Angiotensin actions in the kidney: Renewed insight into the old hormone

Kidney International - Tập 40 - Trang 583-596 - 1991
Iekuni Ichikawa1, Raymond C. Harris1
1Nashville, Tennessee, USA

Tài liệu tham khảo

Bohr, 1974, Angiotensin on vascular smooth muscle, 37, 424 Laragh, 1960, The effect of epinephrine, norepinephrine, angiotensin II, and others on the secretory rate of aldosterone in man, J Am Med Assoc, 174, 234, 10.1001/jama.1960.03030030014003 Ballerman, 1984, Reduced glomerular angiotensin II receptor density in early untreated diabetes mellitus in the rat, Am J Physiol, 247, F110 Bianchi, 1986, Distinct localization of atrial natriuretic factor and angiotensin II binding sites in the glomerulus, Am J Physiol, 251, F594 Kastner, 1984, Control of glomerular filtration rate: Role of intrarenally formed angiotensin II, Am J Physiol, 246, F897 Ichikawa, 1984, Role of angiotensin II in the altered renal function of congestive heart failure, Circ Res, 55, 669, 10.1161/01.RES.55.5.669 Hall, 1982, Regulation of renal hemodynamics, 26, 243 Avar, 1984, Contribution of the renin-angiotensin system to the control of intrarenal hemodynamics, Kidney Int, 25, 857, 10.1038/ki.1984.102 Ichikawa, 1979, Reversal of renal cortical actions of angiotensin II by verapamil and manganese, Kidney Int, 16, 137, 10.1038/ki.1979.115 Edwards, 1983, Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels, Am J Physiol, 244, F526 Yuan, 1990, Effect of angiotensin II and norepinephrine on isolated rat afferent and efferent arterioles, Am J Physiol, 258, F741 Mitchell, 1987, Superficial nephron responses to peritubular capillary infusions of angiotensins I and II, Am J Physiol, 252, F818 Rosivall, 1983, Effects on renal hemodynamics of intra-arterial infusions of angiotensins I and II, Am J Physiol, 252, F181 Schor, 1980, Glomerular adaptations to chronic dietary salt restriction or excess, Am J Physiol, 238, F428 Blantz, 1976, Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat, J Clin Invest, 57, 419, 10.1172/JCI108293 Anderson, 1981, Angiotensin II stimulates phosphorylation of the myosin light chain in cultured vascular smooth muscle cells, J Biol Chem, 256, 4693, 10.1016/S0021-9258(19)69303-8 Yoshimoto, 1990, Effect of vasoactive agents on myosin light-chain phosphorylation in rat mesangial cells, J Am Soc Nephrol, 1, 736 Okuda, 1986, Angiotensin II and vasopressin stimulate calcium activated chloride conductance in rat mesangial cells, J Clin Invest, 78, 1443, 10.1172/JCI112734 Fogo, 1990, Role for the mesangium in glomerular neutrophil entrapment, Kidney Int, 37, 551 Yared, 1985, Mechanism of preservation of glomerular perfusion and filtration during acute extracellular fluid volume depletion. Importance of intrarenal vasopressin-prostaglandin interaction for protecting kidneys from constrictor action of vasopressin, J Clin Invest, 75, 1477, 10.1172/JCI111851 Kimbrough, 1977, Effect of intrarenal angiotensin II blockade on renal function in conscious dogs, Cir Res, 40, 174, 10.1161/01.RES.40.2.174 Ploth, 1979, Tubulo-glomerular feedback and single nephron function after converting enzyme inhibition in the rat, J Clin Invest, 64, 1325, 10.1172/JCI109589 Navar, 1982, Influence of converting enzyme inhibition on renal hemodynamics and glomerular dynamics in sodium-restricted dogs, Hypertension, 4, 58, 10.1161/01.HYP.4.1.58 Carmines, 1983, Renal hemodynamic