Transcriptional control of occludin expression in vascular endothelia: Regulation by Sp3 and YY1

Wolburg, 2002, Tight junctions of the blood–brain barrier: development, composition and regulation, Vasc. Pharm., 38, 323, 10.1016/S1537-1891(02)00200-8 Begley, 2004, ABC transporters and the blood–brain barrier, Curr. Pharm. Res., 10, 1295, 10.2174/1381612043384844 Janzer, 1987, Astrocytes induce blood–brain barrier properties in endothelial cells, Nature, 325, 253, 10.1038/325253a0 Risau, 1986, Brain induces the expression of an early cell surface marker for blood–brain barrier specific endothelium, EMBO J., 5, 3179, 10.1002/j.1460-2075.1986.tb04627.x Holloway, 2007, Action of transcription factors in the control of transferrin receptor expression in human brain endothelium, J. Mol. Biol., 365, 1271, 10.1016/j.jmb.2006.10.071 Wachtel, 1999, Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition, J. Cell Sci., 112, 4347, 10.1242/jcs.112.23.4347 Burns, 2000, Analysis of tight junctions during neutrophil transendothelial migration, J. Cell Sci., 113, 45, 10.1242/jcs.113.1.45 Schneeberger, 2004, The tight junction: a multifunctional complex, Am. J. Cell Physiol., 286, C1213, 10.1152/ajpcell.00558.2003 Risau, 1998, Differentiation of blood–brain endothelial cells, Pathol. Biol., 46, 171 Oettgen, 2001, Transcriptional regulation of vascular development, Circulation Res., 89, 380, 10.1161/hh1701.095958 Suske, 1999, The Sp-family of transcription factors, Gene, 238, 291, 10.1016/S0378-1119(99)00357-1 Austen, 1997, Characterization of the transcriptional regulator YY1, J. Biol. Chem., 272, 1709, 10.1074/jbc.272.3.1709 Thomas, 1999, Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?, Gene, 236, 197, 10.1016/S0378-1119(99)00261-9 Van Itallie, 1997, Occludin confers adhesiveness when expressed in fibroblasts, J. Cell Sci., 110, 1113, 10.1242/jcs.110.9.1113 Mankertz, 2000, Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma, J. Cell Sci., 113, 2085, 10.1242/jcs.113.11.2085 Weksler, 2005, Blood brain barrier specific properties of a human adult brain endothelial cell line, FASEB J., 19, 1872, 10.1096/fj.04-3458fje Hillyer, 2003, Chemokines, chemokine receptors and adhesion molecules on different human endothelia, Clin. Exp. Immunol., 134, 431, 10.1111/j.1365-2249.2003.02323.x Staal, 1990, Intracellular thiols regulate activation of nuclear factor-κB and transcription of human immunodeficiency virus, Proc. Natl. Acad. Sci., 87, 9943, 10.1073/pnas.87.24.9943 Zhu, 2007, TNF-alpha represses transcription of bone morphogenetic protein-4 in lung epithelial cells, Gene, 393, 70, 10.1016/j.gene.2007.01.016 Blume, 1999, Mithramycin inhibits Sp1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo, J. Clin. Invest., 88, 1613, 10.1172/JCI115474 Opitz, 2000, Interaction between Sp1 and cell cycle regulatory proteins is important in transactivation of a differentiation-related gene, Cancer Res., 60, 2825 Cowan, 1998, The human ICAM-2 promoter is endothelial cell-specific in vitro and in vivo and contains critical Sp1 and GATA binding sites, J. Biol. Chem., 273, 11737, 10.1074/jbc.273.19.11737 Kennett, 1997, Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription, Nucleic Acids Res., 25, 3110, 10.1093/nar/25.15.3110 Chen, 1997, Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2,5 regulates cardiac α-actin promoter activity, Mol. Endocrinol., 11, 812, 10.1210/me.11.6.812 Donohoe, 1999, Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality, Mol. Cell. Biol., 19, 7237, 10.1128/MCB.19.10.7237 Wang, 2004, YY1AP, a novel co-activator of YY1, J. Biol.Chem., 279, 17750, 10.1074/jbc.M310532200 Shrivastava, 1994, An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1, Nucleic Acids Res., 22, 5151, 10.1093/nar/22.24.5151 Yao, 2001, Regulation of transcription factor YY1 by acetylation and deacetylation, Mol. Cell. Biol., 21, 5979, 10.1128/MCB.21.17.5979-5991.2001 McNeil, 1998, Targeting of the transcription factor YY1 to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking, J. Cell Biochem., 65, 500, 10.1002/(SICI)1097-4644(19980315)68:4<500::AID-JCB9>3.0.CO;2-U Ye, 1996, Characterization of the human granulocyte-macrophage colony-stimulating factor gene promoter: an AP1 and an Sp1-related complex transactivate the promoter activity that is suppressed by a YY1 complex, Mol. Cell. Biol., 16, 157, 10.1128/MCB.16.1.157 Seto, 1993, Interaction between Sp1 and YY1, Nature, 365, 462, 10.1038/365462a0 Rao, 2005, Dimethylation of histone H3 at lysine 36 demarcates regulatory and non-regulatory chromatin, genome-wide, Mol. Cell. Biol., 25, 9447, 10.1128/MCB.25.21.9447-9459.2005 Honda, 2006, Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells, J. Biol. Chem., 281, 21433, 10.1074/jbc.M603767200 Rezai-Zadeh, 2003, Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1, Genes Dev., 17, 1019, 10.1101/gad.1068003 Palko, 2003, The yin-yang (YY1) protein undergoes a DNA-associated replication switch in localisation from the nucleus to the cytoplasm at the onset of S phase, J. Cell Sci., 117, 465, 10.1242/jcs.00870 Ikenouchi, 2003, Regulation of tight junctions during the epithelium–mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail, J. Cell Sci., 116, 1959, 10.1242/jcs.00389 Balda, 1993, Two classes of tight junctions are revealed by ZO-1 isoforms, Am. J. Physiol. Cell Physiol., 264, C918, 10.1152/ajpcell.1993.264.4.C918 Li, 2000, Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin, J. Cell Biol., 148, 791, 10.1083/jcb.148.4.791