Successful immunotherapy and irradiation in a HIV-positive patient with metastatic Merkel cell carcinoma

Koh, 2009, Role of definitive radiotherapy in treating patients with inoperable Merkel cell carcinoma: the Westmead Hospital experience and a review of the literature, Australas J Dermatol, 50, 249, 10.1111/j.1440-0960.2009.00532.x Lemos, 2010, Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system, J Am Acad Dermatol, 63, 751, 10.1016/j.jaad.2010.02.056 Fitzgerald, 2015, Dramatic increase in the incidence and mortality from merkel cell carcinoma in the United States, Am Surg, 81, 802, 10.1177/000313481508100819 Heath, 2008, Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features, J Am Acad Dermatol, 58, 375, 10.1016/j.jaad.2007.11.020 Feng, 2008, Clonal integration of a polyomavirus in human Merkel cell carcinoma, Science, 319, 1096, 10.1126/science.1152586 Lipson, 2013, PD-L1 expression in the Merkel cell carcinoma microenvironment: association with inflammation, Merkel cell polyomavirus and overall survival, Cancer Immunol Res, 1, 54, 10.1158/2326-6066.CIR-13-0034 Wong, 2015, UV-associated mutations underlie the etiology of MCV-negative merkel cell carcinomas, Cancer Res, 75, 5228, 10.1158/0008-5472.CAN-15-1877 Goh, 2016, Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy, Oncotarget, 7, 3403, 10.18632/oncotarget.6494 Wobser, 2009, Therapy of metastasized Merkel cell carcinoma with liposomal doxorubicin in combination with radiotherapy, J Dtsch Dermatol Ges, 7, 521 Nghiem, 2016, PD-1 blockade with pembrolizumab in advanced merkel-cell carcinoma, N Engl J Med, 374, 2542, 10.1056/NEJMoa1603702 Kaufman, 2016, Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial, Lancet Oncol, 17, 1374, 10.1016/S1470-2045(16)30364-3 Kaufman, 2018, Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial, J Immunother Cancer, 6, 7, 10.1186/s40425-017-0310-x D'Angelo, 2018, Efficacy and safety of first-line avelumab treatment in patients with stage IV metastatic merkel cell carcinoma: a preplanned interim analysis of a clinical trial, JAMA Oncol, 4 Vatner, 2014, Combinations of immunotherapy and radiation in cancer therapy, Front Oncol, 4, 325, 10.3389/fonc.2014.00325 Velu, 2009, Enhancing SIV-specific immunity in vivo by PD-1 blockade, Nature, 458, 206, 10.1038/nature07662 Heppt, 2017, Checkpoint blockade for metastatic melanoma and Merkel cell carcinoma in HIV-positive patients, Ann Oncol, 28, 3104, 10.1093/annonc/mdx538 Ostios-Garcia, 2018, Safety and efficacy of PD-1 inhibitors among HIV-positive patients with non-small cell lung cancer, J Thorac Oncol, 13, 1037, 10.1016/j.jtho.2018.03.031 Reuss, 2016, Sarcoidosis in the setting of combination ipilimumab and nivolumab immunotherapy: a case report & review of the literature, J Immunother Cancer, 4, 94, 10.1186/s40425-016-0199-9 Danlos, 2016, Nivolumab-induced sarcoid-like granulomatous reaction in a patient with advanced melanoma, Chest, 149, e133, 10.1016/j.chest.2015.10.082 Navarro, 2018, HIV-positive patients with lung cancer: is immunotherapy a safe and active option for them?, J Thorac Oncol, 13, 874, 10.1016/j.jtho.2018.05.005