SIRT1 in Neurodevelopment and Brain Senescence
Tài liệu tham khảo
Abe, 2011, Altered sirtuin deacetylase gene expression in patients with a mood disorder, J. Psychiatr. Res., 45, 1106, 10.1016/j.jpsychires.2011.01.016
Adamec, 1999, DNA strand breaks in Alzheimer’s disease, Brain Res., 849, 67, 10.1016/S0006-8993(99)02004-1
Albani, 2009, The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide, J. Neurochem., 110, 1445, 10.1111/j.1471-4159.2009.06228.x
Arai, 2006, TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis, Biochem. Biophys. Res. Commun., 351, 602, 10.1016/j.bbrc.2006.10.093
Ardestani, 2012, Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells, Nucleus, 3, 442, 10.4161/nucl.21134
Asher, 2008, SIRT1 regulates circadian clock gene expression through PER2 deacetylation, Cell, 134, 317, 10.1016/j.cell.2008.06.050
Bai, 2011, PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation, Cell Metab., 13, 461, 10.1016/j.cmet.2011.03.004
Barber, 2012, SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation, Nature, 487, 114, 10.1038/nature11043
Bellet, 2011, The time of metabolism: NAD+, SIRT1, and the circadian clock, Cold Spring Harb. Symp. Quant. Biol., 76, 31, 10.1101/sqb.2011.76.010520
Bellet, 2013, Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1, Proc. Natl. Acad. Sci. USA, 110, 3333, 10.1073/pnas.1214266110
Bizat, 2010, Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans, J. Neurosci., 30, 5394, 10.1523/JNEUROSCI.5831-09.2010
Blanchet, 2008, Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice, Prog. Neuropsychopharmacol. Biol. Psychiatry, 32, 1243, 10.1016/j.pnpbp.2008.03.024
Blesa, 2012, Classic and new animal models of Parkinson’s disease, J. Biomed. Biotechnol., 2012, 845618
Braidy, 2013, Mapping NAD metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence, Biogerontology
Brinkmann, 2011, Molecular mechanisms of androgen action–a historical perspective, Methods Mol. Biol., 776, 3, 10.1007/978-1-61779-243-4_1
Brunet, 2004, Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase, Science, 303, 2011, 10.1126/science.1094637
Byles, 2010, Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells, Int. J. Biol. Sci., 6, 599, 10.7150/ijbs.6.599
Cakir, 2009, Hypothalamic Sirt1 regulates food intake in a rodent model system, PLoS ONE, 4, e8322, 10.1371/journal.pone.0008322
Cantó, 2012, The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity, Cell Metab., 15, 838, 10.1016/j.cmet.2012.04.022
Chang, 2013, SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging, Cell, 153, 1448, 10.1016/j.cell.2013.05.027
Chen, 2005, SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling, J. Biol. Chem., 280, 40364, 10.1074/jbc.M509329200
Chen, 2008, The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration, Exp. Gerontol., 43, 1086, 10.1016/j.exger.2008.08.050
Chopra, 2012, The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models, Cell Rep, 2, 1492, 10.1016/j.celrep.2012.11.001
Codocedo, 2012, SIRT1 regulates dendritic development in hippocampal neurons, PLoS One, 7, e47073, 10.1371/journal.pone.0047073
Cohen, 2009, Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction, Genes Dev., 23, 2812, 10.1101/gad.1839209
Cohen, 2011, The acetylation of tau inhibits its function and promotes pathological tau aggregation, Nat Commun, 2, 252, 10.1038/ncomms1255
Conte, 2003, Synergistic protection of PC12 cells from beta-amyloid toxicity by resveratrol and catechin, Brain Res. Bull., 62, 29, 10.1016/j.brainresbull.2003.08.001
Coppari, 2012, Metabolic actions of hypothalamic SIRT1, Trends Endocrinol. Metab., 23, 179, 10.1016/j.tem.2012.01.002
Cozzolino, 2012, Amyotrophic lateral sclerosis: new insights into underlying molecular mechanisms and opportunities for therapeutic intervention, Antioxid. Redox Signal., 17, 1277, 10.1089/ars.2011.4328
DeJesus-Hernandez, 2011, Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS, Neuron, 72, 245, 10.1016/j.neuron.2011.09.011
Deng, 2011, Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia, Nature, 477, 211, 10.1038/nature10353
