Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review

Journal of Ethnopharmacology - Tập 159 - Trang 158-183 - 2015
Longfei Lin1, Boran Ni1, Hongmei Lin1, Miao Zhang1, Xuechun Li1, Xingbin Yin1, Changhai Qu1, Jian Ni1
1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China

Tài liệu tham khảo

Achenbach, 1992, New lignin glucosides from Stemmadenia minima, Planta Medica, 58, 270, 10.1055/s-2006-961451 Bai, 2013 Bhadauria, 2010, Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats, Experimental and Toxicologic Pathology, 62, 627, 10.1016/j.etp.2009.08.006 Birgitte, 2007, Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action, The International Journal of Biochemistry & Cell Biology, 39, 227, 10.1016/j.biocel.2006.08.006 Cai, 2011, Quality evaluation of raw and prepared radix polygonui multiflori from different producing areas and markets, Traditional Chinese Drug Research & Clinical Pharmacology, 22, 204 Chan, 2002, Beneficial effects of different Polygonum multiflorum Thunb. extracts on memory and hippocampus morphology, Journal of Nutritional Science and Vitaminology, 48, 491, 10.3177/jnsv.48.491 Chan, 2003, Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice, American Journal of Chinese Medicine, 31, 171, 10.1142/S0192415X03000862 Chang, 2012, Emodin induces embryonic toxicity in mouse blastocysts through apoptosis, Toxicology, 299, 25, 10.1016/j.tox.2012.05.006 Chen, 2006, Effect of heshouwu and roucongrong compound on immunological function of elderly patients with kidney deficiency and blood stasis, Chinese Journal of Clinical Rehabilitation, 10, 13 Chen, 1999, Identification index of Polygonum multiflorum thunb and its Adulterants (I.Plant, Macrostructure), Lishizhen Medicine and Materia Medica Research, 10, 44 Chen, 1998, Gel electrophoresis identification of radix polygoni multiflori and its adulterants, Journal of Chinese Medicinal Materials, 21, 71 Chen, 2013 Chen, 2012, Polygonflavanol A, a novel flavonostilbene glycoside from the roots of Polygonum multiflorum, Phytochemistry Letters, 5, 756, 10.1016/j.phytol.2012.08.007 Chen, 2012, Chemical characterization and immunostimulatory effects of a polysaccharide from Polygoni Multiflori Radix Praeparata in cyclophosphamide-induced anemic mice, Carbohydrate Polymers, 88, 1476, 10.1016/j.carbpol.2012.02.055 Chen, 2012, Content changes of 5 components in Polygohum muhiflorum during processing, Chinese Journal of Experimental Traditional Medical Formulae, 18, 66 Chen, 2012, The content change of 5 kinds of chemical components in Polygonum multiflorum Thunb during the processing, Chinese Journal of Experimental Traditional Medical Formulae, 18, 66 Chen, 1999, Studies on the chemical constituents of radix Polygoni multiflori preparata, Academic Journal of Second Military Medical University, 20, 438 Chen, 2000, Structural elucidation of a new tetrahydroxystilbene of radix polygoni multiflori preparata and study on its cardiovascular activity, Acta Pharmaceutica Sinica, 35, 906 Chen, 2001, Studies on nootropic activity and mechanism of emodin-8-O-β-d-glucopyranoside, Chinese Traditional and Herbal Drugs, 32, 39 Chen, 2000, A new fatty ketone of radix Polygoni multiflori preparata, China Journal of Chinese Materia Medica, 25, 476 Chen, 2001, Studies on two new phospholipids of radix Polygoni multiflori preparata, Chinese Pharmaceutical Journal, 36, 155 Chen, 2000, Two new compounds of radix polygoni multiflori preparata, Acta Pharmaceutica Sinica, 35, 273 Chen, 2001, Analysis of the constituents of essential oil from radix Polygoni multiflori preparata, Journal of Chinese Medicinal Materials, 23, 684 Chen, 1999, 2,2-Diphenyl-1-picrylhydrazyl radical-scavenging active components from Polygonum multiflorum thunb, Journal of Agricultural and Food Chemistry, 47, 2226, 10.1021/jf990092f Cheng, 2005, Identification of fleece-flower root cut crude drug and spurious breed airpotato yam in crude drug, Journal of Anhui Traditional Chinese Medical College, 24, 24 Cheng, 2005, Identification of fleece-flower root cut crude drug and spurious breed airpotato yam in crude drug, Journal of Anhui TCM College, 24, 52 Cheung, 2014, Tyrosinase inhibitory activity of