Bone tissue engineering scaffolding: computer-aided scaffolding techniques

Chen A, Tsang V, Albrecht D, Bhatia S (2007) 3-D fabrication technology for tissue engineering. In: Ferrari M, Desai T, Bhatia S (eds) BioMEMS and biomedical nanotechnology. Springer, Berlin, pp 23–38 Oliveira AL, Costa SA, Sousa RA, Reis RL (2009) Nucleation and growth of biomimetic apatite layers on 3D plotted biodegradable polymeric scaffolds: effect of static and dynamic coating conditions. Acta Biomaterialia 5:1626–1638 Lode A, Meissner K, Luo Y, Sonntag F, Glorius S, Nies B, Vater C, Despang F, Hanke T, Gelinsky M (2012) Fabrication of porous scaffolds by three-dimensional plotting of a pasty calcium phosphate bone cement under mild conditions. J Tissue Eng Regenerat Med Martins A, Chung S, Pedro AJ, Sousa RA, Marques AP, Reis RL, Neves NM (2009) Hierarchical starch-based fibrous scaffold for bone tissue engineering applications. J Tissue Eng Regenerat Med 3:37–42 Duan B, Wang M (2010a) Customized CaP/PHBV nanocomposite scaffolds for bone tissue engineering: design, fabrication, surface modification and sustained release of growth factor. J R Soc Interf 7:S615–S629 Duan B, Wang M, Zhou WY, Cheung WL, Li ZY, Lu WW (2010) Three-dimensional nanocomposite scaffolds fabricated via selective laser sintering for bone tissue engineering. Acta Biomaterialia 6:4495–4505 Sundback CA, Shyu JY, Wang Y, Faquin WC, Langer RS, Vacanti JP, Hadlock TA (2010) Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material. Biomaterials 26:5454–5464 Vacanti CA (2000) Foreword. In: Lanza RP, Langer R, Vacanti JP (eds) Principles of tissue engineering, 2 edn. Academic Press, California, p xxix Vacanti CA, Bonassar LJ, Vacanti JP (2000) Structure tissue engineering. In: Lanza RP, Langer R, Vacanti JP (eds) Principles of tissue engineering, 2 edn. Academic Press, California, pp 671–682 Brown CD, Hoffman AS (2002) Modification of natural polymer: Chitosan. In: Atala A, Lanza RP (eds) Methods of tissue engineering. Academic Press, California, pp 565–574 Mota C, Puppi D, Chiellini F, Chiellini E (2012) Additive manufacturing techniques for the production of tissue engineering constructs. J Tissue Eng Regenerat Med Lam CXF, Olkowski R, Swieszkowski W, Tan KC, Gibson I, Hutmacher DW (2009) Composite PLDLLA/TCP scaffolds for bone engineering: mechanical and in vitro evaluations. In: The 13th international conference on biomedical engineering, Singapore, pp 1480–1483 Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R (1996) Novel approach to fabricate porous sponges of poly(d,l-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials 17:1417–1422 Stuckey DJ, Ishii H, Chen QZ, Boccaccini AR, Hansen U, Carr CA, Roether JA, Jawad H, Tyler DJ, Ali NN, Clarke K, Harding SE (2010) Magnetic resonance imaging evaluation of remodeling by cardiac elastomeric tissue scaffold biomaterials in a rat model of myocardial infarction. Tissue Eng Part A Tissue Eng 16:3395–3402 Hutmacher DW, Hoque ME, Wong YS (2008) Design, fabrication and physical characterization of scaffolds made from biodegradable synthetic polymers in combination with RP systems based on melt extrusion. In: Bidanda B, Bártolo PJ (eds) Virtual prototyping & bio manufacturing in medical applications. Springer, New York, pp 261–291 Melchels FPW, Barradas AMC, Blitterswijk CAV, Boer JD, Feijen J, Grijpma DW (2010a) Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing. Acta Biomaterialia 6:4208–4217 Kim GD, Oh YT (2008) A benchmark study on rapid prototyping processes and machines: quantitative comparisons of mechanical properties, accuracy, roughness, speed, and material cost. Proc Inst Mech Eng Part B J Eng Manuf 222:201–215 Lee G, Barlow JW (1993) Selective laser sintering of bioceramic materials for implants. In: Proceedings of solid freeform fabrication symposium, Austin, TX, pp 376–380 Tartarisco G, Gallone G, Carpi F, Vozzi G (2009) Polyurethane unimorph bender microfabricated with Pressure Assisted Microsyringe (PAM) for biomedical applications. Mater Sci Eng C 29:1835–1841 Vozzi G, Tirella A, Ahluwalia A (2012) Rapid prototyping composite and complex scaffolds with PAM2. Methods Mol Biol (Clifton, N.J.) 868:57–69 Cornejo IA, McNulty TF, Lee SY, Bianchi E, Danforth SC, Safari A (2000) Development of bioceramic tissue scaffolds via fused deposition of ceramics. In: George L (ed) Bioceramics: materials and applications III. American Ceramic Society, Westerville, pp 183–195 Reichert JC, Hutmacher DW (2011) Bone tissue engineering. In: Tissue Engineering, N. Pallua and C. V. Suschek, Eds., ed New York: Springer, 2011, pp. 431-456 Cesarano J, Segalman R, Calvert P (1998) Robocasting provides moldless fabrication from slurry deposition. Ceram Ind 148:94–102 Smay JE, Lewis JA (2012) Solid free-form fabrication of 3-D ceramic structures. In: Bansal NP, Boccaccini AR (eds) Ceramics and composites processing methods, 1st edn. Wiley, New Jersey, pp 459–484 Jansen J, Melchels FPW, Grijpma DW, Feijen J (2008) Fumaric acid monoethyl ester-functionalized poly(D,L-lactide)/N-vinyl-2-pyrrolidone resins for the preparation of tissue engineering scaffolds by stereolithography. Biomacromolecules 10:214–220 Stuecker JN, Cesarano Iii J, Hirschfeld DA (2003) Control of the viscous behavior of highly concentrated mullite suspensions for robocasting. J Mater Process Technol 142:318–325 Temenoff JS, Lu L, Mikos AG (2000) Bone tissue engineering using synthetic biodegradable polymer scaffolds. In: Davies JE (ed) Bone engineering. EM Squared, Toronto, pp 455–462 Swift KG, Booker JD (2013) Rapid prototyping processes. In: Manufacturing process selection handbook. Butterworth-Heinemann, Oxford, pp 227–241 Schwartzalder K, Somers AV (1963) Method of making a porous shape of sintered refractory ceramic articles Hench LL (1999) Bioactive glasses and glasses–ceramics. In: Shackelford JF (ed) Biocaramics-applications of ceramic and glass materials in medicine. Trans Tech Publication, Switzerland, pp 37–64 Ye L, Zeng X, Li H, Ai Y (2010) Fabrication and biocompatibility of nano non-stoichiometric apatite and poly(ε-caprolactone) composite scaffold by using prototyping controlled process. J Mater Sci Mater Med 21:753–760 Murphy MB, Mikos AG (2007) Polymer scaffold fabrication. In: Lanza R, Langer R, Vacanti J (eds) Principles of tissue engineering, 3 edn. Academic Press, California, pp 309–321 O’Donnell MD (2012) Melt-derived bioactive glass. In: Jones JR, Clare AG (eds) Bio-glasses: an introduction. Wiley, West Sussex Gurr M, Mülhaupt R (2012) Rapid prototyping. In: