Practice Guidelines for the Diagnosis and Management of Skin and Soft-Tissue Infections

Clinical Infectious Diseases - Tập 41 Số 10 - Trang 1373-1406 - 2005
Dennis L. Stevens1,2, Alan L. Bisno3, Henry F. Chambers4,5, E. Dale Everett6, Patchen Dellinger7, Ellie J. C. Goldstein8,9, Sherwood L. Gorbach10, Jan V. Hirschmann11,2, Edward L. Kaplan12,13, José G. Montoya14,15,16, James C. Wade17
1 Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho
2University of Washington School of Medicine, Seattle, Washington
3University of Miami Miller School of Medicine, Miami, Florida
4 Infectious Diseases, San Francisco General Hospital, San Francisco
5University of California—San Francisco, San Francisco
6 University of Missouri Health Science Center, University of Missouri, Columbia
7 Department of Surgery, Seattle, Washington
8 R. M. Alden Research Laboratory, Santa Monica
9 University of California, Los Angeles School of Medicine, Los Angeles
10Tufts University School of Medicine, Boston, Massachusetts
11Seattle Veterans Affairs Medical Center, Seattle, Washington
12Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, Minnesota
13University of Minnesota Medical School, Minneapolis, Minnesota
14 Department of Medicine, Palo Alto, California
15 Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Palo Alto, California
16 Research Institute, Palo Alto Medical Foundation, Palo Alto, California
17Division of Neoplastic Diseases and Related Disorders, Medical College of Wisconsin, Milwaukee, Wisconsin

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Wong, 2004, The LRINEC (Laboratory risk indicator for necrotizing fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections, Crit Care Med, 32, 1535, 10.1097/01.CCM.0000129486.35458.7D

Thorell, 2004, Antimicrobial resistance of Staphylococcus aureus from Kansas City children: what is the appropriate current therapy for pediatric staphylococcal infections [abstract 252]?, Proceedings and abstracts of the 42nd Annual Meeting of the Infectious Diseases Society of America (Boston), 81

Ruhe, 2004, Use of tetracyclines for infections caused by methicillin-resistant Staphylococcus aureus [abstract 516], Proceedings and abstracts of the 42nd Annual Meeting of the Infectious Diseases Society of America (Boston), 139

Van Beneden, 2004, Erythromycin resistance among invasive group A streptococcal infections, United States, 1999–2001 [abstract 345], Proceedings and abstracts of the 42nd Annual Meeting of the Infectious Diseases Society of America (Boston), 102

Yun, 2003, Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital, J Antimicrob Chemother, 51, 619, 10.1093/jac/dkg140

Committee on Infectious Diseases, American Academy of Pediatrics, 2003, Antimicrobial agents and related therapy, Red book 2003 report of the Committee on Infectious Diseases, 6th ed., 693

Miller, 2005, Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles, N Engl J Med, 352, 1445, 10.1056/NEJMoa042683

Ferrieri, 1972, Natural history of impetigo. 1. Site sequence of acquisition and familial patterns of spread of cutaneous streptococci, J Clin Invest, 51, 2851, 10.1172/JCI107108

Adams, 2002, Dermatologic disorders of the athlete, Sports Med, 32, 309, 10.2165/00007256-200232050-00003

Fehrs, 1987, Group A beta-hemolytic streptococcal skin infections in a US meat-packing plant, JAMA, 258, 3131, 10.1001/jama.1987.03400210073028

Hirschmann, 2002, Impetigo: etiology and therapy, Curr Clin Top Infect Dis, 22, 42

Darmstadt, 1994, Impetigo: an overview, Pediatr Dermatol, 11, 293, 10.1111/j.1525-1470.1994.tb00092.x

Demidovich, 1990, Impetigo: current etiology and comparison of penicillin, erythromycin, and cephalexin therapies, Am J Dis Child, 144, 1313, 10.1001/archpedi.1990.02150360037015

Kaplan, 1970, The influence of the site of infection on the immune response to group A streptococci, J Clin Invest, 49, 1405, 10.1172/JCI106358

Bisno, 1973, Factors influencing serum antibody response in streptococcal pyoderma, J Lab Clin Med, 81, 410

Kaplan, 1976, Suppression of the anti-streptolysin O response by cholesterol and by lipid extracts of rabbit skin, J Exp Med, 144, 754, 10.1084/jem.144.3.754

Derrick, 1971, Impetigo contagiosa, Am Fam Physician, 4, 75

Ferrieri, 1974, A controlled study of penicillin prophylaxis against streptococcal impetigo, J Infect Dis, 129, 429, 10.1093/infdis/129.4.429

Dagan, 1989, Comparison of amoxicillin and clavulanic acid (augmentin) for the treatment of nonbullous impetigo, Am J Dis Child, 143, 916

Barton, 1987, Impetigo: a reassessment of etiology and therapy, Pediatr Dermatol, 4, 185, 10.1111/j.1525-1470.1987.tb00776.x

