Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine

Psychopharmacology - Tập 108 - Trang 313-319 - 1992
John H. Krystal1,2, Christopher J. McDougle2, Scott W. Woods2, Lawrence H. Price2, George R. Heninger2, Dennis S. Charney1,2
1VA-yale Alcoholism Research Center, Yale University School of Medicine, West Haven VA Medical Center, West Haven, USA
2Clinical Neuroscience Research Unit, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, USA

Tóm tắt

The effects of oral administration of the α2 adrenergic receptor antagonists idazoxan (20 mg, 40 mg, 80 mg) and yohimbine (20 mg) were compared using a placebo-controlled within-subjects design. Healthy subjects completed 5 test days during which medication effects on mood and anxiety states, physiologic indices, plasma cortisol levels, and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) were assessed. Idazoxan dose-dependently increased plasma MHPG, plasma cortisol, systolic and diastolic blood pressure, and Panic Attack Symptom Scale scores in healthy subjects. Overall, yohimbine and idazoxan produced a similar pattern of behavioral and neuroendocrine responses. Since idazoxan possesses relatively greater receptor specificity compared to yohimbine, it may be a more useful α2 antagonist in humans.

Tài liệu tham khảo

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