Krzysztof M, Martin M (eds) Polymer science: a comprehensive reference. Elsevier, Amsterdam, pp 77–99 Potoczek M, Zima A, Paszkiewicz Z, Slosarczyk A (2009) Manufacturing of highly porous calcium phosphate bioceramics via gel-casting using agarose. Ceram Int 35:2249–2254 Hopkinson N, Dickens P (2006) Emerging rapid manufacturing processes. In: Hopkinson N, Hague RJM, Dickens PM (eds) Rapid manufacturing: an industrial revolution for the digital age. Wiley, West Sussex, pp 55–80 Dalton PD, Woodfield T, Hutmacher DW (2009) Snapshot: polymer scaffolds for tissue engineering. Biomaterials 30:701–702 Bartolo PJ, Almeida HA, Rezende RA, Laoui T, Bidanda B (2008) Advanced processes to fabricate scaffolds for tissue engineering. In: Bidanda B, Bartolo PJ (eds) Virtual prototyping of biomanufacturing in medical application. Springer, New York, pp 149–170 Wolfe PS, Sell SA, Bowlin GL (2011) Natural and synthetic scaffolds. In: Pallua N, Suschek CV (eds) Tissue engineering. Springer, New York, pp 41–67 Ma PX, Langer R (1995) Degradation, structure and properties of fibrous poly(glycolic acid) scaffolds for tissue engineering. In: Mikos AG (ed) Polymers in medicine and pharmacy, vol 394. Materials Research Society, Pennsylvania, pp 99–110 Chen Q, Liang S, Thouas GA (2013) Elastomeric biomaterials for tissue engineering. Progress in polymer science, vol 38, pp 584–671 Fu Q, Saiz E, Tomsia AP (2011a) Direct ink writing of highly porous and strong glass scaffolds for load-bearing bone defects repair and regeneration. Acta Biomaterialia 7:3547–3554 Chen QZ (2007) Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering. PhD, Materials, Imperial College London, London Chen QZ, Roether JA, Boccaccini AR (2008) Tissue engineering scaffolds from bioactive glass and composite materials. In: Ashammakhi N, Reis R, Chiellini F (eds) Topics in tissue engineering, vol 4. BTE group, pp 1–23 Chen Q-Z, Bismarck A, Hansen U, Junaid S, Tran MQ, Harding SE, Ali NN, Boccaccini AR (2008b) Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue. Biomaterials 29:47–57 Chen Q-Z, Harding SE, Ali NN, Lyon AR, Boccaccini AR (2008) Biomaterials in cardiac tissue engineering: ten years of research survey. Mater Sci Eng R Rep 59:1–37 Muzzarelli RAA, Muzzarelli C (2005) Chitosan chemistry: relevance to the biomedical sciences. In: Polysaccharides 1: structure, characterization and use. Springer, Berlin, pp 151–209 Kohn J, Langer R (1996) Bioresorbable and bioerodible materials. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) Biomaterials science: an introduction to materials in medicine. Academic Press, New York, pp 64–72 Danforth S, Safari A, JMA, Langrana N (1998) Solid free form fabrication (SFF) of functional advanced ceramic components. Naval research review, office of naval research three, vol L, pp 27–38 Hollister SJ (2005) Porous scaffold design for tissue engineering. Nat Mater 4:518–524 Onagoruwa S, Bose S, Bandyopadhyay A (2001) Fused deposition of ceramics (FDC) and composites. In: Solid freeform fabrication symposium, The University of Texas at Austin, pp 224–231 Padilla S, Sánchez-Salcedo S, Vallet-Regí M (2006) Bioactive glass as precursor of designed-architecture scaffolds for tissue engineering. J Biomed Mater Res 81A:224–232 Liang S-L, Cook WD, Thouas GA, Chen Q-Z (2010) The mechanical characteristics and in vitro biocompatibility of poly(glycerol sebacate)-Bioglass® elastomeric composites. Biomaterials 31:8516–8529 Pereira TF, Oliveira MF, Maia IA, Silva JVL, Costa MF, Thiré RMSM (2012) 3D printing of poly(3-hydroxybutyrate) porous structures using selective laser sintering. Macromolecular Symposia 319:64–73 Grimm T (2004) User’s guide to rapid prototyping. Society of Manufacturing Engineers (SME), Dearborn, pp 367–396 Chu TM, Halloran JW, Wagner WC (1997) Hydroxyapatite suspension for implant fabrication by stereolithography. In: Ghosh A, Barks RE, Hiremath B (eds) Case studies in ceramic product development. American Ceramic Society, Westerville, pp 119–125 Chu TM, Halloran JW, Wagner WC (1996) Ultraviolet curing of highly loaded hydroxyapatite suspension. In: Rusin RP, Fischman GS (eds) Bioceramics: materials and applications II. American Ceramic Society, Westerville, pp 57–66 Niemelä T, Kellomäki M (2011) Bioactive glass and biodegradable polymer composites. In: Ylänen HO (ed) Bioactive glasses: materials, properties and applications. Woodhead Publishing Limited, Cambridge, pp 227–245 Chu TMG (2006) Solid freeform fabrication of tissue engineering scaffolds. In: Ma PX, Elisseeff J (eds) Scaffolding in tissue engineering. CRC Press, Florida, pp 139–153 Popov VK, Antonov EN, Bagratashvili VN, Konovalov AN, Howdle SM (2004) Selective laser sintering of 3-D biodegradable scaffolds for tissue engineering. In: Materials research society symposium proceeding, pp F.5.4.1–F.5.4.3 Correlo VM, Oliveira JM, Mano JF, Neves NM, Reis RL (2011) Natural origin materials for bone tissue engineering e properties, processing, and performance. In: Atala A, Lanza R, Thomson JA, Nerem RM (eds) Principles of regenerative medicine, 2 edn. Academic Press, Canada, pp 557–586 Sun W, Starly B, Nam J, Darling A (2005) Bio-CAD modeling and its applications in computer-aided tissue engineering. Comput-Aided Des 37:1097–1114 Morsi YS, Wong CS, Patel SS (2008) Conventional manufacturing processes for three-dimensional scaffolds. In: Bidanda B, Bartolo PJ (eds) Virtual prototyping of biomanufacturing in medical application. Springer, New York, pp 129–148 Andrade JCT, Camilli JA, Kawachi EY, Bertran CA (2002) Behavior of dense and porous hydroxyapatite implants and tissue response in rat femoral defects. J Biomed Mater Res 62:30–36 Anithaa R, Arunachalam S, Radhakrishnan P (2001) Critical parameters in ̄uencing the quality of prototypes in fused deposition modelling. J Mater Process Technol 118:385–388 Antonov EN, Bagratashvili VN, Whitaker MJ, Barry JJA, Shakesheff KM, Konovalov AN, Popov VK, Howdle SM (2005) Three-dimensional bioactive and biodegradable scaffolds fabricated by surface-selective laser sintering. Adv Mater 17:327–330 Arafat MT, Lam CXF, Ekaputra AK, Wong SY, Li X, Gibson I (2011) Biomimetic composite coating on rapid prototyped scaffolds for bone tissue engineering. Acta Biomater 7:809–820 Arcaute K, Mann B, Wicker R (2010) Stereolithography of spatially controlled multi-material bioactive poly(ethylene glycol) scaffolds. Acta Biomater 6:1047–1054 Attawin MA, Herbert KM, Laurencin CT (1995) Osteoblast-like cell adherence and migration through 3-dimensional porous polymer matrices. Biochem