, 2515, 10.1007/s00204-017-1938-5 El Sohafy, 2009, Quantification of flavonoids of Psidium guajava L. preparations by planar chromatography (HPTLC), Pharmacogn. Mag., 5, 61 Fentrow, 1999 Ferlay, 2015, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int. J. Cancer, 136, E359, 10.1002/ijc.29210 Fulda, 2011, Mitochondria as therapeutic targets for the treatment of malignant disease, Antioxid. Redox Signal., 15, 2937, 10.1089/ars.2011.4078 Geetha, 2013, An overview on Arachis hypogaea plant, Int. J. Pharm. Sci. Res., 4, 4508 Gerwirtz, 2005, Apoptiosis as predominant tumor cell response to chemotherapy and irradiation: a case of TUNEL vision?, Curr. Opin. Investig. Drugs, 6, 1199 Ghasemi, 2009, Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues, Pak. J. Pharm. Sci., 22, 277 Gillet, 2004, Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes, Cancer Res., 64, 8987, 10.1158/0008-5472.CAN-04-1978 Gillet, 2007, Chemotherapy-induced resistance by ATP-binding cassette transporter genes, Biochim. Biophys. Acta, 1775, 237 Guzman-Rodriguez, 2016, The defensin from avocado (Persea americana var. drymifolia) PaDef induces apoptosis in the human breast cancer cell line MCF-7, Biomed. Pharmacother., 82, 620, 10.1016/j.biopha.2016.05.048 Hientz, 2017, The role of p53 in cancer drug resistance and targeted chemotherapy, Oncotarget, 8, 8921, 10.18632/oncotarget.13475 Hossain, 2015, Nutritional value and medicinal benefits of pineapple, Int. J. Nutr. Food Sci., 4, 84, 10.11648/j.ijnfs.20150401.22 Ibegbulem, 2012, Medicinal values of Elaeis guineensis and Raphia hookeri wines, J. Res. Biol., 2, 589 Irvine, 1961 Jacob, 2010, Stability of carotenoids, phenolic compounds, ascorbic acid and antioxidant capacity of tomatoes during thermal processing, Arch. Latinoam. Nutr., 60, 192 Jafarian, 2012, The effects of methanolic, chloroform, and ethylacetate extracts of the Cucurbita pepo L. on the delay type hypersensitivity and antibody production, Res. Pharm. Sci., 7, 217 Jagtap, 2010, Artocarpus: a review of its traditional uses, phytochemistry and pharmacology, J. Ethnopharmacol., 129, 142, 10.1016/j.jep.2010.03.031 Kadioglu, 2016, Genomic and transcriptomic profiling of resistant CEM/ADR-5000 and sensitive CCRF-CEM leukaemia cells for unravelling the full complexity of multi-factorial multidrug resistance, Sci. Rep., 6, 36754, 10.1038/srep36754 Kalpana, 2014, Studies on the antidiabetic activity of Ananas comosus leaves in STZ induced diabetic rats, Pharm. Lett., 6, 190 Karpagam, 2011, Effect of different doses of Cucurbita pepo linn extract as an anti-inflammatory and analgesic nutraceautical agent on inflamed rats, Int. J. Periodontics Restor. Dent., 3, 184 Kartner, 2009, Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein, Cancer Res., 43, 4413 Kimmig, 1990, Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells, Cancer Res., 50, 6793 Kirbaşlar, 2009, Antimicrobial activity of Turkish Citrus peel oils, Pak. J. Bot., 41, 3207 Kuete, 2016, Cytotoxicity of 15 Cameroonian medicinal plants against drug sensitive and multi-drug resistant cancer cells, J. Ethnopharmacol., 186, 196, 10.1016/j.jep.2016.04.001 Kuete, 2015, African flora has the potential to fight multidrug resistance of cancer, BioMed. Res. Int., 2015, 914813, 10.1155/2015/914813 Kuete, 2011, Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts, J. Ethnopharmacol., 134, 803, 10.1016/j.jep.2011.01.035 Kuete, 2011, Cytotoxicity and mode of action of four naturally occurring flavonoids from the genus Dorstenia: gancaonin Q, 4-hydroxylonchocarpin, 6-prenylapigenin, and 6,8-diprenyleriodictyol, Planta Med, 77, 1984, 10.1055/s-0031-1280023 Kuete, 2013, Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat cancers: Echinops giganteus, Xylopia aethiopica, Imperata cylindrica and Piper capense, J. Ethnopharmacol., 149, 245, 