The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation

Langer, 1993, Tissue engineering, Science, 260, 920, 10.1126/science.8493529 Bolland, 2007, Adult mesenchymal stem cells and impaction grafting: a new clinical paradigm shift, Expet Rev Med Dev, 4, 393, 10.1586/17434440.4.3.393 Kneser, 2006, Tissue engineering of bone: the reconstructive surgeon's point of view, J Cell Mol Med, 10, 7, 10.1111/j.1582-4934.2006.tb00287.x Murphy, 2004, Bone regeneration via a mineral substrate and induced angiogenesis, J Dent Res, 83, 204, 10.1177/154405910408300304 Levenberg, 2005, Engineering vascularized skeletal muscle tissue, Nat Biotechnol, 23, 879, 10.1038/nbt1109 Yang, 2004, Human osteoprogenitor bone formation using encapsulated bone morphogenetic protein 2 in porous polymer scaffolds, Tissue Eng, 10, 1037, 10.1089/ten.2004.10.1037 Huang, 2005, Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration, J Bone Miner Res, 20, 848, 10.1359/JBMR.041226 Kaigler, 2006, VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects, J Bone Miner Res, 21, 735, 10.1359/jbmr.060120 Putnam, 1996, Tissue engineering using synthetic extracellular matrices, Nat Med, 2, 824, 10.1038/nm0796-824 Richardson, 2001, Polymeric system for dual growth factor delivery, Nat Biotechnol, 19, 1029, 10.1038/nbt1101-1029 Brey, 2002, A technique for quantitative three-dimensional analysis of microvascular structure, Microvasc Res, 63, 279, 10.1006/mvre.2002.2395 Carano, 2003, Angiogenesis and bone repair, Drug Discov Today, 8, 980, 10.1016/S1359-6446(03)02866-6 Gerber, 1999, VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation, Nat Med, 5, 623, 10.1038/9467 Mayr-Wohlfart, 2002, Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts, Bone, 30, 472, 10.1016/S8756-3282(01)00690-1 Wang, 2007, The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development, J Clin Invest, 117, 1616, 10.1172/JCI31581 Bouletreau, 2002, Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells: implications for fracture healing, Plast Reconstr Surg, 109, 2384, 10.1097/00006534-200206000-00033 Deckers, 2002, Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A, Endocrinology, 143, 1545, 10.1210/endo.143.4.8719 Hausman, 2001, Prevention of fracture healing in rats by an inhibitor of angiogenesis, Bone, 29, 560, 10.1016/S8756-3282(01)00608-1 Street, 2002, Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover, Proc Natl Acad Sci U S A, 99, 9656, 10.1073/pnas.152324099 Kanczler, 2008, The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation, Biomaterials, 29, 1892, 10.1016/j.biomaterials.2007.12.031 Simmons, 2004, Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells, Bone, 35, 562, 10.1016/j.bone.2004.02.027 Ginty, 2008, Controlling protein release from scaffolds using polymer blends and composites, Eur J Pharm Biopharm, 68, 82, 10.1016/j.ejpb.2007.05.023 Oreffo, 1997, Modulation of osteogenesis and adipogenesis by human serum in human bone marrow cultures, Eur J Cell Biol, 74, 251 Jaffe, 1973, Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria, J Clin Invest, 52, 2745, 10.1172/JCI107470 Sojo, 2005, Immunohistochemical study of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2, -4 (BMP-2, -4) on lengthened rat femurs, J Craniomaxillofac Surg, 33, 238, 10.1016/j.jcms.2005.02.004 Weiss, 2009, The systemic angiogenic response during bone healing, Arch Orthop Trauma Surg, 129, 989, 10.1007/s00402-008-0777-5 Howdle, 2001, Supercritical fluid mixing: preparation of thermally sensitive polymer composites containing bioactive materials, Chem Commun, 01, 109, 10.1039/b008188o Hou, 2007, Tissue engineering bone formation in novel recombinant human bone morphogenic protein 2-atelocollagen composite scaffolds, J Periodontol, 78, 335, 10.1902/jop.2007.060106 Bancroft, 2002, Enzyme histochemistry and its diagnostic applications, 596 Miao, 2002, Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage, J Histochem Cytochem, 50, 333, 10.1177/002215540205000305 Kanczler, 2007, Supercritical carbon dioxide generated vascular endothelial growth factor encapsulated poly(DL-lactic acid) scaffolds induce angiogenesis in vitro, Biochem Biophys Res Commun, 352, 135, 10.1016/j.bbrc.2006.10.187 Uchida, 2003, Vascular endothelial growth factor is expressed along with its receptors during the healing process of bone and bone marrow after drill-hole injury in rats, Bone, 32, 491, 10.1016/S8756-3282(03)00053-X Kanczler, 2008, Osteogenesis and angiogenesis: the potential for engineering bone, Eur Cell Mater, 15, 100, 10.22203/eCM.v015a08 Kaigler, 2003, Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells, Tissue Eng, 9, 95, 10.1089/107632703762687573 Wan, 2008, Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration, Proc Natl Acad Sci U S A, 105, 686, 10.1073/pnas.0708474105 Guillotin, 2008, Interaction between human umbilical vein endothelial cells and human osteoprogenitors triggers pleiotropic effect that may support osteoblastic function, Bone, 42, 1080, 10.1016/j.bone.2008.01.025 Ferrari, 2006, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis, Proc Natl Acad Sci, 103, 17260, 10.1073/pnas.0605556103 Saito, 2003, Local bone formation by injection of recombinant human bone morphogenetic protein-2 contained in polymer carriers, Bone, 32, 381, 10.1016/S8756-3282(03)00028-0 Bessho, 2002, Experimental studies on bone induction using low-molecular-weight poly (DL-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein- 2, J Biomed Mater Res, 61, 61, 10.1002/jbm.10169 Wei, 2007, The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres, Biomaterials, 28, 2087, 10.1016/j.biomaterials.2006.12.028 Geiger, 2005, Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects, J Bone Miner Res, 20, 2028, 10.1359/JBMR.050701 Peng, 2005, VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis, J Bone Miner Res, 20, 2017, 10.1359/JBMR.050708 Oest, 2007, Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects, J Orthop Res, 25, 941, 10.1002/jor.20372 Patel, 2008, Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical sized defect model, Bone, 43, 931, 10.1016/j.bone.2008.06.019 Kempen, 2009, Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration, Biomaterials, 30, 2816, 10.1016/j.biomaterials.2009.01.031 Kaigler, 2005, Endothel cell modulation bone marrow stromal cell osteogenic potential, FASEB J, 19, 665, 10.1096/fj.04-2529fje Yu, 2008, Promotion of osteogenesis in tissue-engineered bone by pre-seeding endothelial progenitor cells-derived endothelial cells, J Orthop Res, 26, 1147, 10.1002/jor.20609