A Randomized, Noninferiority Trial Comparing ICS + LABA with ICS + LABA + LAMA in Asthma-COPD Overlap (ACO) Treatment: The ACO Treatment with Optimal Medications (ATOMIC) Study

Leung, 2017, Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets, BMJ, 358, j3772, 10.1136/bmj.j3772 Postma, 2015, The asthma-COPD overlap syndrome, N Engl J Med, 373, 1241, 10.1056/NEJMra1411863 Soler-Cataluna, 2012, Consensus document on the overlap phenotype COPD-asthma in COPD, Arch Bronconeumol, 48, 331, 10.1016/j.arbr.2012.06.017 Cosio, 2016, Defining the asthma-COPD overlap syndrome in a COPD cohort, Chest, 149, 45, 10.1378/chest.15-1055 Sin, 2016, What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion, Eur Respir J, 48, 664, 10.1183/13993003.00436-2016 Cataldo, 2017, A Belgian survey on the diagnosis of asthma-COPD overlap syndrome, Int J Chron Obstruct Pulmon Dis, 12, 601, 10.2147/COPD.S124459 Lee, 2015, A diagnostic approach and natural course of a patient with asthma-COPD overlap syndrome, Respirol Case Rep, 3, 119, 10.1002/rcr2.130 Park, 2019, Longitudinal analysis to better characterize asthma-COPD overlap syndrome: findings from an adult asthma cohort in Korea (COREA), Clin Exp Allergy, 49, 603, 10.1111/cea.13339 Tkacova, 2016, Airway hyperresponsiveness in chronic obstructive pulmonary disease: a marker of asthma-chronic obstructive pulmonary disease overlap syndrome?, J Allergy Clin Immunol, 138, 1571, 10.1016/j.jaci.2016.04.022 van Boven, 2016, Comorbidome, pattern, and impact of asthma-COPD overlap syndrome in real life, Chest, 149, 1011, 10.1016/j.chest.2015.12.002 Hardin, 2014, The clinical and genetic features of COPD-asthma overlap syndrome, Eur Respir J, 44, 341, 10.1183/09031936.00216013 Gibson, 2009, The overlap syndrome of asthma and COPD: what are its features and how important is it?, Thorax, 64, 728, 10.1136/thx.2008.108027 Nunez, 2019, Practical guide to the identification and diagnosis of asthma-COPD overlap (ACO), COPD, 16, 1, 10.1080/15412555.2019.1575802 Alvarado-Gonzalez, 2015, Tiotropium bromide in chronic obstructive pulmonary disease and bronchial asthma, J Clin Med Res, 7, 831, 10.14740/jocmr2305w Kim, 2009, Factors associated with severity and exacerbation of asthma: a baseline analysis of the cohort for reality and evolution of adult asthma in Korea (COREA), Ann Allergy Asthma Immunol, 103, 311, 10.1016/S1081-1206(10)60530-3 Park, 2019, Novel trajectories for identifying asthma phenotypes: a longitudinal study in Korean asthma cohort, COREA. J Allergy Clin Immunol Pract, 7, 1850, 10.1016/j.jaip.2019.02.011 Kim, 2013, Identification of asthma clusters in two independent Korean adult asthma cohorts, Eur Respir J, 41, 1308, 10.1183/09031936.00100811 Kerstjens, 2012, Tiotropium in asthma poorly controlled with standard combination therapy, N Engl J Med, 367, 1198, 10.1056/NEJMoa1208606 Marsh, 2008, Proportional classifications of COPD phenotypes, Thorax, 63, 761, 10.1136/thx.2007.089193 Christenson, 2015, Asthma-COPD overlap: clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 191, 758, 10.1164/rccm.201408-1458OC Maselli, 2019, Management of asthma COPD overlap, Ann Allergy Asthma Immunol, 123, 335, 10.1016/j.anai.2019.07.021 Cosio, 2018, Asthma-COPD overlap: identification and optimal treatment, Ther Adv Respir Dis, 12, 10.1177/1753466618805662 Nielsen, 2015, Clinical characteristics of the asthma-COPD overlap syndrome--a systematic review, Int J Chron Obstruct Pulmon Dis, 10, 1443 Lazarus, 2001, Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial, JAMA, 285, 2583, 10.1001/jama.285.20.2583 Ishiura, 2019, Effect of triple therapy in patients with asthma-COPD overlap, Int J Clin Pharmacol Ther, 57, 384, 10.5414/CP203382