10.1016/j.jep.2013.06.029 Kuete, 2014, Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells, Invest. New Drugs, 32, 1053, 10.1007/s10637-014-0137-y Kuete, 2014, Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells, J. Ethnopharmacol., 153, 207, 10.1016/j.jep.2014.02.025 Kuete, 2015, Cytotoxic compounds from the fruits of Uapaca togoensis towards multi-factorial drug-resistant cancer cells, Planta Med, 81, 32 Kuete, 2015, Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells, BMC Complement. Altern. Med., 15, 309, 10.1186/s12906-015-0841-y Lee, 2012, Antioxidant activities of essential oil of Psidium guajava L. leaves, Asia-Pac. Chem. Biol. Environ. Eng Procedia, 86 Mahattanatawee, 2006, Total antioxidant activity and fiber content of select Florida-grown tropical fruits, J. Agric. Food Chem., 54, 7355, 10.1021/jf060566s Manekeng, 2017, 80 Manuel, 2012, Antimicrobial activity of artocarpesin from Artocarpus heterophyllus Lam. against methicillin-resistant Staphylococcus aureus (MRSA), J. Med. Plants Res., 6, 4879 Mazur, 2000, Phyto-oestrogen content of berries, and plasma concentrations and urinary excretion of enterolactone after a single strawberry-meal in human subjects, Br. J. Nutr., 83, 381 Mbaveng, 2017, Potential of Central, Eastern and Western Africa medicinal plants for cancer therapy: spotlight on resistant cells and molecular targets, Front. Pharmacol., 8, 343, 10.3389/fphar.2017.00343 Milind, 2012, Orange: range of benefits, Int. Res. J. Pharmacol., 3, 59 Moderno, 2009, Recent patents on Camellia sinensis: source of health promoting compounds, Recent Pat. Food Nutr. Agric., 1, 182, 10.2174/2212798410901030182 Muanza, 1995, Screening for antitumor and anti-HIV activities of nine medicinal plants from Zaire, Int. J. Pharmacol., 33, 98 Murcia, 2004, Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure, J. Agric. Food Chem., 52, 1872, 10.1021/jf0303114 Nagja, 2016, Myristica fragrans: a comprehensive review, Int. J. Pharm. Pharm. Sci., 8, 27 Newman, 2012, Natural products as sources of new drugs over the 30 years from 1981 to 2010, J. Nat. Prod., 75, 311, 10.1021/np200906s Nisha, 2011, GC-MS analysis and anti-microbial activity of Psidium guajava (leaves) grown in Malva region of India, Int. J. Drug Dev. Res., 3, 237 Noumedem, 2013, Antibacterial activities of the methanol extracts of ten Cameroonian vegetables against Gram-negative multidrug-resistant bacteria, BMC Complement. Altern. Med., 13, 26, 10.1186/1472-6882-13-26 Nundkumar, 2002, Studies on the antiplasmodial properties of some South African medicinal plants used as antimalarial remedies in Zulu folk medicine, Methods Find. Exp. Clin. Pharmacol., 24, 397, 10.1358/mf.2002.24.7.696540 Nwosu, 2008, Vitamins, phytochemicals and toxic elements in the pulp and seed of raphia palm fruit (Raphia hookeri), EDP Sci. J., 63, 297 O'Brien, 2000, Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity, Eur. J. Biochem., 267, 5421, 10.1046/j.1432-1327.2000.01606.x Oboh, 2016, Physico-chemical and nutritional characteristics, and antimicrobial activity of oil palm syrup, raffia palm syrup and honey, IOSR J. Pharm. Biol. Sci., 11, 73 Omodamiro, 2013, The phytochemical content, antioxidant, antimicrobial and anti-inflammatory activities of Lycopersicon esculentum (tomato), Asian J. Plant Sci. Res., 3, 70 Omosa, 2017, Chapter 19 – Curcuma longa, 425 Oomah, 2000, Characteristics of raspberry (Rubus idaeus L.) seed oil, Food Chem., 69, 187, 10.1016/S0308-8146(99)00260-5 Özgür, 2014, Evaluation of biological activities of Physalis peruviana ethanol extracts and expression of Bcl-2 genes in HeLa cells, Food Sci. Technol., 34, 422, 10.1590/fst.2014.0060 Parvez, 2016, Pharmacological activities of mango (Mangifera indica): a review, J. Pharmacogn. Phytochem, 5, 1 Peng, 2004, CML cell line K562 cell apoptosis induced by