An immunocytochemical study of endocrine pancreas of snakes

Springer Science and Business Media LLC - Tập 235 Số 3 - Trang 657-661 - 1984
Buchan, A. M. J.1,2
1Departments of Physiology, University of British Columbia, Vancouver, Canada
2Histochemistry Royal Postgraduate Medical School, Hammersmith Hospital, London, England

Tóm tắt

The pancreas from eleven species of snakes representing both advanced and primitive families has been investigated for the presence of eleven regulatory peptides reported to occur in the mammalian endocrine pancreas. Of the eleven peptides studied, insulin, pancreatic glucagon and somatostatin were present in endocrine cells within the islets of all the species investigated. The neuropeptide, vasoactive intestinal polypeptide, was located within nerve terminals innervating the islets in the Boidinae, Colubrinae, Elaphidae and Crotalidae but absent from the Natricinae investigated. No immunoreactivity was demonstrable with the antisera to substance P, met-enkephalin, C-terminal gastrin, bombesin, glicentin and gastric inhibitory polypeptide. Pancreatic polypeptide-like immunoreactivity was demonstrable only in the boid snakes and exclusively stained by a C-terminal specific antiserum.

Tài liệu tham khảo

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