a glucosylated hydroxystilbene in mouse melan-a melanocytes, Journal of Natural Products, 77, 1270, 10.1021/np4008798 Chiu, 2009, Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells, Anticancer Research, 29, 4503 Committee on the programming teaching material for higher TCM education, 1996, 235 Da, 2009, The toxic effects of rhein and emodin on human renal tubular epithelial cells in vitro, Chinese Traditional and Herbal Drugs, 40, 102 Deng, 2008, Proliferative effects of different extract of Polygonum multiflorum thunberg on spleen lymphocytes in mice, Chinese Journal of Modern Drug Application, 2, 1 Dong, 2014, Eighteen cases of liver injury following ingestion of Polygonum multiflorum, Complementary Therapies in Medicine, 22, 70, 10.1016/j.ctim.2013.12.008 Du, 2012, Preliminary study on the processing mechanism of Polygonum multiflorum Thunb by microbial fermentation, Natural Product Research & Development, 24, 212 1998, 25, 102 2010, 164 Fahad, 2014, Stem cells and the treatment of Parkinson׳s disease, Experimental Neurology, 260, 3, 10.1016/j.expneurol.2012.12.017 Fresno Vara, 2004, PI3K/Akt signalling pathway and cancer, Cancer Treatment, 30, 193, 10.1016/j.ctrv.2003.07.007 Fu, 2013, HPLC determination of the main chemical ingredients content in polygonum multiflorum during the processing, Asia-Pacific Traditional Medicine, 9, 50 Gao, 2007, Blood lipid-regulation of stilbene glycoside from Polygonum multiflorum, China Journal of Chinese Materia Medica, 32, 323 Ge, 2007, Polysaccharide from Polygonum multiflorum Thunb potentiates the immunological function in immunosuppressed mice, Chinese Journal of New Drugs, 16, 2040 Ge, 2011, Identification of fallopia multiflora and its adulterants, Chinese Wild Plant Resources, 30, 64 Guo, 2007, Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation, Acta Pharmacologica Sinica, 28, 1991, 10.1111/j.1745-7254.2007.00707.x Guo, 2007, Quality identification on the authenticity of fleece-flower root, Journal of Traditional Chinese Medicine University of Hunan, 27, 71 He, 2010, Physical and chemical identification of radix polygoni multiflori and its adulterants, Aerospace Medicine, 21, 380 Ho, 2007, Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction, Antiviral Research, 74, 92, 10.1016/j.antiviral.2006.04.014 Hsu, 2010, Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells, Biochemical and Biophysical Research Communications, 392, 473, 10.1016/j.bbrc.2009.10.153 Hu, 2007, Experimental study of Radix Plygoni Multiflori peparata on liver׳s biochemical matters, Journal of Shaanxi College of Traditional Chinese Medicine, 30, 63 Hu, 2009, Effect of polygonum multiflorum and polygonum multiflorum preparation on immunoglobulin in rats, Tianjin Journal of Traditional Chinese Medicine, 26, 139 Hu, 2006, Experimental study on the toxicology of prepared Radix Polygoni Multiflori to the rats׳ liver, Journal of Shaanxi College of Traditional Chinese Medicine, 29, 40 Hu, 2006, Study on liver injury induced by prepared Radix Polygoni Multiflori, Shaanxi Journal of Traditional Chinese Medicine, 27, 625 Huang, 2013, TSG (2,3,4′,5-tetrahydroxystilbene 2-O-β-d-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia, Journal of Neuroinflammation, 10, 129, 10.1186/1742-2094-10-129 Huang, 2007, Chinese herb Radix Polygoni Multiflori as a therapeutic drug for liver cirrhosis in mice, Journal of Ethnopharmacology, 114, 199, 10.1016/j.jep.2007.07.034 Huang, 2010, Comparative study on acute toxicity of different components of Polygonum multiflorum in mice, Chinese Journal of Pharmacovigilance, 7, 705 Huang, 2011, Experimental study on the “dose- time- toxicity” relationship of acute hepatotoxicity induced by different components from Polygonum multiflorum in mice, Chinese Journal of Pharmacovigilance, 8, 193 Jang, 2013, Hexane extract from Polygonum multiflorum attenuates glutamate-induced apoptosis in primary cultured cortical neurons, Journal of Ethnopharmacology, 145, 261, 10.1016/j.jep.2012.10.061 Jung, 2011, Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of polygonum multiflorum thunb, Gut Liver, 5, 493, 10.5009/gnl.2011.5.4.493 Kato, 1987, Anthraquinones components in Rumex