mangiferin, Zhongguo Shi Yan Xue Ye Xue Za Zhi, 12, 590 Piaru, 2012, Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia, J. Sci. Food Agric., 92, 593, 10.1002/jsfa.4613 Popoca, 1998, Cytotoxic activity of selected plants used as antitumorals in Mexican traditional medicine, J. Ethnopharmacol., 59, 173, 10.1016/S0378-8741(97)00110-4 Qin, 2017, Meroterpenoids with antitumor activities from Guava (Psidium guajava), J. Agric. Food Chem., 65, 4993, 10.1021/acs.jafc.7b01762 Qiu, 2004, Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation, Zhong Yao Cai, 27, 823 Radwan, 2014, Antifungal compounds from turmeric and nutmeg with activity against plant pathogens, Fitoterapia, 99, 341, 10.1016/j.fitote.2014.08.021 Ramadan, 2003, Oil goldenberry (Physalis peruviana L.), J. Agric. Food Chem., 51, 969, 10.1021/jf020778z Ranade, S., Thiagarajan P., 2015. A review on Persea americana Mill. (Avocado) – its fruit and oil. Robinson, 2011 Rodríguez, 2007, Efecto de la ingesta de Physalis peruviana (aguaymanto) sobre la glicemia postprandial en adultos jóvenes, Rev. MedVallejiana, 4, 43 Ryan, 2001, Antibacterial activity of raspberry cordial in vitro, Res. Vet. Sci., 71, 155, 10.1053/rvsc.2001.0502 Saidan, 2004, Lipid evaluation of some Tunisian Citrus seeds, J. Food Lipids, 11, 242, 10.1111/j.1745-4522.2004.01136.x Samarghandian, 2011, Chrysin reduces proliferation and induces apoptosis in the human protate cancer cell line PC-3, Clinics, 66, 1073, 10.1590/S1807-59322011000600026 Sarkar, 2008, Effect of ripe fruit pulp extract of Cucurbita pepo Linn. in aspirin induced gastric and duodenal ulcer in rats, Indian J. Exp. Biol., 46, 639 Shabani, 2014, The antimicrobial in vitro effects of different concentrations of some plant extracts including tamarisk, march, acetone and mango, J. Appl. Pharm. Sci., 5, 75 Sharangi, 2009, Medicinal and therapeutic potentialities of tea (Camellia sinensis L.) – s review, Food Res. Int., 42, 529, 10.1016/j.foodres.2009.01.007 Shen, 2008, Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats, Phytother. Res., 22, 1458, 10.1002/ptr.2476 Silalahi, 2002, Anticancer and health protective properties of citrus fruits components, Asian Pac. J. Clin. Nutr., 11, 79, 10.1046/j.1440-6047.2002.00271.x Silaste, 2007, Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation, Br. J. Nutr., 98, 1251, 10.1017/S0007114507787445 Suffness, 1990, Assays related to cancer drug discovery, 71 Tajuddin, 2003, Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study, BMC Complement. Altern. Med, 3, 6, 10.1186/1472-6882-3-6 Thapa, 2016, Study of phytochemical, antioxidant and antimicrobial activity of Artocarpus heterophyllus, Nepal J. Biotechnol., 4, 47, 10.3126/njb.v4i1.16347 Tona, 2000, Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo, Phytomedicine, 7, 31, 10.1016/S0944-7113(00)80019-7 Valero, 2003, Antibacterial activity of 11 essential oils against Bacillus cereus in tyndallized carrot broth, Int. J. Food Microbiol., 85, 73, 10.1016/S0168-1605(02)00484-1 Valle, 2015, Antibacterial activities of ethanol extracts of Philippine medicinal plants against multidrug-resistant bacteria, Asian Pac. J. Trop. Biomed., 7, 532, 10.1016/j.apjtb.2015.04.005 Vega-Vega, 2013, Antimicrobial and antioxidant properties of by product extracts of mango fruit, J. Appl. Bot. Food Qual., 86, 205 Volm, 1988, Induced multidrug-resistance in murine sarcoma 180 cells grown in vitro and in vivo and associated changes in expression of multidrug-resistance DNA-sequences and membrane glycoproteins, Anticancer Res., 8, 1169 Yang, 2008, New neolignan from seed of Myristica fragrans, Zhongguo Zhong Yao Za Zhi, 33, 397 Zofou, 2011, In vitro antiplasmodial activity and cytotoxicity of extracts of selected medicinal plants used by traditional healers of Western cameroon, Malar. Res. Treat., 2011, 561342