A self-healing hydrogel eye drop for the sustained delivery of decorin to prevent corneal scarring

Maurice, 1957, The structure and transparency of the cornea, J. Physiol., 136, 263, 10.1113/jphysiol.1957.sp005758 Keay, 2006, Microbial keratitis: predisposing factors and morbidity, Ophthalmology, 113, 109, 10.1016/j.ophtha.2005.08.013 Wilson, 2003, Corneal cells: chatty in development, homeostasis, wound healing, and disease, Am. J. Ophthalmol., 136, 530, 10.1016/S0002-9394(03)00085-0 Reza, 2000, Twenty-five–Year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection, Cornea, 19, 625, 10.1097/00003226-200009000-00008 Dua, 2004, The amniotic membrane in ophthalmology, Surv. Ophthalmol., 49, 51, 10.1016/j.survophthal.2003.10.004 Tseng, 1997, Amniotic membrane transplantation for conjunctival surface reconstruction, Am. J. Ophthalmol., 124, 765, 10.1016/S0002-9394(14)71693-9 Tseng, 2001, Amniotic membrane transplantation for ocular surface reconstruction, Biosci. Rep., 21, 481, 10.1023/A:1017995810755 Kim, 1995, Transplantation of preserved human amniotic membrane for surface reconstruction in severly damaged rabbit corneas, Cornea, 14, 473, 10.1097/00003226-199509000-00006 Hao, 2000, Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane, Cornea, 19, 348, 10.1097/00003226-200005000-00018 Shimmura, 2001, Antiinflammatory effects of amniotic membrane transplantation in ocular surface disorders, Cornea, 20, 408, 10.1097/00003226-200105000-00015 V Dudok, 2015, Effects of amniotic membrane extract on primary human corneal epithelial and limbal cells, Clin. Exp. Ophthalmol., 43, 443, 10.1111/ceo.12480 Kordic, 2013, Application of the amniotic membrane extract (AMX) for the persistent epithelial defect (PED) of the cornea, Coll. Antropol., 37, 161 Salminen, 1990, Review: systemic absorption of topically applied ocular drugs in humans, J. Ocul. Pharmacol., 6, 243, 10.1089/jop.1990.6.243 Ludwig, 2005, The use of mucoadhesive polymers in ocular drug delivery, Adv. Drug Deliv. Rev., 57, 1595, 10.1016/j.addr.2005.07.005 Osmałek, 2014, Application of gellan gum in pharmacy and medicine, Int. J. Pharm., 466, 328, 10.1016/j.ijpharm.2014.03.038 Gupta, 2012, Sustained ophthalmic delivery of moxifloxacin hydrochloride from an pH triggered in situ gelling system, Res. J. Pharm. Technol., 5, 1538 Miller, 1982, Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits, Int. J. Pharm., 12, 147, 10.1016/0378-5173(82)90114-4 Balasubramaniam, 2003, In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin, Acta Pharm., 53, 251 Cascone, 2001, Gellan/poly(vinyl alcohol) hydrogels: characterization and evaluation as delivery systems, Polym. Int., 50, 1241, 10.1002/pi.768 Duan, 2015, Novel in situ gel systems based on P123/TPGS mixed micelles and gellan gum for ophthalmic delivery of curcumin, Colloids Surfaces B Biointerfaces, 128, 322, 10.1016/j.colsurfb.2015.02.007 Vijan, 2012, Microwave assisted synthesis and characterization of acrylamide grafted gellan, application in drug delivery, Carbohydr. Polym., 90, 496, 10.1016/j.carbpol.2012.05.071 Norton, 2010, Designer colloids—towards healthy everyday foods?, Soft Matter, 6, 3735, 10.1039/c001018a Norton, 1999, A molecular model for the formation and properties of fluid gels, Int. J. Biol. Macromol., 26, 255, 10.1016/S0141-8130(99)00091-4 Cooke, 2018, Structuring of hydrogels across multiple length scales for biomedical applications, Adv. Mater., 10.1002/adma.201705013 Garrec, 2013, Kappa carrageenan fluid gel material properties. Part 1: Rheology, Food Hydrocolloids, 33, 151, 10.1016/j.foodhyd.2013.02.014 Fernández Farrés, 2014, Formation kinetics and rheology of alginate fluid gels produced by in-situ calcium release, Food Hydrocolloids, 40, 76, 10.1016/j.foodhyd.2014.02.005 Prezotti, 2014, Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs, Carbohydr. Polym., 113, 286, 10.1016/j.carbpol.2014.07.021 Wang, 2008, A novel gellan gel-based microcarrier for anchorage-dependent cell delivery, Acta Biomater., 4, 1226, 10.1016/j.actbio.2008.03.008 Fernández Farrés, 2014, Designing biopolymer fluid gels: a microstructural approach, Food Hydrocolloids, 42, 362, 10.1016/j.foodhyd.2014.03.014 Yamaguchi, 1990, Negative regulation of transforming growth factor-beta