Models of human lung airways and their application to inhaled particle deposition
Tóm tắt
Models of the human respiratory tract were developed based on detailed morphometric measurements of a silicone rubber cast of the human tracheobronchial airways. Emphasis was placed on the “Typical Path Lung Model” which used one typical pathway to represent a portion of the lung, such as a lobe, or to represent the whole lung. The models contain geometrical parameters, including airway segment diameters, lengths, branching angles and angles of inclination to gravity, which are needed for estimating inhaled particle deposition. Aerosol depositions for various breathing patterns and particle sizes were calculated using these lung models and the modified Findeisen-Landahl computational scheme. The results agree reasonably well with recent experimental data. Regional deposition, including lobar deposition fractions, are also calculated and compared with results based on the ICRP lung deposition model.
Tài liệu tham khảo
Altshuler, B., E. D. Palmes and N. Nelson. 1967. “Regional Aerosol Deposition in the Human Respiratory Tract.” In:Inhaled Particles and Vapours, II, pp. 323–335, edited by C. N. Davies. New York: Pergamon Press.
Beeckmans, J. M. 1965a. “The Deposition of Aerosols in the Respiratory Tract: I. Mathematical Analysis and Comparison with Experimental Data.”Can. J. Physiol. Pharmacol. 43, 157–172.
Beeckmans, J. M. 1965b. “Correction Factor for Size-selective Sampling Results, Based on a New Computed Alveolar Deposition Curve.”Ann. Occup. Hyg. 8, 221–231.
Davies, C. N. 1961. “A Formalized Anatomy of the Human Respiratory Tract.” In:Inhaled Particles and Vapours, pp. 82–87, edited by C. N. Davies. New York: Pergamon Press.
Davies, C. N. 1973. “The Deposition of Aerosol in the Human Lung.” In:Aerosole in Physik, Medizin und Technik, pp. 90–99. Bad Soden, W. Germany: Gesellschaft fur Aerosolforschung.
Findeisen, W. 1935. “Uber das Absetzen Kleiner, in der Luft Suspendierter Teilchen in der Menschlichen Lunge bei der Atmung.”Pfluegers Arch. Ges. Physiol. 236, 367–379.
Giacomelli-Maltoni, G., C. Melandri, V. Prodi and G. Tarroni. 1972. “Deposition Efficiency of Monodisperse Particles in Human Respiratory Tract.”Am. Ind. Hyg. Assoc. J. 33(9), 603–610.
Heyder, J., L. Armbruster, J. Gebhart, E. Grein and W. Stahlhofen. 1975. “Total Deposition of Aerosol Particles in the Human Respiratory Tract for Nose and Mouth Breathing.”J. Aerosol Sci. 6, 311–328.
Horsfield, K., G. Dart, D. E. Olson, G. F. Filley and G. Cumming 1971. “Models of the Human Bronchial Tree.”J. Appl. Physiol. 31(2), 207–217.
International Commision on Radiological Protection (ICRP). 1974.Report of the Task Group on Reference Man. ICRP Publication 23. Oxford: Pergamon Press.
Landahl, H. D. 1950. “On the Removal of Air-borne Droplets by the Human Respiratory Tract: I. The Lung.”Bull. Math. Biophys. 12, 43–56.
Landahl, H. D., T. N. Tracewell and W. H. Lassen. 1951. “On the Retention of Air-borne Particulates in the Human Lung.”A.M.A. Arch. Ind. Hyg. Occup. Med. 3, 359–366.
Lever, J. 1973. Cited by C. N. Davies. Davies, C. N. 1973. “.
Lippmann, M. 1977. Regional Deposition of Particles in the Human Respiratory Tract. In:Handbook of Physiology, Section 9:Reactions to Environmental Agents, pp. 213–232, edited by D. H. K. Lee. Bethesda, Md.: Am. Physiology Soc.
Mercer, T. T. 1975. “The Deposition Model of the Task Group on Lung Dynamics: A Comparison with Recent Experimental Data.”Hlth Phys. 29, 673–680.
Olson, D. E., G. A. Dart and G. F. Filley. 1970. “Pressure Drop and Fluid Flow Regime of Air Inspired into the Human Lung.”J. Appl. Physiol. 28(4), 482–494.
Phalen, R. F., H. C. Yeh, O. G. Raabe and D. J. Velasquez. 1973. “Casting the Lungsin situ.”Anat. Rec. 177, 255–263.
Phalen, R. F., H. C. Yeh, G. M. Schum and O. G. Raabe. 1978. “Application of an Idealized Model to Morphometry of the Mammalian Tracheobronchial Tree.”Anat. Rec. 190(2), 167–176.
Schum, G. M. and H. C. Yeh. 1979. “Theoretical Evaluation of Aerosol Deposition in Anatomical Models of Mammalian Lung Airways.”Bull. Math. Biol. 42, 1–15.
Task Group on Lung Dynamics. 1966. “Deposition and Retention Models for Internal Dosimetry of the Human Respiratory Tract.”Hlth Phys. 12, 173–207.
Taulbee, D. B. and C. P. Yu. 1975. “A Theory of Aerosol Deposition in the Human Respiratory Tract.”J. Appl. Physiol. 38(1), 77–85.
Weibel, E. R. 1963.Morphometry of the Human Lung. New York: Academic Press.
Yeh, H. C., A. J. Hulbert, R. F. Phalen, D. J. Velasquez and T. D. Harris. 1975. “A Stereoradiographic Technique and Its Application to the Evaluation of Lung Casts.”Invest. Radiol. 10, 351–357.
Yeh, H. C., R. F. Phalen and O. G. Raabe. 1976. “Factors Influencing the Deposition of Inhaled Particles.”Environ. Hlth Perspect. 15, 147–156.
Yeh, H. C., G. M. Schum and M. T. Duggan. 1979. “Anatomical Models of the Tracheobronchial and Pulmonary Regions of the Rat.”Anat. Rev. 195, 483–492.
Yeh, H. C. 1979, “Modeling of Biological Tree Structures,”Bull. Math. Biol. 41, 893–898.