The HD Mutation Does Not Alter Neuronal Death in the Striatum of HdhQ92 Knock-in Mice after Mild Focal Ischemia

Bergeron, 1999, Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischemia in rat brain, Eur. J. Neurosci., 11, 4159, 10.1046/j.1460-9568.1999.00845.x

Boutell, 1999, Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin, Hum. Mol. Genet., 8, 1647, 10.1093/hmg/8.9.1647

Dragatsis, 2000, Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice, Nat. Genet., 26, 300, 10.1038/81593

Du, 1996, Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis?, J. Cereb. Blood Flow Metab., 16, 195, 10.1097/00004647-199603000-00003

Fink, 1998, Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation, J. Cereb. Blood Flow Metab., 18, 1071, 10.1097/00004647-199810000-00003

Goldberg, 1996, Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract, Nat. Genet., 13, 442, 10.1038/ng0896-442

Gusella, 2000, Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease, Nat. Rev. Neurosci., 1, 109, 10.1038/35039051

Hara, 1996, Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion, J. Cereb. Blood Flow Metab., 16, 605, 10.1097/00004647-199607000-00010

Hilditch-Maguire, 2000, Huntingtin: An iron-regulated protein essential for normal nuclear and perinuclear organelles, Hum. Mol. Genet., 9, 2789, 10.1093/hmg/9.19.2789

Huang, 1994, Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase, Science, 265, 1883, 10.1126/science.7522345

1993, Cell, 72, 971, 10.1016/0092-8674(93)90585-E

Leavitt, 2001, Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo, Am. J. Hum. Genet., 68, 313, 10.1086/318207

Levine, 1999, Enhanced sensitivity to N-methyl-d-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease, J. Neurosci. Res., 58, 515, 10.1002/(SICI)1097-4547(19991115)58:4<515::AID-JNR5>3.0.CO;2-F

Li, 2001, Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice, J. Neurosci, 21, 8473, 10.1523/JNEUROSCI.21-21-08473.2001

Lin, 2001, Neurological abnormalities in a knock-in mouse model of Huntington's disease, Hum. Mol. Genet., 10, 137, 10.1093/hmg/10.2.137

MacDonald, 1999, Evidence for the GluR6 gene associated with younger onset age of Huntington's disease, Neurology, 53, 1330, 10.1212/WNL.53.6.1330

MacManus, 1997, Gene expression induced by cerebral ischemia: An apoptotic perspective, J. Cereb. Blood Flow Metab., 17, 815, 10.1097/00004647-199708000-00001

Namura, 1998, Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia, J. Neurosci., 18, 3659, 10.1523/JNEUROSCI.18-10-03659.1998

Nath, 2000, Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: Marker for neuronal apoptosis, Neurochem. Int., 37, 351, 10.1016/S0197-0186(00)00040-1

O'Kusky, 1999, Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene, Brain Res., 818, 468, 10.1016/S0006-8993(98)01312-2

Rigamonti, 2000, Wild-type huntingtin protects from apoptosis upstream of caspase-3, J. Neurosci., 20, 3705, 10.1523/JNEUROSCI.20-10-03705.2000

Roth, 2001, Caspases, apoptosis, and Alzheimer disease: Causation, correlation, and confusion, J. Neuropathol. Exp. Neurol., 60, 829, 10.1093/jnen/60.9.829

Rubinsztein, 1997, Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease, Proc. Natl. Acad. Sci. USA, 94, 3872, 10.1073/pnas.94.8.3872

Schulz, 1999, Caspases as treatment targets in stroke and neurodegenerative diseases, Ann. Neurol., 45, 421, 10.1002/1531-8249(199904)45:4<421::AID-ANA2>3.0.CO;2-Q

Trettel, 2000, Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells, Hum. Mol. Genet., 9, 2799, 10.1093/hmg/9.19.2799

Wellington, 1998, Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract, J. Biol. Chem., 273, 9158, 10.1074/jbc.273.15.9158

Wellington, 2000, Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and non neuronal cells, J. Biol. Chem., 275, 19831, 10.1074/jbc.M001475200

Wheeler, 2000, Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92, and HdhQ111 knock-in mice, Hum. Mol. Genet., 9, 503, 10.1093/hmg/9.4.503

Wheeler, 2002, Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice, Hum. Mol. Genet., 11, 633, 10.1093/hmg/11.6.633

White, 1997, Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion, Nat. Genet., 17, 404, 10.1038/ng1297-404

Yokota, 1995, Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease, Stroke, 26, 1901, 10.1161/01.STR.26.10.1901

Zuccato, 2001, Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease, Science, 293, 493, 10.1126/science.1059581