Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

New England Journal of Medicine - Tập 384 Số 20 - Trang 1885-1898 - 2021
Shabir А. Madhi1,2, Vicky L. Baillie1,2, Clare Cutland3, Merryn Voysey4, Anthonet Koen1,2, Lee Fairlie5, Sherman D. Padayachee6, Keertan Dheda7,8,9, Shaun L. Barnabas10, Qasim Bhorat11, Carmen Briner12, Gaurav Kwatra1,2, Khatija Ahmed6, Parvinder K. Aley4, Sutika Bhikha1,2, Jinal N. Bhiman13, As’ad E. Bhorat11, Jeanine du Plessis2, Aliasgar Esmail8,9, Marisa Groenewald10, Elizea Horne5, Shi-Hsia Hwa14,15, Aylin Jose2, Teresa Lambe16, Matt Laubscher2, Mookho Malahleha6, Masebole Masenya5, Mduduzi Masilela6, Shakeel McKenzie2, Kgaogelo Molapo6, Andrew Moultrie2, Suzette Oelofse8, Faeezah Patel5, Sureshnee Pillay17, Sarah Rhead4, Hylton Rodel14,15, Lindie Rossouw10, Carol Taoushanis2, Houriiyah Tegally17, Asha Thombrayil2, Samuel van Eck5, Constantinos Kurt Wibmer13, Nicholas M. Durham18, Elizabeth J. Kelly18, Tonya Villafana18, Sarah C. Gilbert16, Andrew J. Pollard4, Túlio de Oliveira17, Penny L. Moore13, Alex Sigal14,17, Alane Izu1,2
1Department of Science and Innovation/National Research Foundation South African Research Chair Initiative in Vaccine Preventable Diseases Unit, University of the Witwatersrand
2South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit
3African Leadership in Vaccinology Expertise
4Oxford Vaccine Group, Department of Paediatrics
5Wits Reproductive Health and HIV Institute
6Johannesburg, Setshaba Research Centre, Tshwane
7Division of Infection and Immunity, University College London, London
8Division of Pulmonology, Groote Schuur Hospital and the University of Cape Town
9University of Oxford, Oxford, the Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London
10Family Centre for Research with Ubuntu, Department of Paediatrics, University of Stellenbosch
11Cape Town, Soweto Clinical Trials Centre, Soweto
12Perinatal HIV Research Unit, Faculty of Health Sciences
13Antibody Immunity Research Unit, School of Pathology
14Africa Health Research Institute
15Max Planck Institute for Infection Biology, Berlin
16Jenner Institute, Nuffield Department of Medicine
17University of KwaZulu-Natal
18AstraZeneca Biopharmaceuticals, Cambridge

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