acetosa L, Shoy akugaku Zasshi, 41, 67 Kim, 2013, Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells, Journal of Ethnopharmacology, 150, 108, 10.1016/j.jep.2013.08.014 Lan, 1959, 111 Lang, 1998, Parkinson׳s disease. First of two parts, New England Journal of Medicine, 339, 1044, 10.1056/NEJM199810083391506 Lee, 2012, Hepatoprotection of emodin and Polygonum multiflorum against CCl(4)-induced liver injury, Pharmaceutical Biology, 50, 351, 10.3109/13880209.2011.604335 Lee, 2014, Hexane extracts of Polygonum multiflorum improve tissue and functional outcome following focal cerebral ischemia in mice, Molecular Medicine Reports, 9, 1415, 10.3892/mmr.2014.1943 Li, 2012, Determination of emodin in L-02 cells and cell culture media with liquid chromatography-mass spectrometry: application to a cellular toxicokinetic study, Journal of Pharmaceutical and Biomedical Analysis, 71, 71, 10.1016/j.jpba.2012.07.031 Li, 2010, Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway, European Journal of Pharmacology, 649, 382, 10.1016/j.ejphar.2010.09.004 Li, 2013, Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-kB and MAPKs signal pathways, European Journal of Pharmacology, 705, 79, 10.1016/j.ejphar.2013.02.021 Li, 1995, Studies on the traditional Chinese medicine Shouwu II. botanical origins and applied drugs, Chinese Traditional and Herbal Drugs, 26, 33 Li, 1993, Study on the chemical constituents of polygonum multiflorum Thunb, Chinese Traditional and Herbal Drugs, 3, 115 Li, 2012, Investigation of antioxidant activities and free radical scavenging of flavonoids in leaves of polygonum multiflorum thumb, China Food Additives, 2, 69 Li, 2010, Effects of tetrahydroxystilbene glucoside on multiple targets of Alzheimer׳s disease in seven Alzheimerlike animal models, Alzheimer׳s & Dementia, 6, S579, 10.1016/j.jalz.2010.05.1974 Li, 2012, Effects of lipid regulation using raw and processed radix Polygoni multiflori in rats fed a high-Fat diet, Evidence-Based Complementary and Alternative Medicine, 10.1155/2012/329171 Li, 2013, High dosage administration of Polygonum multiflorum alcohol extract caused the multi-organ injury in rats, Global Traditional Chinese Medicine, 6, 1 Li, 2013, Five new stilbene glycosides from the roots of Polygonum multiflorum, Journal of Asian Natural Products Research, 15, 1145, 10.1080/10286020.2013.837454 Li, 2012, 58 cases of Xiaohuoluo pill in treating knee osteoarthritis, Henan Traditional Chinese Medicine, 32, 489 Li, 2012, Study on liver injury induced by different processing of prepared Radix Polygoni multiflori, Guangming Journal of Chinese Medicine, 27, 595 Li, 2012, Quality standard of Polygonum by different processing methods, China Medical Herald, 9, 41 Li, 2012, Study on the quality standard of high-pressure steamed radix polygoni multiflori at different time, Guide of China Medicine, 10, 396 Li, 2005, Neuroprotective effects of Polygonum multiflorumon nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice, Pharmacology, Biochemistry and Behavior, 82, 345, 10.1016/j.pbb.2005.09.004 Li, 2010, Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation, Neuroscience Letters, 483, 1, 10.1016/j.neulet.2010.07.027 Li, 2006, Chemical constituents from tubers of Polygonum multiflorum Thunb, Journal of Tropical and Subtropical Botany, 17, 617 Li, 2003, Germplasm appraisements of Plolygonum Multiflorum from main producing areas in China by content of tetrahydroxystilbene, Chemistry and Industry of Forest Products, 23, 37 Li, 2008, Experimental study on the active situs of radix polygoni multiflori to reduce blood lipid and their dose-effect relation, China Practical Medicine, 3, 3 Liang, 2009, Chemical cnstituents of Caulis Polygoni Multiflori(the stem of Polygonum multiflorum Thunb.), Journal of Shenyang Pharmaceutical University, 26, 536 Lim, 2014, Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in isolated rat thoracic aorta, British Journal of Pharmacology, 171, 4300, 10.1111/bph.12804 Lin, 1996, Hepatoprotective effects of emodin from Ventilago leiocarpa, Journal of Ethnopharmacoiogy, 52, 107, 10.1016/0378-8741(96)01397-9 Lin, 2008, Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer׳s