Mechanisms involved in the endothelium-dependent vasodilatory effect of an ethyl acetate fraction of Cyathea phalerata Mart. in isolated rats’ aorta rings

Dutra, 2016, Medicinal plants in Brazil: pharmacological studies, drug discovery, challenges and perspectives, Pharmacol Res, 112, 4, 10.1016/j.phrs.2016.01.021 Vora, 2005, Herbs and alternative therapies: relevance to hypertension and cardiovascular diseases, Curr Hypertens Rep, 7, 275, 10.1007/s11906-005-0025-0 Moran, 2008, A “new” tree fern species from southeastern Brazil: Cyathea myriotricha (Cyatheaceae), Brittonia, 60, 362, 10.1007/s12228-008-9040-1 Das Talukdar, 2011, A review on pteridophyte antioxidants and their potential role in discovery of new drugs, Assam Univ J Sci Technol Biol Environ Sci, 7 Goswami, 2016, Pteridophytes: evolutionary boon as medicinal plants, Plant Genet Resour Util, 14, 328, 10.1017/S1479262116000290 Janakiraman, 2015, Toxicological studies inter specific variation studies on cyathea species using phyto- chemical and fluorescence analysis, 3, 25 Hiraoka, 1975, Flavonoid glycosides from five Cyathea species, Bot Mag Tokyo, 88, 127, 10.1007/BF02491247 Hiraoka, 1979, A new acylated flavonol glycoside from Cyathea contaminans Copel. and its distribution in the Pterophyta, Chem Pharm Bull, 27, 3130, 10.1248/cpb.27.3130 Arai, 1995, Ferns constituents: triterpenoids isolated from leaflets of Cyathea lepifera, Chem Pharm Bull, 43, 1849, 10.1248/cpb.43.1849 Bringmann, 1999, Isolation of 4-O-beta- D-glucopyranosylcaffeic acid and gallic acid from Cyathea dregei Kunze (Cyatheaceae), Pharmaceut Pharmacol Lett, 9, 41 Dey, 2013, Antioxidant and anti-inflammatory activity of methanol extracts of bark of Cyathea gigantea, J Nat Pharm, 4, 126 Kiran, 2012, Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats, Asian Pac J Trop Biomed, 2, 352, 10.1016/S2221-1691(12)60055-0 Brighente, 2007, Antioxidant activity and total phenolic content of some Brazilian species, Pharm Biol, 45, 156, 10.1080/13880200601113131 Hort, 2008, Antioxidant and hepatoprotective effects of Cyathea phalerata Mart. (Cyatheaceae), Basic Clin Pharmacol Toxicol, 103, 17, 10.1111/j.1742-7843.2008.00214.x Pizzolatti, 2007, Cyathenosin A, a spiropyranosyl derivative of protocatechuic acid from Cyathea phalerata, Phytochemistry, 68, 1327, 10.1016/j.phytochem.2007.02.009 Cazarolli, 2006, Follow-up studies on glycosylated flavonoids and their complexes with vanadium: their anti-hyperglycemic potential role in diabetes, Chem Biol Interact, 163, 177, 10.1016/j.cbi.2006.07.010 Yamasaki, 2011, Study of kaempferol glycoside as an insulin mimic reveals glycon to be the key active structure, ACS Med Chem Lett, 2, 17, 10.1021/ml100171x Andrade, 2014, Chemical analysis, antioxidant, antichemotactic and monoamine oxidase inhibition effects of some pteridophytes from Brazil, Phcog Mag, 10, S100, 10.4103/0973-1296.127354 Andriambeloson, 1999, Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta, J Cardiovasc Pharmacol, 33, 248, 10.1097/00005344-199902000-00011 Michiels, 2003, Endothelial cell functions, J Cell Physiol, 196, 430, 10.1002/jcp.10333 He, 2005, Endothelial function related to vascular tone in cardiac surgery, Heart Lung Circ, 14, 13, 10.1016/j.hlc.2004.11.003 Fitzpatric, 1995, Endothelium-dependent vasorelaxation caused by various plant extracts, J Cardiovasc Pharmacol, 26, 90, 10.1097/00005344-199507000-00015 Schuldt, 2005, An ethyl acetate fraction obtained from a Southern Brazilian red wine relaxes rat mesenteric arterial bed through hyperpolarization and NO-cGMP pathway, Vasc Pharmacol, 43, 62, 10.1016/j.vph.2005.04.002 Hernandez-Perez, 2014, Aortic relaxant activity of Crataegus gracilior phipps and identification of some of its chemical constituents, Molecules, 19, 20962, 10.3390/molecules191220962 Padilla, 2005, Relationship between vasodilation