effects of captopril in anesthetised sodium-restricted dogs: Relative contributions of prostaglandin stimulation and suppressed angiotensin activity, Renal Physiol, 6, 281 Dzau, 1980, Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure, N Engl J Med, 302, 1373, 10.1056/NEJM198006193022501 Steiner, 1979, Glomerular hemodynamics in rats with chronic sodium depletion. Effect of saralasin, J Clin Invest, 64, 503, 10.1172/JCI109488 Hall, 1979, Chronic blockade of angiotensin II formation during sodium deprivation, Am J Physiol, 237, F424 Yoshioka, 1986, Role of angiotensin II in an overt functional proteinuria, Kidney Int, 30, 538, 10.1038/ki.1986.219 Fagard, 1978, Renal responses to angiotensin II and l-Sar-8-Ala-AII in sodium replete and deplete doges, Pflügers Arch, 374, 199, 10.1007/BF00581302 Clappison, 1981, Renal hemodynamics and renal kinins after angiotensin converting enzyme inhibition, Kidney Int, 20, 615, 10.1038/ki.1981.184 Hall, 1977, Control of glomerular filtration rate by the renin-angiotensin system, Am J Physiol, 233, F366 Ichikawa, 1980, Importance of efferent arteriolar vascular tone in regulation of proximal tubule fluid reabsorption and glomerulotubular balance in the rat, J Clin Invest, 65, 1192, 10.1172/JCI109774 Schor, 1980, Pathophysiology of altered glomerular function in aminoglycoside-treated rats, Kidney Int, 19, 288, 10.1038/ki.1981.19 Ho, 1985, Multiple defects in the renin-angiotensin system in alloxan-diabetic kidney, Proc Soc Exp Biol Med, 178, 297, 10.3181/00379727-178-42013 Anderson, 1989, Short arid long term effects of antihypertensive therapy in the diabetic rat, Kidney Int, 36, 526, 10.1038/ki.1989.227 Yoshioka, 1988, “Intact nephrons” as the primary origin of proteinuria in chronic renal disease, J Clin Invest, 82, 1614, 10.1172/JCI113773 Pelayo, 1990, Angiotensin II control of the renal microcirculation in rats with reduced renal mass, Am J Physiol, 258, F414 Oken, 1989, Does the ultrafiltration coefficient play a key role in regulating glomerular filtration, Am J Physiol, 256, F505 Ichikawa, 1983, Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome, J Clin Invest, 71, 91, 10.1172/JCI110756 Ichikawa, 1979, Maturational development of glomerular ultrafiltration in the rat, Am J Physiol, 236, F465 Kon, 1985, The role of renal sympathetic nerves in mediating hypoperfusion of renal cortical microcirculation in experimental congestive heart failure and acute ECF volume depletion, J Clin Invest, 76, 1913, 10.1172/JCI112187 Ichikawa, 1983, Relative contributions of vasopressin and angiotensin II to the altered renal microcirculatory dynamics in two-kidney Goldblatt hypertension, Cir Res, 53, 592, 10.1161/01.RES.53.5.592 Ichikawa, 1985, Dietary protein intake conditions the degree of renal vasoconstriction in acute renal failure caused by ureteral obstruction, Am J Physiol, 249, F54 Yarger, 1981, Obstructive nephropathy in the rat: Possible roles for the renin-angiotensin system, prostaglandins and thromboxanes in post-obstructive renal function, J Clin Invest, 65, 1400 Yoshioka, 1987, Role of abnormally high transmural pressure in the permselec-tivity defect of glomerular capillary wall: A study in early passive Heymann nephritis, Circ Res, 61, 531, 10.1161/01.RES.61.4.531 Blantz, 1981, Glomerular immune injury in the rat: The influence of All and α-adrenergic inhibitors, Kidney Int, 20, 452, 10.1038/ki.1981.161 