disease, Chemico-Biological Interactions, 175, 352, 10.1016/j.cbi.2008.05.030 Lin, 2006, Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway, The Jouranl of Urology, 175, 343, 10.1016/S0022-5347(05)00005-4 Lin, 2012, Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats, Journal of Ethnopharmacology, 144, 671, 10.1016/j.jep.2012.10.009 Liu, 2005, Changes before and after processing of Radix Polygoni Multiflori HPLC fingerprints, Chinese Traditional and Herbal Drugs, 36, 1644 Liu, 2005, Influence of process methods on contents of chemical component Radix Polygoni Multiflori, China Journal of Chinese Materia Medica, 30, 336 Liu, 1992, Effect of the root of Polygonum multiflorum Thunb and its processed products on fat accumulation in the liver of mice, China Journal of Chinese Materia Medica, 17, 595 Liu, 2003, Apoptosis of human hepatoma HepG2 cells induced by emodin in vitro, Chinese Journal of Cancer, 22, 1280 Liu, 2008, Effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside on learning and memory abilities of rats with chronic cerebral ischemia, Chinese Journal of Pharmacology and Toxicology, 22, 108 Liu, 2009, The mechanism about the inhibition effects of emodin on the proliferation of EC-109 cell in esophageal cancer, Journal of Shantou University Medical College, 22, 12 Liu, 2013, Influence of high pressure processing on contents of active ingredients from Polygoni multiflori radix, Chinese Journal of Experimental Traditional Medical Formulae, 19, 37 Liu, 2011, Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide, Journal of Pharmaceutical and Biomedical Analysis, 54, 1157, 10.1016/j.jpba.2010.12.004 Liu, 2004, The effects of tetrahydroxylstilbene on learning and memory ability and NMDA-receptor binding to [3H]MK801 in forebrain of ischemia-reperfusion gerbils, Chinese New Drugs Journal, 13, 223 Liu, 2008, HPLC-ELSD determination of the content change of monosaccharides and disaccharides in polygonum multiflorum during the processing, Chinese Journal of Experimental Traditional Medical Formulae, 14, 6 Liu, 2007, Quality Evaluation of Radix Polygoni Multiflori, Journal of Chinese Medicinal Materials, 30, 278 Liu, 2008, Content analysis of the newly generated component in radix polygoni multiflori after processing, China Journal of Chinese Materia Medica, 33, 2326 Liu, 2009, Study on chemical constituents of radix polygoni multiflori after processing, Natural Product Research & Development, 21, 239 Liu, 2007, New chemical constituents from radix polygoni multiflori after processing, Journal of Chinese Medicinal Materials, 30, 1505 Liu, 2009, HPLC analysis of the content change of gallic acid and catechin which antioxidant constituents in radix polygoni multiflori before and after processing, Chinese Traditional Patent Medicine, 31, 1392 Liu, 2005, The impact of different processing methods on the component content of polygonum multiflorum, China Journal of Chinese Materia Medica, 30, 336 Long, 2003, What׳s new in Alzheimer׳s disease?, Home Health Nurse, 21, 8, 10.1097/00004045-200301000-00002 Lu, 2012, Identification of unknown unqualified polygonum mulitflorum system, Chinese Archives of Traditional Chinese Medicine, 30, 1087 Luo, 2008, HPLC fingerprint chromatogram of Polygonum multiflorum Thunb, Journal of Beijing University of Traditional Chinese Medicine, 31, 557 Lv, 2011, Pharmacokinetics and tissue distribution of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats, Journal of Ethnopharmacology, 137, 449, 10.1016/j.jep.2011.05.049 Lv, 2001, Preliminary study on the Anti-inflammatory effect of Polygonum multiflorum, China Pharmacy, 12, 712 Lv, 2014, Purification, antioxidant activity and antiglycation of polysaccharides from Polygonum multiflorum Thunb, Carbohydrate Polymers, 99, 765, 10.1016/j.carbpol.2013.09.007 Lv, 2007, Antioxidant activity of stilbene glycoside from Polygonum multiflorum Thunb in vivo, Food Chemistry, 104, 1678, 10.1016/j.foodchem.2007.03.022 Ma, 2013, Stilbene glucoside inhibits the glucuronidation of emodin in rats through the down-regulation of UDP-glucuronosyltransferases 1A8: application to a drug-drug interaction study in Radix Polygoni Multiflori, Journal