Biophys Res Commun 213:639–644 Bael SV, Desmet T, Chai YC, Pyka G, Dubruel P, Kruth J-P, Schrooten J (2013) In vitro cell-biological performance and structural characterization of selective laser sintered and plasma surface functionalized polycaprolactone scaffolds for bone regeneration. Mater Sci Eng C 33:3404–3412 Baino F, Vitale-Brovarone C (2011) Three-dimensional glass-derived scaffolds for bone tissue engineering: current trends and forecasts for the future. J Biomed Mater Res Part A 97A:514–535 Barroca N, Daniel-da-Silva AL, Vilarinho PM, Fernandes MHV (2010) Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass addition. Acta Biomater 6:3611–3620 Bergmann C, Lindner M, Zhang W, Koczur K, Kirsten A, Telle R, Fischer H (2010) 3D printing of bone substitute implants using calcium phosphate and bioactive glasses. J Eur Ceram Soc 30:2563–2567 Bergsma EJ, Rozema FR, Bos RRM, Debruijn WC (1993) Foreign-body reactions to resorbable poly(l-lactide) bone plates and screws used for the fixation of unstable zygomatic fractures. J Oral Maxillofac Surg 51:666–670 Bernardo JR (2010) Indirect tissue scaffold fabrication via additive manufacturing and biomimetic mineralization. Master of Science, Mechanical Engineering, The Virginia Polytechnic Institute and State University, Blacksburg, Virginia Bettahalli NMS, Arkesteijn ITM, Wessling M, Poot AA, Stamatialis D (2013) Corrugated round fibers to improve cell adhesion and proliferation in tissue engineering scaffolds. Acta Biomater 9:6928–6935 Bettinger CJ (2011) Biodegradable elastomers for tissue engineering and cell–biomaterial interactions. Macromol Biosci 11:467–482 Billiet T, Vandenhaute M, Schelfhout J, Vlierberghe SV, Dubruel P (2012) A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering. Biomaterials 33:6020–6041 Blaker JJ, Gough JE, Maquet V, Notingher I, Boccaaccini AR (2003) In vitro evaluation of novel bioactive composites based on Bioglass®-filled polylactide foams for bone tissue engineering scaffolds. J Biomed Mater Res Part A 67A:1401–1411 Blaker JJ, Maquet V, Jerome R, Boccaaccini AR, Nazhat SN (2005) Mechanical properties of highly porous PDLLA/Bioglass® composite foams as scaffolds for bone tissue engineering. Acta Biomater 1:643–652 Boccaaccini AR, Notingher I, Maquet V, Jerome R (2003) Bioresorbable and bioactive composite materials based on polylactide foams filled with and coated by Bioglass® particles for tissue engineering applications. J Mater Sci Mater Med 14:443–450 Boccaccini AR, Blaker JJ (2005) Bioactive composite materials for tissue engineering scaffolds. Expert Rev Med Dev 2:303–317 Bose S, Suguira S, Bandyopadhyay A (1999) Processing of controlled porosity ceramic structures via fused deposition. Scripta Mater 41:1009–1014 Bostman OM, Pihlajamaki HK (2000) Adverse tissue reactions to bioabsorbable fixation devices. Clin Orthop Relat Res 371:216–227 Bretcanu O, Boccaccini AR (2012) Poly-DL-lactic acid coated Bioglass® scaffolds: toughening effects and osteosarcoma cell proliferation. J Mater Sci 47:5661–5672 Bretcanu O, Chen QZ, Misara SK, Boccaaccini AR, Roy I, Verne E, Brovarone CV (2007) Biodegradable polymer coated 45S5 Bioglass-derived glass-ceramic scaffolds for bone tissue engineering. Glass Technol Eur J Glass Sci Technol Part A 48:227–234 Bretcanu O, Misra SK, Roy I, Renghini C, Fiori F, Boccaccini AR (2009) In vitro biocompatibility of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate). J Tissue Eng Regener Med 3:139–148 Brovarone CV, Verne E, Appendino P (2006) Macroporous bioactive glass-ceramic scaffolds for tissue engineering. J Mater Sci Mater Med 17:1069–1078 Brovarone CV, Verne E, Robiglio L, Martinasso G, Canuto RA, Muzio G (2008) Biocompatible glass–ceramic materials for bone substitution. J Mater Sci Mater Med 19:471–478 Brown RF, Day DE, Day TE, Jung S, Rahaman MN, Fu Q (2008) Growth and differentiation of osteoblastic cells on 13–93 bioactive glass fibers and scaffolds. Acta Biomater 4:387–396 Bruder SP, Caplan AI (2000) Bone regeneration through cellular engineering. In: Lanza RP, Lannger R, Vacanti JP (eds) Principles of tissue engineering, 2 edn. Academic Press, California, pp 683–696 Burg KJL, Porter S, Kellam JF (2000) Biomaterial developments for bone tissue engineering. Biomaterials 21:2347–2359 Cao H, Kuboyama N (2010) A biodegradable porous composite scaffold of PGA/β-TCP for bone tissue engineering. Bone 46:386–395 Chai YC, Carlier A, Bolander J, Roberts SJ, Geris L, Schrooten J, Van Oosterwyck H, Luyten FP (2012) Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies. Acta Biomater 8:3876–3887 Chen QZ (2011) Foaming technology of tissue engineering scaffolds—a review. Bubble Sci Eng Technol 3:34–47 Chen QZ, Boccaccini AR (2006) Poly(d, l-lactic acid) coated 45S5 Bioglass®-based scaffolds: processing and characterization. J Biomed Mater Res Part A 77A:445–457 Chen QZ, Thouas GA (2011) Fabrication and characterization of sol–gel derived 45S5 Bioglass®–ceramic scaffolds. Acta Biomater 7:3616–3626 Chen GQ, Wu Q (2005) The application of polyhydroxyalkanoates as tissue engineering materials. Biomaterials 26:6565–6578 Chen QZ, Thompson ID, Boccaaccini AR (2006) 45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials 27:2414–2425 Chen QZ, Efthymiou A, Salih V, Boccaccini AR (2008d) Bioglass®-derived glass–ceramic scaffolds: study of cell proliferation and scaffold degradation in vitro. J Biomed Mater Res 84A:1049–1060 Chen QZ, Li Y, Jin LY, Quinn JMW, Komesaroff PA (2010) A new sol–gel process for producing Na2O-containing bioactive glass ceramics. Acta Biomater 6:4143–4153 Chen QZ, Zhu CH, Thouas GA (2012a) Progress and challenges in biomaterials for tissue engineering. Progr Biomater 1:2 Chen QZ, Zhu CH, Thouas GA (2012b) Progress and challenges in biomaterials used for bone tissue engineering: bioactive glasses and elastomeric composites. Progr Biomater 1:1–22 Chen QZ, Xu JL, Yu LG, Fang XY, Khor KA (2012c) Spark plasma sintering of sol–gel derived 45S5 Bioglass®-ceramics: mechanical properties and biocompatibility evaluation. Mater Sci Eng C 32:494–502 Choi J-W, Wicker R, Lee S-H, Choi K-H, Ha C-S, Chung I (2009) Fabrication of 3D biocompatible/biodegradable micro-scaffolds using dynamic mask projection microstereolithography. J Mater Process Technol 209:5494–5503 Chu T-MG, Orton DG, Hollister SJ, Feinberg SE, Halloran JW (2002) Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures. Biomaterials 23:1283–1293 Chua CK, Leong KF, Sudarmadji N, Liu MJJ, Chou SM (2011) Selective laser sintering of functionally graded