Age dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-γ production

Anderson, 2005, Deaths: leading causes for 2002, Natl Vital Stat. Rep., 53, 1 Aspinall, 2000, Thymic involution in aging, J. Clin. Immunol., 20, 250, 10.1023/A:1006611518223 Beers, M. H., Berkow, R., 2000. The Merck Manual of Geriatrics, third ed. Beers, M. H., Berkow R. (Eds.), 1. 1 vols. Merck Research Laboratories, New Jersey. Berg, 2002, Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18, Eur. J. Immunol., 32, 2807, 10.1002/1521-4141(2002010)32:10<2807::AID-IMMU2807>3.0.CO;2-0 Berg, 2003, Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen, J. Exp. Med., 198, 1583, 10.1084/jem.20031051 Brooks, 2001, Boosting vaccine for tuberculosis, Infect. Immun., 69, 2714, 10.1128/IAI.69.4.2714-2717.2001 Cooper, 1995, Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis, Infect. Immun., 63, 3259, 10.1128/IAI.63.9.3259-3265.1995 Cooper, 1993, Disseminated tuberculosis in interferon gamma gene-disrupted mice, J. Exp. Med., 178, 2243, 10.1084/jem.178.6.2243 Dutt, 1992, Tuberculosis, Clin. Geriatr. Med., 8, 761, 10.1016/S0749-0690(18)30443-9 Eaton, 2004, Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses, J. Exp. Med., 200, 1613, 10.1084/jem.20041395 Ehrchen, 2004, Senescent BALB/c mice are able to develop resistance to Leishmania major infection, Infect. Immun., 72, 5106, 10.1128/IAI.72.9.5106-5114.2004 Ernst, 1993, The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression, J. Immunol., 151, 575, 10.4049/jimmunol.151.2.575 Flynn, 1993, An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection, J. Exp. Med., 178, 2249, 10.1084/jem.178.6.2249 Gavazzi, 2002, Ageing and infection, Lancet Infect. Dis., 2, 659, 10.1016/S1473-3099(02)00437-1 Haynes, 2003, CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly, Proc. Natl. Acad. Sci. USA, 100, 15053, 10.1073/pnas.2433717100 He, W., Sengupta, M., Velkoff, V.A., 2005. U.S. Census Bureau. 65+ in the United States: 2005. Jouanguy, 1999, IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men, Curr. Opin. Immunol., 11, 346, 10.1016/S0952-7915(99)80055-7 Kalache, 2002, Compression of morbidity and active ageing: key priorities for public health policy in the 21st century, Bull. World Health Organ., 80, 243 Klinman, 1997, The B-cell biology of aging, Immunol. Rev., 160, 103, 10.1111/j.1600-065X.1997.tb01031.x Lerner, 1989, Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A, Eur. J. Immunol., 19, 977, 10.1002/eji.1830190604 Linton, 2004, Age-related changes in lymphocyte development and function, Nat. Immunol., 5, 133, 10.1038/ni1033 Lovik, 1985, Effect of aging on antimicrobial immunity: old mice display a normal capacity for generating protective T cells and immunologic memory in response to infection with Listeria monocytogenes, J. Immunol., 135, 3479, 10.4049/jimmunol.135.5.3479 Pawelec, 1998, T cells and aging, Front Biosci., 3, d59, 10.2741/A266 Pawelec, 1998, Impact of aging on innate immunity, J. Leukoc Biol., 64, 703, 10.1002/jlb.64.6.703 Presky, 1996, A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits, Proc. Natl. Acad. Sci. USA, 93, 14002, 10.1073/pnas.93.24.14002 Renshaw, 2002, Cutting edge: impaired Toll-like receptor expression and function in aging, J. Immunol., 169, 4697, 10.4049/jimmunol.169.9.4697 Saule, 2006, Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment, Mech. Ageing Dev., 127, 274, 10.1016/j.mad.2005.11.001 Scharton-Kersten, 1996, In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection, J. Immunol., 157, 4045, 10.4049/jimmunol.157.9.4045 Sercan, 2006, Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis, J. Immunol., 176, 735, 10.4049/jimmunol.176.2.735 Smeltz, 2001, Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4, J. Exp. Med., 194, 143, 10.1084/jem.194.2.143 Stead, 1991, Tuberculosis in elderly persons, Annu. Rev. Med., 42, 267, 10.1146/annurev.me.42.020191.001411 Stein, 1994, Vaccinating elderly people. Protecting from avoidable disease, Drugs Aging, 5, 242, 10.2165/00002512-199405040-00002 Turner, 2002, Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells, Infect. Immun., 70, 4628, 10.1128/IAI.70.8.4628-4637.2002 Turner, 2004, The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-gamma) but not IFN type I, Mech. Ageing Dev., 125, 1, 10.1016/j.mad.2003.09.002 Vesosky, 2006, Th1 cytokines facilitate CD8-T-cell-mediated early resistance to infection with Mycobacterium tuberculosis in old mice, Infect. Immun., 74, 3314, 10.1128/IAI.01475-05 Webster, 2000, Immunity to influenza in the elderly, Vaccine, 18, 1686, 10.1016/S0264-410X(99)00507-1 Whitmire, 2005, Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection, J. Exp. Med., 201, 1053, 10.1084/jem.20041463 Wilson, T.W., 2004. Centers for Disease Control and Prevention. Reported Tuberculosis in the United States, 2003.