Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice

Biochemical Genetics - Tập 32 - Trang 397-407 - 1994
Richard W. Hyman1, Susan Frank2, Craig H. Warden2, Aaron Daluiski2, Renu Heller3, Aldons J. Lusis2,4
1Stanford DNA Sequence and Technology Center, Department of Biochemistry, Stanford University School of Medicine, Stanford
2Division of Cardiology, Department of Medicine, UCLA, Los Angeles
3Syntex Research, Palo Alto
4Department of Microbiology and Molecular Genetics and Molecular Biology Institute, UCLA, Los Angeles

Tóm tắt

Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumablyApoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.

Tài liệu tham khảo

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