tissue scaffolds, Matrials Research Society, vol 36, pp 1006–1014 Cooke MN, Fisher JP, Dean D, Rimnac C, Mikos AG (2002) Use of stereolithography to manufacture critical-sized 3D biodegradable scaffolds for bone ingrowth. J Biomed Mater Res B Appl Biomater 64B:65–69 Crouch AS, Miller D, Luebke KJ, Hu W (2009) Correlation of anisotropic cell behaviors with topographic aspect ratio. Biomaterials 30:1560–1567 Cruz F, Simoes J, Coole T (2005) Direct manufacture of hydroxyapatite based bone implants by selective laser sintering. In: 2nd international conference on advanced research in virtual rapid protrotyping, Leiria, Portugal, p 119 Daoud JT, Petropavlovskaia MS, Patapas JM, Degrandpre CE, DiRaddo RW, Rosenberg L, Tabrizian M (2011) Long-term in vitro human pancreatic islet culture using three-dimensional microfabricated scaffolds. Biomaterials 32:1536–1542 Dawson JI, Wahl DA, Lanham SA, Kanczler JM, Czernuszk JT, Oreffo ROC (2008) Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells. Biomaterials 29:3105–3116 Day RM, Boccaccini AR, Shurey S, Roether JA, Forbes A, Hench LL, Gabe SM (2004) Assessment of polyglycolic acid mesh and bioactive glass for soft-tissue engineering scaffolds. Biomaterials 25:5857–5866 Dellinger JG, Cesarano J III, Jamison RD (2006) Robotic deposition of model hydroxyapatite scaffolds with multi architectures and multiscale porosity for bone tissue engineering. J Biomed Mater Res 82A:383–394 Devin JE, Attawin MA, Laurencin CT (1996) Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. J Biomater Sci Polym Ed 7:661–669 Dhandayuthapani B, Yoshida Y, Maekawa T, Kumar DS (2011) Polymeric scaffolds in tissue engineering application: a review. Int J Polym Sci 2011:1–19 Doi Y, Kitamura S, Abe H (1995) Microbial synthesis and characterization of poly(3-hydroxyburyrate-co-3-hydroxyhexanoate). Macromolecules 28:4822–4828 Doyle C, Tanner ET, Bonfield W (1991) In vitro and in vivo evaluation of polyhydroxyburyrate and polyhydroxybutyrate reinforced with hydroxyapatite. Biomaterials 12:841–847 Duan B, Wang M (2010b) Encapsulation and release of biomolecules from CaP/PHBV nanocomposite microspheres and three-dimensional scaffolds fabricated by selective laser sintering. Polym Degrad Stab 95:1655–1664 Elomaa L, Teixeira S, Hakala R, Korhonen H, Grijpma DW, Seppala JV (2011) Preparation of poly(ε-caprolactone)-based tissue engineering scaffolds by stereolithography. Acta Biomater 7:3850–3856 Elomaa L, Kokkari A, Narhi T, Seppala JV (2013) Porous 3D modeled scaffolds of bioactive glass and photocrosslinkable poly(ε-caprolactone) by stereolithography. Compos Sci Technol 74:99–106 Eosoly S, Brabazon D, Lohfeld S, Looney L (2010) Selective laser sintering of hydroxyapatite/poly-ε-caprolactone scaffolds. Acta Biomater 6:2511–2517 Eosoly S, Vrana NE, Lohfeld S, Hindie M, Looney L (2012) Interaction of cell culture with composite effects on the mechanical properties of polycaprolactone-hydroxypatite scaffolds fabricated via selective laser sintering (SLS). Mater Sci Eng C 32:2250–2257 Eshraghi S, Das S (2010) Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering. Acta Biomater 6:2467–2476 Eslaminejad MB, Mirzadeh H, Mohamadi Y, Nickmahzar A (2007) Bone differentiation of marrow-derived mesenchymal stem cells using β-tricalcium phosphate–alginate–gelatin hybrid scaffolds. J Tissue Eng Regener Med 1:417–424 Felzmann R, Gruber S, Mitteramskogler G, Tesavibul P, Boccaccini AR, Liska R, Stampfl J (2012) Lithography-based additive manufacturing of cullular ceramic structures. Adv Eng Mater 14:1052–1058 Ferreira AM, Gentile P, Chiono V, Ciardelli G (2012) Collagen for bone tissue regeneration. Acta Biomater 8:3191–3200 Fielding GA, Bandyopadhyay A, Bose S (2012) Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds. Dent Mater 28:113–122 Fierz FC, Beckmann F, Huser M, Irsen SH, Leukers B, Witte F, Degistirici O, Andronache A, Thie M, Muller B (2008) The morphology of anisotropic 3D-printed hydroxyapatite scaffolds. Biomaterials 29:3799–3806 Fisher JP, Dean D, Engel PS, Mikos AG (2001) Photoinitiated polymerization of biomaterials. Annu Rev Mater Sci 31:171–181 Fu Q, Rahaman MN, Bal BS, Brown RF, Day DE (2008) Mechanical and in vitro performance of 13–93 bioactive glass scaffolds prepared by a polymer foam replication technique. Acta Biomater 4:1854–1864 Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011b) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Mater Sci Eng C 31:1245–1256 Fukasawa T, Deng ZY, Ando M, Ohji T, Goto Y (2001) Pore structure of porous ceramics synthesized from water-based slurry by freeze-dry process. J Mater Sci 36:2523–2527 Ge Z, Wang L, Heng CB, Tian X-F, Lu K, Fan VTW, Yeo JF, Cao T, Tan E (2009) Proliferation and differentiation of human osteoblasts within 3D printed poly-lactic-co-glycolic acid scaffolds. J Biomater Appl 23:533–547 Gerhardt L-C, Boccaccini AR (2010) Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials 3:3867–3910 Gollwitzer H, Ibrahim K, Meyer H, Mittelmeier W, Busch R, Stemberger A (2003) Antibacterial poly(d, l-lactic acid) coating of medical implants using a biodegradable drug delivery technology. J Antimicrob Chemother 51:585–591 Gollwitzer H, Thomas P, Diehl P, Steinhauser E, Summer B, Barnstorf S (2005) Biomechanical and allergological characteristics of a biodegradable poly(d, l-lactic acid) coating for orthopaedic implants. J Orthoped Res 23:802–809 Goodridge RD (2004) Indirect selective laser sintering of an apatite-mullite glass–ceramic. PhD School of Mechanical Engineering, University of Leeds Goodridge RD, Wood DJ, Ohtsuki C, Dalgarno KW (2007) Biological evaluation of an apatite–mullite glass-ceramic produced via selective laser sintering. Acta Biomater 3:221–231 Guan L, Davies JE (2004) Preparation and characterization of a highly macroporous biodegradable composite tissue engineering scaffold. J Biomed Mater Res Part A 71A:480–487 Harris LD, Kim B-S, Mooney DJ (1998) Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res 42:396–402 Hattiangadi A, Bandyopadhyay A (2000) Modeling of multiple pore ceramic materials fabricated via fused deposition process. Scripta Mater 42:581–588 Haugen H, Will J, Kohler A, Hopfner U, Aigner J, Wintermantel E (2004) Ceramic TiO2-foams: characterisation of a potential scaffold. J Eur Ceram Soc 24:661–668 Hayati AN, Rezaie HR, Hosseinalipour SM (2011) Preparation of poly(3-hydroxybutyrate)/nano-hydroxyapatite composite scaffolds for bone tissue engineering. Mater Lett 65:736–739 Heller C, Schwentenwein M, Russmueller G, Varga F, Stampfl