Ageing and gut microbes: Perspectives for health maintenance and longevity

Pharmacological Research - Tập 69 Số 1 - Trang 11-20 - 2013
Elena Biagi1, Marco Candela1, Silvia Turroni1, Paolo Garagnani2, Claudio Franceschi2, Patrizia Brigidi1
1Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
2Department of Experimental Pathology and CIG - Interdipartimental Center L. Galvani, University of Bologna, Bologna, Italy

Tóm tắt

Từ khóa


Tài liệu tham khảo

The 2012 ageing report: underlying assumptions and projection methodologies. Available from: http://ec.europa.eu/economy_finance/publications/european_economy/2011/pdf/ee-2011-4_en.pdf.

Martin, 2011, The biology of aging: 1985–2010 and beyond, FASEB Journal, 25, 3756, 10.1096/fj.11-1102.ufm

WHO. | 10 facts on ageing and the life course; 2012. Available from: http://www.who.int/features/factfiles/ageing/ageing_facts/en/index.html.

Roberfroid, 2002, Functional foods: concepts and application to inulin and oligofructose, British Journal of Nutrition, 87, S139, 10.1079/BJN/2002529

Hooper, 2010, Immune adaptations that maintain homeostasis with the intestinal microbiota, Nature Reviews Immunology, 10, 159, 10.1038/nri2710

Palmer, 2007, Development of the human infant intestinal microbiota, PLoS Biology, 5, e177, 10.1371/journal.pbio.0050177

Koenig, 2011, Succession of microbial consortia in the developing infant gut microbiome, Proceedings of the National Academy of Sciences of the United States of America, 108, 4578, 10.1073/pnas.1000081107

Biagi, 2012, Ageing of the human metaorganism: the microbial counterpart, Age, 34, 247, 10.1007/s11357-011-9217-5

Biagi, 2010, Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians, PLoS ONE, 5, e10667, 10.1371/journal.pone.0010667

Dominguez-Bello, 2011, Development of the human gastrointestinal microbiota and insights from high-throughput sequencing, Gastroenterology, 140, 1713, 10.1053/j.gastro.2011.02.011

Watanabe, 2003, Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects, Journal of Allergy and Clinical Immunology, 111, 587, 10.1067/mai.2003.105

Penders, 2007, Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study, Gut, 56, 661, 10.1136/gut.2006.100164

Martin, 2010, Early life: gut microbiota and immune development in infancy, Beneficial Microbes, 1, 367, 10.3920/BM2010.0027

Biagi, 2011, The aging gut microbiota: new perspectives, Ageing Research Reviews, 10, 428, 10.1016/j.arr.2011.03.004

Cheng, 2011, Contribution of the intestinal microbiota to human health: from birth to 100 years of age, Current Topics in Microbiology, 10.1007/82_2011_189

Claesson, 2011, Composition, variability, and temporal stability of the intestinal microbiota of the elderly, Proceedings of the National Academy of Sciences of the United States of America, 108, 4586, 10.1073/pnas.1000097107

Rea, 2012, Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota, Journal of Clinical Microbiology, 50, 867, 10.1128/JCM.05176-11

Rajilić-Stojanović, 2009, Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults, Environmental Microbiology, 11, 1736, 10.1111/j.1462-2920.2009.01900.x

Zwielehner, 2009, Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, Bifidobacteria and Clostridium cluster IV in institutionalized elderly, Experimental Gerontology, 44, 440, 10.1016/j.exger.2009.04.002

Mueller, 2006, Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study, Applied and Environment Microbiology, 72, 1027, 10.1128/AEM.72.2.1027-1033.2006

Mäkivuokko, 2010, The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition, British Journal of Nutrition, 103, 227, 10.1017/S0007114509991553

Hayashi, 2003, Molecular analysis of fecal microbiota in elderly individuals using 16S rDNA library and T-RFLP, Microbiology and Immunology, 47, 557, 10.1111/j.1348-0421.2003.tb03418.x

Tiihonen, 2008, The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology, British Journal of Nutrition, 100, 130, 10.1017/S000711450888871X

van Tongeren, 2005, Fecal microbiota composition and frailty, Applied and Environment Microbiology, 71, 6438, 10.1128/AEM.71.10.6438-6442.2005

Bartosch, 2004, Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota, Applied and Environment Microbiology, 70, 3575, 10.1128/AEM.70.6.3575-3581.2004

Woodmansey, 2004, Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects, Applied and Environment Microbiology, 70, 6113, 10.1128/AEM.70.10.6113-6122.2004

Lahtinen, 2009, Probiotics modulate the Bifidobacterium microbiota of elderly nursing home residents, Age, 31, 59, 10.1007/s11357-008-9081-0