Dietrich, 2010, Agrp neurons mediate Sirt1’s action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity, J. Neurosci., 30, 11815, 10.1523/JNEUROSCI.2234-10.2010
Dietrich, 2012, AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors, Nat. Neurosci., 15, 1108, 10.1038/nn.3147
Dokmanovic, 2007, Histone deacetylase inhibitors: overview and perspectives, Mol. Cancer Res., 5, 981, 10.1158/1541-7786.MCR-07-0324
Donmez, 2010, SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10, Cell, 142, 320, 10.1016/j.cell.2010.06.020
Donmez, 2012, SIRT1 protects against α-synuclein aggregation by activating molecular chaperones, J. Neurosci., 32, 124, 10.1523/JNEUROSCI.3442-11.2012
Du, 2011, Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase, Science, 334, 806, 10.1126/science.1207861
Eskandarian, 2013, A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection, Science, 341, 1238858, 10.1126/science.1238858
Ferguson, 2013, Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action, J. Neurosci., 33, 16088, 10.1523/JNEUROSCI.1284-13.2013
Fernández-Rhodes, 2011, Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial, Lancet Neurol., 10, 140, 10.1016/S1474-4422(10)70321-5
Ferrante, 1997, Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis, J. Neurochem., 69, 2064, 10.1046/j.1471-4159.1997.69052064.x
Fonseca-Kelly, 2012, Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis, Front. Neurol., 3, 84, 10.3389/fneur.2012.00084
Ford, 2006, Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription, Genes Dev., 20, 1075, 10.1101/gad.1399706
Frye, 1999, Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity, Biochem. Biophys. Res. Commun., 260, 273, 10.1006/bbrc.1999.0897
Frye, 2000, Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins, Biochem. Biophys. Res. Commun., 273, 793, 10.1006/bbrc.2000.3000
Fu, 2006, Hormonal control of androgen receptor function through SIRT1, Mol. Cell. Biol., 26, 8122, 10.1128/MCB.00289-06
Gao, 2010, A novel pathway regulates memory and plasticity via SIRT1 and miR-134, Nature, 466, 1105, 10.1038/nature09271
Gomes, 2013, Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging, Cell, 155, 1624, 10.1016/j.cell.2013.11.037
Gregoretti, 2004, Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis, J. Mol. Biol., 338, 17, 10.1016/j.jmb.2004.02.006
Guarente, 2013, Calorie restriction and sirtuins revisited, Genes Dev., 27, 2072, 10.1101/gad.227439.113
Guo, 2011, Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling, J. Neurosci. Res., 89, 1723, 10.1002/jnr.22725
Haigis, 2006, SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells, Cell, 126, 941, 10.1016/j.cell.2006.06.057
Han, 2004, Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C, Br. J. Pharmacol., 141, 997, 10.1038/sj.bjp.0705688
Han, 2012, Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice, Brain Res., 1483, 112, 10.1016/j.brainres.2012.09.022
Hathorn, 2011, Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington’s disease, Neurobiol. Dis., 41, 43, 10.1016/j.nbd.2010.08.017
Hirschey, 2010, SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation, Nature, 464, 121, 10.1038/nature08778
Hisahara, 2008, Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation, Proc. Natl. Acad. Sci. USA, 105, 15599, 10.1073/pnas.0800612105
Ho, 2010, Resveratrol protects against peripheral deficits in a mouse model of Huntington’s disease, Exp. Neurol., 225, 74, 10.1016/j.expneurol.2010.05.006
Hong, 2012, Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals, PLoS Genet., 8, e1002857, 10.1371/journal.pgen.1002857
Hubbard, 2013, Evidence for a common mechanism of SIRT1 regulation by allosteric activators, Science, 339, 1216, 10.1126/science.1231097
Imaoka, 2012, Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study, Oncol. Rep., 28, 923, 10.3892/or.2012.1872
Imai, 2000, Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase, Nature, 403, 795, 10.1038/35001622
Jang, 2003, Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death, Free Radic. Biol. Med., 34, 1100, 10.1016/S0891-5849(03)00062-5
Jeong, 2012, Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway, Nat. Med., 18, 159, 10.1038/nm.2559
