Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves

Bonnar, 1994, Haemostasis and coagulation disorders in pregnancy, 570 Iturbe-Alessio, 1986, Pregnant women with artificial heart valves, N Engl J Med, 315, 1390, 10.1056/NEJM198611273152205 Born, 1992, Pregnancy in patients with prosthetic heart valves, Am Heart J, 124, 413, 10.1016/0002-8703(92)90606-V Elkayam, 1996, Anticoagulation in pregnant women with prosthetic heart valves, J Am Coll Cardiol, 27, 1704, 10.1016/0735-1097(96)00080-0 Hanania, 1994, Pregnancy and prosthetic heart valves, Eur Heart J, 15, 1651, 10.1093/oxfordjournals.eurheartj.a060448 Gohlke-Barwolf, 1995, Guide-lines for prevention of thrombo-embolic events in valvular heart disease, Eur Heart J, 16, 1320, 10.1093/oxfordjournals.eurheartj.a060739 Sbarouni, 1994, Outcome of pregnancy in women with valve prostheses, Br Heart J, 71, 196, 10.1136/hrt.71.2.196 Oakley, 1995, Anticoagulants in pregnancy, Br Heart J, 74, 107, 10.1136/hrt.74.2.107 Salazar, 1996, Failure of adjusted doses of subcutaneous heparin to prevent thromboembolic phenomena in pregnant patients with mechanical cardiac valve prostheses, J Am Coll Cardiol, 27, 1698, 10.1016/0735-1097(96)00072-1 Cotrufo, 1991, Coumarin anticoagulation during pregnancy in patients with mechanical valve prostheses, Eur J Cardiothorac Surg, 3, 300, 10.1016/1010-7940(91)90039-M Sareli, 1989, Maternal and fetal sequelae of anticoagulation during pregnancy in patients with mechanical heart valve prostheses, Am J Cardiol, 63, 1462, 10.1016/0002-9149(89)90008-8 Quick, 1946, Experimentally induced changes in the prothrombin level of the blood. Prothrombin concentration of newborn pups of a mother given dicoumarol before parturition, J Biol Chem, 164, 371, 10.1016/S0021-9258(18)43077-3 Krauss, 1949, Danger of dicoumarol treatment in pregnancy, JAMA, 139, 758, 10.1001/jama.1949.02900290004002 Hirsh, 1970, Fetal effects of coumadin administered during pregnancy, Blood, 623, 10.1182/blood.V36.5.623.623 Reverdiau-Moalic, 1996, Evolution of blood coagulation activators and inhibitors in the healthy human fetus, Blood, 88, 900, 10.1182/blood.V88.3.900.900 Pauli, 1988, Mechanism of bone and cartilage maldevelopment in the warfarin embryopathy, Pathol Immunopathol Res, 7, 107, 10.1159/000157104 Milano A, Bortolotti U, Mazzucco A, et al. Heart valve replacement with the Sorin tilting-disc prosthesis. A 10-year experience. J Thorac Cardiovasc Surg 1992;103:267–5.