Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele

Brody, 2002, Am. J. Hum. Genet., 71, 1207, 10.1086/344213 Chen, 1997, Human methionine synthase. cDNA cloning, gene localization and expression, J. Biol. Chem., 272, 3628, 10.1074/jbc.272.6.3628 Chen, 2001, Influence of methionin synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction, Atherosclerosis, 154, 667, 10.1016/S0021-9150(00)00469-X Dalsgaard-Nielsen, 1970, Prophylactic treatment of migraine with vitamin B12, Ugeskr. Laeg., 132, 339 Doolin, 2002, Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida, Am. J. Hum. Genet., 71, 1222, 10.1086/344209 Evers, 1997, Plasma homocysteine levels in primary headache, 215 Frosst, 1995, A candidate genetic risk factor for vascular disease: a common mutation to methylenetetrahydrofolate reductase, Nat. Genet., 10, 111, 10.1038/ng0595-111 Hering-Hanit, 2001, Is blood homocysteine elevated in migraine?, Headache, 41, 779, 10.1046/j.1526-4610.2001.01143.x Hol, 1998, Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthase) in patients with neural tube defects, Clin. Genet., 53, 119, 10.1111/j.1399-0004.1998.tb02658.x Horie, 1997, Identification of functional elements in the promoter region of the human gene for thymidylate synthase and nuclear factors that regulate the expression of the gene, J. Biol. Chem., 272, 18375, 10.1074/jbc.272.29.18375 Kara, 2003, Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk, Mol. Brain Res., 111, 84, 10.1016/S0169-328X(02)00672-1 Kawakami, 1999, Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers, Anticancer Res., 19, 3249 Kopjas, 1969, The use of folic acid in vascular headache of the migraine type, Headache, 8, 167, 10.1111/j.1526-4610.1969.hed0804167.x Kowa, 2000, The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine, Am. J. Med. Genet., Part B Neuropsychiatr. Genet., 96, 762, 10.1002/1096-8628(20001204)96:6<762::AID-AJMG12>3.0.CO;2-X Lea, 2004, The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine aura, BMC Med., 2, 3, 10.1186/1741-7015-2-3 Leclerc, 1996, Human methionin synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders, Hum. Mol. Genet., 5, 1867, 10.1093/hmg/5.12.1867 Ma, 1999, A polymorphism of the methionin synthase gene: association with plasma folate, vitamin B12, homocysteine, and colorectal cancer risk, Cancer Epidemiol., Biomarkers Prev., 8, 825 Marsh, 2000, Novel thymidylate synthase enhancer region alleles in African populations, Hum. Mutat., 16, 528, 10.1002/1098-1004(200012)16:6<528::AID-HUMU11>3.0.CO;2-W Marsh, 1999, Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasians and Asian populations, Genomics, 58, 310, 10.1006/geno.1999.5833 Matsuo, 2001, Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma, Blood, 97, 3205, 10.1182/blood.V97.10.3205 Oterino, 2004, MTHFR T667 homozygosis influences the presence of aura in migraineurs, Cephalalgia, 24, 491, 10.1111/j.1468-2982.2004.00692.x Relton, 2004, Gene–gene interaction in folate-related genes and risk of neural tube defects in a UK population, J. Med. Genet., 41, 256, 10.1136/jmg.2003.010694 Schoenen, 1994, High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study, Cephalalgia, 14, 328, 10.1046/j.1468-2982.1994.1405328.x Schoenen, 1998, Effectiveness of high-dose riboflavine in migraine prophylaxis: a randomized controlled trial, Neurology, 50, 466, 10.1212/WNL.50.2.466 Selhub, 1999, Homocysteine metabolism, Annu. Rev. Nutr., 19, 217, 10.1146/annurev.nutr.19.1.217 Skibola, 2002, Polymorphisms in the thymidylate synthase and serine hydroxymehtyltransferase genes and risk of adult acute lymphocytic leukemia, Blood, 99, 3786, 10.1182/blood.V99.10.3786 Snell, 2000, The genetic organization and protein crystallographic structure of human serine hydroximethyltransferase, Adv. Enzyme Regul., 40, 353, 10.1016/S0065-2571(99)00035-7 Trinh, 2002, Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels, Hum. Genet., 111, 299, 10.1007/s00439-002-0779-2 Ulrich, 2002, Thymidylate synthase promoter polymorphism, interaction with folate intake and risk of colorectal adenomas, Cancer Res., 62, 3361 Van der Kuy, 2002, Hydroxicobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study, Cephalalgia, 22, 513, 10.1046/j.1468-2982.2002.00412.x Wang, 1999, Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population, Atherosclerosis, 146, 133, 10.1016/S0021-9150(99)00111-2 Weisberg, 1998, A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity, Mol. Genet. Metab., 64, 169–172, 10.1006/mgme.1998.2714