J, Liska R (2009) Vinyl esters: low cytotoxicity monomers for the fabrication of biocompatible 3D scaffolds by lithography based additive manufacturing. J Polym Sci Part A Polym Chem 47:6941–6954 Hench LL (1998) Bioceramics. J Am Ceram Soc 81:1705–1728 Hench LL (2006) The story of Bioglass®. J Mater Sci Mater Med 17:967–978 Hench LL, Wilson J (1999) An Introduction to bioceramics. Word Scientific, London Hench LL, Splinter RJ, Allen WC (1971) Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res Symp 2:117–141 Heo S-J, Kim S-E, Wei J, Hyun Y-T, Yun H-S, Kim D-H, Shin JW, Shin J-W (2009) Fabrication and characterization of novel nano-and micro-HA/PCL composite scaffolds using a modified rapid prototyping process. J Biomed Mater Res 89A:108–116 Hoelzle DJ, Alleyne AG, Johnson AJW (2008) Micro-robotic deposition guidelines by a design of experiments approach to maximize fabrication reliability for the bone scaffold application. Acta Biomater 4:897–912 Hoque ME, Chuan YL, Pashby I (2011) Extrusion based rapid prototyping technique: an advanced platform for tissue engineering scaffold fabrication. Biopolymers 97:83–93 Hsu S-H, Yen H-J, Tseng C-S, Cheng C-S, Tsai C-L (2007) Evaluation of the growth of chondrocytes and osteoblasts seeded into precision scaffolds fabricated by fused deposition manufacturing. J Biomed Mater Res B Appl Biomater 80B:519–527 Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529–2543 Hutmacher DW, Cool S (2007) Concepts of scaffold-based tissue engineering-the rationale to use solid free-form fabrication techniques. J Cell Mol Med 11:654–669 Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH, Tan KC (2001) Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 55:203–216 Hutmacher DW, Sittinger M, Risbud MV (2004) Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol 22:354–362 Ishizaki K, Komarneni S, Nanko M (1998) Porous materials: processing technology and applications. Kluwer Academic Publisher, The Netherlands Iyer S, McIntosh J, Bandyopadhyay A, Langrana N, Safari A, Danforth SC, Clancy RB, Gasdaska C, Whalen PJ (2008) Microstructural characterization and mechanical properties of Si3N4 fomed by fused deposition of ceramics. Int J Appl Ceram Technol 5:127–137 Jones JR (2013) Review of bioactive glass: from Hench to hybrids. Acta Biomater 9:4457–4486 Kalita SJ, Bose S, Hosick HL, Bandyopadhyay A (2003) Development of controlled porosity polymer–ceramic composite scaffolds via fused deposition modeling. Mater Sci Eng C 23:611–620 Kanczler JM, Mirmalek-Sani S-H, Hanley NA, Ivanov AL, Barry JJA, Upton C, Shakesheff KM, Howdle SM, Antonov EN, Bagratashvili VN, Popov VK, Oreffo ROC (2009) Biocompatibility and osteogenic potential of human fetal femur-derived cells on surface selective laser sintered scaffolds. Acta Biomater 5:2063–2071 Kemppainen JM, Hollister SJ (2010) Tailoring the mechanical properties of 3D-designed poly(glycerol sebacate) scaffolds for cartilage applications. J Biomed Mater Res Part A 94A:9–18 Khoda AKMB, Ozbolat IT, Koc B (2010) Engineered tissue scaffolds with variational porous architecture. J Biomech Eng 133:011001 Kim JY, Cho D-W (2009a) The optimization of hybrid scaffold fabrication process in precision deposition system using design of experiments. Microsyst Technol 15:843–851 Kim JY, Cho D-W (2009b) Blended PCL/PLGA scaffold fabrication using multi-head deposition system. Microelectron Eng 86:1447–1450 Kim SS, Utsunomiya H, Koski JA, Wu BM, Cima MJ, Sohn J, Mukai K, Grifith L, Vacanti JP (1998) Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Ann Surg 228:8–13 Kim HW, Lee SY, Bae CJ, Noh YJ, Kim HE, Kim HM, Ko JS (2003) Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer. Biomaterials 24:3277–3284 Kim HD, Bae EH, Kwon IC, Pal RR, Nam JD, Lee DS (2004) Effect of PEG–PLLA diblock copolymer on macroporous PLLA scaffoldsbythermallyinducedphaseseparation. Biomaterials 25:2319–2329 Kim JY, Jin G-Z, Park IS, Kim J-N, Chun SY, Park EK, Kim S-Y, Yoo J, Kim S-H, Rhie J-W, Cho D-W (2010) Evaluation of solid free-form fabrication-based scaffolds seeded with osteoblasts and human umbilical vein endothelial cells for use in vivo osteogenesis. Tissue Eng Part A 16:2229–2236 Kolan KCR, Leu MC, Hilmas GE, Velez M (2012) Effect of material, process parameters, and simulated body fluids on mechanical properties of 13-93 bioactive glass porous constructs made by selective laser sintering. J Mech Behav Biomed Mater 13:14–24 Korpela J, Kokkari A, Korhonen H, Malin M, Narhi T, Seppala J (2013) Biodegradable and bioactive porous scaffold structures prepared using fused deposition modeling. J Biomed Mater Res B Appl Biomater 101B:610–619 Kruth JP, Wang X, Laoui T, Froyen L (2003) Lasers and materials in selective laser sintering. Assembly Autom 23:357–371 Lam CXF, Hutmacher DW, Schantz J-T, Woodruff MA, Teoh SH (2009b) Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo. J Biomed Mater Res 90A:906–919 Landers R, Pfister A, Hubner U, John H, Schmelzeisen R, Mulhaupt R (2002a) Fabrication of soft tissue engineering scaffolds by means of rapid prototyping techniques. J Mater Sci 37:3107–3116 Landers R, Hubner U, Schmelzeisen R, Mulhaupt R (2002b) Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 23:4437–4447 Langer R, Vacanti JP (1993) Tissue engineering. Science 260:920–927 Langer R, Vacanti JP, Vacanti CA, Atala A, Freed LE, Vunjak-Novakovic G (1995) Tissue engineering biomedical applications. Tissue Eng 1:151–161 Laurencin CT, Attawin MA, Elgendy HE, Herbert KM (1996) Tissue engineered bone-regeneration using degradable polymers: the formation of mineralized matrices. Bone 19:S93–S99 Lee KW, Wang SF, Fox BC, Ritman EL, Yaszemski MJ, Lu LC (2007) Poly(propylene fumalate) bone tissue engineering scaffold fabrication using stereolithography: effects of resin formulations and laser parameters. Biomacromolecules 8:1077–1084 Lee JW, Lan PX, Kim B, Lim G, Dong-Woo C (2008a) Fabrication and characteristic analysis of a poly(propylene fumate) scaffold using micro-stereolithography technology. J Biomed Mater Res B Appl Biomater 87B:1–9 Lee K-S, Kim RH, Yang D-Y, Park SH (2008b) Advances in 3D nano/microfabrication using two-photon initiated polymerization. Prog Polym Sci 33:631–681 Lee J-S, Cha HD, Shim J-H, Jung JW, Kim JY, Cho D-W (2012) Effect of pore architecture and stacking direction on mechanical properties of solid freeform fabrication-based scaffold for bone tissue engineering. J Biomed Mater Res Part A 100A:1846–1853 Leong KF, Cheah CM, Chua CK (2003) Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs. Biomaterials 