of Ethnopharmacology, 147, 335, 10.1016/j.jep.2013.03.013 Ma, 2001, Effect of Shouwushen (SWS) on Ability of learning and memory in mice, Pharmacology and Clinics of Chinese Materia Medica, 17, 35 Ma, 2012, Antitumor effects of emodin on LS1034 human colon cancer cellsin vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model, Food and Chemical Toxicology, 50, 1271, 10.1016/j.fct.2012.01.033 Masaldan, 2014, Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions, Journal of Applied Toxicology, 34, 95, 10.1002/jat.2838 Min, 2008, Twelve cases of toxic hepatitis related to the root of Polygonum multiflorum Thunb, Journal of Hepatology, 48, S356, 10.1016/S0168-8278(08)60953-8 National Toxiclogy Program. NTP technical report, 2001 Nie, 2002, Study overview of the processing of polygonum multiflorum thumb, Shangdong Pharmaceutical Industry, 21, 24 Niu, 1996, A severe liver damage case induced by Shou Wu Pian though oral administration, Chinese Journal of New Drugs and Clinical Remedies, 15, 382 Nonaka, 1982, Stilbene glycoside gallates and proanthocyanidins from Polygonum multiflorum, Phytochemistry, 21, 429, 10.1016/S0031-9422(00)95282-8 Obeso, 2010, Missing pieces in the Parkinson׳s disease puzzle, Nature Medicine, 16, 653, 10.1038/nm.2165 Park, 2001, Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum, Journal of Gastroenterology and Hepatology, 16, 115, 10.1046/j.1440-1746.2001.02309.x Pecere, 2000, Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors, Cancer Research, 60, 2800 Qin, 1990, Study on the immune function influence by Polygonum multiflorum in mice, Immunological Journal, 6, 252 Qin, 2011, Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: The involvement of PI3K/Akt pathway activation, Toxicology Letters, 202, 1, 10.1016/j.toxlet.2011.01.001 Qiu, 2006, Content comparative analysis of water soluble saccharides in radix polygoni multiflori before and after its processing, China Pharmacy, 17, 954 Qiu, 2006, On Processing Technique of Radix Polygoni Multiflori, China Pharmacy, 17, 1270 Qiu, 2013, Profiling of phenolic constituents in Polygonum multiflorum Thunb. by combination of ultra-high-pressure liquid chromatography with linear ion trap-Orbitrap mass spectrometry, Journal of Chromatography A, 1292, 121, 10.1016/j.chroma.2012.11.051 Rao, 2009, Studies on the chemical constituents of the leaves of Polygonum multiflorum, Journal of Chinese Medicinal Materials, 32, 891 Shi, 2003, Study on the influence of concoction over active ingredients in Polygonum multiflorum, Chinese Hospital Pharmacy Journal, 23, 95 Song, 2003, Study on the anti-aging effects of radix Polygonum multiflorum, Journal of Hebei Medical University, 24, 90 Steele, 2013, Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells, Neurochemistry International, 62, 522, 10.1016/j.neuint.2012.08.018 Su, 2014, The treatment of Alzheimer׳s disease using Chinese Medicinal Plants: from disease models to potential clinical applications, Journal of Ethnopharmacology, 152, 403, 10.1016/j.jep.2013.12.053 Sun, 2011, Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cellsagainst MPP+-induced cytotoxicity, European Journal of Pharmacology, 660, 283, 10.1016/j.ejphar.2011.03.046 Sun, 2006, The effect of anthraquinone glycoside from Polygonum multiflorum Thunb on cellular immunological function in mice, Pharmacology and Clinics of Chinese Materia Medica, 22, 30 Sun, 2004 Sun, 2009, HPLC/IT-MS analysis of glycosides in Radix polygoni multiflori, Natural Product Research & Development, 21, 806 Sun, 1996, The differentiation on Polygonum multiflorum thumb and its forgery human-Like Polygonum multiflorum thunb (Musa basjoo Sieb. et Zucc), Journal of North Sichuan Medical College, 11, 54 Sun, 1996, The differentiation on polygonum mulitflorum thunb and its forgery, Journal of North Sichuan Medical College, 11, 44 Sun, 1996, The processing method of Polygonum multiflorum Thunb, China Journal of Chinese Materia Medica, 21, 360 Sun, 2010, Influence of main component of Heshouwu such as emodin, rhein and toluylene glycoside onhepatic cells and hepatomacarcinoma cell, Modern Journal of Integrated Traditional Chinese and Western Medicine, 19, 1315 Sun, 