Anderson, 1990, Renin-angiotensin system during evolution of nephrotic syndrome, Clin Res, 38, 358A Saccomani, 1990, Angiotensin II stimulation of Na+-H+ exchange in proximal tubule cells, Am J Physiol, 258, F1188 Schlondorff, 1990, Angiotensin II stimulates phospholipases C and A2, Am J Physiol, 258, F927 Aiken, 1973, Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin, J Pharmacol Exp Ther, 184, 678 Baylis, 1978, Modulation by prostaglandin synthesis inhibitors of the action of exogenous angiotensin II on glomerular ultrafiltration in the rat, Circ Res, 43, 889, 10.1161/01.RES.43.6.889 Thurau, 1964, Renal hemodynamics, Am J Med, 36, 698, 10.1016/0002-9343(64)90181-0 Thurau, 1974, The intrarenal function of the juxtaglomerular apparatus, 357 Vander, 1967, Control of renin release, Physiol Rev, 47, 359, 10.1152/physrev.1967.47.3.359 Davis, 1976, Mechanisms regulating renin release, Physiol Rev, 56, 1, 10.1152/physrev.1976.56.1.1 Skott, 1987, Direct demonstration of macula densa-mediated renin secretion, Science, 237, 1618, 10.1126/science.3306925 Ploth, 1979, Tubulo-glomerular feedback and single nephron function after converting enzyme inhibition in the rat, Clin Invest, 64, 1325, 10.1172/JCI109589 Stowe, 1979, Feedback regulation of nephron filtration rate during pharmacologic interference with the renin-angiotensin and adrenergic systems in rats, Kidney Int, 15, 473, 10.1038/ki.1979.63 Ploth, 1982, Renal and tubuloglomerular feedback effects of [Sar1, Ala8]-angiotensin II in the rat, Am J Physiol, 242, F149 Ploth, 1982, Renin-angiotensin influences on tubuloglomerular feedback activity in the rat, Kidney Int, 22, S114 Schnermann, 1986, Role of the renin-angiotensin system in tubuloglomerular feedback, Fed Proc, 45, 1426 Mitchell, 1988, Enhanced tubuloglomerular feedback during peritubular infusions of angiotensins I and II, Am J Physiol, 255, F383 Pickering, 1940, The effect of renin on urine formation, J Physiol, 98, 314, 10.1113/jphysiol.1940.sp003852 Bohrer, 1977, Mechanism of angiotensin Il-induced proteinuria in the rat, Am J Physiol, 233, F13 Addis, 1949, Renin proteinuria in the rat: 1. The relation between the proteinuria and the pressor effect of renin, J Exp Med, 89, 131, 10.1084/jem.89.2.131 Deodhar, 1964, Studies on the mechanism of experimental proteinuria induced by renin, J Exp Med, 120, 677, 10.1084/jem.120.4.677 Eisenback, 1975, Effect of angiotensin on the filtration of protein in the rat kidney: A micropuncture study, Kidney Int, 8, 80, 10.1038/ki.1975.83 Farber, 1985, Bovine and human endothelial cell production of neutrophil chemoattractant activity in response to components of the angiotensin system, Circ Res, 57, 898, 10.1161/01.RES.57.6.898 Brandt, 1948, Effect of renin on proteinuria and PAH clearance at low plasma levels, Am J Physiol, 153, 458, 10.1152/ajplegacy.1948.153.3.458 Loon, 1989, Effect of angiotensin II infusion on the human glomerular filtration barrier, Am J Physiol, 257, F608 Farquhar, 1962, Functional evidence for the ex-istance of a third cell type in the renal glomerulus. Phagocytosis of filtration residues by a distinctive “third” cell, J Cell Biol, 13, 55, 10.1083/jcb.13.1.55 Camazine, 1976, Isolation of phagocytic cells from the rat renal glomerulus, Lab Invest, 35, 315 Striker, 1979, Role of marrow-derived monocytes and mesangial cells in removal of immune complexes from renal