24:2363–2378 Leong DT, Gupta A, Bai HF, Wan G, Yoong LF, Too H-P, Chew FT, Hutmacher DW (2007) Absolute quantification of gene expression in biomaterials research using real-time PCR. Biomaterials 28:203–210 Li HY, Chang J (2004) Preparation and characterization of bioactive and biodegradable Wollastonite/poly(d, l-lactic acid) composite scaffolds. J Mater Sci Mater Med 15:1089–1095 Li HY, Du RL, Chang J (2005) Fabrication, characterization, and in vitro degradation of composite scaffolds based on PHBV and bioactive glass. J Biomater Appl 20:137–155 Li J, Zhang L, Lv S, Li S, Wang N, Zhang Z (2011) Fabrication of individual scaffolds based on a patient-specific alveolar bone defect model. J Biotechnol 151:87–93 Li Y, Cook WD, Moorhoff C, Huang WC, Chen QZ (2013a) Synthesis, characterization and properties of biocompatible poly(glycerol sebacate) pre-polymer and gel. Polym Int 62:534–547 Li Z, Chen X, Zhao N, Dong H, Li Y, Lin C (2013b) Stiff macro-porous bioactive glasse ceramic scaffold: fabrication by rapid prototyping template, characterization and in vitro bioactivity. Mater Chem Phys 141:76–80 Liu X, Huang W, Fu H, Yao A, Wang D, Pan H, Lu WW (2009a) Bioactive borosilicate glass scaffolds: improvement on the strength of glass-based scaffolds for tissue engineering. J Mater Sci Mater Med 20:365–372 Liu L, Xiong Z, Yan Y, Zhang R, Wang X, Jin L (2009b) Multinozzle low-temperature deposition system for construction of gradient tissue engineering scaffolds. J Biomed Mater Res B Appl Biomater 88B:254–263 Liu Y, Lim JL, Teoh S-H (2013) Review: development of clinically relevant scaffolds for vascularised bone tissue engineering. Biotechnol Adv 31:688–705 Lohfeld S, Cahill S, Barron V, McHugh P, Dürselen L, Kreja L, Bausewein C, Ignatius A (2012) Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite scaffolds. Acta Biomater 8:3446–3456 Lorrison J, Dalgarno K, Wood D (2005) Processing of an apatite-mullite glass-ceramic and an hydroxyapatite/phosphate glass composite by selective laser sintering. J Mater Sci Mater Med 6:775–781 Lu HH, El-Amin SF, Scott KD, Laurencin CT (2003) Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro. J Biomed Mater Res Part A 64A:465–474 Mano JF, Sousa RA, Boesel LF, Neves NM, Reis RL (2004) Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: state of the art and recent developments. Compos Sci Technol 64:789–817 Maquet V, Boccaaccini AR, Pravata L, Notingher I, Jerome R (2003) Preparation, characterization, and in vitro degradation of bioresorbable and bioactive composites based on Bioglass®-filled polylactide foams. J Biomed Mater Res Part A 66A:335–346 Maquet V, Boccaccinic AR, Pravata L, Notingher I, Jerome R (2004) Porous poly(alpha-hydroxyacid)/Bioglass® composite scaffolds for bone tissue engineering. I: preparation and in vitro characterisation. Biomaterials 25:4185–4194 Marcacci M, Kon E, Moukhachev V, Lavroukov A, Kutepov S, Quarto R (2007) Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng 13:947–955 Martin C, Winet H, Bao JY (1996) Acidity near eroding polylactide–polyglycolide in vitro and in vivo rabbit tibial bone chambers. Biomaterials 17:2373–2380 Martínez-Vázquez FJ, Perera FH, Miranda P, Pajares A, Guiberteau F (2010) Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration. Acta Biomater 6:4361–4368 Melchels FPW, Feijen J, Grijpma DW (2009) A poly(d, l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography. Biomaterials 30:3801–3809 Melchels FPW, Feijen J, Grijpma DW (2010b) A review on stereolithography and its applications in biomedical engineering. Biomaterials 31:6121–6130 Melchels FPW, Domingos MAN, Klein TJ, Malda J, Bartolo PJ, Hutmacher DW (2012) Additive manufacturing of tissues and organs. Prog Polym Sci 37:1079–1104 Meszaros R, Zhao R, Travitzky NA, Fey T, Greil P, Wondraczek L (2011) Three-dimensional printing of a bioactive glass. Glass Technol 52:111–116 Metze A-L, Grimm A, Nooeaid P, Roether JA, Hum J, Newby PJ, Schubert DW, Boccaccini AR (2013) Gelatin coated 45S5 Bioglass®-derived scaffolds for bone tissue engineering. Key Eng Mater 541:31–39 Middleton JC, Tipton AJ (2000) Synthetic biodegradable polymers as orthopedic devices. Biomaterials 21:2335–2346 Mikos AG, Temenoff JS (2000) Formation of highly porous biodegradable scaffolds for tissue engineering. Electron J Biotechnol 3:1–6 Miranda P, Saiz E, Gryn K, Tomsia AP (2006) Sintering and robocasting of β-tricalcium phosphate scaffolds for orthopaedic applications. Acta Biomater 2:457–466 Miranda P, Pajares A, Guiberteau F (2008) Finite element modeling as a tool for predicting the fracture behavior of robocast scaffolds. Acta Biomater 4:1715–1724 Misra SK, Valappil SP, Roy I, Boccaaccini AR (2006) Polyhydroxyalkanoate (PHA)/inorganic phase composites for tissue engineering applications. Biomacromolecules 7:2249–2258 Molladavoodi S, Gorbet M, Medley J, Kwon HJ (2013) Investigation of microstructure, mechanical properties and cellular viability of poly(L-lactic acid) tissue engineering scaffolds prepared by different thermally induced phase separation protocols. J Mech Behav Biomed Mater 17:186–197 Montanaro L, Jorand Y, Fantozzi G, Negro A (1998) Ceramic foams by powder processing. J Eur Ceram Soc 18:1339–1350 Muzzarelli RAA, Zucchini C, Ilari P, Pugnaloni A, Belmonte MM, Biagini G, Castaldini C (1993) Osteoconductive properties of methlpyrrolidinone chitosan in an animal-model. Biomaterials 14:925–929 Nam YS, Park TG (1999) Biodegradable polymeric microcellular foams by modified thermally induced phase separation method. Biomaterials 20:1783–1790 Navarro M, Ginebra MP, Planell JA (2004) Development and cell response of a new biodegradable composite scaffold for guided bone regeneration. J Mater Sci Mater Med 15:419–422 Oliveira AL, Sousa EC, Silva NA, Sousa N, Salgada AJ, Reis RL (2010) Peripheral mineralization of a 3D biodegradable tubular construct as a way to enhance guidance stabilization in spinal cord injury regeneration. J Mater Sci Mater Med 23:2821–2830 Pham QP, Sharma U, Mikos AG (2006) Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng 12:1197–1211 Pham DT, Dotchev KD, Yusoff WAY (2008) Deterioration of polyamide powder properties in the laser sintering process. Proceedings of The Institution of Mechanical Engineers, Part C. J Mech Eng Sci 222:2163–2176 Pitt CG, Gratzel MM, Kimmel GL (1981) Aliphatic polyesters. 