Barton, 1989, Impetigo contagiosa III: comparative efficacy of oral erythromycin and topical mupirocin, Pediatr Dermatol, 6, 134, 10.1111/j.1525-1470.1989.tb01012.x

Britton, 1990, Comparison of mupirocin and erythromycin in the treatment of impetigo, J Pediatr, 117, 827, 10.1016/S0022-3476(05)83352-9

Weinstein, 1971, Does antimicrobial therapy of streptococcal pharyngitis or pyoderma alter the risk of glomerulonephritis?, J Infect Dis, 124, 229, 10.1093/infdis/124.2.229

Meislin, 1977, Cutaneous abscesses: anaerobic and aerobic bacteriology and outpatient management, Ann Intern Med, 87, 145, 10.7326/0003-4819-87-2-145

Ghoneim, 1981, Aerobic and anaerobic bacteriology of subcutaneous abscesses, Br J Surg, 68, 498, 10.1002/bjs.1800680719

Brook, 1990, Aerobic and anaerobic bacteriology of wounds and cutaneous abscesses, Arch Surg, 125, 1445, 10.1001/archsurg.1990.01410230039007

Leach, 1979, Anaerobic axillary abscess, Br Med J, 2, 5, 10.1136/bmj.2.6181.5

Whitehead, 1982, The aetiology of scrotal sepsis, Br J Surg, 69, 729, 10.1002/bjs.1800691215

Edmiston, 1990, The nonpuerperal breast infection: aerobic and anaerobic microbial recovery from acute and chronic disease, J Infect Dis, 162, 695, 10.1093/infdis/162.3.695

Whitehead, 1982, The aetiology of perirectal sepsis, Br J Surg, 69, 166, 10.1002/bjs.1800690319

Diven, 1998, Bacteriology of inflamed and uninflamed epidermal inclusion cysts, Arch Dermatol, 134, 49, 10.1001/archderm.134.1.49

Llera, 1985, Treatment of cutaneous abscess: a double-blind clinical study, Ann Emerg Med, 14, 15, 10.1016/S0196-0644(85)80727-7

Macfie, 1977, The treatment of acute superficial abscesses: a prospective clinical trial, Br J Surg, 64, 264, 10.1002/bjs.1800640410

Decker, 1986, An outbreak of staphylococcal skin infections among river rafting guides, Am J Epidemiol, 124, 969, 10.1093/oxfordjournals.aje.a114486

Sosin, 1989, An outbreak of furunculosis among high school athletes, Am J Sports Med, 17, 828, 10.1177/036354658901700618

Zimakoff, 1988, Recurrent staphylococcal furunculosis in families, Scand J Infect Dis, 20, 403, 10.3109/00365548809032475

Hedstrom, 1981, Recurrent staphylococcal furunculosis: bacteriological findings and epidemiology in 100 cases, Scand J Infect Dis, 13, 115, 10.3109/inf.1981.13.issue-2.07

Raz, 1996, A 1-year trial of nasal mupirocin in the prevention of recurrent staphylococcal nasal colonization and skin infection, Arch Intern Med, 156, 1109, 10.1001/archinte.1996.00040041109010

Lipsky, 1992, Immediate and long-term efficacy of systemic antibiotics for eradicating nasal colonization with Staphylococcus aureus, Eur J Clin Microbiol Infect Dis, 11, 43, 10.1007/BF01971270

Klempner, 1988, Prevention of recurrent staphylococcal skin infections with low-dose oral clindamycin therapy, JAMA, 260, 2682, 10.1001/jama.1988.03410180090035

Bisno, 1996, Streptococcal infections in skin and soft tissues, N Engl J Med, 334, 240, 10.1056/NEJM199601253340407

Chartier, 1990, Erysipelas, Int J Dermatol, 29, 459, 10.1111/j.1365-4362.1990.tb04833.x

Chartier, 1996, Erysipelas: an update, Int J Dermatol, 35, 779, 10.1111/j.1365-4362.1996.tb02971.x

Swartz, 2004, Clinical practice: cellulitis, N Engl J Med, 350, 904, 10.1056/NEJMcp031807

Bernard, 1992, Roxithromycin versus penicillin in the treatment of erysipelas in adults: a comparative study, Br J Dermatol, 127, 155, 10.1111/j.1365-2133.1992.tb08048.x

Martin, 2002, Erythromycin-resistant group A streptococci in schoolchildren in Pittsburgh, N Engl J Med, 346, 1200, 10.1056/NEJMoa013169

York, 1999, Characterization of antimicrobial resistance in Streptococcus pyogenes isolates from the San Francisco Bay area of northern California, J Clin Microbiol, 37, 1727, 10.1128/JCM.37.6.1727-1731.1999

Dupuy, 1999, Risk factors for erysipelas of the leg (cellulitis): case-control study, BMJ, 318, 1591, 10.1136/bmj.318.7198.1591

Dan, 1987, Incidence of erysipelas following venectomy for coronary artery bypass surgery, Infection, 15, 107, 10.1007/BF01650207

