A Computational Model for Cerebral Cortical Dysfunction in Autism Spectrum Disorders

Biological Psychiatry - Tập 67 - Trang 672-678 - 2010
Shashaank Vattikuti1, Carson C. Chow1
1Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland

Tài liệu tham khảo

Rubenstein, 2003, Model of autism: Increased ratio of excitation/inhibition in key neural systems, Genes Brain Behav, 2, 255, 10.1034/j.1601-183X.2003.00037.x Hussman, 2001, Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism, J Autism Dev Disord, 31, 247, 10.1023/A:1010715619091 Casanova, 2003, Disruption in the inhibitory architecture of the cell minicolumn: Implications for autism, Neuroscientist, 9, 496, 10.1177/1073858403253552 Accardo, 2008 Wing, 2000, Catatonia in autistic spectrum disorders, Br J Psychiatry, 176, 357, 10.1192/bjp.176.4.357 Fatemi, 2009, GABA(A) receptor downregulation in brains of subjects with autism, J Autism Dev Disord, 39, 223, 10.1007/s10803-008-0646-7 Abrahams, 2008, Advances in autism genetics: On the threshold of a new neurobiology, Nat Rev Genet, 9, 341, 10.1038/nrg2346 Bourgeron, 2007, The possible interplay of synaptic and clock genes in autism spectrum disorders, Cold Spring Harb Symp Quant Biol, 72, 645, 10.1101/sqb.2007.72.020 Gibson, 2008, Imbalance of neocortical excitation and inhibition and altered up states reflect network hyperexcitability in the mouse model of fragile x syndrome, J Neurophysiol, 100, 2615, 10.1152/jn.90752.2008 Curia, 2009, Downregulation of tonic GABAergic inhibition in a mouse model of fragile x syndrome, Cereb Cortex, 19, 1515, 10.1093/cercor/bhn159 Casanova, 2006, Minicolumnar abnormalities in autism, Acta Neuropathol, 112, 287, 10.1007/s00401-006-0085-5 Rosenhall, 1988, Oculomotor findings in autistic children, J Laryngol Otol, 102, 435, 10.1017/S0022215100105286 Takarae, 2004, Oculomotor abnormalities parallel cerebellar histopathology in autism, J Neurol Neurosurg Psychiatry, 75, 1359, 10.1136/jnnp.2003.022491 Takarae, 2004, Pursuit eye movement deficits in autism, Brain, 127, 2584, 10.1093/brain/awh307 Luna, 2007, Maturation of executive function in autism, Biol Psychiatry, 61, 474, 10.1016/j.biopsych.2006.02.030 Duhamel, 1992, Saccadic dysmetria in a patient with a right frontoparietal lesion, Brain, 115, 1387, 10.1093/brain/115.5.1387 Kapoula, 2005, Role of the posterior parietal cortex in the initiation of saccades and vergence: Right/left functional asymmetry, Ann N Y Acad Sci, 1039, 184, 10.1196/annals.1325.018 Barash, 1991, Saccade related activity in the lateral intraparietal area, J Neurophysiol, 66, 1109, 10.1152/jn.1991.66.3.1109 Bracewell, 1996, Motor intention activity in the macaque's lateral intraparietal area, J Neurophysiol, 76, 1457, 10.1152/jn.1996.76.3.1457 Chafee, 2000, Inactivation of parietal and prefrontal cortex reveals interdependence of neural activity during memory-guided saccades, J Neurophysiol, 83, 1550, 10.1152/jn.2000.83.3.1550 Ben Hamed, 2002, Ocular fixation and visual activity in the monkey lateral intraparietal area, Exp Brain Res, 142, 512, 10.1007/s00221-001-0954-z Melcher, 2008, Trans-saccadic perception, Trends Cogn Sci, 12, 466, 10.1016/j.tics.2008.09.003 Fanini, 2009, Direction selectivity of neurons in the macaque lateral intraparietal area, J Neurophysiol, 101, 289, 10.1152/jn.00400.2007 Laing, 2001, Stationary bumps in networks of spiking neurons, Neural Comput, 13, 1473, 10.1162/089976601750264974 Compte, 2000, Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical networked model, Cereb Cortex, 10, 913, 10.1093/cercor/10.9.910 Wang, 2006, Toward a prefrontal microcircuit model of cognitive deficits in schizophrenia, Pharmacopsychiatry, 39, S80, 10.1055/s-2006-931501 Carter, 2007, Cannabinoid-mediated disinhibition and working memory: Dynamical interplay of multiple feedback mechanisms in a continuous attractor model of prefrontal cortex, Cereb Cortex, 17, i16, 10.1093/cercor/bhm103 Edin, 2009, Mechanism for top-down control of working memory capacity, Proc Natl Acad Sci U S A, 106, 6802, 10.1073/pnas.0901894106 Douglas, 2007, Mapping the matrix: The ways of neocortex, Neuron, 56, 226, 10.1016/j.neuron.2007.10.017 Dias, 1995, Acute activation and inactivation of macaque frontal eye field with GABA-related drugs, J Neurophysiol, 74, 2744, 10.1152/jn.1995.74.6.2744 Chow, 2006, Existence and wandering of bumps in a spiking neural network model, SIAM Journal on Applied Dynamical Systems, 5, 552, 10.1137/060654347 D'Cruz, 2009, Lateralized response timing deficits in autism, Biol Psychiatry, 66, 393, 10.1016/j.biopsych.2009.01.008 Takarae, 2007, Atypical involvement of frontostriatal systems during sensorimotor control in autism, Psychiatry Res, 156, 117, 10.1016/j.pscychresns.2007.03.008 Elsabbagh, 2009, Visual orienting in the early broader autism phenotype: Disengagement and facilitation, J Child Psychol Psychiatry, 50, 637, 10.1111/j.1469-7610.2008.02051.x Ball, 1991, Pharmacology of saccadic eye movements in man: 1, Psychopharmacology (Berl), 105, 361, 10.1007/BF02244431 Reilly, 2008, Pharmacological treatment effects on eye movement control, Brain Cogn, 68, 415, 10.1016/j.bandc.2008.08.026 Brunel, 2000, Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition, J Comput Neurosci, 11, 63, 10.1023/A:1011204814320 Carroll, 2007, Review of adjunctive glutamate antagonist therapy in the treatment of catatonic syndromes, J Neuropsychiatry Clin Neurosci, 19, 406, 10.1176/jnp.2007.19.4.406 Fink, 2006, Catatonia in autistic spectrum disorders: A medical treatment algorithm, Int Rev Neurobiol, 72, 233, 10.1016/S0074-7742(05)72014-6 Northoff, 1999, Decreased density of GABA-A receptors in the left sensorimotor cortex in akinetic catatonia: Investigation of in vivo benzodiazepine receptor binding, J Neurol Neurosurg Psychiatry, 67, 445, 10.1136/jnnp.67.4.445 Muller, 2001, Atypical patterns of cerebral motor activation in autism: A functional magnetic resonance study, Biol Psychiatry, 49, 665, 10.1016/S0006-3223(00)01004-0 Kennedy, 2006, Failing to deactivate: Resting functional abnormalities in autism, Proc Natl Acad Sci U S A, 103, 8275, 10.1073/pnas.0600674103 Minshew, 1999, Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism, Neurology, 52, 917, 10.1212/WNL.52.5.917 Nowinski, 2005, Oculomotor studies of cerebellar function in autism, Psychiatry Res, 137, 11, 10.1016/j.psychres.2005.07.005 Casanova, 2007, The neuropathology of autism, Brain Pathol, 17, 422, 10.1111/j.1750-3639.2007.00100.x