2. The degradation of poly(DL-lactide), poly(ε-caprolactone) and their copolymers in vivo. Biomaterials 2:215–220 Potijanyakul P, Sattayasansakul W, Pongpanich S, Leepong N, Kintarak S (2010) Effects of enamel matrix derivative on bioactive glass in rat calvarium defects. J Oral Implantol 36:195–204 Puppi D, Chiellini F, Piras AM, Chiellini E (2010) Polymeric materials for bone and cartilage repair. Prog Polym Sci 35:403–440 Ramanath HS, Chua CK, Leong KF, Shah KD (2008) Melt flow behaviour of poly-ε-caprolactone in fused deposition modeling. J Mater Sci Mater Med 19:2541–2550 Ramay HR, Zhang MQ (2003) Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods. Biomaterials 24:3293–3302 Rattanakit P, Moulton SE, Santiago KS, Liawruangrath S, Wallace GG (2012) Extrusion printed polymer structures: a facile and versatile approach to tailored drug delivery platforms. Int J Pharm 422:254–263 Raucci MG, Guarino V, Ambrosio L (2010) Hybrid composite scaffolds prepared by sol–gel method for bone regeneration. Compos Sci Technol 70:1861–1868 Reed JS (1988) Principles of ceramic synthesis. Wiley, Chichester Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27:3413–3431 Rich J, Jaakkola T, Tirri T, Narhi T, Yli-Urpo A, Seppala J (2002) In vitro evaluation of poly(ε-caprolactone-co-d,l-lactide)/bioactive glass composites. Biomaterials 23:2143–2150 Roether JA, Gough JE, Boccaccini AR, Hench LL, Maquet V, Jerome R (2002) Novel bioresorbable and bioactive composites based on bioactive glass and polylactide foams for bone tissue engineering. J Mater Sci Mater Med 13:1207–1214 Roy TD, Simon JL, Ricci JL, Rekow ED, Thompson VP, Parsons JR (2003) Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques. J Biomed Mater Res Part A 67:1228–1237 Russell JL, Block JE (1999) Clinical utility of demineralized bone matrix for osseous defects, arthrodesis, and reconstruction: impact of processing techniques and study methodology. Orthopedics 22:524–531 Russias J, Saiz E, Deville S, Gryn K, Liu G, Nalla RK, Tomsia AP (2007) Fabrication and in vitro characterization of three-dimensional organic/inorganic scaffolds by robocasting. J Biomed Mater Res 83A:434–445 Santos CFL, Siilva AP, Lopes L, Pires I, Correia IJ (2012) Design and production of sintered β-tricalcium phosphate 3D scaffolds for bone tissue regeneration. Mater Sci Eng C 32:1293–1298 Schmidmaier G, Wildemann B, Bail H, Lucke M, Fuchs T, Stemberger A (2001a) Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-beta 1) from a biodegradable poly(d,l-lactide) coating of osteosynthetic implants accelerates fracture healing in rats. Bone 28:341–350 Schmidmaier G, Wildemann B, Stemberger A, Haas NP, Raschke M (2001b) Biodegradable poly(d, l-lactide) coating of implants for continuous release of growth factors. J Biomed Mater Res 58:449–455 Seck TM, Melchels FPW, Feijen J, Grijpma DW (2010) Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(d, l-lactide)-based resins. J Controlled Release 148:34–41 Seitz H, Rieder W, Irsen S, Leukers B, Tille C (2005) Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering. J Biomed Mater Res B Appl Biomater 74B:782–788 Seol YJ, Park DY, Park JY, Kim SW, Park SJ, Cho DW (2013) A new method of fabricating robust freeform 3D ceramic scaffolds for bone tissue regeneration. Biotechnol Bioeng 110:1444–1455 Seppala J, Korhonen H, Hakala R, Malin M (2011) Photocrosslinkable polyesters and poly(ester anhydride)s for biomedical applications. Macromol Biosci 11:1647–1652 Sepulveda P, Jones JR, Hench LL (2002) Bioactive sol–gel foams for tissue repair. J Biomed Mater Res 59:340–348 Serra T, Planell JA, Navarro M (2013) High-resolution PLA-based composite scaffolds via 3-D printing technology. Acta Biomater 9:5521–5530 Shanjani Y, Hu Y, Pilliar RM, Toyserkani E (2011) Mechanical characteristics of solid-freeform-fabricated porous calcium polyphosphate structures with oriented stacked layers. Acta Biomater 7:1788–1796 Sharaf B, Faris CB, Abukawa H, Susarla SM, Vacanti JP, Kaban LB, Troulis MJ (2012) Three-dimensionally printed polycaprolactone and β-tricalcium phosphate scaffolds for bone tissue engineering: an in vitro study. J Oral Maxillofac Surg 70:647–656 Sharifi S, Kamali M, Mohtaram NK, Shokrgozar MA, Rabiee SM, Atai M, Imani M, Mirzadeh H (2011) Preparation, mechanical properties, and in vitro biocompatibility of novel nanocomposites based on polyhexamethylene carbonate fumarate and nanohydroxyapatite. Polym Adv Technol 22:605–611 Sherwood JK, Riley SL, Palazzolo R, Brown SC, Monkhouse DC, Coates M, Griffith LG, Landeen LK, Ratcliffe A (2002) A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials 23:4739–4751 Shokrollahi P, Mirzadeh H, Scherman OA, Huck WTS (2010) Biological and mechanical properties of novel composites based on supramolecular polycaprolactone and functionalised hydroxyapatite. J Biomed Mater Res A 95A:209–221 Shor L, Guceri S, Wen X, Gandhi M, Sun W (2007) Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro. Biomaterials 28:5291–5297 Shor L, Guceri S, Chang R, Gordon J, Kang Q, Hartsock L, An Y, Sun W (2009) Precision extruding deposition (PED) fabrication of polycaprolactone (PCL) scaffolds for bone tissue engineering. Biofabrication 1:015003 Shuai C, Zhuang J, Hu H, Peng S, Liu D, Liu J (2013) In vitro bioactivity and degradability of β-tricalcium phosphate porous scaffold fabricated via selective laser sintering. Biotechnol Appl Biochem 00:1–8 Simon JL, Roy TD, Parsons JR, Rekow ED, Thompson VP, Kemnitzer J, Ricci JL (2003) Engineered cellular response to scaffold architecture in a rabbit trephine defect. J Biomed Mater Res Part A 66A:275–282 Smay JE, Cesarano J III, Lewis JA (2002) Colloidal inks for directed assembly of 3-D periodic structures. Langmuir 18:5429–5437 Sobral JM, Caridade SG, Sousa RA, Mano JF, Reis RL (2011) Three-dimentional plotted scaffolds with controlled pore size gradients: effect of scaffold geometry on mechnical performance and cell seeding efficiency. Acta Biomater 7:1009–1018 Stamboulis AG, Boccaaccini AR, Hench LL (2002) Novel biodegradable polymer/bioactive glass composites for tissue engineering applications. Adv Eng Mater 4:105–109 Sudarmadji N, Tan JY, Leong KF, Chua CK, Loh YT (2011) Investigation of the mechanical properties and porosity relationships in selective laser-sintered polyhedral for functionally graded scaffolds. Acta Biomater 7:530–537 Sun J-Y, Yang Y-S, Zhong J, Greenspan DC (2007) The effect of the ionic products of Bioglass® dissolution on human osteoblasts growth cycle in vitro. J Tissue Eng Regener Med 1:281–286 Suuronen R, Pohjonen T, Hietanen J, Lindquist C (1998) A 5-year in vitro and in vivo study of the biodegradation of polylactide plates. J Oral Maxillofac Surg 56:604–614 