Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

Chemistry & Biology - Tập 17 - Trang 471-482 - 2010
Erin M. Bowers1, Gai Yan2, Chandrani Mukherjee1, Andrew Orry3, Ling Wang1, Marc A. Holbert1, Nicholas T. Crump4, Catherine A. Hazzalin4, Glen Liszczak5, Hua Yuan5, Cecilia Larocca2, S. Adrian Saldanha6, Ruben Abagyan7, Yan Sun1, David J. Meyers1, Ronen Marmorstein5,8, Louis C. Mahadevan4, Rhoda M. Alani2, Philip A. Cole1,2
1Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA
2Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
3Molsoft LLC, La Jolla, CA 92037, USA
4Nuclear Signalling Laboratory, Department of Biochemistry, Oxford University, Oxford OX1 3QU, UK
5Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA 19104, USA
6The Scripps Research Institute, Jupiter, FL 33458, USA
7Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
8Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA

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Chemistry & Biology

Tập 17

471-482

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