Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids

Stem Cell Research - Tập 35 - Trang 101383 - 2019
Marco Bardenbacher1, Barbara Ruder2, Nathalie Britzen-Laurent1, Benjamin Schmid3, Maximilian Waldner2, Elisabeth Naschberger1, Michael Scharl4, Werner Müller5, Claudia Günther2, Christoph Becker2, Michael Stürzl1, Philipp Tripal1,3
1Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Translational Research Center, 91054 Erlangen, Germany
2Department of Medicine 1, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Kussmaul Campus, 91054 Erlangen, Germany
3Optical Imaging Centre Erlangen (OICE), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91052 Erlangen, Germany
4Department of Gastroenterology und Hepatology, University Hospital Zürich, 8091 Zürich, Switzerland
5Bill Ford Chair in Cellular Immunology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom

Tài liệu tham khảo

Baugh, 1999, Matrix metalloproteinase levels are elevated in inflammatory bowel disease, Gastroenterology, 117, 814, 10.1016/S0016-5085(99)70339-2 Bendeck, 1996, Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury, Circ. Res., 78, 38, 10.1161/01.RES.78.1.38 Boj, 2017, Forskolin-induced swelling in intestinal organoids: an in vitro assay for assessing drug response in cystic fibrosis patients, J. Visualized Exp. JoVE, 120 Bojarski, 2004, The specific fates of tight junction proteins in apoptotic epithelial cells, J. Cell Sci., 117, 2097, 10.1242/jcs.01071 Britzen-Laurent, 2013, GBP-1 acts as a tumor suppressor in colorectal cancer cells, Carcinogenesis, 34, 153, 10.1093/carcin/bgs310 Bruewer, 2003, Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms, J. Immunol., 171, 6164, 10.4049/jimmunol.171.11.6164 Fatehullah, 2013, Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost, Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci., 368, 10.1098/rstb.2013.0014 Fujita, 2006, Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine, J. Histochem. Cytochem. Off. J. Histochem. Soc., 54, 933, 10.1369/jhc.6A6944.2006 Funderburg, 2013, Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation, Immunology, 140, 87, 10.1111/imm.12114 Gitter, 2001, Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging, Gastroenterology, 121, 1320, 10.1053/gast.2001.29694 Guenzi, 2001, The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines, EMBO J., 20, 5568, 10.1093/emboj/20.20.5568 Heimesaat, 2011, Selective gelatinase blockage ameliorates acute DSS colitis, Eur. J. Microbiol. Immunol., 1, 228, 10.1556/EuJMI.1.2011.3.7 Hill, 2017, Real-time measurement of epithelial barrier permeability in human intestinal organoids, J. Visualized Exp. JoVE, 130 Ito, 2006, Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice, Clin. Exp. Immunol., 146, 330, 10.1111/j.1365-2249.2006.03214.x Jobin, 2017, New intracellular activities of matrix metalloproteinases shine in the moonlight, Biochim. Biophys. Acta, 1864, 2043, 10.1016/j.bbamcr.2017.05.013 Lakso, 1992, Targeted oncogene activation by site-specific recombination in transgenic mice, Proc. Natl. Acad. Sci. U. S. A., 89, 6232, 10.1073/pnas.89.14.6232 Lee, 2015, IFNgamma signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells, PLoS Pathog., 11, 10.1371/journal.ppat.1004635 Lopez-Posadas, 2017, Interplay of GTPases and cytoskeleton in cellular barrier defects during gut inflammation, Front. Immunol., 8, 1240, 10.3389/fimmu.2017.01240 Lubeseder-Martellato, 2002, Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases, Am. J. Pathol., 161, 1749, 10.1016/S0002-9440(10)64452-5 Malemud, 2017, 148, 305, 10.1016/bs.pmbts.2017.03.003 Mankertz, 2000, Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma, J. Cell Sci., 113, 2085, 10.1242/jcs.113.11.2085 Meijer, 2007, Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease, World J. Gastroenterol., 13, 2960, 10.3748/wjg.v13.i21.2960 Mosaliganti, 2012, ACME: automated cell morphology extractor for comprehensive reconstruction of cell membranes, PLoS Comput. Biol., 8, 10.1371/journal.pcbi.1002780 Nava, 2011, JAM-A regulates epithelial proliferation through Akt/beta-catenin signalling, EMBO Rep., 12, 314, 10.1038/embor.2011.16 Nighot, 2015, Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis, Am. J. Physiol. Gastrointest. Liver Physiol., 309, G988, 10.1152/ajpgi.00256.2015 Oshima, 2001, Interferon-gamma and interleukin-10 reciprocally regulate endothelial junction integrity and barrier function, Microvasc. Res., 61, 130, 10.1006/mvre.2000.2288 Pearce, 2018, Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types, BMC Biol., 16, 19, 10.1186/s12915-018-0481-z Rawlings, 2014, MEROPS: the database of proteolytic enzymes, their substrates and inhibitors, Nucleic Acids Res., 42, D503, 10.1093/nar/gkt953 Sato, 2009, Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, 459, 262, 10.1038/nature07935 Sato, 2011, Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium, Gastroenterology, 141, 1762, 10.1053/j.gastro.2011.07.050 Schindelin, 2012, Fiji: an open-source platform for biological-image analysis, Nat. Methods, 9, 676, 10.1038/nmeth.2019 Shuai, 1992, Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein, Science, 258, 1808, 10.1126/science.1281555 Stürzl, 2013, Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line, Int. J. Cancer, 132, 1954, 10.1002/ijc.27849 Tanaka, 2015, Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice, Gut, 64, 1529, 10.1136/gutjnl-2014-308419 Tarlton, 2000, The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis, Am. J. Pathol., 157, 1927, 10.1016/S0002-9440(10)64831-6 Utech, 2010, Endocytosis and recycling of tight junction proteins in inflammation, J Biomed Biotechnol, 484987 Willemsen, 2005, Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition, Clin. Exp. Immunol., 142, 275, 10.1111/j.1365-2249.2005.02906.x Yano, 2017, Apical cytoskeletons and junctional complexes as a combined system in epithelial cell sheets, Ann. N. Y. Acad. Sci., 1405, 32, 10.1111/nyas.13432 Zhang, 2014, Inflammatory bowel disease: pathogenesis, World J. Gastroenterol., 20, 91, 10.3748/wjg.v20.i1.91 Zietek, 2015, Intestinal organoids for assessing nutrient transport, sensing and incretin secretion, Sci. Rep., 5, 16831, 10.1038/srep16831