Mécanismes moléculaires de l’homéostasie du fer

Nelson N. Metal ion transporters and homeostasis.EMBO J1999; 18 : 4361–71.

Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin.Semin Hematol1998; 35 : 35–54.

Trinder D, Baker E. Transferin receptor 2 : a new molecule in iron metabolism.Int J Biochem Cell Biol2003; 35 : 292–6.

Verroust PJ, Kozyraki R. Cubiline : rôle physiopathologique et relations avec la mégaline.Med Sci (Paris)2003; 19 : 337–43.

McKie AT, Barrow D, Latunde-Dada GO,et al.An iron-regulated ferric reductase associated with the absorption of dietary iron.Science2001; 291 : 1755–9.

Gunshin H, Mackenzie B, Berger UV,et al.Cloning and characterization of a mammalian proton-coupled metal-ion transporter.Nature1997; 388 : 482–8.

Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.Blood1999; 93 : 4406–17.

Fleming MD, Trenor CC III, Su MA,et al.Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.Nat Genet1997; 16 : 383–6.

McKie AT, Marciani P, Rolfs A,et al.A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.Mol Cell2000; 5 : 299–309.

Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism.J Biol Chem2000; 275 : 19906–12.

Donovan A, Brownlie A, Zhou Y,et al.Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.Nature2000; 403 : 776–81.

Vulpe CD, Kuo YM, Murphy TL,et al.Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.Nat Genet1999; 21 : 195–9.

Knutson M, Wessling-Resnick M. Iron metabolism in the reticuloendothelial system.Crit Rev Biochem Biol2003; 38 : 61–88.

Montosi G, Donovan A, Totaro A,et al.Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.J Clin Invest2001; 108 : 619–23.

Devalia V, Carter K, Walker AP,et al.Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).Blood2002; 100 : 695–7.

Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.Proc Natl Acad Sci USA1999; 96 : 10812–7.

Harris ZL, Klomp LWJ, Gitlin JD. Aceruloplasminemia : an inherited neurodegenerative disease with impairment of iron homeostasis.Am J Clin Nutr1998; 67 : 972S.

Andrews NC. Disorders of iron metabolism.N Engl J Med1999; 341 : 1986–95.

Feder JN, Gnirke A, Thomas W,et al.A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.Nat Genet1996; 13 : 399–408.

Ramalingam TS, West AP Jr, Lebron JA,et al.Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.Nat Cell Biol2000; 2 : 953–7.

Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.J Biol Chem2002; 277 : 37597–603.

Pigeon C, Ilyin G, Courselaud B,et al.A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.J Biol Chem2001; 276 : 7811–9.

Nicolas G, Bennoun M, Devaux I,et al.Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice.Proc Natl Acad Sci USA2001; 98 : 8780–5.

Roetto A, Papanikolaou G, Politou M,et alMutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.Nat Genet2003; 33 : 21–2.

Nicolas G, Bennoun M, Porteu A,et alSevere iron deficiency anemia in transgenic mice expressing liver hepcidin.Proc Natl Acad Sci USA2002; 99 : 4596–601.

Nicolas G, Viatte L, Lou DQ,et al.Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.Nat Genet2003; 34 : 97–101.

Bridle KR, Frazer DM, Wilkins SJ,et al.Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.Lancet2003; 361 : 669–73.

Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.Blood2003; 101 : 2461–3.

Nicolas G, Chauvet C, Viatte L,et al.The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation.J Clin Invest2002; 110 : 1037–44.