Anti-metatype antibodies in immunoassays
Tóm tắt
In this review anti-metatype antibodies are described invoking new principles in immunoassay development. Anti-metatype antibodies are immunological reagents specific for the conformation of the liganded antibody active site which do not interact with bound ligand or unliganded antibody. Relationships between anti-metatype antibody reactivity and the ligand-induced conformational state of monoclonal antibodies are reviewed with emphasis on the fluorescein hapten as a small molecule model system. One characteristic result of the interaction of anti-metatype antibodies with liganded antibodies is a significant delay in the dissociation rate (k2) of the ligand bound within the primary immune complex. The latter is an important consideration for assay development. Polyclonal and monoclonal anti-metatype antibody reagents are characterized in terms of their differential effects on the ligand dissociation rate. Anti-metatype antibody reactivity is further discussed in terms of protein-protein specificity patterns and relative interactions with idiotype-family members, structural derivatives, and site-specific mutants. Incorporation of principles inherent in the anti-metatype concept and their application to assay development are summarized.
Tài liệu tham khảo
R. R. Porter,Biochem. J. 1959,73, 119.
R. R. Porter,Science 1973,180, 713.
E. W. Voss, Jr., in:Immunology and Biotechnology in Biomedical Research, Vol. 1 (B. P. Ram, M. C. Harris, P. Tyle, eds.), VCH, FL, 1990, p. 49.
E. W. Voss, Jr., M. A. Dombrink-Kurtzman, S. D. Miklasz,Immuno Invest. 1988.,17, 25.
M. Karplus, G. A. Petsko,Nature 1990,347, 631.
R. Eiber, M. Karplus,Science 1987,235, 318.
H. Frauenfelder, F. Parak, R. D. Young,Ann. Rev. Biophys. Biophys. Chem. 1988,17, 451.
A. Ansari, C. M. Jones, E. R. Henry, J. Hofricher, W. A. Eaton,Science 1992,256, 1796.
F. J. Stevens, C. -H. Chang, M. Schiffer,Proc. Natl. Acad. Sci. (USA) 1988,85 6895.
E. W. Voss, Jr., S. D. Miklasz, A. Petrossian, M. A. Dombrink-Kurtzman,Mol. Immunol. 1988,25, 751.
K. M. Weidner, E. W. Voss, Jr.,J. Biol. Chem. 1991,266, 2513.
K. M. Weidner, L. K. Denzin, M. Kim, W. D. Mallender, E. W. Voss, Jr.,Mol. Immunol.1993,30, 1003.
M. L. Kim, E. W. Voss, Jr.,J. Biol. Chem. 1994,269, 8695.
R. M. Bates, D. W. Ballard, E. W. Voss, Jr.,Mol. Immunol. 1985,22, 871.
E. W. Voss, Jr., M. A. Dombrink-Kurtzman, D. W. Ballard,Mol. Immunol. 1989,26, 971.
W. D. Bedzyk, L. S. Johnson, G. S. Riordan, E. W. Voss, Jr.,J. Biol. Chem. 1989,264, 1565.
M. A. Dombrink-Kurtzman, L. S. Johnson, G. S. Riordan, W. D. Bedzyk, E. W. Voss, Jr.,J. Biol. Chem. 1989,264, 4513.
S. D. Miklasz, E. W. Voss, Jr.,J. Molec. Recog. 1995,8, 258.
W. P. Pfund, J. S. Bourdage,Mol. Immunol. 1990,27, 495.
J. E. Butler, L. Ni, W. R. Brown, K. S. Joshi, J. Chang, B. Rosenberg, E. W. Voss, Jr.,Mol. Immunol. 1993,30, 1165.
E. W. Voss, Jr.,Mol. Immunol. 1996,33, 79.
K. M. Weidner, L. K. Denzin, E. W. Voss, Jr.,J. Biol Chem 1992,267, 10281.
K. M. Weidner, E. W. Voss, Jr.,Mol. Immunol. 1992,29, 303.
M. E. Mummert, E. W. Voss, Jr.,Mol. Immunol. 1995,32, 1225.
M. E. Mummert, E. W. Voss, Jr.,Biochemistry 1996, 00.
C. A. Swindlehurst, E. W. Voss, Jr.,Biophys. J. 1991,59, 619.
E. F. Ullman, G. Milburn, J. Jelesko, K. Radika, M. Pirio, T. Kempe, C. Skold,Proc. Natl. Acad. Sci. (USA) 1993,90, 1184.
C. H. Self, J. L. Dessi, L. A. Winger,Clin. Chem. 1994,40, 2035.
J. N. Herron, D. M. Kranz, D. M. Jameson, E. W. Voss, Jr.,Biochemistry 1986,25, 4602.
J. N. Herron, X. -M. He, M. L. Mason, E. W. Voss, Jr., A. B. EdmundsonProteins 1989,5, 271.
J. N. Herron, A. Terry, S. Johnston, X. -M. He, L. Guddat, E. W. Voss, Jr., A. B. Edmundson,Biophys. J. 1994,67, 2167.
M. Whitlow, A. J. Howard, J. F. Wood, E. W. Voss, Jr., K. D. Hardman,Prot. Eng. 1995,8, 749.