Jeong, 2013, Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity, Neurobiol. Aging, 34, 146, 10.1016/j.neurobiolaging.2012.04.002
Jiang, 2013, SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine, Nature, 496, 110, 10.1038/nature12038
Jiang, 2012, Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets, Nat. Med., 18, 153, 10.1038/nm.2558
Jin, 2007, Cytoplasm-localized SIRT1 enhances apoptosis, J. Cell. Physiol., 213, 88, 10.1002/jcp.21091
Johnson, 2010, Exome sequencing reveals VCP mutations as a cause of familial ALS, Neuron, 68, 857, 10.1016/j.neuron.2010.11.036
Kaeberlein, 1999, The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms, Genes Dev., 13, 2570, 10.1101/gad.13.19.2570
Karuppagounder, 2009, Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease, Neurochem. Int., 54, 111, 10.1016/j.neuint.2008.10.008
Katsuno, 2002, Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy, Neuron, 35, 843, 10.1016/S0896-6273(02)00834-6
Katsuno, 2003, Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy, Nat. Med., 9, 768, 10.1038/nm878
Katsuno, 2010, Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial, Lancet Neurol., 9, 875, 10.1016/S1474-4422(10)70182-4
Kim, 1999, Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae, Mol. Biol. Cell, 10, 3125, 10.1091/mbc.10.10.3125
Kim, 2007, SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis, EMBO J., 26, 3169, 10.1038/sj.emboj.7601758
Kishi, 2010, SIRT1 gene is associated with major depressive disorder in the Japanese population, J. Affect. Disord., 126, 167, 10.1016/j.jad.2010.04.003
Kishi, 2011, SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study, Genes Brain Behav., 10, 257, 10.1111/j.1601-183X.2010.00661.x
Kishi, 2011, No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population, Hum. Psychopharmacol., 26, 445, 10.1002/hup.1223
Klar, 1979, MAR1-a Regulator of the HMa and HMalpha Loci in SACCHAROMYCES CEREVISIAE, Genetics, 93, 37, 10.1093/genetics/93.1.37
Körner, 2013, Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?, Neurodegener. Dis., 11, 141, 10.1159/000338048
Kowal, 2013, The current and projected economic burden of Parkinson’s disease in the United States, Mov. Disord., 28, 311, 10.1002/mds.25292
Kumar, 2006, Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms, Behav. Pharmacol., 17, 485, 10.1097/00008877-200609000-00014
Kwiatkowski, 2009, Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis, Science, 323, 1205, 10.1126/science.1166066
La Spada, 2012, Finding a sirtuin truth in Huntington’s disease, Nat. Med., 18, 24, 10.1038/nm.2624
La Spada, 1991, Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy, Nature, 352, 77, 10.1038/352077a0
Landry, 2000, The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases, Proc. Natl. Acad. Sci. USA, 97, 5807, 10.1073/pnas.110148297
Lee, 2012, Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis, Brain Res., 1433, 20, 10.1016/j.brainres.2011.11.019
Li, 2013, Sirt1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3, Mol. Neurobiol., 48, 490, 10.1007/s12035-013-8437-3
Libert, 2011, SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive, Cell, 147, 1459, 10.1016/j.cell.2011.10.054
Liszt, 2005, Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase, J. Biol. Chem., 280, 21313, 10.1074/jbc.M413296200
Liu, 2013, MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration, Genes Dev., 27, 1473, 10.1101/gad.209619.112
Markert, 2010, A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis, J. Med. Food, 13, 1081, 10.1089/jmf.2009.0243
Massudi, 2012, Age-associated changes in oxidative stress and NAD+ metabolism in human tissue, PLoS ONE, 7, e42357, 10.1371/journal.pone.0042357
Matarese, 2013, Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses, Proc. Natl. Acad. Sci. USA, 110, 6193, 10.1073/pnas.1210644110
Merry, 2012, Attacking the flank: targeting new pathways in SBMA, Nat. Med., 18, 1461, 10.1038/nm.2967
Michán, 2010, SIRT1 is essential for normal cognitive function and synaptic plasticity, J. Neurosci., 30, 9695, 10.1523/JNEUROSCI.0027-10.2010
Michishita, 2008, SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin, Nature, 452, 492, 10.1038/nature06736