2013, Promotion effect of constituents from the root of Polygonum multiflorumon on hair growth, Bioorganic & Medicinal Chemistry Letters, 23, 4801, 10.1016/j.bmcl.2013.06.098 Tabolacci, 2010, Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16-F10 melanoma cells, Life Sciences, 87, 316, 10.1016/j.lfs.2010.07.003 Tian, 2007, Optimization of processing technologies for steamed Polygonum multiflorum by colligation score, Journal of Guiyang College of Traditional Chinese Medicine, 29, 15 Toth, 2010, Drug treatment of hyperlipidaemia: a guide to the rational use of lipid-lowering drugs, Drugs, 70, 1363, 10.2165/10898610-000000000-00000 Um, 2006, Protective effect of Polygonum multiflorumThunb on amyloid β-peptide 25-35 induced cognitive deficits in mice, Journal of Ethnopharmacology, 104, 144, 10.1016/j.jep.2005.08.054 Wang, 2007, Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells, Toxicology, 231, 120, 10.1016/j.tox.2006.11.064 Wang, 2005 Wang, 2009, Studies on pharmacokinetics and tissue distribution of stilbene glycoside in the hyperlipide miamodel rats, Chinese Journal of Pharmaceutical Analysis, 29, 1073 Wang, 2001, Clinical observation of tuber fleeceflower root injection in the treatment of hair loss, Journal of Traditional Chinese Medicine and Chinese Materia Medica of Jilin, 1, 35 Wang, 2004, The determination of stilbene glucoside in Fleece-flower root raw product and four kinds of processed products, Studies of Trace Elements and Health, 21, 27 Wang, 2012, Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02, Journal of Ethnopharmacology, 139, 287, 10.1016/j.jep.2011.11.022 Wang, 2007 Wang, 2007, Cytotoxicity of free anthraquinone from Radix et Rhizoma Rhei to HK-2 Cells, Chinese Journal of New Drugs, 16, 189 Wang, 2009, Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation, Free Radical Biology and Medicine, 47, 229, 10.1016/j.freeradbiomed.2009.02.027 Wang, 2011, Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity, European Journal of Pharmacology, 650, 206, 10.1016/j.ejphar.2010.10.002 Wang, 2014, In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism, Journal of Ethnopharmacology, 153, 763, 10.1016/j.jep.2014.03.042 Wang, 2011, Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression, Oncology Reports, 26, 1143 Wang, 2005, Studies on chemical constituents of Polygonum multiflorun from Yunnan, Journal of Yunnan College of Traditional Chinese Medicine, 28, 10 Wang, 2012 Wang, 2008, Protective effects of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice, European Journal of Pharmacology, 578, 339, 10.1016/j.ejphar.2007.09.013 Way, 2014, Emodin represses TWIST1-induced epithelial-mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways, European Journal of Cancer, 50, 366, 10.1016/j.ejca.2013.09.025 Wu, 2008, Effect of emodin on combined hyperlipidemia familial in rats, Anhui Medical and Pharmaceutical Journal, 12, 1026 Wu, 2012, Toxicity of raw and processed roots of Polygonum multiflorum, Fitoterapia, 83, 469, 10.1016/j.fitote.2011.12.012 Wu, 2001, Yiganning granule on liver injury animal model research of protecting liver and reducing enzyme and immune function, Journal of Hunan College of Traditional Chinese Medicine, 21, 14 Wu, 2006, Study on Quality Evaluation for 36 Samples of Radix Polygonui Multiflori by HPLC-Fingerprints, Chinese Pharmaceutical Journal, 41, 257 Xia, 2003, Identification of radix polygoni multiflori and silvervine fleeceflower root, LiShiZhen Medicine and Materia Medica Research, 14, 540 Xiang, 2013, Efficacy of Qishu decoction on 120 NSCLC patients with leucopenia after-Chemotherapy experienced prescription, Gansu Medical Journal, 32, 171 Xiang, 2014, 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (THSG) attenuates human platelet aggregation, secretion and spreading in vitro, Thrombosis Research, 133, 211, 10.1016/j.thromres.2013.11.006 Xiao, 2002, Novel stilbene glycosides from Polygonum multiflorum, Acta Botanica Sinica, 44, 1491 Xiao, 1993, Immunological aspects of Chinese medicinal plants as anti-ageing drugs, Journal of Ethnopharmacology, 38, 167, 10.1016/0378-8741(93)90012-T Xie, 2012, Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia, Journal