Ubiquitination-dependent mechanisms regulate synaptic growth and function

Nature - Tập 412 Số 6845 - Trang 449-452 - 2001
Aaron DiAntonio1, A. Pejmun Haghighi2, Scott L. Portman3, Jason D. Lee2, Andrew M. Amaranto3, Corey S. Goodman2
1Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S. Euclid, Campus Box 8103, St Louis, Missouri 63110, USA.
2Department of Molecular and Cell Biology, University of California, Berkeley, Room 509 Life Sciences Addition, Berkeley, USA
3Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S. Euclid, Campus Box 8103, St Louis, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405–439 (1996).

Wilkinson, K. D. Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. FASEB J. 11, 1245–1256 (1997).

Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425–479 (1998).

Huang, Y., Baker, R. T. & Fischer-Vize, J. A. Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene. Science 270, 1828–1831 (1995).

Baker, R. T., Tobias, J. W. & Varshavsky, A. Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J. Biol. Chem. 267, 23364–23375 (1992).

Wan, H. I. et al. Highwire regulates synaptic growth in Drosophila. Neuron 26, 313–329 (2000).

Rorth, P. et al. Systematic gain-of-function genetics in Drosophila. Development 125, 1049–1057 (1998).

DiAntonio, A. & Schwarz, T. L. The effect on synaptic physiology of synaptotagmin mutants in Drosophila. Neuron 12, 909–920 (1994).

Wu, Z., Li, Q., Fortini, M. E. & Fischer, J. A. Genetic analysis of the role of the Drosophila fat facets gene in the ubiquitin pathway. Dev. Genet. 25, 312–320 (1999).

Joazeiro, C. A. & Weissman, A. M. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102, 549–552 (2000).

Fischer-Vize, J. A., Rubin, G. M. & Lehmann, R. The fat facets gene is required for Drosophila eye and embryo development. Development 116, 985–1000 (1992).

Chen, X. & Fischer, J. A. In vivo structure/function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Genetics 156, 1829–1836 (2000).

Petersen, S. A., Fetter, R. D., Noordermeer, J. N., Goodman, C. S. & DiAntonio, A. Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Neuron 19, 1237–1248 (1997).

DiAntonio, A., Petersen, S. P., Heckmann, M. & Goodman, C. S. Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction. J. Neurosci. 19, 3023–3032 (1999).

Serdaroglu, P., Askanas, V. & Engel, W. K. Immunocytochemical localization of ubiquitin at human neuromuscular junctions. Neuropathol. Appl. Neurobiol. 18, 232–236 (1992).

Chapman, A. P., Smith, S. J., Rider, C. C. & Beesley, P. W. Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities. Neurosci. Lett. 168, 238–242 (1994).

Hegde, A. N. et al. Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89, 115–126 (1997).

Jiang, Y. H. et al. Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron 21, 799–811 (1998).

Yao, K. M. & White, K. Neural specificity of elav expression: defining a Drosophila promoter for directing expression to the nervous system. J. Neurochem. 63, 41–51 (1994).

Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401–415 (1993).

Schuster, C. M., Davis, G. W., Fetter, R. D. & Goodman, C. S. Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron 17, 641–654 (1996).

Stewart, B. A., Atwood, H. L., Renger, J. J., Wang, J. & Wu, C. F. Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J. Comp. Physiol. A 175, 179–191 (1994).

Zito, K., Parnas, D., Fetter, R. D., Isacoff, E. Y. & Goodman, C. S. Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila. Neuron 22, 719–729 (1999).