Cerebellum and Nonmotor Function

Annual Review of Neuroscience - Tập 32 Số 1 - Trang 413-434 - 2009
Peter L. Strick1,2,3, Richard P. Dum1,2, Julie A. Fiez1,4
1Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
2Systems Neuroscience Institute and the Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;
3Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261;
4Learning Research and Development Center and Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;

Tóm tắt

Does the cerebellum influence nonmotor behavior? Recent anatomical studies demonstrate that the output of the cerebellum targets multiple nonmotor areas in the prefrontal and posterior parietal cortex, as well as the cortical motor areas. The projections to different cortical areas originate from distinct output channels within the cerebellar nuclei. The cerebral cortical area that is the main target of each output channel is a major source of input to the channel. Thus, a closed-loop circuit represents the major architectural unit of cerebro-cerebellar interactions. The outputs of these loops provide the cerebellum with the anatomical substrate to influence the control of movement and cognition. Neuroimaging and neuropsychological data supply compelling support for this view. The range of tasks associated with cerebellar activation is remarkable and includes tasks designed to assess attention, executive control, language, working memory, learning, pain, emotion, and addiction. These data, along with the revelations about cerebro-cerebellar circuitry, provide a new framework for exploring the contribution of the cerebellum to diverse aspects of behavior.

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Annual Review of Neuroscience

Tập 32 Số 1

413-434

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