Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis

Vassiliki Koufopanou1, Austin Burt1, John W. Taylor1
1Department of Plant Biology, University of California, Berkeley, CA 94720

Tóm tắt

Simple cladogenetic theory suggests that gene genealogies can be used to detect mixis in a population and delineate reproductively isolated groups within sexual taxa. We have taken this approach in a study of Coccidioides immitis , an ascomycete fungus responsible for a recent epidemic of coccidioidomycosis (Valley fever) in California. To test whether this fungus represents a single sexual species throughout its entire geographic range, we have compared genealogies from fragments of five nuclear genes. The five genealogies show multiple incompatibilities indicative of sex, but also share a branch that partitions the isolates into two reproductively isolated taxa, one centered in California and the other outside California. We conclude that coccidioidomycosis can be caused by two distinct noninterbreeding taxa. This result should aid the future study of the disease and illustrates the utility of the genealogical approach in population genetics.

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Tài liệu tham khảo

10.1016/0025-5564(90)90123-G

10.1038/349029a0

10.1073/pnas.90.10.4384

W Maddison Experimental and Molecular Approaches to Plant Biosystematics, eds P C Hoch, A G Stephenson (Missouri Botanical Gardens, St. Louis), pp. 273–287 (1995).

10.1038/283212a0

10.1128/jb.173.22.7257-7268.1991

10.1073/pnas.90.21.10163

10.1007/978-1-4615-2383-3_17

10.1016/B978-0-12-398760-0.50026-2

J C Avise, R M J Ball Oxf Surv Evol Biol 7, 45–67 (1990).

J W Rippon Medical Mycology (W. B. Saunders, Philadelphia, 1988).

10.1007/978-1-4612-3730-3_6

D Pappagianis, R K Sun, S B Werner, G W I Rutherford, R W Elsea, G B J Miller, N Bootwala, R S Hopkins Morbid Mortal Wkly Rep 42, 21–24 (1993).

10.1093/clinids/19.Supplement_1.14

10.1073/pnas.93.2.770

10.1099/00221287-140-6-1481

10.1007/BF00182186

10.1016/0378-1119(95)00250-A

10.1128/iai.60.2.416-427.1992

10.1128/iai.61.7.3090-3092.1993

10.1016/0378-1119(95)00654-0

10.4148/1941-4765.1335

10.1111/j.1365-294X.1994.tb00131.x

J S Farris hennig 86 (Nat. Hist. Riksmuseet, Stockholm, , Version 1.5. (1988).

10.2307/2992285

10.1111/j.1096-0031.1994.tb00181.x

10.1016/0169-5347(96)10006-9

10.1128/jcm.32.12.3040-3042.1994

10.7312/nei-92038

10.1007/BF02115684

Burt A. Dechairo B. Koenig G. L. Carter D. White T. & Taylor J. W. (1997) Mol. Ecol . in press.

D J Schmidly, K T Wilkins, J N Derr Biology of the Heteromyidae, eds H H Genoways, J H Brown (American Society of of Mammalogists, Shippensburg, PA) 10, 319–356 (1993).

10.2307/1382342

10.1080/02681219480000761