Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors
Tóm tắt
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a variety of clinical manifestations. Although inter-individual variations exist with respect to susceptibility to develop SLE, no study has been carried out to determine the role of different climate conditions in predisposing the susceptible individuals to SLE. The objective of this study was to investigate the role of different seasons and climate factors on SLE activity. From 2000 to 2009, the seasonal distribution of 2,802 active SLE patients recruited from Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University was analyzed retrospectively. The climate data were provided by the Institute of Geographical Sciences and Resources, Chinese Academy of Sciences. The correlation between climate factors and SLE activity was also analyzed. The proportion of active SLE patients in winter, spring, summer, and autumn was 10.06, 10.31, 9.74, and 8.66‰, respectively. In autumn, the proportion was much lower than that in winter and spring (P < 0.05). The proportion among winter, spring, and summer had no statistical difference (P > 0.05). The number of active SLE patients had no correlation with air temperature (r = 0.483, P > 0.05), relative humidity (r = −0.294, P > 0.05), and sunshine percentage (r = 0.503, P > 0.05), but it had positive correlation with amount of precipitation (r = 0.601, P < 0.05), wind velocity (r = 0.713, P < 0.01), and sunshine duration (r = 0.769, P < 0.01) and negative correlation with barometric pressure (r = −0.664, P < 0.05). The disease activity of patients with SLE is affected by seasons and climate factors.
Tài liệu tham khảo
Pan HF, Ye DQ, Li XP (2008) Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus. Nat Clin Pract Rheumatol 4:352–353
Nath SK, Kilpatrick J, Harley JB (2004) Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin Immunol 16:794–800
Font J, Cervera R, Ramos-Casals M et al (2004) Clusters of clinical and immunologic features in systemic lupus erythematosus: analysis of 600 patients from a single center. Semin Arthritis Rheum 33:217–230
Watanabe N, Takabayashi K (2009) Recent investigations on the basis of pathogenesis of SLE and new therapeutic approaches. Nippon Rinsho 67:500–505
Wong M, Tsao BP (2006) Current topics in human SLE genetics. Springer Semin Immunopathol 28:97–107
Carey R, Simmons S, Malherbe M (2008) Clinical features of patients with systemic lupus erythematosus (SLE) attending the SLE outpatient clinic at Universitas hospital in Bloemfontein, South Africa. SA Fam Pract 50(1):68
Nastos PT, Paliatsos AG, Papadopoulos M et al (2008) The effect of weather variability on pediatric asthma admissions in Athens, Greece. J Asthma 45:59–65
Raza N, Sajid MD, Suhail M et al (2008) Onset of chilblains in relation with weather conditions. J Ayub Med Coll Abbottabad 20:17–20
Zhang HL, Xu SC, Tang DS et al (2009) Analysis of seasonal distribution of lupus activity and its correlation with meteorological factors. Chin J Clin (Electronic Edition) 3:56–61 (in Chinese)
Hochberg MC (1997) Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725
Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE. Arthritis Rheum 35:630–640
Maddison PJ (1999) Nature and nurture in systemic lupus erythematosus. Adv Exp Med Biol 455:7–13
Mayes MD (1999) Epidemiologic Studies of environmental agents and systemic autoimmune diseases. Environ Health Perspect 107:743–748
Latman NS (1987) Influence of atmospheric factors on the rheumatic diseases. Experientia 43:32–38
Sabry A, Elbasyouni SR, Sheashaa HA et al (2006) Correlation between levels of TNF-alpha and IL-6 and hematological involvement in SLE Egyptian patients with lupus nephritis. Int Urol Nephrol 38:727–731
Huang X, Hua J, Shen N et al (2007) Dysregulated expression of interleukin-23 and interleukin-21 subunits in systemic lupus erthematosus patients. Mod Rheumatol 17:220–223
Chun HY, Chung JW, Kim HA et al (2007) Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol 27:461–466
Crenesse D, Gugenheim J, Hornoy J et al (2000) Protein kinase activation by warm and cold hypoxia-reoxygenation in primary-cultured rat hepatocytes-JNK(1)/SAPK(1) involvement in apoptosis. Hepatology 32:1029–1036
Knight RJ, Liu H, Fishman E et al (2003) Cold ischemic injury, aortic allograft vasculopathy, and pro-inflammatory cytokine expression. J Surg Res 113:201–207
Monroy FP, Banerjee SK, Duong T et al (1999) Cold stress-induced modulation of inflammatory responses and intracerebral cytokine mRNA expression in acute murine toxoplasmosis. J Parasitol 85:878–886
Shiratsuch H, Basson MD (2005) Differential regulation of monocyte/macrophage cytokine production by pressure. Am J Surg 190:757–762
Ye DQ, Li XP, Zheng HL (1997) The risk factors of systemic lupus erythematosus in Hefei City. Chin J Public Health 13:338–339 (in Chinese)
Golan TD, Dan S, Haim H et al (1994) Solar ultraviolet radiation induces enhanced accumulation of oxygen radicals in murine SLE-derived splenocytes in vitro. Lupus 3:103–106
Foltyn VN, Golan TD (2001) In vitro ultraviolet irradiation induces pro-inflammatory responses in cells from premorbid SLE mice. Lupus 10:272–283