Diesel Exhaust Particle-Treated Human Bronchial Epithelial Cells Upregulate Jagged-1 and OX40 Ligand in Myeloid Dendritic Cells via Thymic Stromal Lymphopoietin

Riedl, 2008, The effect of air pollution on asthma and allergy., Curr. Allergy Asthma Rep., 8, 139, 10.1007/s11882-008-0024-8

Morgenstern, 2008, Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children., Am. J. Respir. Crit. Care Med., 177, 1331, 10.1164/rccm.200701-036OC

McConnell, 2006, Traffic, susceptibility, and childhood asthma., Environ. Health Perspect., 114, 766, 10.1289/ehp.8594

Janssen, 2003, The relationship between air pollution from heavy traffic and allergic sensitization, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren., Environ. Health Perspect., 111, 1512, 10.1289/ehp.6243

Gergen, 1987, The prevalence of allergic skin test reactivity to eight common aeroallergens in the U.S. population: results from the second National Health and Nutrition Examination Survey., J. Allergy Clin. Immunol., 80, 669, 10.1016/0091-6749(87)90286-7

Pénard-Morand, 2005, Prevalence of food allergy and its relationship to asthma and allergic rhinitis in schoolchildren., Allergy, 60, 1165, 10.1111/j.1398-9995.2005.00860.x

Takenaka, 1995, Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: direct effects on B-cell IgE production., J. Allergy Clin. Immunol., 95, 103, 10.1016/S0091-6749(95)70158-3

Diaz-Sanchez, 1997, Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern., J. Immunol., 158, 2406, 10.4049/jimmunol.158.5.2406

Devouassoux, 2002, Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils., J. Allergy Clin. Immunol., 109, 847, 10.1067/mai.2002.122843

Salvi, 1999, Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers., Am. J. Respir. Crit. Care Med., 159, 702, 10.1164/ajrccm.159.3.9709083

Nordenhäll, 2001, Diesel exhaust enhances airway responsiveness in asthmatic subjects., Eur. Respir. J., 17, 909, 10.1183/09031936.01.17509090

Gilmour, 2006, How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma., Environ. Health Perspect., 114, 627, 10.1289/ehp.8380

Diaz-Sanchez, 2005, Diesel effects on human health: a question of stress?, Am. J. Physiol. Lung Cell. Mol. Physiol., 289, L722, 10.1152/ajplung.00217.2005

Holt, 1990, A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium., Int. Arch. Allergy Appl. Immunol., 91, 155, 10.1159/000235107

Reibman, 2003, Airway epithelial cells release MIP-3α/CCL20 in response to cytokines and ambient particulate matter., Am. J. Respir. Cell Mol. Biol., 28, 648, 10.1165/rcmb.2002-0095OC

Ohtoshi, 1998, Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro., J. Allergy Clin. Immunol., 101, 778, 10.1016/S0091-6749(98)70307-0

Boland, 1999, Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production., Am. J. Physiol., 276, L604

Reibman, 2002, Size fractions of ambient particulate matter induce granulocyte macrophage colony-stimulating factor in human bronchial epithelial cells by mitogen-activated protein kinase pathways., Am. J. Respir. Cell Mol. Biol., 27, 455, 10.1165/rcmb.2001-0005OC

Bleck, 2008, Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietin., J. Clin. Immunol., 28, 147, 10.1007/s10875-007-9149-0

Liu, 2007, TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation., Annu. Rev. Immunol., 25, 193, 10.1146/annurev.immunol.25.022106.141718

Provoost, 2010, Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells., J. Immunol., 184, 426, 10.4049/jimmunol.0902564

Cozens, 1994, CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells., Am. J. Respir. Cell Mol. Biol., 10, 38, 10.1165/ajrcmb.10.1.7507342

Bender, 1996, Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood., J. Immunol. Methods, 196, 121, 10.1016/0022-1759(96)00079-8

Baulig, 2003, Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells., Am. J. Physiol. Lung Cell. Mol. Physiol., 285, L671, 10.1152/ajplung.00419.2002

Liu, 2007, Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation., J. Allergy Clin. Immunol., 120, 238, 10.1016/j.jaci.2007.06.004

Amsen, 2004, Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells., Cell, 117, 515, 10.1016/S0092-8674(04)00451-9

Liotta, 2008, Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction., J. Allergy Clin. Immunol., 121, 1000, 10.1016/j.jaci.2008.01.004

Kaliński, 1999, T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal., Immunol. Today, 20, 561, 10.1016/S0167-5699(99)01547-9

Kabelitz, 2006, Regulation of regulatory T cells: role of dendritic cells and Toll-like receptors., Crit. Rev. Immunol., 26, 291, 10.1615/CritRevImmunol.v26.i4.10

Bleck, 2006, Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation., J. Immunol., 176, 7431, 10.4049/jimmunol.176.12.7431

Li, 2002, Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter., Inhal. Toxicol., 14, 459, 10.1080/089583701753678571

Kumagai, 1997, Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome p450 reductase and involvement of the bioactivation in the DNA damage., Free Radic. Biol. Med., 22, 479, 10.1016/S0891-5849(96)00341-3

Liu, 2006, Thymic stromal lymphopoietin: master switch for allergic inflammation., J. Exp. Med., 203, 269, 10.1084/jem.20051745

Wang, 2009, Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses., Clin. Exp. Allergy, 39, 798, 10.1111/j.1365-2222.2009.03241.x

Quentmeier, 2001, Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation., Leukemia, 15, 1286, 10.1038/sj.leu.2402175

Soumelis, 2002, Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP., Nat. Immunol., 3, 673, 10.1038/ni805