Tam J, Rozema FR, Bos RRM, Roodenburg JLN, Nikkels PGJ, Vermey A (1996) Poly(L-lactide) bone plates and screws for internal fixation of mandibular swing osteotomies. Int J Oral Maxillofac Surg 25:20–24 Tatakis DN, Trombelli L (1999) Adverse effects associated with a bioabsorbable guided tissue regeneration device in the treatment of human gingival recession defects: a clinicopathologic case report. J Periodontol 70:542–547 Tellis BC, Szivek JA, Bliss CL, Margolis DS, Vaidyanathan RK, Calvert P (2008) Trabecular scaffolds created using micro CT guided fused deposition modeling. Mater Sci Eng C 28:171–178 Tesavibul P, Felzmann R, Bruber S, Liska R, Thompson I, Boccaaccini AR, Stampfl J (2012) Processing of 45S5 Bioglass® by lithography-based additive manufacturing. Mater Lett 74:81–84 Thein-Han WW, Misra RDK (2009) Biomimetic chitosan–nanohydroxyapatite composite scaffolds for bone tissue engineering. Acta Biomater 5:1182–1197 Tian H, Tang Z, Zhuang X, Chen X, Jing X (2012) Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 37:237–280 Tirella A, Vozzi F, Vozzi G, Ahluwalia A (2011) PAM2 (Piston Assisted Microsyringe): a new rapid prototyping technique for biofabrication of cell incorporated scaffolds. Tissue Eng Part C 17:229–237 Tulliani J-M, Lombardi M, Palmero P, Fornabaio M, Gibson LJ (2013) Development and mechanical characterization of novel ceramic foams fabricated by gel-casting. J Eur Ceram Soc 33:1567–1576 Verma S, Bhatia Y, Valappil SP, Roy I (2002) A possible role of poly-3-hydroxybutyric acid in antibiotic production in streptomyces. Arch Microbiol 179:66–69 Verrier S, Blaker JJ, Maquet V, Hench LL, Boccaaccini AR (2004) PDLLA/Bioglass® composites for soft-tissue and hard-tissue engineering: an in vitro cell biology assessment. Biomaterials 25:3013–3021 Vozzi G, Ahluwalia A (2007) Microfabrication for tissue engineering: rethinking the cells-on-a scaffold approach. J Mater Chem 17:1248–1254 Vozzi G, Previti A, Rossi DD, Ahluwalia A (2002) Microsyringe-based deposition of two-dimensional and three-dimensional polymer scaffolds with a well-defined geometry for application to tissue engineering. Tissue Eng 8:1089–1098 Vozzi G, Flaim C, Ahluwalia A, Bthatia S (2003) Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials 24:2533–2540 Vozzi G, Corallo C, Daraio C (2013) Pressure-activated microsyringe composite scaffold of poly(l-lactic acid) and carbon nanotubes for bone tissue engineering. J Appl Polym Sci 129:528–536 Wang Y, Ameer GA, Sheppard BJ, Langer R (2002) A tough biodegradable elastomer. Nat Biotechnol 20:602–606 Wang F, Shor L, Darling A, Khalil S, Sun W, Güçeri S, Lau A (2004) Precision extruding deposition and characterization of cellular poly-ε-caprolactone tissue scaffolds. Rapid Prototyp J 10:42–49 Warnke PH, Seitz H, Warnke F, Becker ST, Sivananthan S, Sherry E, Liu Q, Wiltfang J, Douglas T (2010) Ceramic scaffolds produced by computer-assisted 3D printing and sintering: characterization and biocompatibility investigations. J Biomed Mater Res B Appl Biomater 93B:212–217 Weiss T, Hildebrand G, Schade R, Liefeith K (2009) Two-photon polymerization for microfabrication of three-dimensional scaffolds for tissue engineering application. Eng Life Sci 9:384–390 Weiss T, Schade R, Laube T, Berg A, Hildebrand G, Wyrwa R, Schnabelrauch M, Liefeith K (2011) Two-photon polymerization of biocompatible photopolymers for microstructured 3D biointerfaces. Adv Eng Mater 13:B264–B273 Williams JM, Adewunmi A, Schek RM, Flanagan CL, Krebsbach PH, Feinberg SE, Hollister SJ, Das S (2005) Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials 26:4817–4827 Winkel A, Meszaros R, Reinsch S, Muller R, Travizky N, Fey T, Greil P, Wondraczek L (2012) Sintering of 3D-printed glass/HAp composites. J Am Ceram Soc 95:3387–3393 Wiria FE, Leong KF, Chua CK, Liu Y (2007) Poly-ε-caprolactone/hydroxyapatite for tissue engineering scaffold fabrication via selective laser sintering. Acta Biomater 3:1–12 Wojtowicz AM, Shekaran A, Oest ME, Dupont KM, Templeman KL, Hutmacher DW, Guldberg RE, Garcıa AJ (2010) Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. Biomaterials 31:2574–2582 Woodruff MA, Hutmacher DW (2010) The return of a forgotten polymer-polycaprolactone in the 21st century. Prog Polym Sci 35:1217–1256 Wu ZY, Hill RG, Yue S, Nightingale D, Lee PD, Jones JR (2011) Melt-derived bioactive glass scaffolds produced by a gel-cast foaming technique. Acta Biomater 7:1807–1816 Xiong Z, Yan Y, Wang S, Zhang R, Zhang C (2002) Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition. Scripta Mater 46:771–776 Xynos ID, Edgar AJ, Buttery LDK, Hench LL, Polak M (2001) Gene expression profiling of human osteoblasts following treatment with the ionic products of Bioglass® 45S5 dissolution. J Biomed Mater Res 55:151–157 Yan Y, Xiong Z, Hu Y, Wang S, Zhang R, Zhang C (2003) Layered manufacturing of tissue engineering scaffolds via multi-nozzle deposition. Mater Lett 57:2623–2628 Yen H-J, Tseng C-S, Hsu S-H, Tsai C-L (2009) Evaluation of chondrocyte growth in the highly porous scaffolds made by fused deposition manufacturing (FDM) filled with type II collagen. Biomed Microdev 11:615–624 Yeong W-Y, Chua C-K, Leong K-F, Chandrasekaran M (2004) Rapid prototyping in tissue engineering: challenges and potential. Trends Biotechnol 22:643–652 Yeong WY, Sudarmadji N, Yu HY, Chua CK, Leong KF, Venkatraman SS, Boey YCF, Tan LP (2010) Porous polycaprolactone scaffold for cardiac tissue engineering fabricated by selective laser sintering. Acta Biomater 6:2028–2034 Yin Y, Ye F, Cui J, Zhang F, Li X, Yao K (2003) Preparation and characterization of macroporous chitosan–gelatin/β-tricalcium phosphate composite scaffolds for bone tissue engineering. J Biomed Mater Res Part A 67A:844–855 Zein I, Hutmacher DW, Tan KC, Teoh SH (2002) Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 23:1169–1185 Zhang K, Wang Y, Hillmyer MA, Francis LF (2004) Processing and properties of porous poly(L-lactide)/bioactive glass composites. Biomaterials 25:2489–2500 Zhang Y, Hao L, Savalani MM, Harris RA, Silvio LD, Tanner KE (2008) In vitro biocompatibility of hydroxyapatite-reinforced polymeric composites manufactured by selective laser sintering. J Biomed Mater Res 91A:1018–1027 Zhou Y, Hutmacher DW, Varawan S-L, Lim TM (2007a) In vitro bone engineering based on polycaprolactone and polycaprolactone–tricalcium phosphate composites. Polym Int 56:333–342 Zhou Y, Chen F, Ho ST, Woodruff MA, Lim TM, Hutmacher DW (2007b) Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts. Biomaterials 28:814–824