glomeruli, J Exp Med, 149, 127, 10.1084/jem.149.1.127 Schreiner, 1981, Characterization of resident glomerular cells in the rat expressing la determinants and manifesting genetically restricted interactions with lymphocytes, J Clin Invest, 68, 920, 10.1172/JCI110347 Michael, 1967, Glomerular localization and transport of aggregated proteins in mice, Lab Invest, 17, 14 Baud, 1983, Reactive oxygen production by cultured rat glomerular mesan-gial cells during phagocytosis is associated with stimulation of lipoxygenase activity, J Exp Med, 158, 1836, 10.1084/jem.158.6.1836 Singhal, 1987, Endocytosis by cultured mesangial cells and associated changes in prostaglandin E2 synthesis, Am J Physiol, 252, F627 Singhal, 1990, Effects of vasoactive agents on uptake of immunoglobulin G complexes by mesangial cells, Am J Physiol, 258, F589 Sterzel, 1982, The mesangium and glomerulonephritis, Klin Wochenschr, 60, 1077, 10.1007/BF01715838 Stein, 1983, Role of angiotensin Il-induced renal functional changes in mesangial deposition of exogenous ferritin in rats, Lab Invest, 49, 270 Raij, 1985, Glomerular mesangium: Its function and relationship to angiotensin II, Am J Med, 79, 24, 10.1016/0002-9343(85)90076-2 Dezsö, 1981, Effect of angiotensin II on the Fc receptor activity of rat macrophages, Immunology, 42, 277 Fóris, 1983, Effect of angiotensin II on macrophage functions, Immunology, 48, 529 Weinstock, 1984, Angiotensin II stimulation of granuloma macrophage phagocytosis and actin polymerization in murine schistosomiasis mansoni, Cell Immunol, 89, 54 Mauer, 1972, The glomerular mesangium. I. Kinetic studies of macromolecular uptake in normal and nephrotic rats, Clin Invest, 51, 1092, 10.1172/JCI106901 Keane, 1985, Relationship among altered glomerular barrier permselectivity, angiotensin II and mesangial uptake of macromolecules, Lab Invest, 52, 599 Diamond, 1986, Focal and segmental glomerulosclerosis following a single intravenous dose of puromycin amino-nucleoside, Am J Pathol, 122, 481 Glasser, 1977, Experimental model of focal sclerosis. I. Relationship to protein excretion in aminonucle-oside nephrosis, Lab Invest, 36, 519 Fogo, 1988, Serial micropuncture analysis of glomerular function in two rat models of glomerular sclerosis, J Clin Invest, 82, 322, 10.1172/JCI113590 Grond, 1985, Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis, Kidney Int, 27, 405, 10.1038/ki.1985.24 Klahr, 1988, The progression of renal disease. TV, Engl J Med, 318, 1657, 10.1056/NEJM198806233182505 Brown, 1982, Angiotensin II binding sites on isolated rat renal brush broder membranes, Endocrinology, 111, 1830, 10.1210/endo-111-6-1830 Brown, 1983, Angiotensin II binding sites and rat and primate isolated renal tubular basolateral membranes, Endocrinology, 112, 2007, 10.1210/endo-112-6-2007 Cox, 1984, Location of [125I]-angiotensin II receptors on rat kidney cortex epithelial cells, Br J Pharmacol, 82, 891, 10.1111/j.1476-5381.1984.tb16487.x Douglas, 1987, Angiotensin receptor subtypes of the kidney cortex, Am J Physiol, 253, F1 Yamada, 1990, Angiotensin II receptors in the kidney. Localization and physiological significance, Am J Hypertens, 3, 250, 10.1093/ajh/3.3.250 Bellucci, 1984, Mechanism of sodium modulation of glomerular angiotensin receptors in the rat, Clin Invest, 74, 1593, 10.1172/JCI111575 Brown, 1987, Influence of transmembrane potential difference of renal tubular