Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): An Introduction to the Scientific Issues

Bentzen, 2007, Increasing toxicity in non-operative head and neck cancer treatment: Investigations and interventions, Int J Radiat Oncol Biol Phys, 69, S79, 10.1016/j.ijrobp.2007.04.080 Center for Disease Control (USA). Cancer survivorship—United States, 1971–2001. Available at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5324a3.htm. Accessed December 1, 2005. Bentzen, 2007, Evaluation of early and late toxicities in chemoradiation trials, J Clin Oncol, 25, 4096, 10.1200/JCO.2007.13.3983 Trotti, 2004, The need for adverse effects reporting standards in oncology clinical trials, J Clin Oncol, 22, 19, 10.1200/JCO.2004.10.911 Papanikolaou, 2004, Availability of large-scale evidence on specific harms from systematic reviews of randomized trials, Am J Med, 117, 582, 10.1016/j.amjmed.2004.04.026 National Cancer Institute. Common Terminology Criteria for Adverse Events v3.0. Available at http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf. Accessed February 9, 2009. Bentzen, 2003, Normal tissue effects: Reporting and analysis, Semin Radiat Oncol, 13, 189, 10.1016/S1053-4296(03)00036-5 Peeters, 2006, Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer, Int J Radiat Oncol Biol Phys, 64, 1151, 10.1016/j.ijrobp.2005.10.002 Emami, 1991, Tolerance of normal tissue to therapeutic irradiation, Int J Radiat Oncol Biol Phys, 21, 109, 10.1016/0360-3016(91)90171-Y Burman, 1991, Fitting of normal tissue tolerance data to an analytic function, Int J Radiat Oncol Biol Phys, 21, 123, 10.1016/0360-3016(91)90172-Z Lyman, 1985, Complication probability as assessed from dose-volume histograms, Rad Res, 104, 10.2307/3576626 Kutcher, 1991, Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations, Int J Radiat Oncol Biol Phys, 21, 137, 10.1016/0360-3016(91)90173-2 Schultheiss, 1983, Models in radiotherapy: Volume effects, Med Phys, 10, 410, 10.1118/1.595312 Withers, 1988, Treatment volume and tissue tolerance, Int J Radiat Oncol Biol Phys, 14, 751, 10.1016/0360-3016(88)90098-3 Källman, 1992, Tumour and normal tissue responses to fractionated non-uniform dose delivery, Int J Radiat Biol, 62, 249, 10.1080/09553009214552071 Liao, 1995, Damage and morbidity from pneumonitis after irradiation of partial volumes of mouse lung [see comments], Int J Radiat Oncol Biol Phys, 32, 1359, 10.1016/0360-3016(94)00660-D Tucker, 1997, Estimation of the spatial distribution of target cells for radiation pneumonitis in mouse lung, Int J Radiat Oncol Biol Phys, 38, 1055, 10.1016/S0360-3016(97)00131-4 Konings, 2006, Secondary radiation damage as the main cause for unexpected volume effects: A histopathologic study of the parotid gland, Int J Radiat Oncol Biol Phys, 64, 98, 10.1016/j.ijrobp.2005.06.042 van Luijk, 2007, The impact of heart irradiation on dose-volume effects in the rat lung, Int J Radiat Oncol Biol Phys, 69, 552, 10.1016/j.ijrobp.2007.05.065 Hopewell, 2000, Volume effects in radiobiology as applied to radiotherapy, Radiother Oncol, 56, 283, 10.1016/S0167-8140(00)00236-X Trott, 1995, The effect of irradiated volume on the chronic radiation damage of the rat large bowel, Strahlenther Onkol, 171, 326 Peeters, 2006, Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: Normal tissue complication probability modeling, Int J Radiat Oncol Biol Phys, 66, 11, 10.1016/j.ijrobp.2006.03.034 Stewart, 2002, Volume effects in normal tissues, 42 van Luijk, 2005, Data on dose-volume effects in the rat spinal cord do not support existing NTCP models, Int J Radiat Oncol Biol Phys, 