Baddour, 1982, Recurrent cellulitis after saphenous venectomy for coronary bypass surgery, Ann Intern Med, 97, 493, 10.7326/0003-4819-97-4-493

Simon, 1992, Cellulitis after axillary lymph node dissection for carcinoma of the breast, Am J Med, 93, 543, 10.1016/0002-9343(92)90583-W

Baddour, 1999, Breast cellulitis complicating breast conservation therapy, J Intern Med, 245, 5, 10.1046/j.1365-2796.1999.00404.x

Bouma, 1988, Recurrent acute leg cellulitis in patients after radical vulvectomy, Gynecol Oncol, 29, 50, 10.1016/0090-8258(88)90146-1

Dankert, 1987, Recurrent acute leg cellulitis after hysterectomy with pelvic lymphadenectomy, Br J Obstet Gynaecol, 94, 788, 10.1111/j.1471-0528.1987.tb03728.x

Perl, 1999, Cost-effectiveness of blood cultures for adult patients with cellulitis, Clin Infect Dis, 29, 1483, 10.1086/313525

Kielhofner, 1988, Influence of underlying disease process on the utility of cellulitis needle aspirates, Arch Intern Med, 148, 2451, 10.1001/archinte.1988.00380110091019

Hook, 1986, Microbiologic evaluation of cutaneous cellulitis in adults, Arch Intern Med, 146, 295, 10.1001/archinte.1986.00360140113016

Sachs, 1990, The optimum use of needle aspiration in the bacteriologic diagnosis of cellulitis in adults, Arch Intern Med, 150, 1907, 10.1001/archinte.1990.00390200091017

Leppard, 1985, The value of bacteriology and serology in the diagnosis of cellulitis and erysipelas, Br J Dermatol, 112, 559, 10.1111/j.1365-2133.1985.tb15264.x

Sigurdsson, 1989, The etiology of bacterial cellulitis as determined by fine-needle aspiration, Scand J Infect Dis, 21, 537, 10.3109/00365548909037882

Newell, 1988, Value of needle aspiration in bacteriologic diagnosis of cellulitis in adults, J Clin Microbiol, 26, 401, 10.1128/JCM.26.3.401-404.1988

Lebre, 1996, Value of fine-needle aspiration in infectious cellulitis, Arch Dermatol, 132, 842, 10.1001/archderm.1996.03890310134030

Lutomski, 1988, Microbiology of adult cellulitis, J Fam Pract, 26, 45

Duvanel, 1989, Quantitative cultures of biopsy specimens from cutaneous cellulitis, Arch Intern Med, 149, 293, 10.1001/archinte.1989.00390020039008

Eriksson, 1996, Erysipelas: clinical and bacteriologic spectrum and serological aspects, Clin Infect Dis, 23, 1091, 10.1093/clinids/23.5.1091

Bernard, 1987, Early detection of streptococcal group antigens in skin samples by latex particle agglutination, Arch Dermatol, 123, 468, 10.1001/archderm.1987.01660280070025

Bernard, 1989, Streptococcal cause of erysipelas and cellulitis in adults: a microbiologic study using a direct immunofluorescence technique, Arch Dermatol, 125, 779, 10.1001/archderm.1989.01670180051004

Baddour, 1984, Recurrent cellulitis after coronary bypass surgery. Association with superficial fungal infection in saphenous venectomy limbs, JAMA, 251, 1049, 10.1001/jama.1984.03340320035023

Semel, 1996, Association of athlete's foot with cellulitis of the lower extremities: diagnostic value of bacterial cultures of ipsilateral interdigital space samples, Clin Infect Dis, 23, 1162, 10.1093/clinids/23.5.1162

Eriksson, 1999, Anal colonization of group G β-hemolytic streptococci in relapsing erysipelas of the lower extremity, Clin Infect Dis, 29, 1319, 10.1086/313467

Burman, 1995, Multifocal cellulitis and monoarticular arthritis as manifestations of Helicobacter cinaedi bacteremia, Clin Infect Dis, 20, 564, 10.1093/clinids/20.3.564

Kirsner, 1993, The clinical spectrum of lipodermatosclerosis, J Am Acad Dermatol, 28, 623, 10.1016/0190-9622(93)70085-8

Jorup-Ronstrom, 1984, The course, costs, and complications of oral versus intravenous penicillin therapy of erysipelas, Infection, 12, 390, 10.1007/BF01645222

Hepburn, 2004, Comparison of short-course (5 days) and standard (10 days) treatment for uncomplicated cellulitis, Arch Intern Med, 164, 1669, 10.1001/archinte.164.15.1669

Bergkvist, 1997, Antibiotic and prednisolone therapy of erysipelas: a randomized, double blind, placebo-controlled study, Scand J Infect Dis, 29, 377, 10.3109/00365549709011834

Bergkvist, 1998, Relapse of erysipelas following treatment with prednisolone or placebo in addition to antibiotics: a 1-year follow-up, Scand J Infect Dis, 30, 206, 10.1080/003655498750003708