epithelial cell on angiotensin II binding, Am J Physiol, 252, F209 Marchetti, 1987, Angiotensin I converting enzyme and kinin-hydrolyzing enzyme along the rabbit nephron, Kidney Int, 31, 744, 10.1038/ki.1987.61 Ikemoto, 1987, Angiotensin converting enzyme predominates in the inner cortex and medulla of the rat kidney, Biochem Biophys Res Comm, 144, 915, 10.1016/S0006-291X(87)80051-7 Brunval, 1986, Angiotensin I converting enzyme in human intestine and kidney. Ultrastructural immunohistochemical localization, Histochemistry, 85, 73, 10.1007/BF00508656 Schulz, 1988, Ultrastructural localization of angiotensin I-converting enzyme (EC3.4.15.1) and neutral metalloendopeptidase (EC 3.4.24.11) in the proximal tubule of the human kidney, Lab Invest, 59, 789 Inglefinger, 1990, In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system, J Clin Invest, 85, 417, 10.1172/JCI114454 Inglefinger, 1986, Sodium regulation of angiotensinogen mRNA expression in rat kidney cortex and medulla, J Clin Invest, 78, 1311, 10.1172/JCI112716 Ellison, 1989, Androgen regulation of rat renal angiotensinogen messenger RNA expression, J Clin Invest, 83, 1941, 10.1172/JCI114102 Harris, 1977, Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney, Pflügers Arch, 367, 295, 10.1007/BF00581370 Schuster, 1984, Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules, J Clin Invest, 73, 507, 10.1172/JCI111237 Liu, 1988, Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanisms and kinetics, J Clin Invest, 82, 601, 10.1172/JCI113638 Cogan, 1990, Regulation and control of bicarbonate reabsorption in the proximal tubule, Semin Nephrol, 10, 115 Peterson, 1979, Mechanism for renal handling angiotensin, Am J Physiol, 236, F365 Liu, 1987, Angiotensin II: A potent regulator of acidification in the rat early proximal convoluted tubule, J Clin Invest, 80, 272, 10.1172/JCI113059 Wang, 1990, Mechanics of angiotensin II action on proximal tubular transport, J Pharm Exp Ther, 252, 689 Gesek, 1990, Hormonal interactions with the proximal Na+-H+ exchanger, Am J Physiol, 258, F514 Vallega, 1988, Vascular smooth muscle Na+-H+ exchanger kinetics and its activation by angiotensin II, Am J Physiol, 254, C751, 10.1152/ajpcell.1988.254.6.C751 Ichikawa, 1984, Role of angiotensin II in the altered renal function of congestive heart failure, Circ Res, 55, 669, 10.1161/01.RES.55.5.669 Kon, 1983, Blood flow dependence of postglomerular fluid transfer and glomerulotubular balance, J Clin Invest, 72, 1716, 10.1172/JCI111131 Brenner, 1968, The relationship between glomerular filtration rate and sodium reabsorption by the proximal tubule of the rat nephron, J Clin Invest, 47, 1358, 10.1172/JCI105828 Ott, 1975, Effect of increased peritubule protein concentration on proximal tubule reabsorption in the presence and absence of extracellular volume expansion, J Clin Invest, 55, 612, 10.1172/JCI107969 Quinn, 1979, Peritubular capillary control of proximal tubule reabsorption in the rat, Am J Physiol, 236, F478 Steiner, 1979, Glomerular hemodynamics in rats with chronic sodium depletion, J Clin Invest, 64, 503, 10.1172/JCI109488 Brenner, 1973, Qualitative importance of changes in postglomerular colloid osmotic pressure in mediating glomerulotubular balance in the rat, J Clin Invest, 52, 190, 10.1172/JCI107164 Lewy, 1968, Peritubular control of proximal tubular reabsorption in the rat kidney, Am J Physiol, 214, 