Michishita, 2005, Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins, Mol. Biol. Cell, 16, 4623, 10.1091/mbc.e05-01-0033
Min, 2010, Acetylation of tau inhibits its degradation and contributes to tauopathy, Neuron, 67, 953, 10.1016/j.neuron.2010.08.044
Montie, 2011, SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA, J. Neurosci., 31, 17425, 10.1523/JNEUROSCI.3958-11.2011
Mostoslavsky, 2006, Genomic instability and aging-like phenotype in the absence of mammalian SIRT6, Cell, 124, 315, 10.1016/j.cell.2005.11.044
Mouchiroud, 2013, The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling, Cell, 154, 430, 10.1016/j.cell.2013.06.016
Mudò, 2012, Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease, Cell. Mol. Life Sci., 69, 1153, 10.1007/s00018-011-0850-z
Musiek, 2013, Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, J. Clin. Invest., 123, 5389, 10.1172/JCI70317
Nakagawa, 2009, SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle, Cell, 137, 560, 10.1016/j.cell.2009.02.026
Nakahata, 2008, The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control, Cell, 134, 329, 10.1016/j.cell.2008.07.002
Nakahata, 2009, Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1, Science, 324, 654, 10.1126/science.1170803
Neumann, 2006, Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis, Science, 314, 130, 10.1126/science.1134108
Nimmagadda, 2013, Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets, J. Immunol., 190, 4595, 10.4049/jimmunol.1202584
Noh, 2013, Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer, Pathol. Res. Pract., 209, 365, 10.1016/j.prp.2013.03.011
North, 2004, Sirtuins: Sir2-related NAD-dependent protein deacetylases, Genome Biol., 5, 224, 10.1186/gb-2004-5-5-224
North, 2007, Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis, PloS One, 2, e784, 10.1371/journal.pone.0000784
North, 2003, The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase, Mol. Cell, 11, 437, 10.1016/S1097-2765(03)00038-8
Olitsky, 1949, Experimental disseminated encephalomyelitis in white mice, J. Exp. Med., 90, 213, 10.1084/jem.90.3.213
Onyango, 2002, SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria, Proc. Natl. Acad. Sci. USA, 99, 13653, 10.1073/pnas.222538099
Outeiro, 2007, Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease, Science, 317, 516, 10.1126/science.1143780
Pallos, 2008, Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease, Hum. Mol. Genet., 17, 3767, 10.1093/hmg/ddn273
Park, 2012, Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases, Cell, 148, 421, 10.1016/j.cell.2012.01.017
Parker, 2005, Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons, Nat. Genet., 37, 349, 10.1038/ng1534
Parker, 2012, Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity, J. Neurosci., 32, 12630, 10.1523/JNEUROSCI.0277-12.2012
Peek, 2013, Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice, Science, 342, 1243417, 10.1126/science.1243417
Peng, 2011, The first identification of lysine malonylation substrates and its regulatory enzyme, Mol. Cell. Proteomics, 10, 012658, 10.1074/mcp.M111.012658
Prozorovski, 2008, Sirt1 contributes critically to the redox-dependent fate of neural progenitors, Nat. Cell Biol., 10, 385, 10.1038/ncb1700
Prusiner, 1998, Prions, Proc. Natl. Acad. Sci. USA, 95, 13363, 10.1073/pnas.95.23.13363
Qin, 2006, Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction, J. Biol. Chem., 281, 21745, 10.1074/jbc.M602909200
Rafalski, 2013, Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain, Nat. Cell Biol., 15, 614, 10.1038/ncb2735
Ramadori, 2008, Brain SIRT1: anatomical distribution and regulation by energy availability, J. Neurosci., 28, 9989, 10.1523/JNEUROSCI.3257-08.2008
Ramadori, 2010, SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity, Cell Metab., 12, 78, 10.1016/j.cmet.2010.05.010
Ramadori, 2011, SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance, Cell Metab., 14, 301, 10.1016/j.cmet.2011.06.014
Ramsey, 2008, Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice, Aging Cell, 7, 78, 10.1111/j.1474-9726.2007.00355.x
Raynes, 2012, Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans, J. Biol. Chem., 287, 29045, 10.1074/jbc.M112.353714
