Peroxisome Proliferator-Activated Receptors-Alpha and Gamma Are Targets to Treat Offspring from Maternal Diet-Induced Obesity in Mice

GJ Howie, 2009, Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet, J Physiol, 587, 905, 10.1113/jphysiol.2008.163477

AJ Drake, 2010, Impact of maternal obesity on offspring obesity and cardiometabolic disease risk, Reproduction, 140, 387, 10.1530/REP-10-0077

BM Gregorio, 2010, Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring, Am J Obstet Gynecol, 203, 495 e491, 10.1016/j.ajog.2010.06.042

B Gustafson, 2007, Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis, Arterioscler Thromb Vasc Biol, 27, 2276, 10.1161/ATVBAHA.107.147835

M Catta-Preta, 2012, Modulation of cytokines, resistin, and distribution of adipose tissue in C57BL/6 mice by different high-fat diets, Nutrition, 28, 212, 10.1016/j.nut.2011.05.011

CS Fox, 2007, Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study, Circulation, 116, 39, 10.1161/CIRCULATIONAHA.106.675355

KM Pou, 2007, Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study, Circulation, 116, 1234, 10.1161/CIRCULATIONAHA.107.710509

RH Eckel, 2005, The metabolic syndrome, Lancet, 365, 1415, 10.1016/S0140-6736(05)66378-7

Aguila M, Fernandes-Santos C, Pinheiro-Mulder A, Faria T, Mandarim-de-Lacerda C (2010) Hepatc insulin resistance and nonalcoholic fatty liver disease. In: J M, L G, editors. Insulin resistance : symptons, causes and treatment. New York: Nova Science pu. pp. 1–44.

EM Brunt, 1999, Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions, Am J Gastroenterol, 94, 2467, 10.1111/j.1572-0241.1999.01377.x

D Festi, 2004, Hepatic steatosis in obese patients: clinical aspects and prognostic significance, Obes Rev, 5, 27, 10.1111/j.1467-789X.2004.00126.x

V Souza-Mello, 2007, Hepatic structural alteration in adult programmed offspring (severe maternal protein restriction) is aggravated by post-weaning high-fat diet, Br J Nutr, 98, 1159, 10.1017/S0007114507771878

C Christodoulides, 2010, PPARs and adipocyte function, Mol Cell Endocrinol, 318, 61, 10.1016/j.mce.2009.09.014

S Takahashi, 2006, Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome, Pharmacol Res, 53, 501, 10.1016/j.phrs.2006.03.019

JM Peters, 2003, Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice, Biochim Biophys Acta, 1632, 80, 10.1016/S1388-1981(03)00065-9

H Tenenbaum, 2007, Long-term effect of bezafibrate on pancreatic beta-cell function and insulin resistance in patients with diabetes, Atherosclerosis, 194, 265, 10.1016/j.atherosclerosis.2006.08.005

A Tenenbaum, 2008, Optimal management of combined dyslipidemia: what have we behind statins monotherapy?, Adv Cardiol, 45, 127, 10.1159/000115192

T Nagasawa, 2006, Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet, Eur J Pharmacol, 536, 182, 10.1016/j.ejphar.2006.02.028

S Reagan-Shaw, 2008, Dose translation from animal to human studies revisited, FASEB J, 22, 659, 10.1096/fj.07-9574LSF

S Barbosa-da-Silva, 2012, Weight cycling enhances adipose tissue inflammatory responses in male mice, PLoS One, 7, e39837, 10.1371/journal.pone.0039837

DR Matthews, 1985, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 28, 412, 10.1007/BF00280883

SA Tschanz, 2011, A simple tool for stereological assessment of digital images: the STEPanizer, J Microsc, 243, 47, 10.1111/j.1365-2818.2010.03481.x

M Catta-Preta, 2011, A critical analysis of three quantitative methods of assessment of hepatic steatosis in liver biopsies, Virchows Arch, 459, 477, 10.1007/s00428-011-1147-1