943, 10.1152/ajplegacy.1968.214.5.943 Ichikawa, 1979, Mechanism of inhibition of proximal tubule fluid reabsorption after exposure of the rat kidney to the physical effects of expansion of extracellular fluid volume, J Clin Invest, 64, 1466, 10.1172/JCI109605 Kon, 1984, Physiologic basis for the maintenance of glomerulotubular balance in young growing rats, Kidney Int, 25, 391, 10.1038/ki.1984.29 Ichikawa, 1982, Mechanism of glomerulotubular balance in the setting of heterogenous glomerular injury: Preservation of a close functional linkage between individual nephrons and surrounding microvasculature, J Clin Invest, 69, 185, 10.1172/JCI110430 Alpern, 1984, Bicarbonate-water interactions in the rat proximal convoluted tubule: An effect of volume flux on active proton secretion, J Gen Physiol, 84, 753, 10.1085/jgp.84.5.753 Fromter, 1973, Phénoménologie description of Na+, Cl- and HCO3 absorption from proximal tubules of rat kidney, Pflügers Arch, 343, 189, 10.1007/BF00586045 Giebisch, 1977, Kinetics of luminal acidification in cortical tubules of the rat kidney, J Physiol, 267, 571, 10.1113/jphysiol.1977.sp011827 Cohn, 1980, Metabolic acidosis and parathyroidectomy increase Na+-H+ exchange in brush border vasicles, Am J Physiol, 245, F217 Green, 1975, Isotonic requirements of proximal tubular sodium transport. I. Bicarbonate and chloride, Am J Physiol, 229, 1216, 10.1152/ajplegacy.1975.229.5.1216 Cogan, 1984, Regulation of proximal bicarbonate reabsorption, Am J Physiol, 247, F387 Cogan, 1979, Control of proximal bicarbonate reabsorption in normal and acidotic rats, J Clin Invest, 64, 1168, 10.1172/JCI109570 Cogan, 1986, Neurogenic regulation of proximal bicarbonate and chloride reabsorption, Am J Physiol, 250, F22 Berry, 1981, Influence of peritubular protein on solute absorption in the rabbit proximal tubule, J Clin Invest, 68, 506, 10.1172/JCI110282 Harris, 1987, Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption, Nature, 326, 697, 10.1038/326697a0 Garvin, 1989, Inhibition of Jv by ANF in rat proximal straight tubues requires angiotensin, Am J Physiol, 257, F907 Liu, 1988, Atrial natriuretic factor does not inhibit basal or angiotensin II-stimulated proximal transport, Am J Physiol, 255, F434 Liu, 1989, Angiotensin II stimulates early proximal bicarbonate absorption in the rat by decreasing cyclic adenosine monophosphate, J Clin Invest, 84, 83, 10.1172/JCI114174 Liu, 1990, Role of protein kinase C in proximal tubule bicarbonate absorption and angiotensin signalling, Am J Physiol, 258, F927 Baum, 1988, Phorbol myristate acetate and dioctanoyl-glycerol inhibit transport in rabbit proximal convoluted tubule, Am J Physiol, 254, F9 Wirthensohn, 1984, Phospholipid metabolism in rat kidney cortical tubules II. Effects of hormones on 32P incorporation, Biochim Biophys Acta, 795, 401, 10.1016/0005-2760(84)90091-2 Norman, 1987, EGF-induced mitogenesis in proximal tubular cells: Potentiation by angiotensin II, Am J Physiol, 253, F299 Romero, 1990, P450 monooxygenase metabolite of arachidonic acid inhibits Na+ absorption in early SI primary cultures, Kidney Int, 37, 350A Lowitz, 1969, Micropuncture study of the action of angiotensin-II on tubular sodium and water reabsorption in the rat, Nephron, 6, 173, 10.1159/000179727 Mujais, 1986, Angiotensin II binding sites in individual segments of the rat nephron, J Clin Invest, 77, 315, 10.1172/JCI112293 