Wang, 2007, IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells., J. Exp. Med., 204, 1837, 10.1084/jem.20070406

Wang, 2006, Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells., Immunity, 24, 827, 10.1016/j.immuni.2006.03.019

Headley, 2009, TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses., J. Immunol., 182, 1641, 10.4049/jimmunol.182.3.1641

Rochman, 2008, Thymic stromal lymphopoietin: a new cytokine in asthma., Curr. Opin. Pharmacol., 8, 249, 10.1016/j.coph.2008.03.002

Ying, 2005, Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity., J. Immunol., 174, 8183, 10.4049/jimmunol.174.12.8183

Ito, 2005, TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand., J. Exp. Med., 202, 1213, 10.1084/jem.20051135

Croft, 2009, The significance of OX40 and OX40L to T-cell biology and immune disease., Immunol. Rev., 229, 173, 10.1111/j.1600-065X.2009.00766.x

Rogers, 2001, OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells., Immunity, 15, 445, 10.1016/S1074-7613(01)00191-1

Gramaglia, 2000, The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion., J. Immunol., 165, 3043, 10.4049/jimmunol.165.6.3043

Salek-Ardakani, 2003, OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation., J. Exp. Med., 198, 315, 10.1084/jem.20021937

Sugamura, 2004, Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40., Nat. Rev. Immunol., 4, 420, 10.1038/nri1371

So, 2007, Cutting edge: OX40 inhibits TGF-β- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells., J. Immunol., 179, 1427, 10.4049/jimmunol.179.3.1427

Arestides, 2002, Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation., Eur. J. Immunol., 32, 2874, 10.1002/1521-4141(2002010)32:10<2874::AID-IMMU2874>3.0.CO;2-4

Hoshino, 2003, Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma., Eur. J. Immunol., 33, 861, 10.1002/eji.200323455

Seshasayee, 2007, In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation., J. Clin. Invest., 117, 3868, 10.1172/JCI33559

Duan, 2008, Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells., J. Immunol., 181, 8650, 10.4049/jimmunol.181.12.8650

Amsen, 2009, The different faces of Notch in T-helper-cell differentiation., Nat. Rev. Immunol., 9, 116, 10.1038/nri2488

Hoyne, 2000, T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling., Immunology, 100, 281, 10.1046/j.1365-2567.2000.00073.x

Napolitani, 2005, Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells., Nat. Immunol., 6, 769, 10.1038/ni1223

Skokos, 2007, CD8− DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS., J. Exp. Med., 204, 1525, 10.1084/jem.20062305

Kubo, 2007, Notch: filling a hole in T helper 2 cell differentiation., Immunity, 27, 3, 10.1016/j.immuni.2007.07.005

Fang, 2007, Notch directly regulates Gata3 expression during T helper 2 cell differentiation., Immunity, 27, 100, 10.1016/j.immuni.2007.04.018

Krawczyk, 2008, Th2 differentiation is unaffected by Jagged2 expression on dendritic cells., J. Immunol., 180, 7931, 10.4049/jimmunol.180.12.7931

Worsley, 2008, Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo., Eur. J. Immunol., 38, 1043, 10.1002/eji.200737335

Minter, 2005, Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21., Nat. Immunol., 6, 680, 10.1038/ni1209x

Tanaka, 2006, The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells., Immunity, 24, 689, 10.1016/j.immuni.2006.04.009

Amsen, 2007, Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch., Immunity, 27, 89, 10.1016/j.immuni.2007.05.021

Kang, 2009, Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses., Am. J. Respir. Crit. Care Med., 179, 875, 10.1164/rccm.200806-893OC

Jahnsen, 2006, Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus., J. Immunol., 177, 5861, 10.4049/jimmunol.177.9.5861

Sung, 2006, A major lung CD103 (αE)-β7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins., J. Immunol., 176, 2161, 10.4049/jimmunol.176.4.2161

Rothen-Rutishauser, 2005, A three-dimensional cellular model of the human respiratory tract to study the interaction with particles., Am. J. Respir. Cell Mol. Biol., 32, 281, 10.1165/rcmb.2004-0187OC

Blank, 2010, Macrophages and dendritic cells express tight junction proteins and exchange particles in an in vitro model of the human airway wall., Immunobiology

Ohtani, 2005, Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response., J. Immunol., 174, 2412, 10.4049/jimmunol.174.4.2412

Williams, 2007, Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells., J. Allergy Clin. Immunol., 119, 488, 10.1016/j.jaci.2006.10.022

Porter, 2007, Diesel-enriched particulate matter functionally activates human dendritic cells., Am. J. Respir. Cell Mol. Biol., 37, 706, 10.1165/rcmb.2007-0199OC

Williams, 2008, Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter., J. Immunol., 181, 4545, 10.4049/jimmunol.181.7.4545

de Haar, 2008, Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity., J. Allergy Clin. Immunol., 121, 1246, 10.1016/j.jaci.2008.01.010

Inoue, 2009, Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice., Exp. Biol. Med. (Maywood), 234, 200, 10.3181/0809-RM-285

Verstraelen, 2005, Flow cytometric characterisation of antigen presenting dendritic cells after in vitro exposure to diesel exhaust particles., Toxicol. In Vitro, 19, 903, 10.1016/j.tiv.2005.06.017

Braun, 2010, Differential impact of diesel particle composition on pro-allergic dendritic cell function., Toxicol. Sci., 113, 85, 10.1093/toxsci/kfp239

Liu, 2009, In vivo analysis of dendritic cell development and homeostasis., Science, 324, 392, 10.1126/science.1170540

Bogunovic, 2009, Origin of the lamina propria dendritic cell network., Immunity, 31, 513, 10.1016/j.immuni.2009.08.010