Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models

PLoS ONE - Tập 11 Số 12 - Trang e0168919
Tzu-Hsuan Wong1, Hung-An Chen2, Rung‐Jiun Gau3, Jeng‐Hsien Yen4,1, Jau‐Ling Suen5,1,6
1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
2Department of Allergy-Immunology-Rheumatology, Chi-Mei Medical Center, Tainan, Taiwan
3Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Tainan, Taiwan
4Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
5Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
6Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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Tài liệu tham khảo

TS Lee, 2002, Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice, Nat Med, 8, 240, 10.1038/nm0302-240

A Schumacher, 2012, Blockage of heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells, PLoS One, 7, e42301, 10.1371/journal.pone.0042301

Y Zhang, 2013, Heme oxygenase-1 exerts a protective role in ovalbumin-induced neutrophilic airway inflammation by inhibiting Th17 cell-mediated immune response, J Biol Chem, 288, 34612, 10.1074/jbc.M113.494369

FM Konrad, 2014, Heme oxygenase-1 attenuates acute pulmonary inflammation by decreasing the release of segmented neutrophils from the bone marrow, Am J Physiol Lung Cell Mol Physiol, 307, L707, 10.1152/ajplung.00145.2014

AC Anyanwu, 2014, Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide, Am J Physiol Lung Cell Mol Physiol, 306, L749, 10.1152/ajplung.00236.2013

S Kikuchi, 2005, Association between neutrophilic and eosinophilic inflammation in patients with severe persistent asthma, International archives of allergy and immunology, 137, 7, 10.1159/000085425

DC Newcomb, 2013, Th17-mediated inflammation in asthma, Current opinion in immunology, 25, 755, 10.1016/j.coi.2013.08.002

M Willart, 2011, Lung dendritic cell-epithelial cell crosstalk in Th2 responses to allergens, Curr Opin Immunol, 23, 772, 10.1016/j.coi.2011.09.008

RM Steinman, 2003, Tolerogenic dendritic cells, Annu Rev Immunol, 21, 685, 10.1146/annurev.immunol.21.120601.141040

SA Fadilah, 2007, Dendritic cell immunobiology and potential roles in immunotherapy, Malays J Pathol, 29, 1

RM Steinman, 2007, Taking dendritic cells into medicine, Nature, 449, 419, 10.1038/nature06175

JA Bluestone, 2003, Natural versus adaptive regulatory T cells, Nat Rev Immunol, 3, 253, 10.1038/nri1032

JA Bluestone, 2005, How do CD4+CD25+ regulatory T cells control autoimmunity?, Curr Opin Immunol, 17, 638, 10.1016/j.coi.2005.09.002

S Sakaguchi, 2005, Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self, Nat Immunol, 6, 345, 10.1038/ni1178

C Baecher-Allan, 2001, CD4+CD25high regulatory cells in human peripheral blood, J Immunol, 167, 1245, 10.4049/jimmunol.167.3.1245

K Karimi, 2012, A Lactobacillus rhamnosus strain induces a heme oxygenase dependent increase in Foxp3+ regulatory T cells, PLoS One, 7, e47556, 10.1371/journal.pone.0047556

K Inaba, 1992, Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor, J Exp Med, 176, 1693, 10.1084/jem.176.6.1693

HA Elshabrawy, 2012, Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing, PLoS One, 7, e50366, 10.1371/journal.pone.0050366

HA Elshabrawy, 2014, Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay, Journal of virology, 88, 4353, 10.1128/JVI.03050-13

HC Probst, 2005, Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4, Nat Immunol, 6, 280, 10.1038/ni1165

T Ito, 2007, Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand, J Exp Med, 204, 105, 10.1084/jem.20061660

H Zhao, 2013, Xenon treatment attenuates early renal allograft injury associated with prolonged hypothermic storage in rats, FASEB J, 27, 4076, 10.1096/fj.13-232173

WW Unger, 2009, Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1, European journal of immunology, 39, 3147, 10.1002/eji.200839103

W Chen, 2003, Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3, J Exp Med, 198, 1875, 10.1084/jem.20030152

K Namba, 2002, Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2, J Leukoc Biol, 72, 946, 10.1189/jlb.72.5.946

X Chen, 2007, Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells, J Immunol, 178, 6123, 10.4049/jimmunol.178.10.6123

E Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, 441, 235, 10.1038/nature04753

N Li, 2000, Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element, J Immunol, 165, 3393, 10.4049/jimmunol.165.6.3393

MK Levings, 2005, Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells, Blood, 105, 1162, 10.1182/blood-2004-03-1211

MK Levings, 2001, IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells, J Immunol, 166, 5530, 10.4049/jimmunol.166.9.5530

CP Chappell, 2012, Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses, J Exp Med, 209, 1825, 10.1084/jem.20120774

D Le Roux, 2012, Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells, Blood, 119, 95, 10.1182/blood-2011-02-336123

HM Ashour, 2007, The role of B cells in the induction of peripheral T cell tolerance, J Leukoc Biol, 82, 1033, 10.1189/jlb.0507310

C Chauveau, 2005, Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression, Blood, 106, 1694, 10.1182/blood-2005-02-0494

MF Mashreghi, 2008, Inhibition of dendritic cell maturation and function is independent of heme oxygenase 1 but requires the activation of STAT3, J Immunol, 180, 7919, 10.4049/jimmunol.180.12.7919

BN Lambrecht, 2000, Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model, J Immunol, 164, 2937, 10.4049/jimmunol.164.6.2937

RJ Creusot, 2009, Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells, Blood, 113, 6638, 10.1182/blood-2009-02-204321

P Bhattacharya, 2015, GM-CSF: An immune modulatory cytokine that can suppress autoimmunity, Cytokine, 75, 261, 10.1016/j.cyto.2015.05.030

P Bhattacharya, 2015, Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy, Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research, 35, 585, 10.1089/jir.2014.0149

P Bhattacharya, 2011, GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms, J Leukoc Biol, 89, 235, 10.1189/jlb.0310154