Zusman, 1977, Prostaglandin synthesis by rabbit renomeduliary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin and arginine vasopressin, J Clin Invest, 60, 215, 10.1172/JCI108758 Cupples, 1988, Angiotensin II and prostaglandins in control of vasa recta blood flow, Am J Physiol, 254, F417 Berk, 1986, Vasoconstriction: A new activity for platelet derived growth factor, Science, 232, 87, 10.1126/science.3485309 Berk, 1985, Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction, J Clin Invest, 75, 1083, 10.1172/JCI111772 Griendling, 1986, Sustained diacylglycerol formation from inositol phospholipids in angiotensin II stimulated vascular smooth muscle cells, J Biol Chem, 261, 5901, 10.1016/S0021-9258(17)38468-5 Ross, 1986, The biology of platelet-derived growth factor, Cell, 46, 155, 10.1016/0092-8674(86)90733-6 Lopez-Rivas, 1984, Ionic responses rapidly elicited by porcine platelet-derived growth factor on Swiss 3T3 cells, EMBO J, 3, 939, 10.1002/j.1460-2075.1984.tb01911.x Berk, 1987, Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells, J Biol Chem, 262, 5057, 10.1016/S0021-9258(18)61153-6 Geisterfer, 1988, Angiotensin II induces hypertrophy not hyperplasia of cultured rat smooth muscle cells, Cir Res, 62, 749, 10.1161/01.RES.62.4.749 Gill, 1977, Angiotensin stimulation of bovine adrenocortical cell growth, Proc Natl Acad Sci USA, 74, 5569, 10.1073/pnas.74.12.5569 Verma, 1987, Proto-oncogene fos: Complex but versatile regulation, Cell, 51, 513, 10.1016/0092-8674(87)90115-2 Taubman, 1989, Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca+ mobilization and protein kinase C activation, J Biol Chem, 264, 526, 10.1016/S0021-9258(17)31290-5 Alexander, 1976, Stimulation of prostaglandin E systhesis in cultured human umbilical vein smooth muscle cells, Proc Natl Acad Sci USA, 73, 1617, 10.1073/pnas.73.5.1617 Buonassisi, 1976, Hormone and neurotransmitter receptors in an established vascular endothelial cell line, Proc Natl Acad Sci USA, 73, 1612, 10.1073/pnas.73.5.1612 Campbell-Boswell, 1981, Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro, Exp Mol Path, 35, 265, 10.1016/0014-4800(81)90066-6 Berk, 1989, Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells, Hypertension, 13, 305, 10.1161/01.HYP.13.4.305 Scott-Burden, 1988, Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cells, Biochem Biophys Res Commun, 151, 583, 10.1016/0006-291X(88)90634-1 Fogo, 1990, Importance of angiogenic angiotensin II in the glomerular growth of maturing kidneys, Kidney Int, 38, 1068, 10.1038/ki.1990.314 Powell, 1989, Inhibitors of angiotensin-con-verting enzyme prevent myointimal proliferation after vascular injury, Science, 245, 186, 10.1126/science.2526370 Loeb, 1986, Antihypertensive drugs inhibit hypertension-associated aortic DNA synthesis in the rat, Hypertension, 8, 1135, 10.1161/01.HYP.8.12.1135 Linz, 1989, Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy in rats, Clin Exper Hyper-Theory Practice, A11, 1325, 10.3109/10641968909038172 Wang, 1990, Captopril reduces aortic and microvascular growth in hypertensive and normotensive rats, Hypertension, 15, 68, 10.1161/01.HYP.15.1.68 Levy, 1989, Effects of chronic converting enzyme inhibition on the structure and function of large arteries in the rat, Clin Exp Theory Prac, 11, 487 Homma, 1990, Angiotensin II induces hypertrophy and stimulates collagen production in cultured rat glomerular