Characterization of CD56–/CD16+natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals

Proceedings of the National Academy of Sciences of the United States of America - Tập 102 Số 8 - Trang 2886-2891 - 2005
Domenico Mavilio1, Gabriella Lombardo1, Janet Benjamin1, Diana Kim1, Dean Follman1, Emanuela Marcenaro1, Marie A. O’Shea1, Audrey Kinter1, Colin Kovacs1, Alessandro Moretta1, Anthony S. Fauci1
1Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Dipartimento di Medicina Sperimentale, University of Genoa, 16132 Genoa, Italy; and Department of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A1

Tóm tắt

Natural killer (NK) cells are an important component of the innate immune response against viral infections. NK cell-mediated cytolytic activity is defective in HIV-infected individuals with high levels of viral replication. In the present study, we examined the phenotypic and functional characteristics of an unusual CD56–/CD16+(CD56–) NK subset that is greatly expanded in HIV-viremic individuals. The higher level of expression of inhibitory NK receptors and the lower level of expression of natural cytotoxicity receptors observed in the CD56–NK fraction compared with that of CD56+NK cells was associated with extremely poorin vitrocytotoxic function of this subset. In addition, the secretion of certain cytokines known to be important in initiating antiviral immune responses was markedly reduced in the CD56–, as compared with the CD56+NK cell subset. These data suggest that the expansion of this highly dysfunctional CD56–NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total NK cell population.

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Tài liệu tham khảo

10.1038/319675a0

10.1016/S0065-2776(08)60664-1

10.1038/nri956

10.1038/ni1114

10.1146/annurev.immunol.14.1.619

10.1146/annurev.immunol.19.1.197

10.1038/35095564

10.1084/jem.182.3.789

10.1097/00002030-199602000-00003

10.2174/1566524023361781

10.1097/00002030-200303070-00003

10.1002/jmv.2053

10.1073/pnas.2336091100

10.1086/382090

10.1002/eji.200324141

10.1172/JCI2323

10.1086/368222

Hu, P. F., Hultin, L. E., Hultin, P., Hausner, M. A., Hirji, K., Jewett, A., Bonavida, B., Detels, R. & Giorgi, J. V. (1995) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 10, 331–340.7552495

10.1097/00126334-199908150-00004

10.1023/A:1015476114409

10.1016/j.it.2003.10.012

Scott-Algara, D., Vuillier, F., Cayota, A. & Dighiero, G. (1992) Clin. Exp. Immunol. 90, 181–187.1424272

10.4049/jimmunol.168.11.5764

10.1023/B:JOCI.0000025449.16468.6f

10.1182/blood.V97.10.3146

10.1046/j.1365-3083.1997.d01-98.x

10.1111/j.1600-0463.2000.tb00006.x

10.1016/S1074-7613(00)80065-5

10.1182/blood-2004-02-0696

10.1097/00002030-200311070-00003

10.1084/jem.20011149

10.1073/pnas.0730640100

10.1097/00002030-200206140-00007

10.1111/j.1749-6632.1993.tb35912.x

Stylianou, E., Aukrust, P., Kvale, D., Muller, F. & Froland, S. S. (1999) Clin. Exp. Immunol. 116, 115–120.10209514

10.1128/JCM.39.1.298-303.2001

10.1073/pnas.0307328101

10.1002/eji.200425251

10.1016/S1471-4906(01)02060-9

Robertson, M. J. (2002) J. Leukocyte Biol. 71, 173–183.11818437

10.2174/1570162033485267

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Proceedings of the National Academy of Sciences of the United States of America

Tập 102 Số 8

2886-2891

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