Sim, 2012, Improved detection of bifidobacteria with optimised 16S rRNA-gene based pyrosequencing, PLoS ONE, 7, e32543, 10.1371/journal.pone.0032543

Frank, 2008, Critical evaluation of two primers commonly used for amplification of bacterial 16S rRNA genes, Applied and Environment Microbiology, 74, 2461, 10.1128/AEM.02272-07

Maukonen, 2012, The currently used commercial DNA-extraction methods give different results of clostridial and actinobacterial populations derived from human fecal samples, FEMS Microbiology Ecology, 79, 697, 10.1111/j.1574-6941.2011.01257.x

Mariat, 2009, The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age, BMC Microbiology, 9, 123, 10.1186/1471-2180-9-123

Pédron, 2008, Commensals, bacterial pathogens and intestinal inflammation: an intriguing ménage à trois, Cell Host & Microbe, 3, 344, 10.1016/j.chom.2008.05.010

Cani, 2009, The role of the gut microbiota in energy metabolism and metabolic disease, Current Pharmaceutical Design, 15, 1546, 10.2174/138161209788168164

Maslowski, 2011, Diet, gut microbiota and immune responses, Nature Immunology, 12, 5, 10.1038/ni0111-5

Neish, 2009, Microbes in gastrointestinal health and disease, Gastroenterology, 136, 65, 10.1053/j.gastro.2008.10.080

Ostan, 2008, Immunosenescence and immunogenetics of human longevity, Neuroimmunomodulation, 15, 224, 10.1159/000156466

Shanley, 2009, An evolutionary perspective on the mechanisms of immunosenescence, Trends in Immunology, 30, 374, 10.1016/j.it.2009.05.001

Guigoz, 2008, The inflammatory status of old age can be nurtured from the intestinal environment, Current Opinion in Clinical Nutrition & Metabolic Care, 11, 13, 10.1097/MCO.0b013e3282f2bfdf

Johansson, 2008, The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria, Proceedings of the National Academy of Sciences of the United States of America, 105, 15064, 10.1073/pnas.0803124105

Sansonetti, 2009, Learning tolerance while fighting ignorance, Cell, 138, 416, 10.1016/j.cell.2009.07.024

Macdonald, 2005, Immunity, inflammation, and allergy in the gut, Science, 307, 1920, 10.1126/science.1106442

Maynard, 2009, Intestinal effector T cells in health and disease, Immunity, 31, 389, 10.1016/j.immuni.2009.08.012

Franceschi, 2007, Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans, Mechanisms of Ageing and Development, 128, 92, 10.1016/j.mad.2006.11.016

Larbi, 2008, Aging of the immune system as a prognostic factor for human longevity, Physiology, 23, 64, 10.1152/physiol.00040.2007

Round, 2009, The gut microbiota shapes intestinal immune responses during health and disease, Nature Reviews Immunology, 9, 313, 10.1038/nri2515

Winter, 2010, Gut inflammation provides a respiratory electron acceptor for Salmonella, Nature, 467, 426, 10.1038/nature09415

Thomas, 2011, Environmental and gut bacteroidetes: the food connection, Frontiers in Microbiology, 2, 93, 10.3389/fmicb.2011.00093

Doty, 1984, Smell identification ability: changes with age, Science, 226, 1441, 10.1126/science.6505700

Newton, 1993, Changes in human jaw muscles with age and dental state, Gerodontology, 10, 16, 10.1111/j.1741-2358.1993.tb00074.x

Wu, 2011, Linking long-term dietary patterns with gut microbial enterotypes, Science, 334, 105, 10.1126/science.1208344

Walker, 2011, Dominant and diet-responsive groups of bacteria within the human colonic microbiota, ISME Journal, 5, 220, 10.1038/ismej.2010.118

Claesson, 2012, Gut microbiota composition correlates with diet and health in the elderly, Nature, 488, 178, 10.1038/nature11319

Hamer, 2012, Functional analysis of colonic bacterial metabolism: relevant to health?, American Journal of Physiology. Gastrointestinal and Liver Physiology, 302, G1, 10.1152/ajpgi.00048.2011

Maloy, 2008, The interleukin-23/interleukin-17 axis in intestinal inflammation, Journal of Internal Medicine, 263, 584, 10.1111/j.1365-2796.2008.01950.x

Schiffrin, 2010, The inflammatory status of the elderly: the intestinal contribution, Mutation Research, 690, 50, 10.1016/j.mrfmmm.2009.07.011

Plottel, 2011, Microbiome and malignancy, Cell Host & Microbe, 10, 324, 10.1016/j.chom.2011.10.003

Rupnik, 2009, Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nature Reviews, Microbiology, 7, 526

Brandt, 2011, Fecal microbiota transplantation for recurrent Clostridium difficile infection, Journal of Clinical Gastroenterology, 45, S159, 10.1097/MCG.0b013e318222e603