of Ethnopharmacology, 140, 345, 10.1016/j.jep.2012.01.027 Xu, 2011, Effect of high pressure processing onstilbene glycoside and phosphatidylcholine in Polygoni Multiflori Radix, Chinese Traditional and Herbal Drugs, 42, 78 Xu, 1986, 102 Xu, 2006, A new stilbene glucoside from the roots of Polygonum multiflorum Thunb, Archives of Pharmacal Research, 29, 946, 10.1007/BF02969276 Xu, 2014, The effect of 2,3,4′,5-tetrahydroxystilbene-2-O-β-d-glucoside on pressure overload-induced cardiac remodeling in rats and its possible mechanism, Planta Medica, 80, 130, 10.1055/s-0033-1360198 Xu, 2009, Simultaneous quantitative determination of eight active components in Polygonum multiflorum thunb by RP­HPLC, Journal of Chinese Pharmaceutical Sciences, 18, 358 Xu, 2013, Mechanism of the protection of stilbene glycoside which is the effective component of tuber fleece flower root on nerve cells, Asia-Pacific Traditional Medicine, 9, 61 Xue, 2004, Determination of Anthraquinone In Polygonum Multiflorum From Different Regions of Yunnan, Journal of Yunnan College of Traditional Chinese Medicine, 27, 42 Yamaguchi, 1969, Synthesis of some new phydroxyphenylpropane monomer, Mokuzai Gakkaishi, 15, 256 Yan, 2014, Polygonumosides A-D, stilbene derivatives from processed roots of Polygonum multiflorum, Journal of Natural Products., 77, 397, 10.1021/np400720y Yang, 2008, Study on the quality standard of Chinese traditional medicine processing excipient of black bean juice, China Association of Chinese Medicine – Processing Branch, 281 Yang, 2005, Reduction of atherosclerosisin cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum, Journal of Pharmacological Sciences, 99, 294, 10.1254/jphs.FP0050333 Yang, 2014, Potential protection of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside against staurosporine-induced toxicity on cultured rat hippocampus neurons, Neuroscience Letters, 576, 79, 10.1016/j.neulet.2014.05.045 Yang, 1998, A New indole derivative isolated from the root of tuber fleeceflower (Polygonum multiflorum), Chinese Traditional and Herbal Drugs, 1, 5 Yang, 1976, The new ingredients of Polygonum multiflorum thunb: hydroxyl on stilbene glucoside, Foreign Medical Reference. SCI, 3, 247 Yang, 1999, 48 cases of Yiganning granules in treating chronic hepatitis B, Hunan Journal of Traditional Chinese Medicine, 15, 13 Yao, 2013, Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats, Biomedicine & Pharmacotherapy, 67, 140, 10.1016/j.biopha.2012.10.007 Ye, 1996, An acute toxic hepatopathy case induced by Radix Polygoni Multiflori, Chinese Journal of Integrative Medicine, 16, 732 Yi, 2007, Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum thunb by HPLC coupled with PAD and ESI/MS, Phytochemical Analysis, 18, 181, 10.1002/pca.963 Yin, 2014, Emodin ameliorated lipopolysaccharide-induced fulminant hepatic failure by blockade of TLR4/MD2 complex expression in d-galactosamine-sensitized mice, International Immunopharmacology, 23, 66, 10.1016/j.intimp.2014.08.018 Yon, 2013, Emodin prevents ethanol-induced developmental anomalies in cultured mouse fetus through multiple activities, Birth Defects Research B: Developmental and Reproductive Toxicology, 98, 268, 10.1002/bdrb.21061 Yoshizaki, 1987, Polygoacetophenoside, a new acetophenone glucoside from Polygonum multiflorum 1, Planta Medica, 53, 273, 10.1055/s-2006-962703 Yu, 2014, The processing history of Polygonum multiflorum, Journal of North Pharmacy, 11, 63 Yu, 2011, Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata, Journal of Ethnopharmacology, 137, 1291, 10.1016/j.jep.2011.07.055 Yu, 2013, Emodin regulates apoptotic pathway in human liver cancer cells, Phytotherapy Research, 27, 251, 10.1002/ptr.4703 Yu, 2008, Two new coumarin glucosides biosynthesized by transgenic hairy roots of Polygonum multiflorum, Chinese Chemical Letters, 19, 76, 10.1016/j.cclet.2007.10.047 Yuan, 2004, Preparation and clinical curative effect observation of Zhentongdieda wine, Journal of Chinese Medicinal Materials, 27, 544 Zeng, 2011, Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway, Molecules, 16, 8552, 10.3390/molecules16108552 Zhai, 2010, Hypolipidemic effect of the polysaccharide