Babb, 1966, Prophylaxis of recurrent lymphangitis complicating lymphedema, JAMA, 195, 871, 10.1001/jama.1966.03100100123046

Kremer, 1991, Long-term antimicrobial therapy in the prevention of recurrent soft-tissue infections, J Infect, 22, 37, 10.1016/0163-4453(91)90898-3

Sjoblom, 1993, Antibiotic prophylaxis in recurrent erysipelas, Infection, 21, 390, 10.1007/BF01728920

Wang, 1997, Role of benzathine penicillin G in prophylaxis for recurrent streptococcal cellulitis of the lower legs, Clin Infect Dis, 25, 685, 10.1086/513752

Kasseroller, 1998, Sodium selenite as prophylaxis against erysipelas in secondary lymphedema, Anticancer Res, 18, 2227

Groom, 2001, Community-acquired methicillin-resistant Staphylococcus aureus in a rural American Indian community, JAMA, 286, 1201, 10.1001/jama.286.10.1201

Herold, 1998, Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk, JAMA, 279, 593, 10.1001/jama.279.8.593

Centers for Disease Control and Prevention, 2003, Outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections—Los Angeles County, California, 2002–2003, MMWR Morb Mortal Wkly Rep, 52, 88

Ma, 2002, Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains, Antimicrob Agents Chemother, 46, 1147, 10.1128/AAC.46.4.1147-1152.2002

Okuma, 2002, Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community, J Clin Microbiol, 40, 4289, 10.1128/JCM.40.11.4289-4294.2002

Dufour, 2002, Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin, Clin Infect Dis, 35, 819, 10.1086/342576

2003, Methicillin-resistant Staphylococcus aureus infections in correctional facilities—Georgia, California, and Texas, 2001–2003, MMWR Morb Mortal Wkly Rep, 52, 992

2003, Methicillin-resistant Staphylococcus aureus infections among competitive sports participants—Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000–2003, MMWR Morb Mortal Wkly Rep, 52, 793

Stevens, 2000, Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections, Antimicrob Agents Chemother, 44, 3408, 10.1128/AAC.44.12.3408-3413.2000

Stevens, 2002, Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections. Linezolid MRSA Study Group, Clin Infect Dis, 34, 1481, 10.1086/340353

Markowitz, 1992, Trimethoprim-sulfamethoxazole compared with vancomycin for the treatment of Staphylococcus aureus infection, Ann Intern Med, 117, 390, 10.7326/0003-4819-117-5-390

Ahrenholz, 1988, Necrotizing soft-tissue infections, Surg Clin North Am, 68, 199, 10.1016/S0039-6109(16)44440-3

Lewis, 1992, Necrotizing soft-tissue infections, Infect Dis Clin North Am, 6, 693, 10.1016/S0891-5520(20)30470-0

Rea, 1970, Necrotizing fasciitis, Ann Surg, 172, 957, 10.1097/00000658-197012000-00005

Giuliano, 1977, Bacteriology of necrotizing fasciitis, Am J Surg, 134, 52, 10.1016/0002-9610(77)90283-5

Stevens, 1989, Reappearance of scarlet fever toxin A among streptococci in the Rocky Mountain West: severe group A streptococcal infections associated with a toxic shock-like syndrome, N Engl J Med, 321, 1, 10.1056/NEJM198907063210101

Chelsom, 1994, Necrotising fasciitis due to group A streptococci in western Norway: incidence and clinical features, Lancet, 344, 1111, 10.1016/S0140-6736(94)90629-7

Zimbelman, 1999, Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection, Pediatr Infect Dis J, 18, 1096, 10.1097/00006454-199912000-00014

Mulla, 2003, Invasive group A streptococcal infections in Florida, South Med J, 96, 968, 10.1097/01.SMJ.0000051060.95210.9A

Stevens, 2003, Dilemmas in the treatment of invasive Streptococcus pyogenes infections, Clin Infect Dis, 37, 341, 10.1086/376652

Kaul, 1999, Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome: a comparative observational study, Clin Infect Dis, 28, 800, 10.1086/515199

Darenberg, 2003, Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial, Clin Infect Dis, 37, 333, 10.1086/376630

Sissolak, 1994, Tropical pyomyositis, J Infect, 29, 121, 10.1016/S0163-4453(94)90530-4

Laucks, 1994, Fournier's gangrene, Surg Clin North Am, 74, 1339, 10.1016/S0039-6109(16)46485-6

Eke, 2000, Fournier's gangrene: a review of 1726 cases, Br J Surg, 87, 718, 10.1046/j.1365-2168.2000.01497.x

Altemeier, 1971, Prevention and treatment of gas gangrene, JAMA, 217, 806, 10.1001/jama.1971.03190060046011

Stevens, 1987, Comparison of single and combination antimicrobial agents for prevention of experimental gas gangrene caused by Clostridium perfringens, Antimicrob Agents Chemother, 31, 312, 10.1128/AAC.31.2.312

Stevens, 1987, Comparison of clindamycin, rifampin, tetracycline, metronidazole, and penicillin for efficacy in prevention of experimental gas gangrene due to Clostridium perfringens, J Infect Dis, 155, 220, 10.1093/infdis/155.2.220