capacity and phenolic content of Spanish wines, Eur J Pharmacol, 517, 84, 10.1016/j.ejphar.2005.04.044 Duarte, 1993, Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships, Gen Pharmacol Vasc Syst, 24, 857, 10.1016/0306-3623(93)90159-U Benkhalti, 2003, Effects of virgin olive oil phenolic compounds on LDL oxidation and vasorelaxation activity, Therapie, 58, 133, 10.2515/therapie:2003019 Gorzalczany, 2013, Artemisia copa aqueous extract as vasorelaxant and hypotensive agent, J Ethnopharmacol, 148, 56, 10.1016/j.jep.2013.03.061 Matsui, 2010, Identification of a new natural vasorelaxatant compound, (+)-osbeckic acid, from rutin-free tartary buckwheat extract, J Agric Food Chem, 58, 10876, 10.1021/jf1028416 Vanhoutte, 2017, Endothelial dysfunction and vascular disease – a 30th anniversary update, Acta Physiol, 219, 22, 10.1111/apha.12646 Vanhoutte, 2016, Thirty years of saying NO: sources, fate, actions, and misfortunes of the endothelium-derived vasodilator mediator, Circ Res, 119, 375, 10.1161/CIRCRESAHA.116.306531 Wang, 2013, Vasorelaxant action of an ethylacetate fraction of Euphorbia humifusa involves NO-cGMP pathway and potassium channels, J Ethnopharmacol, 148, 655, 10.1016/j.jep.2013.05.025 Forstermann, 2012, Nitric oxide synthases: regulation and function, Eur Heart J, 33, 829, 10.1093/eurheartj/ehr304 Kwan, 2003, In vitro relaxation of vascular smooth muscle by atropine: involvement of K+channels and endothelium, Naunyn-Schmiedeberg’s Arch Pharmacol, 368, 1, 10.1007/s00210-003-0759-7 Merrick, 1981, Direct vasodilator activity of atropine in the rat perfused hindlimb preparation, Clin Exp Pharmacol Physiol, 8, 277, 10.1111/j.1440-1681.1981.tb00160.x Haghighi, 2002, Vasorelaxant effects of Atropine : role of nitric oxide/endothelium derived relaxing factor, Indian J Pharmacol, 34, 244 Luckhoff, 1990, Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential, Pflügers Arch - Eur J Physiol., 416, 305, 10.1007/BF00392067 Singer, 1982, Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta, Hypertension, 4, 19, 10.1161/01.HYP.4.3_Pt_2.19 Fleming, 2003, Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase, Am J Physiol Regul Integr Comp Physiol, 284, R1, 10.1152/ajpregu.00323.2002 Anselm, 2007, Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS, Cardiovasc Res, 73, 404, 10.1016/j.cardiores.2006.08.004 Edirisinghe, 2008, Strawberry extract caused endothelium-dependent relaxation through the activation of PI3 kinase/Akt, J Agric Food Chem, 56, 9383, 10.1021/jf801864t Mombouli, 1997, Endothelium-derived hyperpolarizing factor(s): updating the unknown, Trends Pharmacol Sci, 18, 252, 10.1016/S0165-6147(97)90633-7 Félétou, 2009, EDHF: an update, Clin Sci, 117, 139, 10.1042/CS20090096 Busse, 2002, EDHF: bringing the concepts together, Trends Pharmacol Sci, 23, 374, 10.1016/S0165-6147(02)02050-3 DalBo, 2008, Activation of endothelial nitric oxide synthase by proanthocyanidin-rich fraction from Croton celtidifolius (Euphorbiaceae): involvement of extracellular calcium influx in rat thoracic aorta, J Pharmacol Sci, 107, 181, 10.1254/jphs.FP0072385 Ndiaye, 2003, Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism, Biochem Biophys Res Commun, 310, 371, 10.1016/j.bbrc.2003.09.028 Xu, 2015, Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca 2+-activated K + channels, Br J Pharmacol, 172, 3003, 10.1111/bph.13108 Kumar, 2018, Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery, Pharmacol Rep, 70, 863, 10.1016/j.pharep.2018.03.006 Tomasian, 2000, Antioxidants and the bioactivity of endothelium-derived nitric oxide, Cardiovasc Res, 47, 426, 10.1016/S0008-6363(00)00103-6 Andriambeloson, 1997, Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta, Br J Pharmacol, 120, 1053, 10.1038/sj.bjp.0701011 Andriambeloson, 1998, Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta, J Nutr, 128, 2324