Renthal, 2009, Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins, Neuron, 62, 335, 10.1016/j.neuron.2009.03.026
Renton, 2011, A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD, Neuron, 72, 257, 10.1016/j.neuron.2011.09.010
Rine, 1979, A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci, Genetics, 93, 877, 10.1093/genetics/93.4.877
Robison, 1984, DNA damage and chronic neuronal degenerations, J. Neurol. Sci., 64, 11, 10.1016/0022-510X(84)90051-0
Rosen, 1993, Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis, Nature, 362, 59, 10.1038/362059a0
Sampaio-Marques, 2012, SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy, Autophagy, 8, 1494, 10.4161/auto.21275
Sasaki, 2010, Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide, Endocrinology, 151, 2556, 10.1210/en.2009-1319
Satoh, 2010, SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus, J. Neurosci., 30, 10220, 10.1523/JNEUROSCI.1385-10.2010
Satoh, 2013, Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH, Cell Metab., 18, 416, 10.1016/j.cmet.2013.07.013
Schwer, 2002, The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, J. Cell Biol., 158, 647, 10.1083/jcb.200205057
Seo, 2012, SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death, Neurobiol. Aging, 33, 1110, 10.1016/j.neurobiolaging.2010.09.019
Shindler, 2007, SIRT1 activation confers neuroprotection in experimental optic neuritis, Invest. Ophthalmol. Vis. Sci., 48, 3602, 10.1167/iovs.07-0131
Shindler, 2010, Oral resveratrol reduces neuronal damage in a model of multiple sclerosis, J. Neuroophthalmol., 30, 328, 10.1097/WNO.0b013e3181f7f833
Shuto, 2013, Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum, Neurosci. Lett., 542, 107, 10.1016/j.neulet.2013.02.050
Singh, 2007, Resveratrol (trans-3,5,4′-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor, Mol. Pharmacol., 72, 1508, 10.1124/mol.107.038984
Smith, 2000, A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family, Proc. Natl. Acad. Sci. USA, 97, 6658, 10.1073/pnas.97.12.6658
Someya, 2010, Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction, Cell, 143, 802, 10.1016/j.cell.2010.10.002
Sosa-Ortiz, 2012, Epidemiology of dementias and Alzheimer’s disease, Arch. Med. Res., 43, 600, 10.1016/j.arcmed.2012.11.003
Sugino, 2010, Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells, FEBS Lett., 584, 2821, 10.1016/j.febslet.2010.04.063
Sun, 2001, Oxidized lipoproteins, beta amyloid peptides and Alzheimer’s disease, Neurotox. Res., 3, 167, 10.1007/BF03033189
Tanno, 2007, Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1, J. Biol. Chem., 282, 6823, 10.1074/jbc.M609554200
Tanny, 1999, An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing, Cell, 99, 735, 10.1016/S0092-8674(00)81671-2
Vakhrusheva, 2008, Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice, Circ. Res., 102, 703, 10.1161/CIRCRESAHA.107.164558
van Ham, 2008, C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging, PLoS Genet., 4, e1000027, 10.1371/journal.pgen.1000027
Velásquez, 2011, The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin, Diabetes, 60, 1177, 10.2337/db10-0802
Vingtdeux, 2010, AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism, J. Biol. Chem., 285, 9100, 10.1074/jbc.M109.060061
Wang, 2011, Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis, Neurosci. Lett., 503, 250, 10.1016/j.neulet.2011.08.047
Wauters, 2013, Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer, Cancer Res., 73, 2357, 10.1158/0008-5472.CAN-12-3359
Westerheide, 2009, Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1, Science, 323, 1063, 10.1126/science.1165946
Wu, 2011, Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease, Neurosignals, 19, 163, 10.1159/000328516
Yáñez, 2011, CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole, Brain Res., 1423, 77, 10.1016/j.brainres.2011.09.025
Yoshino, 2011, Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice, Cell Metab., 14, 528, 10.1016/j.cmet.2011.08.014
Zhao, 2013, Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway, Biochem. Biophys. Res. Commun., 435, 597, 10.1016/j.bbrc.2013.05.025