Stevens, 1993, Evaluation of hyperbaric oxygen therapy for treatment of experimental Clostridium perfringens infection, Clin Infect Dis, 17, 231, 10.1093/clinids/17.2.231

Talan, 1999, Bacteriologic analysis of infected dog and cat bites. Emergency Medicine Animal Bite Infection Study Group, N Engl J Med, 340, 85, 10.1056/NEJM199901143400202

Goldstein, 1978, Bacteriology of human and animal bite wounds, J Clin Microbiol, 8, 667, 10.1128/jcm.8.6.667-672.1978

Goldstein, 1998, New horizons in the bacteriology, antimicrobial susceptibility and therapy of animal bite wounds, J Med Microbiol, 47, 95, 10.1099/00222615-47-2-95

Goldstein, 1987, Outpatient therapy of bite wounds: demographic data, bacteriology, and a prospective, randomized trial of amoxicillin/clavulanic acid versus penicillin +/- dicloxacillin, Int J Dermatol, 26, 123, 10.1111/j.1365-4362.1987.tb00544.x

Talan, 2003, Clinical presentation and bacteriologic analysis of infected human bites in patients presenting to emergency departments, Clin Infect Dis, 37, 1481, 10.1086/379331

1987, Transmission of HIV by human bite, Lancet, 2, 522

Vidmar, 1996, Transmission of HIV-1 by human bite, Lancet, 347, 1762, 10.1016/S0140-6736(96)90838-7

Dusheiko, 1990, Hepatitis C virus transmitted by human bite, Lancet, 336, 503, 10.1016/0140-6736(90)92049-N

Davis, 1989, Horizontal transmission of hepatitis B virus, Lancet, 1, 889, 10.1016/S0140-6736(89)92876-6

Fiumara, 1981, Primary syphilis following a human bite, Sex Transm Dis, 8, 21, 10.1097/00007435-198101000-00008

Inglesby, 1999, Anthrax as a biological weapon: medical and public health management. Working Group on Civilian Biodefense, JAMA, 281, 1735, 10.1001/jama.281.18.1735

Dixon, 1999, Anthrax, N Engl J Med, 341, 815, 10.1056/NEJM199909093411107

2001, Update: investigation of bioterrorism-related anthrax and interim guidelines for exposure management and antimicrobial therapy, October 2001, MMWR Morb Mortal Wkly Rep, 50, 909

Bass, 1998, Prospective randomized double blind placebo-controlled evaluation of azithromycin for treatment of cat-scratch disease, Pediatr Infect Dis J, 17, 447, 10.1097/00006454-199806000-00002

Reboli, 1989, Erysipelothrix rhusiopathiae: an occupational pathogen, Clin Microbiol Rev, 2, 354, 10.1128/CMR.2.4.354

Venditti, 1990, Antimicrobial susceptibilities of Erysipelothrix rhusiopathiae, Antimicrob Agents Chemother, 34, 2038, 10.1128/AAC.34.10.2038

Srinivasan, 2001, Glanders in a military research microbiologist, N Engl J Med, 345, 256, 10.1056/NEJM200107263450404

Perry, 1997, Yersinia pestis—etiologic agent of plague, Clin Microbiol Rev, 10, 35, 10.1128/CMR.10.1.35

Inglesby, 2000, Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense, JAMA, 283, 2281, 10.1001/jama.283.17.2281

Enderlin, 1994, Streptomycin and alternative agents for the treatment of tularemia: review of the literature, Clin Infect Dis, 19, 42, 10.1093/clinids/19.1.42

Johansson, 2000, Ciprofloxacin for treatment of tularemia in children, Pediatr Infect Dis J, 19, 449, 10.1097/00006454-200005000-00011

Chocarro, 2000, Treatment of tularemia with ciprofloxacin, Clin Infect Dis, 31, 623, 10.1086/313946

Perez-Castrillon, 2001, Tularemia epidemic in northwestern Spain: clinical description and therapeutic response, Clin Infect Dis, 33, 573, 10.1086/322601

Brennan, 1991, Incidence of adverse events and negligence in hospitalized patients: results of the Harvard Medical Practice study I, N Engl J Med, 324, 370, 10.1056/NEJM199102073240604

Mangram, 1999, Guideline for prevention of surgical site infection, 1999: Hospital Infection Control Practices Advisory Committee, Infect Control Hosp Epidemiol, 20, 250, 10.1086/501620

Gaynes, 2001, Surgical site infection (SSI) rates in the United States, 1992–1998: the National Nosocomial Infections Surveillance System basic SSI risk index, Clin Infect Dis, 33, 69, 10.1086/321860

Dellinger, 1998, Approach to the patient with postoperative fever, Infectious diseases in medicine and surgery, 903

Burke, 1961, The effective period of preventive antibiotic action in experimental incisions and dermal lesions, Surgery, 50, 161

Classen, 1992, The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection, N Engl J Med, 326, 281, 10.1056/NEJM199201303260501

