Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

Adachi-Yamada, 1999, p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis, Mol. Cell. Biol., 19, 2322, 10.1128/MCB.19.3.2322 Agaisse, 2003, Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury, Dev. Cell, 5, 441, 10.1016/S1534-5807(03)00244-2 Amcheslavsky, 2009, Tissue damage-induced intestinal stem cell division in Drosophila, Cell Stem Cell, 4, 49, 10.1016/j.stem.2008.10.016 Bach, 2007, GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo, Gene Expr. Patterns, 7, 323, 10.1016/j.modgep.2006.08.003 Becker, 2005, IL-6 signaling promotes tumor growth in colorectal cancer, Cell Cycle, 4, 217, 10.4161/cc.4.2.1413 Biteau, 2008, JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut, Cell Stem Cell, 3, 442, 10.1016/j.stem.2008.07.024 Buchon, 2009, Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation, Cell Host Microbe, 5, 200, 10.1016/j.chom.2009.01.003 Cha, 2007, NSAIDs and cancer prevention: targets downstream of COX-2, Annu. Rev. Med., 58, 239, 10.1146/annurev.med.57.121304.131253 Chao, 2004, Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye, Development, 131, 3839, 10.1242/dev.01258 Chun, 2004, Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention, Biochem. Pharmacol., 68, 1089, 10.1016/j.bcp.2004.05.031 Crosnier, 2006, Organizing cell renewal in the intestine: stem cells, signals and combinatorial control, Nat. Rev. Genet., 7, 349, 10.1038/nrg1840 Freeman, 2008, Colorectal cancer risk in Crohn's disease, World J. Gastroenterol., 14, 1810, 10.3748/wjg.14.1810 Furriols, 2001, A model Notch response element detects Suppressor of Hairless-dependent molecular switch, Curr. Biol., 11, 60, 10.1016/S0960-9822(00)00044-0 Gilbert, 2005, A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation, Mech. Dev., 122, 939, 10.1016/j.mod.2005.03.004 Gregorieff, 2005, Wnt signaling in the intestinal epithelium: from endoderm to cancer, Genes Dev., 19, 877, 10.1101/gad.1295405 Gupta, 2001, Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2, Nat. Rev. Cancer, 1, 11, 10.1038/35094017 Ha, 2005, An antioxidant system required for host protection against gut infection in Drosophila, Dev. Cell, 8, 125, 10.1016/j.devcel.2004.11.007 Hakim, 2001, The role of stem cells in midgut growth and regeneration, In Vitro Cell. Dev. Biol. Anim., 37, 338 Jiang, 2009, EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors, Development, 136, 483, 10.1242/dev.026955 Kanda, 2004, Regulatory roles of JNK in programmed cell death, J. Biochem., 136, 1, 10.1093/jb/mvh098 Karin, 2008, The IkappaB kinase—a bridge between inflammation and cancer, Cell Res., 18, 334, 10.1038/cr.2008.30 Kusaba, 2005, Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors, J. Clin. Pathol., 58, 833, 10.1136/jcp.2004.023416 Lin, 2008, Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells, Nature, 455, 1119, 10.1038/nature07329 Lin, 2007, A cytokine-mediated link between innate immunity, inflammation, and cancer, J. Clin. Invest., 117, 1175, 10.1172/JCI31537 Loeb, 2001, Control of life, death, and differentiation in cultured midgut cells of the lepidopteran, Heliothis virescens, In Vitro Cell. Dev. Biol. Anim., 37, 348 Martin-Blanco, 1998, puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila, Genes Dev., 12, 557, 10.1101/gad.12.4.557 McConnell, 2008, Kruppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection, Gastroenterology, 134, 1007, 10.1053/j.gastro.2008.01.013 McEwen, 2005, Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis, Development, 132, 3935, 10.1242/dev.01949 McGuire, 2004, Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila, Sci. STKE, 2004, pl6 Micchelli, 2006, Evidence that stem cells reside in the adult Drosophila midgut epithelium, Nature, 439, 475, 10.1038/nature04371 Morgan, 1994, The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB, J. Mol. Biol., 239, 347, 10.1006/jmbi.1994.1376 Nakagawa, 2008, Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation, Gastroenterology, 135, 1311, 10.1053/j.gastro.2008.07.006 Ohlstein, 2006, The adult Drosophila posterior midgut is maintained by pluripotent stem cells, Nature, 439, 470, 10.1038/nature04333 Ohlstein, 2007, Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling, Science, 315, 988, 10.1126/science.1136606 Prieto, 2008, Inflammation, HCC and sex: IL-6 in the centre of the triangle, J. Hepatol., 48, 380, 10.1016/j.jhep.2007.11.007 Rigby, 2007, Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon, Oncogene, 26, 4833, 10.1038/sj.onc.1210286 Rummel, 2006, Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain, Am. J. Physiol. Regul. Integr. Comp. Physiol., 291, R1316, 10.1152/ajpregu.00301.2006 Ryoo, 2004, Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways, Dev. Cell, 7, 491, 10.1016/j.devcel.2004.08.019 Ryu, 2008, Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila, Science, 319, 777, 10.1126/science.1149357 Sancho, 2004, Signaling pathways in intestinal development and cancer, Annu. Rev. Cell Dev. Biol., 20, 695, 10.1146/annurev.cellbio.20.010403.092805 Schneider, 2000, Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells, Cancer Lett., 151, 31, 10.1016/S0304-3835(99)00401-2 Tootle, 2008, Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation, Development, 135, 839, 10.1242/dev.017590 Vodovar, 2005, Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species, Proc. Natl. Acad. Sci. USA, 102, 11414, 10.1073/pnas.0502240102 Xuan, 2003, Mechanism of cyclooxygenase-2 upregulation in late preconditioning, J. Mol. Cell. Cardiol., 35, 525, 10.1016/S0022-2828(03)00076-2