61, 892, 10.1016/j.ijrobp.2004.10.035 Fiorino, 2008, Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: Preliminary results of a multicenter prospective study, Int J Radiat Oncol Biol Phys, 70, 1130, 10.1016/j.ijrobp.2007.07.2354 Bentzen, 2006, Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology, Nat Rev Cancer, 6, 702, 10.1038/nrc1950 Dawson, 2005, Use of principal component analysis to evaluate the partial organ tolerance of normal tissues to radiation, Int J Radiat Oncol Biol Phys, 62, 829, 10.1016/j.ijrobp.2004.11.013 Stavreva, 2001, Modelling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits, Int J Radiat Biol, 77, 695, 10.1080/09553000110047555 El Naqa, 2006, Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factors, Int J Radiat Oncol Biol Phys, 64, 1275, 10.1016/j.ijrobp.2005.11.022 Gulliford, 2004, Use of artificial neural networks to predict biological outcomes for patients receiving radical radiotherapy of the prostate, Radiother Oncol, 71, 3, 10.1016/j.radonc.2003.03.001 Chen, 2007, Investigation of the support vector machine algorithm to predict lung radiation-induced pneumonitis, Med Phys, 34, 3808, 10.1118/1.2776669 Khuntia, 2008, Increased oral mucositis after IMRT versus non-IMRT when combined with cetuximab and cisplatin or docetaxel for head and neck cancer: Preliminary results of RTOG 0234 [abstract], Int J Radiat Oncol Biol Phys, 72, S33, 10.1016/j.ijrobp.2008.06.839 Tucker, 2006, Dose-volume modeling of the risk of postoperative pulmonary complications among esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery, Int J Radiat Oncol Biol Phys, 66, 754, 10.1016/j.ijrobp.2006.06.002 Tucker, 2004, Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy, Int J Radiat Oncol Biol Phys, 60, 1589, 10.1016/j.ijrobp.2004.07.712 De Ruysscher, 2007, Maximal neutropenia during chemotherapy and radiotherapy is significantly associated with the development of acute radiation-induced dysphagia in lung cancer patients, Ann Oncol, 18, 909, 10.1093/annonc/mdm005 Bradley, 2007, A nomogram to predict radiation pneumonitis, derived from a combined analysis of RTOG 93-11 and institutional data, Int J Radiat Oncol Biol Phys, 69, 985, 10.1016/j.ijrobp.2007.04.077 Tsougos, 2007, NTCP modelling and pulmonary function tests evaluation for the prediction of radiation induced pneumonitis in non-small-cell lung cancer radiotherapy, Phys Med Biol, 52, 1055, 10.1088/0031-9155/52/4/013 Yorke, 1993, Probability of radiation-induced complications in normal tissues with parallel architecture under conditions of uniform whole or partial organ irradiation, Radiother Oncol, 26, 226, 10.1016/0167-8140(93)90264-9 Deasy, 2002, Methodological issues in radiation dose-volume outcome analyses: summary of a joint AAPM/NIH workshop, Med Phys, 29, 2109, 10.1118/1.1501473 Lawrence, 1996, 3-D conformal radiation therapy in upper gastrointestinal cancer. The University of Michigan experience, Front Radiat Ther Oncol, 29, 221, 10.1159/000424721 Adkison, 2008, Dose escalated, hypofractionated radiotherapy using helical tomotherapy for inoperable non-small cell lung cancer: Preliminary results of a risk-stratified phase I dose escalation study, Technol Cancer Res Treat, 7, 441, 10.1177/153303460800700605 Kong, 2006, Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis, Int J Radiat Oncol Biol Phys, 65, 1075, 10.1016/j.ijrobp.2006.01.051 van Baardwijk, 2008, Individualized radical radiotherapy of non-small-cell lung cancer based on normal tissue dose constraints: A feasibility study, Int J Radiat Oncol Biol Phys, 71, 1394, 10.1016/j.ijrobp.2007.11.070