Stone, 1979, Prophylactic and preventive antibiotic therapy: timing, duration and economics, Ann Surg, 189, 691, 10.1097/00000658-197906000-00004

Dellinger, 1994, Quality standard for antimicrobial prophylaxis in surgical procedures. Infectious Diseases Society of America, Clin Infect Dis, 18, 422, 10.1093/clinids/18.3.422

Bratzler, 2004, Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project, Clin Infect Dis, 38, 1706, 10.1086/421095

McDonald, 1998, Single- versus multiple-dose antimicrobial prophylaxis for major surgery: a systematic review, Aust N Z J Surg, 68, 388, 10.1111/j.1445-2197.1998.tb04785.x

Bartlett, 1982, Toxic shock syndrome associated with surgical wound infections, JAMA, 247, 1448, 10.1001/jama.1982.03320350052030

Raab, 1995, Postoperative toxic shock syndrome, Am J Orthop, 24, 130

Huizinga, 1986, The value of adjuvant systemic antibiotic therapy in localised wound infections among hospital patients: a comparative study, J Infect, 13, 11, 10.1016/S0163-4453(86)92118-3

Mandell, 1995, Mandell, Douglas and Bennett's principles and practice of infectious diseases

Howard, 1988, Surgical infectious diseases

Fry, 1995, Surgical infections

Greenfield, 1993, Surgery: scientific principles and practice

Townsend, 2001, Textbook of surgery: the biologic basis of modern surgical practice

Wilmore, 2002, ACS surgery: principles and practice

Gorbach, 1998, Infectious diseases

Dellinger, 2002, Nosocomial infection, ACS surgery: principles and practice, 1221

Cruse, 1988, Wound infections: epidemiology and clinical characteristics, Surgical infectious diseases, 319

Bobrow, 1997, Incision and drainage of cutaneous abscesses is not associated with bacteremia in afebrile adults, Ann Emerg Med, 29, 404, 10.1016/S0196-0644(97)70354-8

Meislin, 1986, Pathogen identification of abscesses and cellulitis, Ann Emerg Med, 15, 329, 10.1016/S0196-0644(86)80577-7

Dellinger, 1996, Postoperative wound infection, Current therapy of infectious disease, 337

Wade, 1993, Management of infection in patients with acute leukemia, Hematol Oncol Clin North Am, 7, 293, 10.1016/S0889-8588(18)30268-5

Pizzo, 1993, Management of fever in patients with cancer and treatment-induced neutropenia, N Engl J Med, 328, 1323, 10.1056/NEJM199305063281808

Donowitz, 1996, Fever in the compromised host, Infect Dis Clin North Am, 10, 129, 10.1016/S0891-5520(05)70291-9

Wolfson, 1985, Dermatologic manifestations of infections in immunocompromised patients, Medicine (Baltimore), 64, 115, 10.1097/00005792-198503000-00004

Wolfson, 1983, Dermatologic manifestations of infection in the compromised host, Annu Rev Med, 34, 205, 10.1146/annurev.me.34.020183.001225

Hughes, 2002, 2002 Guidelines for the use of antimicrobial agents in neutropenic patients with cancer, Clin Infect Dis, 34, 730, 10.1086/339215

NCCN practice guidelines for fever and neutropenia, 1999, National Comprehensive Cancer Network, Oncology (Williston Park), 13, 197

Lopez, 2001, Dermatologic infections in the immunocompromised (non-HIV) host, Infect Dis Clin North Am, 15, 671, 10.1016/S0891-5520(05)70164-1

Wingard, 1987, Differences between first and subsequent fevers during prolonged neutropenia, Cancer, 59, 844, 10.1002/1097-0142(19870215)59:4<844::AID-CNCR2820590431>3.0.CO;2-U

Chatzinikolaou, 2000, Recent experience with Pseudomonas aeruginosa bacteremia in patients with cancer: retrospective analysis of 245 episodes, Arch Intern Med, 160, 501, 10.1001/archinte.160.4.501

Glauser, 1998, Empiric therapy of bacterial infections in patients with severe neutropenia, Diagn Microbiol Infect Dis, 31, 467, 10.1016/S0732-8893(98)00038-8

Elting, 1992, Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors, Clin Infect Dis, 14, 1201, 10.1093/clinids/14.6.1201

European Organization for Research and Treatment of Cancer (EORTC) International Antimicrobial Therapy Cooperative Group and the National Cancer Institute of Canada-Clinical Trials Group, 1991, Vancomycin added to empirical combination antibiotic therapy for fever in granulocytopenic cancer patients, J Infect Dis, 163, 951, 10.1093/infdis/163.5.951

Edmond, 1996, Vancomycin-resistant enterococcal bacteremia: natural history and attributable mortality, Clin Infect Dis, 23, 1234, 10.1093/clinids/23.6.1234

Martin, 1989, Coagulase-negative staphylococcal bacteremia: mortality and hospital stay, Ann Intern Med, 110, 9, 10.7326/0003-4819-110-1-9

