Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Agulhon, 2010, Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling, Science, 327, 1250, 10.1126/science.1184821

Allen, 2009, Neuroscience: Glia - more than just brain glue, Nature, 457, 675, 10.1038/457675a

Allen, 2012, Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors, Nature, 486, 410, 10.1038/nature11059

Attwell, 2010, Glial and neuronal control of brain blood flow, Nature, 468, 232, 10.1038/nature09613

Banker, 1980, Trophic interactions between astroglial cells and hippocampal neurons in culture, Science, 209, 809, 10.1126/science.7403847

Beach, 1988, Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer’s disease visual cortex, Brain Res., 463, 357, 10.1016/0006-8993(88)90410-6

Christopherson, 2005, Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis, Cell, 120, 421, 10.1016/j.cell.2004.12.020

Chung, 2013, Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways, Nature, 504, 394, 10.1038/nature12776

Chung, 2015, Astrocytes control synapse formation, function, and elimination, Cold Spring Harb. Perspect. Biol., 7, a020370, 10.1101/cshperspect.a020370

Clarke, 2013, Emerging roles of astrocytes in neural circuit development, Nat. Rev. Neurosci., 14, 311, 10.1038/nrn3484

Ding, 2013, α1-adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice, Cell Calcium, 54, 387, 10.1016/j.ceca.2013.09.001

Foo, 2011, Development of a method for the purification and culture of rodent astrocytes, Neuron, 71, 799, 10.1016/j.neuron.2011.07.022

Ge, 2012, Local generation of glia is a major astrocyte source in postnatal cortex, Nature, 484, 376, 10.1038/nature10959

Gordienko, 2002, Crosstalk between ryanodine receptors and IP(3) receptors as a factor shaping spontaneous Ca(2+)-release events in rabbit portal vein myocytes, J. Physiol., 542, 743, 10.1113/jphysiol.2001.015966

Hamilton, 2010, Do astrocytes really exocytose neurotransmitters?, Nat. Rev. Neurosci., 11, 227, 10.1038/nrn2803

Han, 2013, Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice, Cell Stem Cell, 12, 342, 10.1016/j.stem.2012.12.015

Hawrylycz, 2012, An anatomically comprehensive atlas of the adult human brain transcriptome, Nature, 489, 391, 10.1038/nature11405

Haydon, 2014, How do astrocytes participate in neural plasticity?, Cold Spring Harb. Perspect. Biol., 7, a020438, 10.1101/cshperspect.a020438

Huang, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat. Protoc., 4, 44, 10.1038/nprot.2008.211

Huttenlocher, 1979, Synaptic density in human frontal cortex - developmental changes and effects of aging, Brain Res., 163, 195, 10.1016/0006-8993(79)90349-4

Huttenlocher, 1982, Synaptogenesis in human visual cortex--evidence for synapse elimination during normal development, Neurosci. Lett., 33, 247, 10.1016/0304-3940(82)90379-2

Kang, 2011, Spatio-temporal transcriptome of the human brain, Nature, 478, 483, 10.1038/nature10523

Khakh, 2015, Astrocyte calcium signaling: from observations to functions and the challenges therein, Cold Spring Harb. Perspect. Biol., 7, a020404, 10.1101/cshperspect.a020404

Kola, 2004, Can the pharmaceutical industry reduce attrition rates?, Nat. Rev. Drug Discov., 3, 711, 10.1038/nrd1470

Kucukdereli, 2011, Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC, Proc. Natl. Acad. Sci. USA, 108, E440, 10.1073/pnas.1104977108

Kuffler, 1966, Physiological properties of glial cells in the central nervous system of amphibia, J. Neurophysiol., 29, 768, 10.1152/jn.1966.29.4.768

Malik, 2014, Comparison of the gene expression profiles of human fetal cortical astrocytes with pluripotent stem cell derived neural stem cells identifies human astrocyte markers and signaling pathways and transcription factors active in human astrocytes, PLoS ONE, 9, e96139, 10.1371/journal.pone.0096139

McCarthy, 1980, Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue, J. Cell Biol., 85, 890, 10.1083/jcb.85.3.890

Meyer-Franke, 1995, Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture, Neuron, 15, 805, 10.1016/0896-6273(95)90172-8

Molofsky, 2012, Astrocytes and disease: a neurodevelopmental perspective, Genes Dev., 26, 891, 10.1101/gad.188326.112

Mulligan, 2004, Calcium transients in astrocyte endfeet cause cerebrovascular constrictions, Nature, 431, 195, 10.1038/nature02827

Nedergaard, 1994, Direct signaling from astrocytes to neurons in cultures of mammalian brain cells, Science, 263, 1768, 10.1126/science.8134839

Nimmerjahn, 2009, Motor behavior activates Bergmann glial networks, Neuron, 62, 400, 10.1016/j.neuron.2009.03.019

Oberheim, 2006, Astrocytic complexity distinguishes the human brain, Trends Neurosci., 29, 547, 10.1016/j.tins.2006.08.004

Oberheim, 2009, Uniquely hominid features of adult human astrocytes, J. Neurosci., 29, 3276, 10.1523/JNEUROSCI.4707-08.2009

Parpura, 1994, Glutamate-mediated astrocyte-neuron signalling, Nature, 369, 744, 10.1038/369744a0

Paukert, 2014, Norepinephrine controls astroglial responsiveness to local circuit activity, Neuron, 82, 1263, 10.1016/j.neuron.2014.04.038

Pellerin, 1994, Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization, Proc. Natl. Acad. Sci. USA, 91, 10625, 10.1073/pnas.91.22.10625

Rothstein, 1996, Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate, Neuron, 16, 675, 10.1016/S0896-6273(00)80086-0

Schummers, 2008, Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex, Science, 320, 1638, 10.1126/science.1156120

Sun, 2013, Glutamate-dependent neuroglial calcium signaling differs between young and adult brain, Science, 339, 197, 10.1126/science.1226740

Tien, 2012, Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord, Development, 139, 2477, 10.1242/dev.077214

Ullian, 2001, Control of synapse number by glia, Science, 291, 657, 10.1126/science.291.5504.657

Winzeler, 2013, Purification and culture of retinal ganglion cells from rodents, Cold Spring Harb. Protoc., 2013, 643

Zamanian, 2012, Genomic analysis of reactive astrogliosis, J. Neurosci., 32, 6391, 10.1523/JNEUROSCI.6221-11.2012

Zhang, 2014, An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex, J. Neurosci., 34, 11929, 10.1523/JNEUROSCI.1860-14.2014

Zonta, 2003, Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation, Nat. Neurosci., 6, 43, 10.1038/nn980