EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

Molecular Cell - Tập 48 - Trang 771-784 - 2012
Weiwei Yang1, Yan Xia1, Yu Cao2, Yanhua Zheng1, Wen Bu3, Lin Zhang2,4, M. James You5, Mei Yee Koh6, Gilbert Cote7, Kenneth Aldape8, Yi Li3, Inder M. Verma9, Paul J. Chiao2, Zhimin Lu1,2,4
1Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
3Lester and Sue Smith Breast Center & Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
4The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA
5Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
6Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
7Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
8Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
9Laboratory of Genetics and Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA

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