Wenzel, 1998, Perspective: attributable mortality—the promise of better antimicrobial therapy, J Infect Dis, 178, 917, 10.1086/515379

Brown, 1995, Bacterial resistance in the patient with neoplastic disease, Infect Dis Clin Pract, 4, 136

Rubinstein, 2001, Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study, Clin Infect Dis, 32, 402, 10.1086/318486

Ozer, 2000, 2000 Update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. American Society of Clinical Oncology Growth Factors Expert Panel, J Clin Oncol, 18, 3558, 10.1200/JCO.2000.18.20.3558

Cometta, 2003, Vancomycin versus placebo for treating persistent fever in patients with neutropenic cancer receiving piperacillin-tazobactam monotherapy, Clin Infect Dis, 37, 382, 10.1086/376637

Pizzo, 1982, Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia, Am J Med, 72, 101, 10.1016/0002-9343(82)90594-0

EORTC International Antimicrobial Therapy Cooperative Group, 1989, Empiric antifungal therapy in febrile granulocytopenic patients, Am J Med, 86, 668, 10.1016/0002-9343(89)90441-5

Walsh, 2004, Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia, N Engl J Med, 351, 1391, 10.1056/NEJMoa040446

Walsh, 2002, Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever, N Engl J Med, 346, 225, 10.1056/NEJM200201243460403

Goodrich, 1991, Clinical features and analysis of risk factors for invasive candidal infection after marrow transplantation, J Infect Dis, 164, 731, 10.1093/infdis/164.4.731

Rex, 2000, Practice guidelines for the treatment of candidiasis. Infectious Diseases Society of America, Clin Infect Dis, 30, 662, 10.1086/313749

Wingard, 1979, Candida tropicalis: a major pathogen in immunocompromised patients, Ann Intern Med, 91, 539, 10.7326/0003-4819-91-4-539

Jarowski, 1978, Fever, rash, and muscle tenderness: a distinctive clinical presentation of disseminated candidiasis, Arch Intern Med, 138, 544, 10.1001/archinte.1978.03630280026013

Walsh, 1986, Trichosporonosis in patients with neoplastic disease, Medicine (Baltimore), 65, 268, 10.1097/00005792-198607000-00005

Patterson, 2000, Invasive aspergillosis: disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group, Medicine (Baltimore), 79, 250, 10.1097/00005792-200007000-00006

Ascioglu, 2002, Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus, Clin Infect Dis, 34, 7, 10.1086/323335

Lin, 2001, Aspergillosis case-fatality rate: systematic review of the literature, Clin Infect Dis, 32, 358, 10.1086/318483

Kontoyiannis, 2000, Significance of aspergillemia in patients with cancer: a 10-year study, Clin Infect Dis, 31, 188, 10.1086/313918

Allo, 1987, Primary cutaneous aspergillosis associated with Hickman intravenous catheters, N Engl J Med, 317, 1105, 10.1056/NEJM198710293171802

Walmsley, 1993, Invasive Aspergillus infections in a pediatric hospital: a ten-year review, Pediatr Infect Dis J, 12, 673, 10.1097/00006454-199308000-00009

Gartenberg, 1978, Hospital-acquired mucormycosis (Rhizopus rhizopodiformis) of skin and subcutaneous tissue: epidemiology, mycology and treatment, N Engl J Med, 299, 1115, 10.1056/NEJM197811162992007

Dennis, 1980, Nosocomical Rhizopus infection (zygomycosis) in children, J Pediatr, 96, 824, 10.1016/S0022-3476(80)80550-6

Anaissie, 1992, Opportunistic mycoses in the immunocompromised host: experience at a cancer center and review, Clin Infect Dis, 14, 43, 10.1093/clinids/14.Supplement_1.S43

Krcmery, 1997, Fungaemia due to Fusarium spp. in cancer patients, J Hosp Infect, 36, 223, 10.1016/S0195-6701(97)90197-3

Boutati, 1997, Fusarium, a significant emerging pathogen in patients with hematologic malignancy: ten years' experience at a cancer center and implications for management, Blood, 90, 999, 10.1182/blood.V90.3.999

Sheehan, 1999, Current and emerging azole antifungal agents, Clin Microbiol Rev, 12, 40, 10.1128/CMR.12.1.40

Wald, 1997, Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation, J Infect Dis, 175, 1459, 10.1086/516480

Viscoli, 1999, Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC), Clin Infect Dis, 28, 1071, 10.1086/514731

Stevens, 2000, Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of America, Clin Infect Dis, 30, 696, 10.1086/313756

Deresinski, 2003, Caspofungin, Clin Infect Dis, 36, 1445, 10.1086/375080

Wingard, 1999, Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosis, Clin Infect Dis, 29, 1402, 10.1086/313498

Walsh, 1998, Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases, Clin Infect Dis, 26, 1383, 10.1086/516353

Walsh, 1999, Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group, N Engl J Med, 340, 764, 10.1056/NEJM199903113401004

Herbrecht, 2002, Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis, N Engl J Med, 347, 408, 10.1056/NEJMoa020191