by the proteoglycan decorin, Nature, 346, 281, 10.1038/346281a0 Hildebrand, 1994, Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta, Biochem. J., 302, 527, 10.1042/bj3020527 Hill, 2016, Decorin treatment for reversing trabecular meshwork fibrosis in open-angle glaucoma, Neural Regen. Res., 11, 922, 10.4103/1673-5374.184489 Ahmed, 2014, Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds, Neurobiol. Dis., 64, 163, 10.1016/j.nbd.2013.12.008 Botfield, 2013, Decorin prevents the development of juvenile communicating hydrocephalus, Brain, 136, 2842, 10.1093/brain/awt203 Miyoshi, 1996, Rheological and thermal studies of gel-sol transition in gellan gum aqueous solutions, Carbohydr. Polym., 30, 109, 10.1016/S0144-8617(96)00093-8 Mishima, 1977, Determination of tear volume and tear, Investig. Ophthalmol. Vis. Sci., 35, 3799 Li, 2007, Ocular transport model for ophthalmic delivery of timolol through p-HEMA contact lenses, J. Drug Deliv. Sci. Technol., 17, 69, 10.1016/S1773-2247(07)50010-9 Maity, 2016, Ophthalmic drug delivery by contact lenses, J. Chem. Pharm. Res., 8, 644 Li, 2006, Modeling ophthalmic drug delivery by soaked contact lenses, Ind. Eng. Chem. Res., 45, 3718, 10.1021/ie0507934 Dart, 1991, Contact lenses and other risk factors in microbial keratitis, Lancet, 338, 650, 10.1016/0140-6736(91)91231-I Kavanagh, 1998, Rheological characterisation of polymer gels, Prog. Polym. Sci., 23, 533, 10.1016/S0079-6700(97)00047-6 Morgan, 1999, Corneal surface temperature decreases with age, Contact Lens Anterior Eye, 22, 11, 10.1016/S1367-0484(99)80025-3 Korsmeyer, 1981, Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs, J. Membr. Sci., 9, 211, 10.1016/S0376-7388(00)80265-3 Ritger, 1987, A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs, J. Control. Release, 5, 23, 10.1016/0168-3659(87)90034-4 Mcghee, 2002, Locally administered ocular corticosteroids, Drug Saf., 25, 33, 10.2165/00002018-200225010-00004 Fraunfelder, 1976, Extraocular fluid dynamics: how best to apply topical ocular medication, Trans. Am. Ophthalmol. Soc., 74, 457 Hardberger, 1975, Effects of drug vehicles on ocular contact time, Arch. Ophthalmol., 93, 42, 10.1001/archopht.1975.01010020046008 M.E. Cooke, S.W. Jones, B. ter Horst, N. Moiemen, M. Snow, G. Chouhan, L.J. Hill, M. Esmaeli, R.J.A. Moakes, J. Holton, R. Nandra, R.L. Williams, A.M. Smith, L.M. Grover, Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications, Adv. Mater. (n.d.). Garrec, 2012, Understanding fluid gel formation and properties, J. Food Eng., 112, 175, 10.1016/j.jfoodeng.2012.04.001 Sanzgiri, 1993, Gellan-based systems for ophthalmic sustained delivery of methylprednisolone, J. Control. Release, 26, 195, 10.1016/0168-3659(93)90186-9 Logan, 1999, Decorin attenuates gliotic scar formation in the rat cerebral hemisphere, Exp. Neurol., 159, 504, 10.1006/exnr.1999.7180 Keller, 2000, Corneal opacity in lumican-null mice: defects in collagen fibril structure and packing in the posterior stroma, Investig. Ophthalmol. Vis. Sci., 41, 3365 Weber, 1996, Model structure of decorin and implications for collagen fibrillogenesis, J. Biol. Chem., 271, 31767, 10.1074/jbc.271.50.31767 Neame, 2000, Independent modulation of collagen fibrillogenesis by decorin and lumican, Cell. Mol. Life Sci., 57, 859, 10.1007/s000180050048 Schönherr, 1995, Decorin-type I collagen interaction: presence of separate core protein-binding domains, J. Biol. Chem., 270, 8877, 10.1074/jbc.270.15.8877 Castro-Combs, 2008, Corneal wound healing is modulated by topical application of amniotic fluid in an ex vivo organ culture model, Exp. Eye Res., 87, 56, 10.1016/j.exer.2008.04.010 Sriram, 2017, Development of wound healing models to study TGFβ3’s effect on SMA, Exp. Eye Res., 161, 52, 10.1016/j.exer.2017.06.005 Chuck, 2001, Simple organ cornea culture model for re-epithelialization after in vitro excimer laser ablation, Laser Surg. Med., 29, 288, 10.1002/lsm.1121 Chuck, 2001, Re-epithelialization in cornea organ culture after chemical burns and excimer laser treatment, Arch. Ophthalmol., 119, 1637, 10.1001/archopht.119.11.1637 Tran, 2004, Extracellular matrix signaling through growth factor receptors during wound healing, Wound Repair Regen., 12, 262, 10.1111/j.1067-1927.2004.012302.x