mesangial cell, Clin Res, 38, 358 Ardaillou, 1990, Effect of prostaglandin E2 on proline uptake and protein synthesis by cultured human mesangial cells, Kidney Int, 38, 1151, 10.1038/ki.1990.326 Reams, 1986, Enalapril in subjects with renal disease, J Hypertens, 4, S417 Rosenberg, 1990, Effect of dietary protein on rat renin and angiotensinogen gene expression, J Clin Invest, 85, 1144, 10.1172/JCI114546 Ichikawa, 1980, Mechanism of reduced glomerular filtration rate in chronic malnutrition, J Clin Invest, 65, 982, 10.1172/JCI109784 Rosenberg, 1990, Effect of angiotensin II on early growth genes in the kidney, J Am Soc Nephrol, 1, 426 Fine, 1985, Angiotensin II induces hypertrophy of renal proximal tubular cells. Relation to Na+-H+ antiport and PGE2 production, Clin Res, 33, 584A Wolf, 1990, Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells, Am J Physiol, 259, F768 Donnelly, 1990, Epidermal growth factor (EGF) and angiotensin II (All) stimulate S6 kinase activity and protein synthesis in cultured rabbit proximal tubule cells, J Am Soc Nephrol, 1, 468A Chevalier, 1987, Morphologic correlates of renal growth arrest in neonatal partial ureteral obstruction, Ped Res, 21, 338, 10.1203/00006450-198704000-00004 Yoshida, 1989, Effects of antihypertensive drugs on glomerular morphology, Kidney Int, 36, 626, 10.1038/ki.1989.239 Anderson, 1985, Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass, J Clin Invest, 76, 612, 10.1172/JCI112013 Pelayo, 1984, Angiotensin II in adren-ergic-induced alterations in glomerular hemodynamics, Am J Physiol, 247, F799 Wiseman, 1984, Plasma renin activity in insulin-dependent diabetics with raised glomerular filtration rate, Clin Endocrinol, 21, 409, 10.1111/j.1365-2265.1984.tb03228.x Ylitalo, 1976, Effects of varying sodium intake on blood pressure and renin-angiotensin system in subtotally nephrectomized rats, J Lab Clin Med, 88, 807 Anderson, 1986, Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat, J Clin Invest, 77, 1993, 10.1172/JCI112528 Wolf, 1991, Intracellular signaling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubule cells, Cell Reg, 2, 219, 10.1091/mbc.2.3.219 Diamond, 1988, Converting enzyme inhibition lessens tubulointerstitial injury in puromycin aminonucleoside nephrosis, Kidney Int, 33, 373 Shimada, 1978, Binding sites of angiotensin II in human mononuclear leukocytes, J Biochem, 84, 1013, 10.1093/oxfordjournals.jbchem.a132183 Weinstock, 1984, Functional angiotensin II receptors on macrophages from isolated liver granulomas of murine Schistosoma mansoni, J Immunol, 131, 2598 Goetzl, 1980, The preferential human mononuclear leukocyte chemotactic activity of the substituent tetrapeptides of angiotensin II, Biochem Biophys Res Commun, 97, 1097, 10.1016/0006-291X(80)91488-6 Schmid-Schönbein, 1987, Capillary plugging by granulocytes and the no-reflow phenomenon in the microcirculation, Fed Proc, 46, 2397 Worthen, 1989, Mechanics of stimulated neutrophils: Cell stiffening induces retension in capillaries, Science, 245, 183, 10.1126/science.2749255 Farber, 1985, Bovine and human endo-thelial cell production of neutrophil chemoattractant activity in response to components of the angiotensin system, Cir Res, 57, 898, 10.1161/01.RES.57.6.898 Schreiner, 1988, Immunological aspects of acute ureteral obstruction: Immune cell in filtrate in the kidney, Kidney Int, 34, 487, 10.1038/ki.1988.207