Cagnoni, 2000, Pharmacoeconomic analysis of liposomal amphotericin B versus conventional amphotericin B in the empirical treatment of persistently febrile neutropenic patients, J Clin Oncol, 18, 2476, 10.1200/JCO.2000.18.12.2476

Marr, 2000, Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole, J Infect Dis, 181, 309, 10.1086/315193

Ichiki, 1997, Skin infection caused by Mycobacterium avium, Br J Dermatol, 136, 260, 10.1046/j.1365-2133.1997.d01-1183.x

Sanderson, 1982, Disseminated Mycobacterium avium-intracellulare infection appearing as a panniculitis, Arch Pathol Lab Med, 106, 112

Wallace, 1992, Skin, soft tissue, and bone infections due to Mycobacterium chelonae chelonae: importance of prior corticosteroid therapy, frequency of disseminated infections, and resistance to oral antimicrobials other than clarithromycin, J Infect Dis, 166, 405, 10.1093/infdis/166.2.405

Bennett, 1986, Disseminated atypical mycobacterial infection in patients with hairy cell leukemia, Am J Med, 80, 891, 10.1016/0002-9343(86)90634-0

Patel, 1994, Infections due to nontuberculous mycobacteria in kidney, heart, and liver transplant recipients, Clin Infect Dis, 19, 263, 10.1093/clinids/19.2.263

Gaviria, 2000, Nontuberculous mycobacterial infections in hematopoietic stem cell transplant recipients: characteristics of respiratory and catheter-related infections, Biol Blood Marrow Transplant, 6, 361, 10.1016/S1083-8791(00)70012-7

Berkey, 1989, Nocardial infection in patients with neoplastic disease, Rev Infect Dis, 11, 407, 10.1093/clinids/11.3.407

Simpson, 1981, Nocardial infections in the immunocompromised host: a detailed study in a defined population, Rev Infect Dis, 3, 492, 10.1093/clinids/3.3.492

Smego, 1983, Trimethoprim-sulfamethoxazole therapy for Nocardia infections, Arch Intern Med, 143, 711, 10.1001/archinte.1983.00350040101013

Dimino-Emme, 1995, Cutaneous manifestations of disseminated cryptococcosis, J Am Acad Dermatol, 32, 844, 10.1016/0190-9622(95)91544-3

Neuville, 2003, Primary cutaneous cryptococcosis: a distinct clinical entity, Clin Infect Dis, 36, 337, 10.1086/345956

Anderson, 1992, Cryptococcal disease presenting as cellulitis, Clin Infect Dis, 14, 666, 10.1093/clinids/14.3.666

Saag, 2000, Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America, Clin Infect Dis, 30, 710, 10.1086/313757

Shuttleworth, 1989, Cutaneous cryptococcosis: treatment with oral fluconazole, Br J Dermatol, 120, 683, 10.1111/j.1365-2133.1989.tb01356.x

Davies, 1979, Disseminated histoplasmosis in renal transplant recipients, Am J Surg, 137, 686, 10.1016/0002-9610(79)90050-3

Wheat, 2000, Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America, Clin Infect Dis, 30, 688, 10.1086/313752

Locksley, 1985, Infection with varicella-zoster virus after marrow transplantation, J Infect Dis, 152, 1172, 10.1093/infdis/152.6.1172

Arvin, 1980, Cellular and humoral immunity in the pathogenesis of recurrent herpes viral infections in patients with lymphoma, J Clin Invest, 65, 869, 10.1172/JCI109739

Balfour, 1983, Acyclovir halts progression of herpes zoster in immunocompromised patients, N Engl J Med, 308, 1448, 10.1056/NEJM198306163082404

Meyers, 1980, Infection with herpes simplex virus and cell-mediated immunity after marrow transplant, J Infect Dis, 142, 338, 10.1093/infdis/142.3.338

Tyring, 1995, Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group, Ann Intern Med, 123, 89, 10.7326/0003-4819-123-2-199507150-00002

Cowan, 1996, Relationship between antibodies to herpes simplex virus (HSV) and symptoms of HSV infection, J Infect Dis, 174, 470, 10.1093/infdis/174.3.470

Johnson, 1989, A seroepidemiologic survey of the prevalence of herpes simplex virus type 2 infection in the United States, N Engl J Med, 321, 7, 10.1056/NEJM198907063210102

Fleming, 1997, Herpes simplex virus type 2 in the United States, 1976 to 1994, N Engl J Med, 337, 1105, 10.1056/NEJM199710163371601

Balfour, 1994, Management of acyclovir-resistant herpes simplex and varicella-zoster virus infections, J Acquir Immune Defic Syndr, 7, 254

Toome, 1991, Diagnosis of cutaneous cytomegalovirus infection: a review and report of a case, J Am Acad Dermatol, 24, 860, 10.1016/0190-9622(91)70134-N

Mermel, 2001, Guidelines for the management of intravascular catheter-related infections, Clin Infect Dis, 32, 1249, 10.1086/320001