DNA hypermethylation in tumorigenesis: epigenetics joins genetics
Tài liệu tham khảo
Kinzler, 1998, Landscaping the cancer terrain, Science, 280, 1036, 10.1126/science.280.5366.1036
Ng, 1999, DNA methylation and chromatin modification, Curr. Opin. Genet. Dev., 9, 158, 10.1016/S0959-437X(99)80024-0
Bestor, 1996, Creation of genomic methylation patterns, Nat. Genet., 12, 363, 10.1038/ng0496-363
Surani, 1998, Imprinting and the initiation of gene silencing in the germ line, Cell, 93, 309, 10.1016/S0092-8674(00)81156-3
Baylin, 1998, Alterations in DNA methylation: A fundamental aspect of neoplasia, 141
Jones, 1999, Cancer epigenetics comes of age, Nat. Genet., 21, 163, 10.1038/5947
Herman, 1994, Silencing of the VHL tumor suppressor gene by DNA methylation in renal carcinoma, Proc. Natl. Acad. Sci. U. S. A., 91, 9700, 10.1073/pnas.91.21.9700
Sherr, 1996, Cancer cell cycles, Science, 274, 1672, 10.1126/science.274.5293.1672
Kamb, 1994, A cell cycle regulator potentially involved in genesis of many tumor types, Science, 264, 436, 10.1126/science.8153634
Herman, 1995, Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers, Cancer Res., 55, 4525
Aaltonen, 1993, Clues to the pathogenesis of familial colorectal cancer, Science, 260, 812, 10.1126/science.8484121
Thibodeau, 1996, Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes, Cancer Res., 56, 4836
Herman, 1998, Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma, Proc. Natl. Acad. Sci. U. S. A., 95, 6870, 10.1073/pnas.95.12.6870
Xu, 1996, Mutations of the BRCA1 gene in human cancer, Semin. Cancer Biol., 7, 33, 10.1006/scbi.1996.0005
Esteller, 2000, Promoter hypermethylation is a cause of BRCA1 inactivation in sporadic breast and ovarian tumors, J. Natl. Cancer Inst., (in press)
Yoshiura, 1995, Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas, Proc. Natl. Acad. Sci. U. S. A., 92, 7416, 10.1073/pnas.92.16.7416
Graff, 1995, E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas, Cancer Res., 55, 5195
Graff, 1998, Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle’s cell, and poorly differentiated human thyroid carinoma, Cancer Res., 58, 2063
Kane, 1997, Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines, Cancer Res., 57, 808
Esteller, 1998, MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas, Oncogene, 17, 2413, 10.1038/sj.onc.1202178
Leung, 1999, hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability, Cancer Res., 59, 159
Esteller, 2000, Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome, Oncogene, 19, 164, 10.1038/sj.onc.1203227
Herman, 1996, Hypermethylation-associated inactivation indicates a tumor suppressor role for p15(INK4B), Cancer Res., 56, 722
Corn, 1999, Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt’s lymphoma is associated with 5′ CpG island methylation, Cancer Res., 59, 3352
Kawano, 1999, Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation, BLOOD, 94, 1113
Batova, 1997, Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia, Cancer Res., 57, 832
Ottaviano, 1994, Methylation of the estrogen receptor gene CpG island marks loss of estrogen expression in human breast cancer cells, Cancer Res., 54, 2552
Issa, 1994, Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon, Nat. Genet., 7, 536, 10.1038/ng0894-536
Esteller, 1999, Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia, Cancer Res., 59, 793
Lee, 1994, Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis, Proc. Natl. Acad. Sci. U. S. A., 91, 11733, 10.1073/pnas.91.24.11733
Esteller, 1998, Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia, Cancer Res., 58, 4515
Bachman, 1999, Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggests a suppressor role in kidney, brain and other human cancers, Cancer Res., 59, 798
Katzenellenbogen, 1999, Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies, BLOOD, 93, 4347, 10.1182/blood.V93.12.4347
Belinsky, 1998, Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis, Proc. Natl. Acad. Sci. U. S. A., 95, 11891, 10.1073/pnas.95.20.11891
Wong, 1999, Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from Mo growth arrest, Mol. Cell Biol., 19, 5642, 10.1128/MCB.19.8.5642
Nuovo, 1999, In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis, Proc. Natl. Acad. Sci. U. S. A., 96, 12754, 10.1073/pnas.96.22.12754
Kiyono, 1998, Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithlial cells, Nature, 396, 6706, 10.1038/23962
Esteller, 1999, hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis, Am. J. Pathol., 155, 1767, 10.1016/S0002-9440(10)65492-2