Barcenilla, 2000, Phylogenetic relationships of butyrate-producing bacteria from the human gut, Applied and Environment Microbiology, 66, 1654, 10.1128/AEM.66.4.1654-1661.2000

Louis, 2009, Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine, FEMS Microbiology Letters, 294, 1, 10.1111/j.1574-6968.2009.01514.x

Nicholson, 2012, Host–gut microbiota metabolic interactions, Science, 336, 1262, 10.1126/science.1223813

Musso, 2011, Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes, Annual Review of Medicine, 62, 361, 10.1146/annurev-med-012510-175505

Thibault, 2010, Butyrate utilization by the colonic mucosa in inflammatory bowel diseases: a transport deficiency, Inflammatory Bowel Diseases, 16, 684, 10.1002/ibd.21108

Hippe, 2011, Quantification of butyryl CoA:acetate CoA-transferase genes reveals different butyrate production capacity in individuals according to diet and age, FEMS Microbiology Letters, 316, 130, 10.1111/j.1574-6968.2010.02197.x

Donini, 2010, Nutritional interventions in the anorexia of aging, Journal of Nutrition, Health and Aging, 14, 494, 10.1007/s12603-010-0094-x

Ley, 2006, Microbial ecology: human gut microbes associated with obesity, Nature, 444, 1022, 10.1038/4441022a

Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038/nature05414

Macia, 2012, Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases, Immunological Reviews, 245, 164, 10.1111/j.1600-065X.2011.01080.x

Petersson, 2011, Importance and regulation of the colonic mucus barrier in a mouse model of colitis, American Journal of Physiology. Gastrointestinal and Liver Physiology, 300, G327, 10.1152/ajpgi.00422.2010

Barcelo, 2000, Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon, Gut, 46, 218, 10.1136/gut.46.2.218

Suzuki, 2008, Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability, British Journal of Nutrition, 100, 297, 10.1017/S0007114508888733

Candela, 2011, Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer, Critical Reviews in Microbiology, 37, 1, 10.3109/1040841X.2010.501760

Ou, 2012, Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations, Nutrition and Cancer, 64, 34, 10.1080/01635581.2012.630164

Holmes, 2011, Understanding the role of gut microbiome–host metabolic signal disruption in health and disease, Trends in Microbiology, 19, 349, 10.1016/j.tim.2011.05.006

Monleón, 2009, Metabolite profiling of fecal water extracts from human colorectal cancer, NMR in Biomedicine, 22, 342, 10.1002/nbm.1345

Boyle, 2005, Mortality and survival in breast and colorectal cancer, Nature Clinical Practice Oncology, 2, 424, 10.1038/ncponc0288

Kraus, 2009, Inflammation and colorectal cancer, Current Opinion in Pharmacology, 9, 405, 10.1016/j.coph.2009.06.006

Lee, 2010, ERK activation drives intestinal tumorigenesis in Apc(min/+) mice, Nature Medicine, 16, 665, 10.1038/nm.2143

Killeen, 2009, Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system, British Journal of Cancer, 100, 1589, 10.1038/sj.bjc.6604942

Wilson, 2009, Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring, Proceedings of the National Academy of Sciences of the United States of America, 106, 14187, 10.1073/pnas.0907721106

Sousa, 2008, The gastrointestinal microbiota as a site for the biotransformation of drugs, International Journal of Pharmaceutics, 363, 1, 10.1016/j.ijpharm.2008.07.009

Gotto, 2007, Statin therapy and the elderly: SAGE Advice?, Circulation, 115, 681, 10.1161/CIRCULATIONAHA.106.678300

Aura, 2011, Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro, Molecular BioSystems, 7, 437, 10.1039/C0MB00023J

Kaddurah-Daouk, 2011, Enteric microbiome metabolites correlate with response to simvastatin treatment, PLoS ONE, 6, e25482, 10.1371/journal.pone.0025482

Kinross, 2011, Gut microbiome–host interactions in health and disease, Genome Medicine, 3, 14, 10.1186/gm228

Nagata, 2011, Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged, British Journal of Nutrition, 106, 549, 10.1017/S000711451100064X

Tiihonen, 2010, Human intestinal microbiota and healthy ageing, Ageing Research Reviews, 9, 107, 10.1016/j.arr.2009.10.004

Toward, 2012, Effect of prebiotics on the human gut microbiota of elderly persons, Gut Microbes, 3, 57, 10.4161/gmic.19411

Björklund, 2012, Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol, Age, 34, 987, 10.1007/s11357-011-9294-5

Walton, 2012, A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age, British Journal of Nutrition, 107, 1466, 10.1017/S0007114511004697

Lahtinen, 2012, Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM® modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly, Age, 34, 133, 10.1007/s11357-011-9208-6