V Souza-Mello, 2010, Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet, Clin Sci (Lond), 119, 239, 10.1042/CS20100061

AM Samuelsson, 2008, Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming, Hypertension, 51, 383, 10.1161/HYPERTENSIONAHA.107.101477

EL Sullivan, 2011, Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood, Neuroendocrinology, 93, 1, 10.1159/000322038

C Fernandes-Santos, 2009, Pan-PPAR agonist beneficial effects in overweight mice fed a high-fat high-sucrose diet, Nutrition, 25, 818, 10.1016/j.nut.2008.12.010

MH Vickers, 2001, Dysregulation of the adipoinsular axis – a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming, J Endocrinol, 170, 323, 10.1677/joe.0.1700323

CT De Souza, 2010, Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice, J Physiol, 588, 2239, 10.1113/jphysiol.2009.183996

T Teramoto, 2012, Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study, Cardiovasc Diabetol, 11, 29, 10.1186/1475-2840-11-29

EY Kwon, 2012, Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity, BMC Genomics, 13, 450, 10.1186/1471-2164-13-450

JK Lee, 2010, Activation of PPARalpha Attenuates IFNgamma and IL-1beta-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway, Korean J Physiol Pharmacol, 14, 185, 10.4196/kjpp.2010.14.3.185

R Kleemann, 2003, Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation, Blood, 101, 545, 10.1182/blood-2002-06-1762

CM Steppan, 2001, The hormone resistin links obesity to diabetes, Nature, 409, 307, 10.1038/35053000

A Okuno, 1998, Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats, J Clin Invest, 101, 1354, 10.1172/JCI1235

T Goto, 2011, Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes, J Lipid Res, 52, 873, 10.1194/jlr.M011320

AH Berg, 2002, ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism, Trends Endocrinol Metab, 13, 84, 10.1016/S1043-2760(01)00524-0

A Kudoh, 2011, Pioglitazone upregulates adiponectin receptor 2 in 3T3-L1 adipocytes, Life sci, 88, 1055, 10.1016/j.lfs.2011.04.001

T Hays, 2005, Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis, Carcinogenesis, 26, 219, 10.1093/carcin/bgh285

Ma Berger, 2002, The mechanisms of action of PPARs, Annu Rev Med, 53, 409, 10.1146/annurev.med.53.082901.104018

M Rakhshandehroo, 2009, Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human, PLoS One, 4, e6796, 10.1371/journal.pone.0006796

B Desvergne, 1999, Peroxisome proliferator-activated receptors: nuclear control of metabolism, Endocr Rev, 20, 649

A Tenenbaum, 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons, Cardiovasc Diabetol, 4, 14, 10.1186/1475-2840-4-14

HJ Lee, 2002, Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats, Biochem Biophys Res Commun, 296, 293, 10.1016/S0006-291X(02)00822-7

G Serviddio, 2011, Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet, PLoS One, 6, e24084, 10.1371/journal.pone.0024084

P Pettinelli, 2011, Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction, J Clin Endocrinol Metab, 96, 1424, 10.1210/jc.2010-2129

G Chen, 2004, Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver, Proc Natl Acad Sci U S A, 101, 11245, 10.1073/pnas.0404297101

SE Campbell, 2004, A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria, J Biol Chem, 279, 36235, 10.1074/jbc.M400566200

H Vosper, 2001, The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages, J Biol Chem, 276, 44258, 10.1074/jbc.M108482200

A Cabrero, 2003, Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages, Metabolism, 52, 652, 10.1053/meta.2003.50100

P Pettinelli, 2009, Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion, Biochim Biophys Acta, 1792, 1080, 10.1016/j.bbadis.2009.08.015

MS Brown, 1997, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5

G Liang, 2002, Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c, J Biol Chem, 277, 9520, 10.1074/jbc.M111421200

O Gavrilova, 2003, Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass, J Biol Chem, 278, 34268, 10.1074/jbc.M300043200

JM Way, 2001, Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues, Endocrinology, 142, 1269, 10.1210/endo.142.3.8037