Myohanen, 1998, Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia, Cancer Res., 58, 591
Jones, 1998, Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription, Nat. Genet., 19, 187, 10.1038/561
Nan, 1998, Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex, Nature, 393, 386, 10.1038/30764
Wade, 1999, Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation, Nat. Genet., 23, 62, 10.1038/12664
Ng, 1999, MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex, Nat. Genet., 23, 58, 10.1038/12659
Cameron, 1999, Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer, Nat. Genet., 21, 103, 10.1038/5047
Mannervik, 1999, Transcriptional coregulators in development, Science, 284, 606, 10.1126/science.284.5414.606
Struhl, 1998, Histone acetylation and transcriptional regulatory mechanisms, Genes Dev., 12, 599, 10.1101/gad.12.5.599
Toyota, 1999, CpG island methylator phenotype in colorectal cancer, Proc. Natl. Acad. Sci. U. S. A., 96, 8681, 10.1073/pnas.96.15.8681
Melki, 1999, Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia, Cancer Res., 59, 3730
Esteller, 1999, Hypermethylation-associated inactivation of p14ARF is independent of p16INK4A methylation and p53 mutational status, Cancer Res., 60, 129
Esteller, 1999, Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients, Cancer Res., 59, 67
Beard, 1995, Loss of methylation activates Xist in somatic but not in embryonic cells, Genes Dev., 9, 2325, 10.1101/gad.9.19.2325
Li, 1997, Role of DNA methylation in development in genomic imprinting, 1
Okano, 1998, Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases, Nat. Genet., 19, 219, 10.1038/890
Okano, 1999, DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development, Cell, 99, 247, 10.1016/S0092-8674(00)81656-6
Lengauer, 1997, DNA methylation and genetic instability in colorectal cancer cells, Proc. Natl. Acad. Sci. U. S. A., 94, 2545, 10.1073/pnas.94.6.2545
Robertson, 1999, The human DNA methyltransferases (DNMTs) 1, 3a and 3b, Nucleic Acids Res., 27, 2291, 10.1093/nar/27.11.2291
Wu, 1993, Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells, Proc. Natl. Acad. Sci. U. S. A., 90, 8891, 10.1073/pnas.90.19.8891
Bakin, 1999, Role of DNA 5-methylcytosine transferase in cell transformation by fos, Science, 283, 387, 10.1126/science.283.5400.387
Laird, 1995, Suppression of intestinal neoplasia by DNA hypomethylation, Cell, 81, 197, 10.1016/0092-8674(95)90329-1
MacLeod, 1995, Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis, J. Biol. Chem., 270, 8037, 10.1074/jbc.270.14.8037
Vertino, 1996, De Novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase, Mol. Cell Biol., 16, 4555, 10.1128/MCB.16.8.4555
Rhee, 2000, CpG methylation is maintained in cancer cells lacking DNMT, Nature, (in press)
Macleod, 1998, An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene, Mol. Cell Biol., 18, 4433, 10.1128/MCB.18.8.4433
Brandeis, 1994, Sp1 elements protect a CpG island from de novo methylation, Nature, 29, 435, 10.1038/371435a0
Macleod, 1994, Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island, Genes Dev., 8, 2282, 10.1101/gad.8.19.2282
Marin, 1997, Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation, Cell, 4, 619, 10.1016/S0092-8674(00)80243-3
Siegfried, 1999, DNA methylation represses transcription in vivo, Nat. Genet., 22, 203, 10.1038/9727
Pollard, 1998, Chromatin remodeling: a marriage between two families?, BioEssays, 20, 771, 10.1002/(SICI)1521-1878(199809)20:9<771::AID-BIES10>3.0.CO;2-V
Jeddeloh, 1999, Maintenance of genomic methylation requires a SWI2/SNF2-like protein, Nat. Genet., 22, 94, 10.1038/8803
Herman, 1996, Methylation-specific PCR, Proc. Natl. Acad. Sci. U. S. A., 93, 9821, 10.1073/pnas.93.18.9821
Sadri, 1996, Rapid analysis of DNA methylation using new restriction enzyme sites created by bisulfite modification, Nucleic Acids Res., 24, 5058, 10.1093/nar/24.24.5058
Wong, 1999, Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients, Cancer Res., 59, 71
Momparler, 1997, Pharmacological approach for optimization of the dose schedule of 5-Aza-2′-deoxycytidine (Decitabine) for the therapy of leukemia, Leukemia, 11, S1, 10.1038/sj.leu.2400550
Juttermann, 1994, Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation, Proc. Natl. Acad. Sci. U. S. A., 91, 11797, 10.1073/pnas.91.25.11797
Ferguson, 1997, Role of estrogen receptor gene demethylation and DNA methyltransferase DNA adduct formation in 5-Aza-2′-deoxycytidine-induced cytotoxicity in human breast cancer cells, J. Biol. Chem., 272, 32260, 10.1074/jbc.272.51.32260