Hickson, 2007, Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial, BMJ, 335, 80, 10.1136/bmj.39231.599815.55

Kee, 2012, Clostridium difficile infection in older adults: a review and update on its management, American Journal of Geriatric Pharmacotherapy, 10, 14, 10.1016/j.amjopharm.2011.12.004

An, 2010, Efficacy of lactic acid bacteria (LAB) supplement in management of constipation among nursing home residents, Nutrition Journal, 9, 5, 10.1186/1475-2891-9-5

Carlsson, 2009, The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB 21, and Lactococcus lactis L1A—a pilot study among old people with dementia in a residential care facility, Journal of Nutrition, Health and Aging, 13, 813, 10.1007/s12603-009-0218-3

Pitkala, 2007, Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial, Journal of Nutrition, Health and Aging, 11, 305

Candore, 2008, Immunosenescence and anti-immunosenescence therapies: the case of probiotics, Rejuvenation Research, 11, 425, 10.1089/rej.2008.0662

Thomas, 2012, New insights into the impact of the intestinal microbiota on health and disease: a symposium report, British Journal of Nutrition, 107, S1, 10.1017/S0007114511006970

Fukushima, 2007, Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533), British Journal of Nutrition, 98, 969, 10.1017/S0007114507764723

Ibrahim, 2010, Probiotics and immunosenescence: cheese as a carrier, FEMS Immunology and Medical Microbiology, 59, 53, 10.1111/j.1574-695X.2010.00658.x

Matsumoto, 2006, Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512, Bioscience, Biotechnology, and Biochemistry, 70, 1287, 10.1271/bbb.50464

Moro-García, 2012, Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects, Age, 10.1007/s11357-012-9434-6

Schiffrin, 2007, Systemic inflammatory markers in older persons: the effect of oral nutritional supplementation with prebiotics, Journal of Nutrition, Health and Aging, 11, 475

Vulevic, 2008, Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers, American Journal of Clinical Nutrition, 88, 1438, 10.3945/ajcn.2008.26242

Boge, 2009, A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials, Vaccine, 27, 5677, 10.1016/j.vaccine.2009.06.094

Bosch, 2012, Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly, Nutricion Hospitalaria, 27, 504

Namba, 2010, Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly, Bioscience, Biotechnology, and Biochemistry, 74, 939, 10.1271/bbb.90749

Guillemard, 2010, Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial, British Journal of Nutrition, 103, 58, 10.1017/S0007114509991395

Cusack, 2011, How beneficial is the use of probiotic supplements for the aging gut?, Aging Health, 7, 179, 10.2217/ahe.11.8

Shen, 2011, In vitro and in vivo antioxidant activity of Bifidobacterium animalis 01 isolated from centenarians, Current Microbiology, 62, 1097, 10.1007/s00284-010-9827-7

Yang, 2009, Oral administration of live Bifidobacterium substrains isolated from centenarians enhances intestinal function in mice, Current Microbiology, 59, 439, 10.1007/s00284-009-9457-0

Yang, 2009, Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice, Nutrition Research, 29, 281, 10.1016/j.nutres.2009.03.010

Ottaviani, 2011, Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms, Biogerontology, 12, 599, 10.1007/s10522-011-9352-5

Matsumoto, 2011, Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production, PLoS ONE, 6, e23652, 10.1371/journal.pone.0023652

Matsumoto, 2007, The relationship between microbiota and polyamine concentration in the human intestine: a pilot study, Microbiology and Immunology, 51, 25, 10.1111/j.1348-0421.2007.tb03887.x

Matsumoto, 2004, Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects, Mutation Research, 568, 147, 10.1016/j.mrfmmm.2004.07.016

Matsumoto, 2009, Dynamics of fecal microbiota in hospitalized elderly fed probiotic LKM512 yogurt, Microbiology and Immunology, 53, 421, 10.1111/j.1348-0421.2009.00140.x

Ouwehand, 2009, Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters, British Journal of Nutrition, 101, 367, 10.1017/S0007114508003097

Matsumoto, 2011, Probiotics-induced increase of large intestinal luminal polyamine concentration may promote longevity, Medical Hypotheses, 77, 469, 10.1016/j.mehy.2011.06.011

Franceschi, 1999, Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load, Experimental Gerontology, 34, 911, 10.1016/S0531-5565(99)00068-6

Cevenini, 2008, Human models of aging and longevity, Expert Opinion on Biological Therapy, 8, 1393, 10.1517/14712598.8.9.1393

O’Hara, 2006, The gut flora as a forgotten organ, EMBO Reports, 7, 688, 10.1038/sj.embor.7400731

Van Puyenbroeck, 2012, Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents, American Journal of Clinical Nutrition, 95, 1165, 10.3945/ajcn.111.026831