The conundrum of human immune system “senescence”

Mechanisms of Ageing and Development - Tập 192 - Trang 111357 - 2020
Graham Pawelec1,2, Anne M. Bronikowski3, Stephen C. Cunnane4, Luigi Ferrucci5, Claudio Franceschi6,7, Tamàs Fülöp8,9, Pierrette Gaudreau10,11, Vadim N. Gladyshev12, Efstathios S. Gonos13, Vera Gorbunova14, Brian K. Kennedy15,16,17,18, Anis Larbi19, Jean‐François Lemaître20,21, Guang‐Hui Liu22, Andrea B. Maier23,24, José A. Morais25, Otávio Tolêdo Nóbrega26,27, Alexey Moskalev28, Marcel G. M. Olde Rikkert29, Andrei Seluanov14, Alistair M. Senior, Svetlana Ukraintseva, Quentin Vanhaelen, Jacek M. Witkowski, Alan A. Cohen26
1Department of Immunology, University of Tübingen, Tübingen, Germany
2Health Sciences North Research Institute, Sudbury, ON, Canada
3Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA, 50011, United States
4Department of Medicine and Research Center on Aging, Université de Sherbrooke, Sherbrooke, Québec, Canada
5National Institute on Aging, 241 Bay View Boulevard, Baltimore, MD, 21225, United States
6Laboratory of Systems Biology of Healthy Aging, Department of Applied Mathematics, Lobachevsky State University, Nizhny Novgorod, Russia
7Mater Studiorum University of Bologna, Italy
8Department of Medicine, Geriatric Division, University of Sherbrooke, 3001 12 Ave N, Sherbrooke, QC J1H 5N4, Canada
9Research Center on Aging, 1036 Rue Belvédère S, Sherbrooke, QC J1H 4C4, Canada
10Centre Hospitalier de l'Université de Montréal Research Centre, Montreal, Quebec, Canada
11Department of Medicine, University of Montreal, Montreal, Quebec, Canada
12Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, United States
13National Hellenic Research Foundation, Institute of Chemical Biology, Athens, Greece
14Departments of Biology and Medicine, University of Rochester, Rochester, NY, 14627, United States
15Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, United States
16Centre for Healthy Longevity, National University Health System, Singapore, 1E Kent Ridge Rd., 119228, Singapore
17Healthy Longevity Programme, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr., 117597, Singapore
18Singapore Institute of Clinical Sciences, A⁎STAR, Singapore, 117609, Singapore
19A⁎STAR, 8 Biomedical Grove, #07, Neuros, Singapore, 138665, Singapore
20Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Évolutive, F-69622 Villeurbanne, France
21Université de Lyon, F-69000, Lyon, France
22State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
23Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands
24Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
25Division of Geriatric Medicine, Faculty of Medicine, McGill University and Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
26McGill University Health Center (MUHC), Glen site, 1001 Boul. Décarie, H4A 3J1, Montreal, QC, Canada
27Medical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900 Brasília, DF, Brazil
28Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Center of RAS, Kommunisticheskaya St.28, 167982, Syktyvkar, Russia
29Dept Geriatric Medicine, Radboud University Medical Center, Nijmegen, the Netherlands

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