from polygonum multiflorum, Food and Machinery, 26, 87 Zhang, 2008 Zhang, 2007, Analysis of rDNA ITS sequences in root tuber of Polygonum multiflorum from various habitats, Chinese Traditional and Herbal Drugs, 38, 911 Zhang, 2004, Mechanism of the protection of stilbene glycoside which is the effective component of tuber fleece flower root on nerve cells, Chinese Journal of Clinical Rehabilitation, 8, 118 Zhang, 2010, Effects of tetrahydroxystilbene glucoside on mapks signaltransduction pathway in APP transgenic model of Alzheimer׳s disease, Alzheimers & Dementia, 7, S668, 10.1016/j.jalz.2011.05.1924 Zhang, 2013, Influence of processing on pharmacokinetic of typical constituents in radix polygoni multiflori after oral administration by LC-ESI-MS/MS, Journal of Ethnopharmacology, 148, 246, 10.1016/j.jep.2013.04.020 Zhang, 2006, Learning-memory deficit with aging in APP transgenic mice of Alzheimer׳s disease and intervention by using tetrahydroxystilbene glucoside, Behavioural Brain Research, 173, 246, 10.1016/j.bbr.2006.06.034 Zhang, 2013, Neuroprotection by tetrahydroxystilbene glucoside in the MPTP mouse model of Parkinson׳s disease, Toxicology Letters, 222, 155, 10.1016/j.toxlet.2013.07.020 Zhang, 2009, Comparative study of pre and post processed Polygonum multiforum anthraquinones content, Journal of Zhejiang Chinese Medical University, 33, 872 Zhang, 2003, Comparison the content of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside of wild and cultivated Radix Polygoni Multiflori from different areas of Guizhou, China Journal of Chinese Materia Medica, 28, 786 Zhang, 2007, Inhibitory effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside on experimental inflammation and cyclooxygenase 2 activity, Journal of Asian Natural Products Research, 9, 355, 10.1080/10286020600727772 Zhang, 2006, Studies on the anthraquinone chemical constituents of radix Polygoni multiflori, Chinese Traditional and Herbal Drugs, 37, 1311 Zhang, 2006, Studies on the non-anthraquinone chemical constituents of radix Polygoni multiflori, China Journal of Chinese Materia Mediea, 31, 1027 Zhang, 2008, Study on the immune function influence by polysaccharide from Polygonum multiflorum Peparata in mice, Traditional Chinese Medicinal Research, 21, 18 Zhao, 2011, Experimental studies on the anti-inflammatory and analgesic effects of Gou-pi plaster, Pharmacy and Clinics of Chinese Materia Medica, 2, 27 Zhao, 2014, A new chromone glycoside from roots of Polygonum multiflorum, China Journal of Chinese Materia Medica, 39, 1441 Zhao, 1998, Study on the identification of radix polygoni multiflori and its adulterants of rodgersia aesculifolia, ShiZhen Journal of Traditional Chinese Medicine Research, 9, 147 Zhao, 2011, Rhein protects against acetaminophen-induced hepatic and renal toxicity, Food and Chemical Toxicology, 49, 1705, 10.1016/j.fct.2011.04.011 Zheng, 2009, Molecular identification of fallopia multiflora by PCR-RFLP based on rDNA ITS sequence, Journal of South China University of Technology, 37, 74 Zheng, 2010 Zhou, 2005, Effects of processing on the content of effective components in Radix Polygoni Multiflori, TCM Research, 18, 18 Zhou, 1994, Chemical studies on the ethyl acetate insoluble fraction of the roots of Polygonum mutifloum thunb, Acta Pharmaceutica Sinica, 29, 107 Zhou, 1993, 265 Zhou, 2010, 82 cases of Sanshen pill in treating male erectile dysfunction, Chinese Medicine Modern Distance Education of China, 8, 176 Zhou, 2013, Protective effect of tetrahydroxystilbene glucoside against d-galactose induced aging process in mice, Phytochemistry Letters, 6, 372, 10.1016/j.phytol.2013.05.002 Zhou, 2010, The processing history research of Radix Polygoni multiflori, China Medical Herald, 7, 9 Zhu, 2011, Evaluation of in vitro genotoxicity of emodinanrhein, Carcinogenesis,Teratogenesis, and Mutagenesis, 23, 65 Zhu, 2011, Clinical observation of treating pregnancy constipation with Polygonum multiflorum granule therapy in 52 cases, Zhejiang Journal of Traditional Chinese Medicine, 46, 129 Zuo, 2008, Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection, Journal of Chromatography A, 1200, 43, 10.1016/j.chroma.2008.01.058