Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

Journal of Neurochemistry - Tập 81 Số 5 - Trang 1084-1091 - 2002
Michio Hashimoto1, Shahdat Hossain2,1, Toshio Shimada3, Kozo Sugioka4, Hiroshi Yamasaki1, Yoshimi Fujii1, Yutaka Ishibashi3, Jun‐Ichiro Oka5, Osamu Shido1
1Department of Physiology and the
2Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh
3Fourth Department of Internal Medicine, Shimane Medical University, Izumo, Japan
4First Department of Anatomy, School of Medicine, Kobe University, Kobe, Japan
5Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan

Tóm tắt

AbstractDocosahexaenoic acid (C22:6, n‐3), a major n‐3 fatty acid of the brain, has been implicated in restoration and enhancement of memory‐related functions. Because Alzheimer's disease impairs memory, and infusion of amyloid‐β (Aβ) peptide (1–40) into the rat cerebral ventricle reduces learning ability, we investigated the effect of dietary pre‐administration of docosahexaenoic acid on avoidance learning ability in Aβ peptide‐produced Alzheimer's disease model rats. After a mini‐osmotic pump filled with Aβ peptide or vehicle was implanted in docosahexaenoic acid‐fed and control rats, they were subjected to an active avoidance task in a shuttle avoidance system apparatus. Pre‐administration of docosahexaenoic acid had a profoundly beneficial effect on the decline in avoidance learning ability in the Alzheimer's disease model rats, associated with an increase in the cortico‐hippocampal docosahexaenoic acid/arachidonic acid molar ratio, and a decrease in neuronal apoptotic products. Docosahexaenoic acid pre‐administration furthermore increased cortico‐hippocampal reduced glutathione levels and glutathione reductase activity, and suppressed the increase in lipid peroxide and reactive oxygen species levels in the cerebral cortex and hippocampus of the Alzheimer's disease model rats, suggesting an increase in antioxidative defence. Docosahexaenoic acid is thus a possible prophylactic means for preventing the learning deficiencies of Alzheimer's disease.

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Journal of Neurochemistry

Tập 81 Số 5

1084-1091

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