Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Phelan, 2020, The novel coronavirus originating in Wuhan, China: challenges for global health governance, JAMA, 10.1001/jama.2020.1097 Gorbalenya, 2020, Severe acute respiratory syndrome-related coronavirus: the species and its viruses—a statement of the Coronavirus Study Group, bioRxiv Chan, 2003, Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS), Thorax, 58, 686, 10.1136/thorax.58.8.686 Li, 2020, Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia, N Engl J Med, 10.1056/NEJMoa2001316 Huang, 2020, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, 395, 497, 10.1016/S0140-6736(20)30183-5 Wang, 2020, Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA, 10.1001/jama.2020.1585 Chen, 2020, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, 395, 507, 10.1016/S0140-6736(20)30211-7 Kalil, 2016, Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society, Clin Infect Dis, 63, e61, 10.1093/cid/ciw353 Khwaja, 2012, KDIGO clinical practice guidelines for acute kidney injury, Nephron Clin Pract, 120, c179, 10.1159/000339789 Ranieri, 2012, Acute respiratory distress syndrome: the Berlin Definition, JAMA, 307, 2526 Yang, 2020, Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, Lancet Respir Med, 10.1016/S2213-2600(20)30079-5 Arabi, 2017, Middle East respiratory syndrome, N Engl J Med, 376, 584, 10.1056/NEJMsr1408795 Choi, 2003, Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong, Ann Intern Med, 139, 715, 10.7326/0003-4819-139-9-200311040-00005 Hong, 2018, Predictors of mortality in Middle East respiratory syndrome (MERS), Thorax, 73, 286, 10.1136/thoraxjnl-2016-209313 Smits, 2010, Exacerbated innate host response to SARS-CoV in aged non-human primates, PLoS Pathog, 6, e1000756-e, 10.1371/journal.ppat.1000756 Opal, 2005, The immunopathogenesis of sepsis in elderly patients, Clin Infect Dis, 41, S504, 10.1086/432007 Singer, 2016, The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), JAMA, 315, 801, 10.1001/jama.2016.0287 Ferreira, 2001, Serial evaluation of the SOFA score to predict outcome in critically ill patients, JAMA, 286, 1754, 10.1001/jama.286.14.1754 Zhou, 2019, Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network, Eur Respir J, 54, 1802406, 10.1183/13993003.02406-2018 Marrie, 2007, Community-acquired pneumonia requiring admission to an intensive care unit: a descriptive study, Medicine (Baltimore), 86, 103, 10.1097/MD.0b013e3180421c16 Corrales-Medina, 2013, Acute pneumonia and the cardiovascular system, Lancet, 381, 496, 10.1016/S0140-6736(12)61266-5 Udell, 2013, Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis, JAMA, 310, 1711, 10.1001/jama.2013.279206 Blackburn, 2018, Laboratory-confirmed respiratory infections as predictors of hospital admission for myocardial infarction and stroke: time-series analysis of English data for 2004–2015, Clin Infect Dis, 67, 8, 10.1093/cid/cix1144 Milbrandt, 2009, Prevalence and significance of coagulation abnormalities in community-acquired pneumonia, Mol Med, 15, 438, 10.2119/molmed.2009.00091 Rodelo, 2012, D-dimer is a significant prognostic factor in patients with suspected infection and sepsis, Am J Emerg Med, 30, 1991, 10.1016/j.ajem.2012.04.033 Smeeth, 2004, Risk of myocardial infarction and stroke after acute infection or vaccination, N Engl J Med, 351, 2611, 10.1056/NEJMoa041747 Corrales-Medina, 2012, Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality, Circulation, 125, 773, 10.1161/CIRCULATIONAHA.111.040766 Davidson, 2019, Cardiovascular complications of acute respiratory infections: current research and future directions, Expert Rev Anti Infect Ther, 17, 939, 10.1080/14787210.2019.1689817 Gallagher, 2008, Regulation of ACE2 in cardiac myocytes and fibroblasts, Am J Physiol Heart Circ Physiol, 295, H2373, 10.1152/ajpheart.00426.2008 Mendoza-Torres, 2015, ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension, Ther Adv Cardiovasc Dis, 9, 217, 10.1177/1753944715597623 Xu, 2020, Pathological findings of COVID-19 associated with acute respiratory distress syndrome, Lancet Respir Med, 10.1016/S2213-2600(20)30076-X Xu, 2005, Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase, Eur J Clin Microbiol Infect Dis, 24, 165, 10.1007/s10096-005-1299-5 Corman, 2016, Viral shedding and antibody response in 37 patients with Middle East Respiratory Syndrome coronavirus infection, Clin Infect Dis, 62, 477 Oh, 2016, Viral load kinetics of MERS coronavirus infection, N Engl J Med, 375, 1303, 10.1056/NEJMc1511695 Wang, 2018, Factors associated with prolonged viral shedding in patients with avian influenza A(H7N9) virus infection, J Infect Dis, 217, 1708, 10.1093/infdis/jiy115 Zou, 2020, SARS-CoV-2 viral load in upper respiratory specimens of infected patients, N Engl J Med, 10.1056/NEJMc2001737