Dietary Xylooligosaccharide Downregulates IFN-γ and the Low-Grade Inflammatory Cytokine IL-1β Systemically in Mice

Esteve, 2011, Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve with insulin resistance?, Curr Opin Clin Nutr Metab Care., 14, 483, 10.1097/MCO.0b013e328348c06d Maachi, 2004, Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women., Int J Obes Relat Metab Disord., 28, 993, 10.1038/sj.ijo.0802718 Trøseid, 2010, The role of interleukin-18 in the metabolic syndrome., Cardiovasc Diabetol., 9, 11, 10.1186/1475-2840-9-11 Gibson, 2004, Dietary modulation of the human colonic microbiota: updating the concept of prebiotics., Nutr Res Rev., 17, 259, 10.1079/NRR200479 Nakamura, 2012, Metabolic diseases and pro- and prebiotics: mechanistic insights., Nutr Metab (Lond)., 9, 60, 10.1186/1743-7075-9-60 Artis, 2008, Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut., Nat Rev Immunol., 8, 411, 10.1038/nri2316 Cash, 2006, Symbiotic bacteria direct expression of an intestinal bactericidal lectin., Science., 313, 1126, 10.1126/science.1127119 Vinolo, 2011, Regulation of inflammation by short chain fatty acids., Nutrients., 3, 858, 10.3390/nu3100858 Brown, 2003, The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids., J Biol Chem., 278, 11312, 10.1074/jbc.M211609200 Maslowski, 2009, Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43., Nature., 461, 1282, 10.1038/nature08530 Pokusaeva, 2011, Carbohydrate metabolism in Bifidobacteria., Genes Nutr., 6, 285, 10.1007/s12263-010-0206-6 Andersen, 2011, Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus., Proc Natl Acad Sci USA., 108, 17785, 10.1073/pnas.1114152108 Campbell, 1997, Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats., J Nutr., 127, 130, 10.1093/jn/127.1.130 Gibson, 1995, Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin., Gastroenterology., 108, 975, 10.1016/0016-5085(95)90192-2 Gobinath, 2010, Beneficial effect of xylo-oligosaccharides and fructo-oligosaccharides in streptozotocin-induced diabetic rats., Br J Nutr., 104, 40, 10.1017/S0007114510000243 Petersen, 2010, Analysis of the intestinal microbiota of oligosaccharide fed mice exhibiting reduced resistance to Salmonella infection., Benef Microbes., 1, 271, 10.3920/BM2010.0016 Lecerf, 2012, Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties., Br J Nutr., 108, 1847, 10.1017/S0007114511007252 Http://www.altromin.de/altro_engl/specifications/sonderdiaeten/C1000.pdf. 24.01.2013. Bergström, 2012, Nature of bacterial colonization influences transcription of mucin genes in mice during the first week of life., BMC Res Notes., 5, 402, 10.1186/1756-0500-5-402 Ramakers, 2003, Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data., Neurosci Lett., 339, 62, 10.1016/S0304-3940(02)01423-4 Vandesompele, 2002, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes., Genome Biol., 3, 10.1186/gb-2002-3-7-research0034 Hansen, 2012, Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse., Diabetologia., 55, 2285, 10.1007/s00125-012-2564-7 Natividad, 2012, Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1−/− Nod2−/− mice., Inflamm Bowel Dis., 18, 1434, 10.1002/ibd.22848 Yang, 2012, An energy-rich diet enhances expression of Na(+)/H(+) exchanger isoform 1 and 3 messenger RNA in rumen epithelium of goat., J Anim Sci., 90, 307, 10.2527/jas.2011-3854 Mantovani, 2011, Neutrophils in the activation and regulation of innate and adaptive immunity., Nat Rev Immunol., 11, 519, 10.1038/nri3024 Okamura, 1998, Regulation of interferon-gamma production by IL-12 and IL-18., Curr Opin Immunol., 10, 259, 10.1016/S0952-7915(98)80163-5 Konieczna, 2012, Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells., Gut., 61, 354, 10.1136/gutjnl-2011-300936 Hsu, 2004, Xylooligosaccharides and fructooligosaccharides affect the intestinal microbiota and precancerous colonic lesion development in rats., J Nutr., 134, 1523, 10.1093/jn/134.6.1523 Mäkeläinen, 2010, Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures., Benef Microbes., 1, 139, 10.3920/BM2009.0029 Moura, 2008, In vitro fermentation of selected xylo-oligosaccharides by piglet intestinal microbiota., Food Sci Technol., 41, 1952 Vaishnava, 2011, The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine., Science., 334, 255, 10.1126/science.1209791 Van Craeyveld, 2008, Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats., J Nutr., 138, 2348, 10.3945/jn.108.094367 Leung, 2009, Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan., Eur J Immunol., 39, 3529, 10.1002/eji.200939454 Kaji, 2011, Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide., J Mol Histol., 42, 27, 10.1007/s10735-010-9304-4 Vinolo, 2011, SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor., PLoS ONE., 6, e21205, 10.1371/journal.pone.0021205 Vulevic, 2008, Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers., Am J Clin Nutr., 88, 1438, 10.3945/ajcn.2008.26242 Dinarello, 2009, Immunological and inflammatory functions of the interleukin-1 family., Annu Rev Immunol., 27, 519, 10.1146/annurev.immunol.021908.132612 Tuttle, 2004, Proinflammatory cytokines are increased in type 2 diabetic women with cardiovascular disease., J Diabetes Complications., 18, 343, 10.1016/S1056-8727(03)00088-6 Bhatia, 2009, Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells., Blood., 113, 6440, 10.1182/blood-2008-09-171728 van Eijk, 2009, Application of liquid chromatography-mass spectrometry to measure short chain fatty acids in blood., J Chromatogr B Analyt Technol Biomed Life Sci., 877, 719, 10.1016/j.jchromb.2009.01.039 Pomare, 1985, Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood., J Clin Invest., 75, 1448, 10.1172/JCI111847